FOURIER
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
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Nov 2018 – Nov 2025Where it's discussed
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News88 articles
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X / Twitter74 posts
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Facebook22 posts
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Blogs8 articles
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YouTube6 videos
AI synopsis
What people are saying
In the discussions, many users mention the implications of the ODYSSEY trial, emphasizing phrases like 'groundbreaking' and 'significant reduction' to underscore the importance of the findings. Users also engage with deeper statistical analyses, such as discussing the NNT (number needed to treat) for preventing cardiovascular events, demonstrating both interest and methodical engagement with the content. This choice of language, coupled with a semi-technical tone, reflects a blend of professional interest and general enthusiasm toward the research outcomes.
The posts generally reflect a positive view towards the findings reported in the publication, with many quoting and supporting the conclusions drawn from the study.
There is a strong curiosity among users, as noted by frequent references to related trials and ongoing discussions about the medication.
While there is some deep engagement, particularly with users referencing study designs and statistical analysis, other posts show a more casual interaction with the content.
Many discussions highlight the potential significant impact of alirocumab on cardiovascular health, citing its effect on serious cardiovascular events and suggesting changes in treatment protocols.
Abstract in brief
- The study investigated if alirocumab, a monoclonal antibody aimed at lowering LDL cholesterol, could enhance cardiovascular outcomes in patients recovering from acute coronary syndrome while on high-intensity statin therapy.
- A large-scale, randomized trial included 18,924 patients and compared the effects of alirocumab versus placebo over a median follow-up of 2.8 years, targeting low LDL cholesterol levels.
- Results showed that patients receiving alirocumab had a lower occurrence of serious cardiovascular events (9.5% vs. 11.1% in the placebo group), indicating a significant reduction in risk and associated mortality benefits.
Top posts
Most liked on X and BlueskyAlirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome https://t.co/QBqfgUU3p9 via @YouTube
@sciencescanner I’ll dig in but honestly a little skeptical of these sorts of post-hoc exercises. It also defies all other data showing robust benefits of PCSK9I either genetically or pharmacologically including most importantly this: https://t.co/HHlx3ga0RZ
@SBakerMD Does it make sense to want to reduce heart attacks or all-cause death? https://t.co/xtHCai9YcU https://t.co/BP6uT9Wo8U
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome P... https://t.co/9BdRvCYGGr via @YouTube @mjack2050
21) Check out the great video summary at https://t.co/6GfIN8ASuL https://t.co/BaYMYrhbvm
All mentions
Impact of Cholesterol Medications on Brain Health and Cardiac Outcomes
Does low cholesterol harm the brain? This video explores the effects of statins and other cholesterol-lowering drugs on dementia risk, alongside insights from a study on alirocumab's benefits for cardiovascular outcomes…
Key Cardiological Trials Impacting 2018 Outcomes
This video reviews the top 10 cardiology trials of 2018, highlighting significant studies including those on PCI strategies in cardiogenic shock and the effects of various treatments on cardiovascular outcomes. Discover…
Advances in Stroke Prevention for Atrial Fibrillation Patients
This video discusses recent research on left atrial appendage closure as a safe and effective alternative to anticoagulation in high-risk atrial fibrillation patients. It highlights reduced bleeding complications and…
