Publications by authors named "David A Sinclair"

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Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation.
Lynn-Jee Kim, Timothy J Chalmers, Romanthi Madawala, Greg C Smith, Catherine Li, Abhirup Das, Eric Wing Keung Poon, Jun Wang, Simon P Tucker, David A Sinclair

FEBS Lett· September 2023

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Human age reversal: Fact or fiction?
Adiv A Johnson, Bradley W English, Maxim N Shokhirev, David A Sinclair, Trinna L Cuellar

Aging Cell· August 2022

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The economic value of targeting aging.
Andrew J Scott, Martin Ellison, David A Sinclair

Nat Aging· July 2021

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Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.
Devin Wahl, Samantha M Solon-Biet, Qiao-Ping Wang, Jibran A Wali, Tamara Pulpitel, Ximonie Clark, David Raubenheimer, Alistair M Senior, David A Sinclair, Gregory J Cooney

November 2018

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Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Alice E Kane, David A Sinclair

Circ Res· September 2018

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Luis Rajman, Karolina Chwalek, David A Sinclair

Cell Metab· March 2018

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Slowing ageing by design: the rise of NAD and sirtuin-activating compounds.
Michael S Bonkowski, David A Sinclair

November 2016

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The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
Samantha M Solon-Biet, Aisling C McMahon, J William O Ballard, Kari Ruohonen, Lindsay E Wu, Victoria C Cogger, Alessandra Warren, Xin Huang, Nicolas Pichaud, Richard G Melvin

March 2014

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Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A Baur, David A Sinclair

Nat Rev Drug Discov· June 2006

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Multiomic clocks to predict phenotypic age in mice.
Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, David A Sinclair

J Gerontol A Biol Sci Med Sci· October 2025

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Associations Between Frailty and Cognitive Outcomes Across the Lifespan of Mice.
Sydney Bartman, Lauren Gaspar, Alice Kane, Emily Potts, David A Sinclair

bioRxiv· October 2025

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DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model.
Sydney Bartman, Dakota Hunter, Lauren Gaspar, Hannah Tobias-Wallingford, Danielo Zamor, David A Sinclair

bioRxiv· October 2025

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Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice.
Laena Pernomian, Emily W Waigi, Vi Nguyen, Ahmed D Mohammed, Tiago J Costa, David A Sinclair

Circ Res· September 2025

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Emerging strategies, applications and challenges of targeting NAD in the clinic.
Jianying Zhang, He-Ling Wang, Sofie Lautrup, Hilde Loge Nilsen, Jonas T Treebak, David A Sinclair

Nat Aging· September 2025

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Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
Yuancheng Ryan Lu, James C Cameron, Yan Hu, Han Shen, Shintaro Shirahama, David A Sinclair

bioRxiv· September 2025

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A bile acid could explain how calorie restriction slows ageing.
David A Sinclair

Nature· July 2025

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Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
Dantong Zhu, Judy Z Wu, Patrick T Griffin, Brady A Samuelson, David A Sinclair

NPJ Aging· May 2025

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Multiomic clocks to predict phenotypic age in mice.
Daniel L Vera, Patrick T Griffin, David Leigh, Jason Kras, Enrique Ramos, David A Sinclair

bioRxiv· May 2025

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Invigorating discovery and clinical translation of aging biomarkers.
Erik Jacques, Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, David A Sinclair

Nat Aging· April 2025

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Cellular rejuvenation protects neurons from inflammation-mediated cell death.
Sienna S Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, David A Sinclair

Cell Rep· February 2025

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Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.
Dantong Zhu, Judy Z Wu, Patrick Griffin, Brady A Samuelson, David A Sinclair

bioRxiv· January 2025

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Fertility protection during chemotherapy treatment by boosting the NAD(P) metabolome.
Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, David A Sinclair

EMBO Mol Med· October 2024

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Sex dimorphism and tissue specificity of gene expression changes in aging mice.
Dantong Zhu, Matt Arnold, Brady A Samuelson, Judy Z Wu, Amber Mueller, David A Sinclair

Biol Sex Differ· October 2024

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Correction: The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth.
Ron Firestein, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, David A Sinclair

PLoS One· June 2024

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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Alice E Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew Arnold, Jien Li, David A Sinclair

bioRxiv· June 2024

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A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice.
Laena Pernomian, Emily W Waigi, Vi Nguyen, Ahmed D Mohammed, Tiago J da Costa, David A Sinclair

bioRxiv· May 2024

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Publisher Correction: Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.
Andrea Cipriano, Mahdi Moqri, Sun Y Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, David A Sinclair

Nat Aging· February 2024

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Human trials exploring anti-aging medicines.
Leonard Guarente, David A Sinclair, Guido Kroemer

Cell Metab· February 2024

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TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.
Patrick T Griffin, Alice E Kane, Alexandre Trapp, Jien Li, Matthew Arnold, David A Sinclair

Nat Aging· February 2024

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Response to: The information theory of aging has not been tested.
Jae-Hyun Yang, Motoshi Hayano, Luis A Rajman, David A Sinclair

Cell· February 2024

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Loss of epigenetic information as a cause of mammalian aging.
Jae-Hyun Yang, Motoshi Hayano, Patrick T Griffin, João A Amorim, Michael S Bonkowski, David A Sinclair

Cell· February 2024

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Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.
Andrea Cipriano, Mahdi Moqri, Sun Y Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, David A Sinclair

Nat Aging· January 2024

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The Information Theory of Aging.
Yuancheng Ryan Lu, Xiao Tian, David A Sinclair

Nat Aging· December 2023

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