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The discussions reflect strong agreement on the importance of CAC scores in guiding statin therapy, illustrated by comments about the Walter Reed cohort's long-term data and NNT values. The tone is analytical and cautious, often citing studies and emphasizing the importance of precise patient selection, which underscores high interest in personalized medicine and potential shifts in prevention guidelines.
Most discussions acknowledge that the findings support targeted statin use based on CAC scores, especially highlighting benefit in higher scores.
The discussions demonstrate high curiosity about the implications of CAC scores and statin benefits, with many references to specific studies and data.
Participants are engaging deeply, referencing studies, long-term data, and debating nuances such as zero CAC scores and treatment thresholds.
The emphasis on personalized treatment based on calcium scoring and the potential to refine prevention strategies indicates significant clinical implications.
We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins. https://t.co/Tgxqpu51Ay This is one of many such studies. Let's treat the disease, not everyone dies of CVD. https://t.co/98ax9znbA1
In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://t.co/p2cBAs1yp4 https://t.co/NSuzRg43i8
@braun_lynne @BudoffMd Large-scale, long-term observational data from the Walter Reed Cohort suggests benefit from statins in lower CAC scores and findings consistent with treatment recommendations in current #ACC Prevention guidelines. CAC>100, NNT=12. https://t.co/sVbqqsxsrt https://t.co/IRBuaLrtux
Recent meta analysis failed to show LDL as reason for mortality reduction: https://t.co/869ATFOuPD Power of zero: https://t.co/3cji0jETkA Statins calcify plaques: https://t.co/NLzOPD3EPt
@richcollins @DoctorTro This is a figure I like to review with patients. Data on statins and MACE over 12 years at different CAC cut offs https://t.co/43vE9nqxtO https://t.co/ltG01ce2eF
https://t.co/TFgkGVywLm Trabajo muy interesante que trata este tema. Creo que cada vez más vamos a tener que repensar la predicción del riesgo, a medida que tengamos información más precisa y validada. https://t.co/uZHsSRVUoM
In this video, I discuss the risks and benefits of statin therapy, particularly focusing on how coronary artery calcium (CAC) scores can predict which patients will benefit most from statin treatment. Discover if…
@ApoDudz @nplusyears This study is far from perfect (associational) but does indicate no sig benefit of statins for people with CAC = 0 as well as CAC = 1-100 https://t.co/Wl6c3aUukJ https://t.co/3HUJpIUMKh
https://t.co/Zp2Ete3Ejp
@drpablocorral @drpablocorral is there evidence that high risk groups (diabetes) even, at low CAC, have different lipid lowering interventional trajectory than the top two panels? https://t.co/DnHkNeuHyi https://t.co/H82QaWKs46
@CRYPT0N1TE 0 CAC is favorable. Here is a presentation from @khurramn1 on the power of ZERO calcium scores: https://t.co/gHVolz4b6R Here is a study: https://t.co/ZnTfKgMf8H KETO-CTA adds to the knowledge base. They looked at heart CT angio with Cleerly AI. Much more granular then just the
RT @MattCalkinsMD: @richcollins @DoctorTro This is a figure I like to review with patients. Data on statins and MACE over 12 years at diffe…
@richcollins @DoctorTro This is a figure I like to review with patients. Data on statins and MACE over 12 years at different CAC cut offs https://t.co/43vE9nqxtO https://t.co/ltG01ce2eF
@richcollins @realDaveFeldman I’m sure you’ve seen this one, Rich (this is for statins though). https://t.co/5KDEMBVuEY https://t.co/c4Et8Po23C
https://t.co/toug4HecZd
@BPujanauski @lipo_fan @RaphaS896035 @DoctorTro @DrIngold @MohammedAlo https://t.co/toug4HecZd
@shivadas29 Not that I'm aware of...would be interesting to do this in the HAUSER cohort of kids with FH. Conversely, there's this: https://t.co/LiZDXCbPUE
@RZubiranS @theproof
@soonergise @BiggestComeback https://t.co/toug4HdF9F
@terrysimpson @JohnKastelein @theproof What do you mean by “bigger”? I think it’s fairly straightforward Eg Walter Reed Cohort at 10 yr f/u: NNT for statin w/ CAC >100 is 12 NNT for statin w/ CAC 0 is 3571 https://t.co/toug4HdF9F
@DrCCaroli @clinicasac No desestimemos el poder de CERO, si seleccionamos bien los pacientes https://t.co/EE8wA2DqeG https://t.co/E3Rph2jDK4
@lipo_fan @DudzLightLime @drpablocorral @khurramn1 @eatthesunnow NNT in CAC 0 group was 3571 over 10 years to prevent 1st event https://t.co/GxS9PCwX4g
https://t.co/507G66heLh https://t.co/0GnSRaDGyL
@usambcuba This one I believe is what I was referring to https://t.co/p2cBAsjHDc
Did this 2018 observational study "accidentally" show, *statins* increase calcification of the heart??? Table 1 on page 2326 of "Journal of the American College of Cardiology" https://t.co/ZtYQG90yeX https://t.co/oGttgPWrGO
@LowCarbEyeDoc @Lipoprotein Maybe this paper may help. https://t.co/toug4HdF9F https://t.co/W1mXqQpgCa
@holmanm @LewDrakePhD Ugh here we go https://t.co/3cji0jETkA
Es lindo ver que en medicina, como en el resto de las ciencias, no está todo dicho.