Cardiovascular Outcomes with Alirocumab Post-Acute Syndrome
This week’s Café com Journal updates recent cardiology publications. We discuss the JAMA study on alirocumab's effects on cardiovascular outcomes after acute coronary syndrome, revealing a significant reduction in…
Analyzing Troponin I Levels and Mortality Risks After Cardiac Surgery
This week, we delve into the critical findings regarding cardiac troponin I levels. A recent study reveals a significant correlation between elevated troponin levels post-surgery and increased 30-day mortality…
Impact of Inclisiran and Alirocumab on Cardiovascular Health
This video discusses causes of sudden death, inclisiran, and cardiovascular outcomes associated with alirocumab for patients recovering from acute coronary syndrome. Learn how these treatments can significantly reduce…
RT @cardiomet_CE: 9c) #ODYSSEY OUTCOMES demonstrated that the monoclonal antibody #PCSK9 inhibitor #alirocumab significantly reduced ischem…
9c) #ODYSSEY OUTCOMES demonstrated that the monoclonal antibody #PCSK9 inhibitor #alirocumab significantly reduced ischemic events in patients with a history of an acute coronary syndrome. See
@meg_texas @michael_hoerger Plenty of studies showing benefit of treating cardiovascular disease to lower LDL targets with statins +/- other medications with improved outcomes Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | New England Journal of Medicine https://t.co/lUOV2sDDca
@SBakerMD Does it make sense to want to reduce heart attacks or all-cause death? https://t.co/xtHCai9YcU https://t.co/BP6uT9Wo8U
@euglycemic @thelowcarb_rd Both FOURIER (stable CAD, high risk) and ODYSSEY OUTCOMES (ACS) lowered MACE
@Jikkyleaks @karrichapus @TonyNikolic10 @SabinehazanMD @rackusup @BroadbentMP @JohnRuddick2 @VirusFighterVi1 @AMPS_RedUnion @craigkellyXXX @PierreKory @DJSpeicher @toobaffled @SenatorRennick @PGtzsche1 @dystopian_DU https://t.co/ivUExQSwhn
@MohammedAlo @lrak456 statistical misunderstanding point estimate for ACM in FOURIER was 1.04, smack in the middle of the CI and p=0.54 in ODISSEY ACM did reach stat sig (a reduction of 15%), surprising for 2.8y followup https://t.co/EQR8hd9ViO https://t.co/4KVpOVGxWF
RT @sigal_alan: Links para mas info: https://t.co/9Ani2CwOHe https://t.co/VW3LeD30zo https://t.co/BN70Bnt2jK https://t.co/1cknwROFf8 ht…
Links para mas info: https://t.co/9Ani2CwOHe https://t.co/VW3LeD30zo https://t.co/BN70Bnt2jK https://t.co/1cknwROFf8 https://t.co/8oDAFUQ4Zh
@assiri99 @KFAFHCards @fayezbaraah @Amgen @drptca @wagarhabib @Sultanotb @mohamed_elsabah @ibrahem_albakry The landmark trial specifically designed to capture outcomes in ACS was the Odyssey w Alirocumab @NEJM https://t.co/vkjujJn8tB
FOURIER
@Ikat0 @im_dori2 @Drlipid @jpapi7 https://t.co/nY7u8f5J3r NNT of like 200 to prevent 1 CV death. https://t.co/7PsE6feVcO No CV death improvement, NNT 100 to prevent an MI. Total mortality benefit likely noise given lack of CV death benefit (eg would mean it reduces infection or CA death better than CV).
@JeffA47854828 @drpablocorral @Drlipid @MattBMartin @NEJM @JohnKastelein @society_eas @BNordestgaard @ProfKausikRay @LaleTokgozoglu @DrMarthaGulati @ErinMichos @rauldsf_santos @KarleziAlonso @Lpa_Doc https://t.co/NFsGAhmnQ2 https://t.co/XZOJKLUFAh https://t.co/01hDvJxldo https://t.co/SS9uD60C1Y
11/ Addition of #PCSK9 inhibitors to optimised #statin therapy further reduces #CV risk, but residual risk remains.
RT @gabrielsteg: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jxIRQIpKG1
@DoctorTro @DanClintonRN @Lipoprotein @MohammedAlo @professionaldog @dreamer_legal @trailrunner402 @degriffin10 @realDaveFeldman @Tellit007 @hightouchinv @Bernard22190947 Man this is embarrassing... It's the Odyssey outcomes: https://t.co/MWGY2or3Tw A total of 334 patients (3.5%) in the alirocumab group and 392 patients (4.1%) in the placebo group died (hazard ratio, 0.85; 95% CI, 0.73 to 0.98). Again, what's wrong with HR?
