PubHawk
Cochrane Database Syst Rev November 2018 PMID 30484286

Oral isotretinoin for acne.

Caroline S Costa, Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera

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Mentions

82
Peak: 16 in Jul 2022
across 6 sources since Jan 2019

Extended reach

463,405
potential audience

Total likes

2,969

Video views

185,456

Mentions per month

Jan 2019 – Nov 2025

Where it's discussed

  • X / Twitter70 posts
  • News5 articles
  • Facebook3 posts
  • Blogs2 articles
  • Bluesky1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussions demonstrate strong agreement and high interest, emphasizing the importance of proper counseling, treatment adjustments, and the robustness of research findings, as seen in posts referencing systematic reviews and clinical considerations. The tone varies from technical to cautious, reflecting the multifaceted impact of the publication on both clinical practice and public perception.

AgreementModerate agreement

Most discussions acknowledge the efficacy and importance of isotretinoin for treating severe acne, reflecting general consensus.

InterestHigh interest

The posts show high interest, with many referencing clinical details, counseling advice, and research findings.

EngagementModerate engagement

Several comments delve into methodological aspects, potential side effects, and clinical recommendations, indicating moderate engagement.

ImpactModerate impact

The discussions highlight the significance of the publication in shaping clinical practice and understanding of the drug's safety and efficacy.

Abstract in brief

  • Acne vulgaris affects over 80% of teenagers and is a chronic inflammatory disease that can impact social and mental health, with isotretinoin being the only drug that addresses all primary causes but has potential side effects.
  • The study reviewed 31 randomized clinical trials involving 3,836 participants aged 12 to 55 to evaluate the efficacy and safety of oral isotretinoin compared to placebo and other treatments, using standard Cochrane methodologies.
  • Results showed most studies were conducted in Asia, Europe, and North America, with common follow-up periods between eight to 32 weeks, indicating a systematic approach to determining the drug's effectiveness across various dosages and formulations.
Read the full abstract

Top posts

Most liked on X and Bluesky
John McGrath
@BJDEditor · X

Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates are actually LOWER than in those given antibiotics.

Jul 13, 2022 · 102 likes · 21 shares · 664 followers View post →
Dr. Muhammad Moor
@MoarSahitoPTI · X

Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 81 likes · 11 shares · 45,262 followers View post →
John Barbieri, MD, MBA
@DrJohnBarbieri · X

Oral #isotretinoin for #acne is a unique treatment in that it consistently provides a durable remission, even after stopping the medication. I think of it as an “acne modifying” treatment since often the acne never comes back. And if it does, it’s usually much easier to manage. https://t.co/SEpldfVvIL

Dec 2, 2019 · 13 likes · 7,062 followers View post →
BJGP
@bjgp.bsky.social · Bluesky

Isotretinoin is an effective treatment for severe #acne, but what clinical competencies are required for prescribing oral #isotretinoin for acne in #PrimaryCare? This scoping review identifies what's needed youtu.be/bZJOP6iD5B0 Read the research: doi.org/10.3399/BJGP...  #dermatology #prescribing

Sep 9, 2025 · 3 likes · 3 shares View post →
John Barbieri, MD, MBA
@DrJohnBarbieri · X

@GuzzeSzn Likely lack of high-quality clinical trials to include in the NMA. There isn't much data about isotretinoin. https://t.co/DZRoq6KeK4

Feb 13, 2024 · 1 like · 7,062 followers View post →
caravaggio tropical
@emmetharveyKL · X

@mobnaosabe @sailorpalota @genitaldepombo são, sim. mas vale lembrar que, além da presença de estudos que já desmistificam, o termo de consentimento do roacutan tirando essas questões por si só já é BEM alarmante, e há muito não é revisado. segue: https://t.co/sl8A57c4Yg e https://t.co/YlFlWdQtu0

Apr 24, 2024 · 1 like · 750 followers View post →

All mentions

POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Nov 9, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Oct 27, 2025 · 5,237 followers View post →
EurekaMag
@EurekaMag · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/z4WmihlFNF

Oct 24, 2025 · 6,547 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Oct 14, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Oct 1, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Sep 18, 2025 · 5,237 followers View post →
BJGP
@bjgp.bsky.social · Bluesky

Isotretinoin is an effective treatment for severe #acne, but what clinical competencies are required for prescribing oral #isotretinoin for acne in #PrimaryCare? This scoping review identifies what's needed youtu.be/bZJOP6iD5B0 Read the research: doi.org/10.3399/BJGP...  #dermatology #prescribing

Sep 9, 2025 · 3 likes · 3 shares View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Sep 5, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Aug 23, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Aug 10, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Jul 28, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Jul 15, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Jul 2, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Jun 19, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Jun 6, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

May 24, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

May 10, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Apr 26, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Apr 15, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Mar 31, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Mar 18, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Mar 4, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Feb 17, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Jan 20, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Jan 6, 2025 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Dec 23, 2024 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtZk13

Dec 11, 2024 · 5,237 followers View post →
POPLINE
@POPLINE_org · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/FaCVOtYMbv

