The discussions highlight excitement about discovering how NMN interacts with gut bacteria, as seen in phrases like 'unveils the mysteries' and mentions of 'transformative potential' of microbiome research. The tone and choice of words convey both interest and a recognition of the research's relevance to aging and health.
AgreementModerate agreement
Most discussions acknowledge the importance of the study in understanding NMN metabolism and host-microbiome interactions, showing general support for its findings.
InterestHigh interest
Posts express high interest, especially with mentions of breakthroughs in NAD metabolism and potential implications for aging, indicating curiosity and enthusiasm.
EngagementModerate engagement
The discussions include references to the research process and its broader implications, such as the tease about the 'mysteries' of NMN, reflecting active engagement.
ImpactModerate impact
While the posts recognize the significance of the findings, the overall impact is viewed as promising but preliminary, with some emphasizing the need for further research.
Abstract in brief
The study explores how orally administered NMN, a precursor to NAD used for potential anti-aging therapies, interacts with the gut microbiome, which can alter its metabolic fate.
It was found that NMN can be deamidated by gut bacteria and incorporated into mammalian tissues via the de novo pathway, but this process is reduced when antibiotics are used to eliminate gut bacteria.
The research suggests that the microbiome may compete with the host for dietary NAD precursors, as antibiotics increased NAD metabolite availability, highlighting complex host-microbiome interactions influencing NMN's effectiveness.]
Pleased to share our latest paper, showing that orally delivered NMN can undergo deamidation and incorporation via the de novo pathway due to actions from the gut microbiome.
https://t.co/QurJKL95dq
Aug 10, 2023 · 4 likes · 1 share · 2,351 followersView post →
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ModernHealthspan
@MHealthspan · X
Thanks to @LindsayWu_UNSW for coming on Modern Healthspan. Had a great conversation about the mysteries NAD metabolism and how the impact of the gut microbiome. https://t.co/WVWpCvV357 https://t.co/lOKmXraAie
Dr Wu discusses a study on how the microbiome influences NMN metabolism, highlighting the impact of gut bacteria on NAD precursor pathways and potential anti-aging effects.
This video discusses how orally administered NMN interacts with the gut microbiome, affecting its metabolic fate. It highlights how antibiotics influence NAD metabolite availability, revealing complex host-microbiome…
Dr Wu discusses the balance of rapamycin and protein intake for muscle building and longevity, highlighting the role of the gut microbiome in NAD precursor metabolism and its impact on anti-aging strategies.
Let's talk about mitochondria. Dysfunction of mitochondria leads to various chronic diseases, including cancer, by disrupting energy production and cell regulation.
Jan 18, 2024 · 3 shares · 5,572 followersView post →
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ModernHealthspan
@MHealthspan · X
Thanks to @LindsayWu_UNSW for coming on Modern Healthspan. Had a great conversation about the mysteries NAD metabolism and how the impact of the gut microbiome. https://t.co/WVWpCvV357 https://t.co/lOKmXraAie
RT @LindsayWu_UNSW: Pleased to share our latest paper, showing that orally delivered NMN can undergo deamidation and incorporation via the…
Aug 10, 2023 · 1 share · 2,082 followersView post →
LW
Lindsay Wu
@LindsayWu_UNSW · X
Pleased to share our latest paper, showing that orally delivered NMN can undergo deamidation and incorporation via the de novo pathway due to actions from the gut microbiome.
https://t.co/QurJKL95dq
Aug 10, 2023 · 4 likes · 1 share · 2,351 followersView post →
Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation. Kim LJ, Chalmers TJ, Madawala R, Smith GC, Li C, Das A, Poon EWK, Wang J ...
Understanding the role of somatic-germline interactions ... Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation', FEBS Letters, 597, pp.
NRH, a potent NAD+ enhancer, improves glucose homeostasis and ...
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19. Kim, L.J. ∙ Chalmers, T.J. ∙ Madawala, R. ... Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation. FEBS Lett. 2023; 597:2196 ...
β-Nicotinamide Mononucleotide, an Anti-Aging Candidate ...
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Of those, β-nicotinamide mononucleotide (β-NMN) has been focused on. ... Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation.
Host–microbiome interactions in nicotinamide mononucleotide ...
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Microbial deamidation of nicotinamide mononucleotide (NMN). L.-J. Kim et al. Page 10. amidase activity, given the magnitude of the impact of antibiotics ...
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