Theoretical tool bridging cell polarities with development of robust morphologies.

Silas Boye Nissen, Steven Rønhild, Ala Trusina, Kim Sneppen

November 2018 Elife

Synopsis of Social media discussions

The discussions reflect enthusiasm for the article, with examples such as commenters stating ‘This is very neat!’ and noting the paper's novelty and potential relevance to their work, indicating high interest and recognition of its importance. The tone and words like ‘thought-provoking’ and ‘support’ contribute to an overall perception of a significant advancement in understanding cell morphologies.

A
Agreement
 Moderate agreement

Most discussions express enthusiasm and support for the research, highlighting its novelty and potential compatibility with existing models.

I
Interest
 High level of interest

The discussions show high engagement with the topic, with commenters excited to find the paper and relate it to their work or theories.

E
Engagement
 Moderate level of engagement

Participants reflect on the paper’s methodology and implications, indicating thoughtful engagement beyond surface level reactions.

I
Impact
 Moderate level of impact

The positive remarks from reviewers and the recognition of the paper's contribution suggest it could influence future research directions.

Social Mentions

YouTube

2 Videos

Twitter

12 Posts

Blogs

3 Articles

News

11 Articles

Metrics

Video Views

237

Total Likes

22

Extended Reach

400,853

Social Features

28

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Impact of Proliferation Rate and Matrigel Resistance on Organoid Folding Dynamics

Impact of Proliferation Rate and Matrigel Resistance on Organoid Folding Dynamics

In silico organoids grown from 200 to 16000 cells show that increased proliferation leads to more surface folds, while resistance from matrigel saturates deep fold formation. The study explores how cell behaviors influence tissue morphology.

Silas Boye Nissen

December 9, 2018

141 views

Modeling Complex Organism Development Through Cell Polarities and Adhesion

Modeling Complex Organism Development Through Cell Polarities and Adhesion

This presentation discusses a new theoretical model that explains how the stability, diversity, and complexity of organism shapes emerge from collective polarized cell behavior, focusing on cell adhesion, polarity, and proliferation in developmental processes.

Silas Boye Nissen

March 13, 2020

96 views

  • bioRxiv Published
    @biorxiv_pubd (Twitter)

    Theoretical Tool Bridging Cell Polarities with Development of Robust Morphologies published as: https://t.co/JwpEmXhsCm @eLife #biorxiv
    view full post

    December 21, 2020

  • Figshare
    @figshare (Twitter)

    Theoretical tool bridging cell polarities with development of robust morphologies: https://t.co/ucdRJurYyl #biophysics https://t.co/wtInRiVerp
    view full post

    June 23, 2019

    1

  • Genikhovich Group
    @genikhovich (Twitter)

    https://t.co/pGY4Mf8qKU
    view full post

    January 21, 2019

  • Dr S Markham
    @DrSMarkham (Twitter)

    RT @MathCancer: This is very neat! And **finally** found their paper! https://t.co/FNysSqqi4h I like the way they work out polarity--som…
    view full post

    January 16, 2019

    1

  • Paul Macklin
    @MathCancer (Twitter)

    This is very neat! And **finally** found their paper! https://t.co/FNysSqqi4h I like the way they work out polarity--something we haven't done much of yet, but I think is compatible with #PhysiCell's potential functions. Sweet. https://t.co/A9IjiGhoPJ
    view full post

    January 16, 2019

    4

    1

  • Dr S Markham
    @DrSMarkham (Twitter)

    Theoretical Tool Bridging Cell Polarities with Development of Robust Morphologies @MathCancer Stability, Complexity & Diversity as Emergent Properties in Populations of Proliferating Polarized Cells https://t.co/x1g6fK8i9g #ComplexMorphology #PolarAdhesion #CellProliferation
    view full post

    January 16, 2019

    3

  • Hernán Andrés : hernanmn.bsky.social
    @andresm_1986 (Twitter)

    RT @eLife: The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provokin…
    view full post

    January 11, 2019

    5

  • eLife - the journal
    @eLife (Twitter)

    RT @eLife: The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provokin…
    view full post

    January 11, 2019

    5

  • Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
    @Alexis_Lomakin (Twitter)

    RT @eLife: The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provokin…
    view full post

    January 4, 2019

    5

  • Arjuna Rajakumar, PhD
    @ArjunaRajakumar (Twitter)

    RT @eLife: The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provokin…
    view full post

    January 4, 2019

    5

  • Luís Carreira
    @luis_antoniu (Twitter)

    RT @eLife: The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provokin…
    view full post

    January 4, 2019

    5

  • eLife - the journal
    @eLife (Twitter)

    The reviewers and editor greatly appreciated the novelty of this theory paper, finding it to be "a creative and thought-provoking contribution to the field of development" https://t.co/WKX0BFGB2O #fromthedecissionletter #devbio
    view full post

    January 4, 2019

    9

    5

Abstract Synopsis

  • The study proposes that the stability, complexity, and diversity of organismal shapes arise from the collective behavior of populations of polarized cells rather than just individual proteins.
  • A new theoretical model that accounts for different types of cell adhesions and polarities is used to understand how developmental processes like gastrulation and tissue folding occur.
  • The model predicts that factors such as the strength and direction of cell adhesion, cell polarity, and proliferation rates are key in controlling morphological stability and diversity, which can be tested through experiments.]