RT @raphaels7: fun debate w/ @DoctorTro yesterday! all-cause mortality in statins: HPSCG 2005 https://t.co/nmL25pLZFy, 4S trial 1994 https…
@Anthony41172027 @skathire Bempedoic acid did not show a mortality benefit and it had LONGER treatment duration and follow up. Praluent, on the other hand, did (with shorter treatment period). https://t.co/XTQPvDdkrc
@kaulcsmc @DLBHATTMD @rgiugliano @BartoszHudzik @bmj_latest @DrMarthaGulati @mmamas1973 @gbiondizoccai @HeartOTXHeartMD @drjohnm @cardskrish @Hragy @gina_lundberg @hvanspall @ErinMichos @iamritu @MKIttlesonMD @djc795 @AndrewJSauer @CMichaelGibson @TIMIStudyGroup Yes in that range. I guess I’m conforted by Oddssey https://t.co/xtHCai9qnm, the genetics and the design of these trials. In a parallel universe where PCSK9 inhibitors beat statins to the market, I’d predict we’d be having a very different conversation
RT @ethanjweiss: @sciencescanner I’ll dig in but honestly a little skeptical of these sorts of post-hoc exercises. It also defies all other…
@KlendathuCap Derp. https://t.co/XTQPvDdkrc
@sciencescanner I’ll dig in but honestly a little skeptical of these sorts of post-hoc exercises. It also defies all other data showing robust benefits of PCSK9I either genetically or pharmacologically including most importantly this: https://t.co/HHlx3ga0RZ
@Umair2017 https://t.co/Vuntso5XWf
@medinternajg Odyssey outcomes trial https://t.co/2shhYgv0Gc
27b)
RT @cardiomet_CE: 21) Check out the great video summary at https://t.co/6GfIN8ASuL https://t.co/BaYMYrhbvm
RT @cardiomet_CE: 19) And then there's #alirocumab, studied in the #ODYSSEY OUTCOMES trial (
21) Check out the great video summary at https://t.co/6GfIN8ASuL https://t.co/BaYMYrhbvm
19) And then there's #alirocumab, studied in the #ODYSSEY OUTCOMES trial (
@ePatientDave @hcooperman1 @pheski Well, off the top of my head, since that blog post was written several things happened. The alirocumab (Praluent) trial was published. That's a PCSK9 inhibitor similar to evolocumab. https://t.co/qRxVznwcme
RT @cardiomet_CE: 29) The ODYSSEY OUTCOMES (
29) The ODYSSEY OUTCOMES (
RT @cardiomet_CE: 13) 2⃣ large outcome trials of PCSK9 monoclonal antibodies demonstrated significant ⬇️in CV events when added to #statin…
RT @cardiomet_CE: 13) 2⃣ large outcome trials of PCSK9 monoclonal antibodies demonstrated significant ⬇️in CV events when added to #statin…
13) 2⃣ large outcome trials of PCSK9 monoclonal antibodies demonstrated significant ⬇️in CV events when added to #statin therapy:
@SABOURETCardio @cpcannon @atishmathurmd @DLBHATTMD @atunuguntla1 @DrAnkitKPatel @jaymukherjeemd @purviparwani I do wish the Odyssey trialists had allowed the same. However, they had protocols to down titrate treatment for those who went below 25 mg/dL. https://t.co/GmI48A6Ji4 https://t.co/joKEVDXz9d
@REV_Insulin_Res @NutritionMadeS3 If ApoB is the culprit, why did this work? https://t.co/M5wDrKuzm8 And before this, why did so many statin CVOTs work? ApoB is clearly not the only culprit, and LDL IS a culprit.
@bohdyone @NutritionMadeS3 Facts are facts. But an autoimmune response??? LOL Probably not a good idea. It seems insane. https://t.co/M5wDrKuzm8
fun debate w/ @DoctorTro yesterday! all-cause mortality in statins: HPSCG 2005 https://t.co/nmL25pLZFy, 4S trial 1994 https://t.co/J0EYwvWxGa, Kristensen 2015 https://t.co/KP5HqbmIdp And PCSK9i: FOURIER 2017 https://t.co/9hvNxT5SfS, Schwartz 2018 https://t.co/psJvTKidxz https://t.co/Wyjy2dsY4S https://t.co/uBwH9RGg3u
@MacroFour @Plant_proof @AmandaZZ100 @ScepticalDoctor @dylanarmbruste3 @krosenque @NutritionMadeS3 @deirdre_tobias @realDaveFeldman @MacroEight @MattMadore576 @MyNutritionSci @drmatthewnagra @The_Nutrivore Here are PCSK9 inhibitors added to statin therapy, lowering LDL, and all cause mortality compared to placebo (just receiving statins) @The_Nutrivore may be able to share other relevant studies. https://t.co/4aw4xDRctS https://t.co/5rgjNAZBvw
@raphaels7 @DoctorTro https://t.co/k8JLqd9q3z https://t.co/kqJKuhdEK0
@dbechek1 @Lpa_Doc @Drlipid @ionispharma 1. https://t.co/Io1MD7CU6O 2. https://t.co/M5wDrKuzm8
https://t.co/bkiqHyT934 https://t.co/o6LOVbFaTr
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome reu... https://t.co/YqMGgkdRO8 via @YouTube @mjack2050
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome P... https://t.co/9BdRvCYGGr via @YouTube @mjack2050
RT @LostNic__: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome: https://t.co/Oi8UPCTe4T
RT @LostNic__: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome: https://t.co/Oi8UPCTe4T
RT @ikramhaq_: Link to full papers: - https://t.co/rNWj11TxhX - https://t.co/DpDa8T81ak - https://t.co/WymzT1HeIg
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome https://t.co/QBqfgUU3p9 via @YouTube
RT @ikramhaq_: Link to full papers: - https://t.co/rNWj11TxhX - https://t.co/DpDa8T81ak - https://t.co/WymzT1HeIg
Link to full papers: - https://t.co/rNWj11TxhX - https://t.co/DpDa8T81ak - https://t.co/WymzT1HeIg
@DaveKeto https://t.co/9IBKwVbBwV You can do the quick math. Death from cardiovascular causes: 240 to 271 Death from all causes: 334 to 392.
