PubHawk
November 2018 PMID 30463018

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Devin Wahl, Samantha M Solon-Biet, Qiao-Ping Wang, Jibran A Wali, Tamara Pulpitel, Ximonie Clark, David Raubenheimer, Alistair M Senior, David A Sinclair, Gregory J Cooney, Rafael de Cabo, Victoria C Cogger, Stephen J Simpson, David G Le Couteur

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Mentions

84
Peak: 2 in Jul 2021
across 6 sources since Dec 2019

Extended reach

16,325
potential audience

Total likes

224

Video views

10,617

Mentions per month

Dec 2019 – Jul 2024

Where it's discussed

  • News50 articles
  • Facebook10 posts
  • X / Twitter8 posts
  • Blogs8 articles
  • Reddit6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions primarily focus on methodological aspects such as the inclusion of RRIDs, indicating a respect for scientific rigor and reproducibility, with comments like 'RRIDs improve reproducibility.' The tone is informational, emphasizing research integrity rather than expressing strong opinions on dietary impacts, which explains the moderate scores across all dimensions.

AgreementModerate agreement

Most discussions support the idea that the research offers valuable insights into diet and brain aging, with some emphasizing the importance of reproducibility and scientific rigor.

InterestModerate interest

Participants show a moderate interest, highlighting the significance of the research methods and potential implications, but with limited enthusiasm for broader dietary recommendations.

EngagementNeutral engagement

There is some engagement regarding methodological details like RRIDs and reproducibility, but fewer conversations delve into the scientific mechanisms or applications.

ImpactModerate impact

The discussions reflect recognition of the study's contribution to scientific understanding, especially in emphasizing reproducibility and cellular-level research, though without extensive calls for action.

Abstract in brief

  • Calorie restriction (CR) in mice was found to increase lifespan and enhance brain health, similar to ad libitum low-protein, high-carbohydrate (LPHC) diets.
  • RNA expression patterns and nutrient-sensing proteins in the hippocampus showed similar responses between CR and LPHC diets, indicating potential shared mechanisms for longevity.
  • Both CR and LPHC diets improved structural features in neurons and memory performance in tasks like the Barnes maze and novel object recognition, suggesting LPHC diets could mimic some benefits of CR on brain aging.
Read the full abstract

Top posts

Most liked on X and Bluesky
OpenSci Talk
@OpenSciTalk · X

RT @RobotRrid: The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper…

Jul 30, 2021 · 1 share · 4,097 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice https://t.co/EBElooY05k Visit https://t.co/X6HUOniPOB to find more ideas related to ageing, cognition, learning, memory, lifespan extension and so on

Dec 9, 2019 · 875 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF). We appreciate the author's support of reproducibility. #OpenScience #accelerateopenscience

Sep 3, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #STMpublishing

Aug 29, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF). Thank you for making your #methodsmatter. #reproducibility

Aug 11, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #RRID #OpenScience

Jul 30, 2021 · 1 share · 161 followers View post →

All mentions

Adam
@adam_cole_dev · X

@usermadridista @TheJackBly https://t.co/dzvRpRQ0RN You should look into more of David Sinclair's work. He researches at the cellular level so his discoveries are explained by specific systems that happen at the microscopic level rather than vague sweeping statements about what foods you should eat.

Nov 17, 2022 · 13 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF). We appreciate the author's support of reproducibility. #OpenScience #accelerateopenscience

Sep 3, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #STMpublishing

Aug 29, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Reports paper "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF). Thank you for making your #methodsmatter. #reproducibility

Aug 11, 2021 · 161 followers View post →
OpenSci Talk
@OpenSciTalk · X

RT @RobotRrid: The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper…

Jul 30, 2021 · 1 share · 4,097 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Comparing the Effects of Low-Protein and High-Carb…" (https://t.co/yc0B1urELF) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #RRID #OpenScience

Jul 30, 2021 · 1 share · 161 followers View post →
Neil is where?
@Neil_is_where · X

@mkaeberlein Cell Rep, 2018 vol. 25(8) pp. 2234-2243.e6 Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice Wahl, D; Solon-Biet, SM; Wang, QP; Wali, JA; Pulpitel, T; Clark, X; Raubenheimer, D; Senior, AM; Sinclair, DA; Cooney, GJ; d

Feb 1, 2021 · 76 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice https://t.co/EBElooY05k Visit https://t.co/X6HUOniPOB to find more ideas related to ageing, cognition, learning, memory, lifespan extension and so on

Dec 9, 2019 · 875 followers View post →