@CarlSmytheCells @CaryDavid722 @BeckyJohnson222 @adiosmuchachos4 @mass_rising @davideyoungmd @iXeno @hotmessmouse @dirk_fasshauer @AstroTurfTears @DopplerEffect93 @tenebra99 @webb0412 @BurgerLab12 @TheDrJon @ErinHNN @BGLTHMND @epigeneticallyj @cappsie @higgsri @jtmayes3 @Scary7Dr @Earthdriver @ChrisJohnsonMD @SkepticalMutant @PatrickSquirrel @exohalophiles @DemsRRacePimps @BlueLionBlog @FillmoreWhite @crabb_vicki @Alex_on_A14 @AndrewLazarus4 @ncdave4life @TMGFlorida @Roper_Lab @trillionofcells @ktibus @SecedeFromFools @TorySnyc @RonMortimer3 @lasikeyecenter1 @Hanky1844607 @Awithonelison @NoGlobalist778 @EugeneBu @AcampbelTeacher @EdwardDS15 @VickiCoyle10019 A brief explanation of mechanisms which remove substances from the brain. https://t.co/FuQGJ6DyaD
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier.
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Jun 2021 – Jan 2025Where it's discussed
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What people are saying
The discussions largely appreciate the detailed explanation of how substances are cleared from the brain, with comments praising the description of the glymphatic system and the role of different transport pathways. The tone suggests curiosity and recognition of the importance of these mechanisms in neuroscience research, with examples like references to 'brain cleaning' and 'removal of water-soluble substances' illustrating engagement with the article's complex content.
Most discussions acknowledge the significance of the article, with many emphasizing the importance of understanding brain clearance pathways, though some remain cautiously optimistic.
The topic of brain clearance mechanisms clearly elicits high interest, as evidenced by numerous mentions of the glymphatic system and its implications.
Participants frequently reference specific mechanisms like perivascular pathways and transporters, showing active engagement with the scientific content.
While some discussions highlight potential relevance for neurological diseases, overall perceived impact is moderate, reflecting ongoing debates and curiosity.
Abstract in brief
- This review discusses how substances are cleared from the brain through perivascular pathways and the blood-brain barrier, with total clearance measured as the sum of all routes, including those pathways that help wash out water-soluble substances.
- Evidence from experiments using labeled tracers like sucrose and albumin shows that perivascular clearance plays a role, especially for substances not eliminated across the blood-brain barrier, with different clearance rates depending on the substance's properties and transport mechanisms.
- Although small molecules like inulin and water cross the blood-brain barrier via passive diffusion with low clearance rates, specific transporters facilitate the removal of compounds like glucose and lactate, while ions such as Na and Cl mainly move through tight junctions, indicating complex processes involved in maintaining brain chemical balance.]
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Most liked on X and BlueskyElimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier https://t.co/oVY3HgiZhD #GlymphaticSystem
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@CarlSmytheCells @CaryDavid722 @BeckyJohnson222 @adiosmuchachos4 @mass_rising @davideyoungmd @iXeno @hotmessmouse @dirk_fasshauer @AstroTurfTears @DopplerEffect93 @tenebra99 @webb0412 @BurgerLab12 @TheDrJon @ErinHNN @BGLTHMND @epigeneticallyj @cappsie @higgsri @jtmayes3 @Scary7Dr @Earthdriver @ChrisJohnsonMD @SkepticalMutant @PatrickSquirrel @exohalophiles @DemsRRacePimps @BlueLionBlog @FillmoreWhite @crabb_vicki @Alex_on_A14 @AndrewLazarus4 @ncdave4life @TMGFlorida @Roper_Lab @trillionofcells @ktibus @SecedeFromFools @TorySnyc @RonMortimer3 @lasikeyecenter1 @Hanky1844607 @Awithonelison @NoGlobalist778 @EugeneBu @AcampbelTeacher @EdwardDS15 @VickiCoyle10019 A brief explanation of mechanisms which remove substances from the brain. https://t.co/FuQGJ6DyaD
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier https://t.co/oVY3HgiZhD #GlymphaticSystem