Transl Psychiatry November 2018 PMID 30397195

Methylenetetrahydrofolate reductase and psychiatric diseases.

Lin Wan, Yuhong Li, Zhengrong Zhang, Zuoli Sun, Yi He, Rena Li

Mentions

61
Peak: 25 in Feb 2024
across 5 sources since May 2019

Extended reach

111,516
potential audience

Total likes

2,481

Video views

97,673

Mentions per month

May 2019 – Dec 2025

Where it's discussed

  • Reddit43 posts
  • Facebook10 posts
  • X / Twitter5 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

Discussions frequently reflect interest in the genetic mechanisms linking MTHFR to mental health disorders, with posts using phrases like 'genetic variations' and 'DNA methylation' to emphasize scientific depth. The tone is generally analytical, with some posts suggesting promising treatments like folate supplements, which indicates moderate engagement and perceived impact.

AgreementModerate agreement

Most discussions seem to support the idea that MTHFR has relevance to psychiatric disorders, with some posts emphasizing genetic links and potential treatment avenues.

InterestHigh interest

The discussions indicate a high level of curiosity about the connection between genetics and mental health, with many posts exploring implications and research findings.

EngagementModerate engagement

Participants reference specific studies and potential therapeutic implications, showing moderate depth in engagement.

ImpactModerate impact

While some discussions highlight potential clinical impacts, others are more speculative, so the perceived overall influence is moderate.

Abstract in brief

  • MTHFR is an important enzyme involved in processing folate and homocysteine, and its genetic variations can reduce enzyme activity, affecting DNA methylation, which is linked to mental health issues.
  • It is unclear if MTHFR polymorphisms directly cause certain psychiatric symptoms or if they increase the risk for specific disorders like schizophrenia, depression, autism, or bipolar disorder.
  • The review explores recent research on MTHFR genetic differences, their impact on mental health, and whether folate supplements could help treat psychiatric conditions related to MTHFR defects.

Top posts

Most liked on X and Bluesky
G
@softandsupples · X

Methylenetetrahydrofolate reductase and psychiatric diseases https://t.co/wv3OP1l7d3

Dec 6, 2020 · 1 like · 351 followers View post →
PF Anderson @pfanderson@disabled.social
@pfanderson · X

Methylenetetrahydrofolate reductase and psychiatric diseases. https://t.co/AQzHONNm1H #mthfr

May 10, 2019 · 10,753 followers View post →
にゃあ
@kirikami · X

RT @uranus_2: 様々な精神障害におけるメチレンテトラヒドロ葉酸還元酵素(MTHFR)遺伝子多型とDNAメチル化との関連、特定の精神障害におけるMTHFR活性と葉酸関連機能との関連。レビュー。Methylenetetrahydrofolate reductase an…

May 14, 2019 · 2 shares · 1,860 followers View post →
yuna
@YunaOikawa1 · X

Wan, L., Li, Y., Zhang, Z. et al. Methylenetetrahydrofolate reductase and psychiatric diseases. Transl Psychiatry 8, 242 (2018). https://t.co/ZIrXiXzFMg https://t.co/LJ35B1p0Pt

Feb 17, 2025 · 231 followers View post →

All mentions

yuna
@YunaOikawa1 · X

Wan, L., Li, Y., Zhang, Z. et al. Methylenetetrahydrofolate reductase and psychiatric diseases. Transl Psychiatry 8, 242 (2018). https://t.co/ZIrXiXzFMg https://t.co/LJ35B1p0Pt

Feb 17, 2025 · 231 followers View post →
G
@softandsupples · X

Methylenetetrahydrofolate reductase and psychiatric diseases https://t.co/wv3OP1l7d3

Dec 6, 2020 · 1 like · 351 followers View post →
Carolyn
@CFitzenreiter · X

Methylenetetrahydrofolate reductase and psychiatric diseases https://t.co/ApFrzjIt98

Apr 26, 2020 · 105 followers View post →
にゃあ
@kirikami · X

RT @uranus_2: 様々な精神障害におけるメチレンテトラヒドロ葉酸還元酵素(MTHFR)遺伝子多型とDNAメチル化との関連、特定の精神障害におけるMTHFR活性と葉酸関連機能との関連。レビュー。Methylenetetrahydrofolate reductase an…

May 14, 2019 · 2 shares · 1,860 followers View post →
PF Anderson @pfanderson@disabled.social
@pfanderson · X

Methylenetetrahydrofolate reductase and psychiatric diseases. https://t.co/AQzHONNm1H #mthfr

May 10, 2019 · 10,753 followers View post →
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