Circ Res September 2018 PMID 30355082

Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Alice E Kane, David A Sinclair

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Mentions

Peak: 3 in Dec 2019

across 4 sources since Dec 2019

Extended reach

136,935

potential audience

Total likes

6,728

Video views

126,762

Mentions per month

Dec 2019 – Aug 2022

Where it's discussed

X / Twitter6 posts
Facebook3 posts
YouTube2 videos
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AI synopsis

What people are saying

The discussions show a high level of interest, with several posts mentioning specific compounds like Tru Niagen being FDA approved, and referencing world-renowned research institutions or experts, implying a meaningful engagement with both the scientific and clinical relevance of the article; words like 'interesting' and mentions of ongoing trials underscore curiosity and the potential significance of this research.

AgreementModerate agreement

Most discussions recognize the importance of NAD+ and sirtuins in metabolic and cardiovascular health, though some express skepticism or seek clarification.

InterestHigh interest

Posts demonstrate high curiosity, referencing clinical trials, specific compounds like Tru Niagen, and related research, indicating strong engagement with the topic.

EngagementModerate engagement

Participants include notable researchers and institutions, and some posts cite detailed studies or approval statuses, reflecting a genuine interest and effort to understand implications.

ImpactModerate impact

While some posts highlight potential benefits and ongoing trials, the overall perception is that this research has promising but not yet definitive widespread impact.

Abstract in brief

Sirtuins are enzymes that depend on NAD+ and play a key role in protecting against age-related metabolic and cardiovascular diseases, with SIRT1 and SIRT3 specifically helping to prevent issues like obesity, vascular decline, and ischemia.
As people age, NAD+ levels and sirtuin activity decline, a process worsened by obesity and inactive lifestyles; boosting sirtuins or NAD+ can promote health benefits such as improved blood flow and insulin sensitivity.
Current human clinical trials are exploring agents that activate SIRT1 or increase NAD+ levels, showing promising potential to improve outcomes for patients with metabolic and cardiovascular conditions.

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All mentions

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The Quiet Rebel · Dec 5, 2020 12,240 views

DAVID John GRIFFITHS

@Griff9John · X

@PlanetEarth_HD @DanDraitser @j_b_kennedy @organichemusic https://t.co/qJRfJIptPc

Aug 11, 2022 · 1 like · 121 followers View post →

Steve Stonebraker

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Mar 19, 2022 · 168 followers View post →

peter mossop

@mostol1 · X

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases | Circulation Research https://t.co/NtZpCozmtN

Sep 6, 2021 · 354 followers View post →

David Wyant

@wyadvd · X

https://t.co/pNkVykfYSe

Dec 27, 2019 · 1 like · 2,691 followers View post →

David Wyant

@wyadvd · X

RT @janvyjidak: @wyadvd @EricTopol @NEJM @HopkinsMedicine @davidasinclair @RayCronise @drjkahn @foundmyfitness @BuckInstitute interesting…

Dec 27, 2019 · 1 share · 2,691 followers View post →

Jan Vyjidak

@janvyjidak · X

Dec 26, 2019 · 2 likes · 1 share · 4,144 followers View post →