https://t.co/TFgkGVywLm Trabajo muy interesante que trata este tema. Creo que cada vez más vamos a tener que repensar la predicción del riesgo, a medida que tengamos información más precisa y validada. https://t.co/uZHsSRVUoM
@Bluzeman123 @Mangan150 @190 @65 https://t.co/Wl6c3bbxmJ @ShawnBarryMDPh1 https://t.co/2fWV8JyH7i
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
RT @BudoffMd: We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins.…
We have great long term data from Walter Reed showing those persons with CAC=0 derive 0% benefit from 10+ years of statins. https://t.co/Tgxqpu51Ay This is one of many such studies. Let's treat the disease, not everyone dies of CVD. https://t.co/98ax9znbA1
@LDLSkeptic @DrScottMurray @khurramn1 @MichaelJBlaha The statin efficacy in individuals with very high CAC scores really isn’t ambiguous, by the way. https://t.co/ctfiUx8imO https://t.co/WMO40E652k https://t.co/0KnkJGeW2U
@richardbeall10 @LDLSkeptic https://t.co/ctfiUx8imO Good starting point
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
RT @Mangan150: In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://…
In people with coronary artery calcium (CAC) of zero, statins showed no benefit in reducing cardiovascular events. https://t.co/p2cBAs1yp4 https://t.co/NSuzRg43i8
RT @DoctorTro: Recent meta analysis failed to show LDL as reason for mortality reduction: https://t.co/869ATFOuPD Power of zero: https:…
RT @DoctorTro: Recent meta analysis failed to show LDL as reason for mortality reduction: https://t.co/869ATFOuPD Power of zero: https:…
Recent meta analysis failed to show LDL as reason for mortality reduction: https://t.co/869ATFOuPD Power of zero: https://t.co/3cji0jETkA Statins calcify plaques: https://t.co/NLzOPD3EPt
@DrPaulMason https://t.co/5dqLJD6afz @khurramn1 CAC score more important than most things here. 68% RRR for CVD events if CAC score >100
@dremilyportermd @DBelardoMD It’s not possible to answer this without knowing more info about you but I suggest you read this paper on calcium scoring if you are h hesitant about statin primary prevention. https://t.co/3fEOxvjNPh
RT @ToddVillinesMD: @braun_lynne @BudoffMd Large-scale, long-term observational data from the Walter Reed Cohort suggests benefit from stat…
@braun_lynne @BudoffMd Large-scale, long-term observational data from the Walter Reed Cohort suggests benefit from statins in lower CAC scores and findings consistent with treatment recommendations in current #ACC Prevention guidelines. CAC>100, NNT=12. https://t.co/sVbqqsxsrt https://t.co/IRBuaLrtux
@korebeau @FatEmperor True answer: I don't know. I decided, based on the study linked, that a statin probably makes sense for CAC score > 100. For CAC < 100, my thought is a statin may not be justified. I hope this helps! https://t.co/mhMvkHOjU6 https://t.co/g1ZPKEfIwF https://t.co/VNF4zmGs7I
Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring https://t.co/Hl4oZKZA9Y
@AlexJLeaf @The_Nutrivore 10.1016/j.jacc.2018.09.051
@VenkatThoughts Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring https://t.co/UrI4V3PvQd
RT @drjkahn: Take a Statin or No? Get a Calcium CT Scan if You Do Not Have Known Heart Disease: Impact of Statins on Cardiovascular Outcom…
RT @drjkahn: Take a Statin or No? Get a Calcium CT Scan if You Do Not Have Known Heart Disease: Impact of Statins on Cardiovascular Outcom…
Take a Statin or No? Get a Calcium CT Scan if You Do Not Have Known Heart Disease: Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring https://t.co/CW5gPBgJm2
Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring https://t.co/rMWJVO20BS
Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring - Higher is the score more is the benefit https://t.co/2bwEtUJm9m