@ProfDFrancis I understand what you are trying to say the first time and the answer is the pcsk9 studies showed comparable / higher increase. Look at the bottom on page 30 of this appendix https://t.co/11d1jqAj7n. If i recall correctly water was the placebo in the PCSK9 study. Another Vexabo?
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jH67S0HYcs
@holmanm @kevinnbass @OhhiyoGarmen @DrPaulMason @Drlipid @PeterAttiaMD @FatEmperor @DaveKeto @POhukainen @ArsenaultBenoit https://t.co/t73hEBkr4J
I’m bored but not I wanna read a 5 page research paper on “Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome” bored. Stupid professional school.
RT @gabrielsteg: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jxIRQIpKG1
RT @gabrielsteg: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jxIRQIpKG1
@BioBoyScout @AndyBiotech Ignorance. It's not bliss. https://t.co/XTQPvDdkrc
RT @SVNefro: @EstebanDL @drfherediaz @jlgorriz @SVCardio @ValleAlfonso @Cokeino @SEHLELHA140_90 @SEMG_ES @semfyc @SEMERGENap @cristinatejer…
RT @SVNefro: @EstebanDL @drfherediaz @jlgorriz @SVCardio @ValleAlfonso @Cokeino @SEHLELHA140_90 @SEMG_ES @semfyc @SEMERGENap @cristinatejer…
RT @SVNefro: @EstebanDL @drfherediaz @jlgorriz @SVCardio @ValleAlfonso @Cokeino @SEHLELHA140_90 @SEMG_ES @semfyc @SEMERGENap @cristinatejer…
@EstebanDL @drfherediaz @jlgorriz @SVCardio @ValleAlfonso @Cokeino @SEHLELHA140_90 @SEMG_ES @semfyc @SEMERGENap @cristinatejerap @almucastro01 @sinaptopodina Fourier evolocumab https://t.co/LeBLpOEJYd Odyssey alirocumab https://t.co/FINFGozwVb
RT @gabrielsteg: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jxIRQIpKG1
At today's Szarek Fellowship Awards Ceremony, Dr. Szarek discussed ODYSSEY OUTCOMES, a groundbreaking multinational clinical trial assessing the effectiveness of alirocumab for improving cardiovascular outcomes, recently published in @NEJM https://t.co/X2lmUcitOp https://t.co/67Nll6GoVQ
RT @gabrielsteg: Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/jxIRQIpKG1
@TuckerGoodrich @DrNadolsky @DaveKeto @ethanjweiss @puddleg This is: https://t.co/bctEdzwfJF
@UMKCBioMed Alirocumab decreased the risk of recurrent ischemic cardiovascular events in comparison to placebo among patients who had a history of acute coronary syndrome and taking high intensity statin therapy #UMKCRCT https://t.co/OdLHQwaEwB https://t.co/wijlO71hRj
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/cdtPkv758q
ODYSSEY OUTCOMES Trial Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome https://t.co/VTYCg6T8eK https://t.co/Q3NJjwB7WR
RT @61Morillas: Publicación de reducción de eventos CV después de SCA con alirocumab en NEJM, que debe replantear las indicaciones de iPCSK…
RT @a_saratzis: 4) Even more evidence favouring the use of PCSK9 inhibitors in high-risk patients. https://t.co/EKu42l9L16
4) Even more evidence favouring the use of PCSK9 inhibitors in high-risk patients. https://t.co/EKu42l9L16
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome | NEJM https://t.co/ESlL7wqsRr