Nov 25, 2024 · 5,237 followers View post →
Roberto Arcadio
@Robertoarcadio_ · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 24, 2024 · 11 shares · 307 followers View post →
Mahmoud Akraym, MD
@DrJarhaman · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 24, 2024 · 11 shares · 444 followers View post →
Jeremiah
@Jeremiah1963171 · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 24, 2024 · 11 shares · 36 followers View post →
danny-kim 254
@danny65569879 · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 24, 2024 · 11 shares · 116 followers View post →
PH. Alzahraa
@6al_3omry_ · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 11 shares · 684 followers View post →
Alberto Máximo Pérez Calero
@CaleroAlberto · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 11 shares · 980 followers View post →
Ms Cheryl Tunt
@bikutoli · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 11 shares · 555 followers View post →
Nana Kwame Cassy
@HaganCassius · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 11 shares · 273 followers View post →
lil dude from across d street
@MINATO18096896 · X

RT @MoarSahitoPTI: Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 11 shares · 375 followers View post →
Dr. Muhammad Moor
@MoarSahitoPTI · X

Which counseling advice should be given to patients receiving oral isotretinoin for acne.? https://t.co/uVyenyleoD

May 23, 2024 · 81 likes · 11 shares · 45,262 followers View post →
caravaggio tropical
@emmetharveyKL · X

@mobnaosabe @sailorpalota @genitaldepombo são, sim. mas vale lembrar que, além da presença de estudos que já desmistificam, o termo de consentimento do roacutan tirando essas questões por si só já é BEM alarmante, e há muito não é revisado. segue: https://t.co/sl8A57c4Yg e https://t.co/YlFlWdQtu0

Apr 24, 2024 · 1 like · 750 followers View post →
John Barbieri, MD, MBA
@DrJohnBarbieri · X

@GuzzeSzn Likely lack of high-quality clinical trials to include in the NMA. There isn't much data about isotretinoin. https://t.co/DZRoq6KeK4

Feb 13, 2024 · 1 like · 7,062 followers View post →
Scien.net
@Scien_net · X

RT @EurekaMag: Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 65 followers View post →
GeoScience.net
@GeoSciences · X

RT @EurekaMag: Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 404 followers View post →
amnatacharoen
@amnatacharoen · X

RT @EurekaMag: Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 4 followers View post →
POPLINE
@POPLINE_org · X

RT @EurekaMag: Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 5,237 followers View post →
Science Alerts
@Science_Alerts · X

RT @EurekaMag: Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 1,234 followers View post →
EurekaMag
@EurekaMag · X

Oral isotretinoin for acne, adjusting treatment according to patient's response https://t.co/evFX9tFau0

Oct 16, 2023 · 5 shares · 6,547 followers View post →
Aline Magalhaes
@alinefortuna2 · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Aug 5, 2022 · 21 shares · 8,515 followers View post →
Dominique du Crest
@ducrest · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Aug 2, 2022 · 21 shares · 8,016 followers View post →
Jazmin Newton, MD
@_midwestmelanin · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 14, 2022 · 21 shares · 561 followers View post →
Matt Cox
@mattcox7003 · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 14, 2022 · 21 shares · 379 followers View post →
Rajani Nalluri
@drjinniderm · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 14, 2022 · 21 shares · 42 followers View post →
B2
@tefitaB2mi · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 14, 2022 · 21 shares · 184 followers View post →
TJ Chao
@TJChao · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 86 followers View post →
A Springer
@AteamKY · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 107 followers View post →
Lamiaa Hamieh
@LamiaaHamieh · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 204 followers View post →
Jonny Guckian
@JonnyGucks · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 8,459 followers View post →
Alex Gan
@alexgan112 · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 53 followers View post →
Tracy Bale
@tracybale1 · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 208 followers View post →
Thomas King
@darkwings87 · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 130 followers View post →
Maria Teresa García Romero
@teresadefresa · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 1,115 followers View post →
durey.khatry@gmail.c
@DureyKhatry · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares View post →
Hung Doan MD, PhD, FAAD
@HungMD · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 28 followers View post →
Mughal Dermatology
@MughalDerm · X

RT @BJDEditor: Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates a…

Jul 13, 2022 · 21 shares · 729 followers View post →
John McGrath
@BJDEditor · X

Population data show oral isotretinoin for #acne is NOT associated with adverse neuropsychiatric outcomes; incidence rates are actually LOWER than in those given antibiotics.

Jul 13, 2022 · 102 likes · 21 shares · 664 followers View post →
Dermatology_UKDCTN
@UK_DCTN · X

RT @CochraneSkin: "Acne vulgaris, a chronic inflammatory disease associated with socialization and mental health problems. Isotretinoin is…

Jun 29, 2022 · 1 share · 4,277 followers View post →
Cochrane Skin
@CochraneSkin · X

"Acne vulgaris, a chronic inflammatory disease associated with socialization and mental health problems. Isotretinoin is widely recognized as a very effective treatment for severe acne". In 2018, "Oral isotretinoin for acne" was released. Read more at https://t.co/I5LzMxTxbe https://t.co/pi6mMv06Td

Jun 29, 2022 · 1 like · 1 share · 460 followers View post →
John Barbieri, MD, MBA
@DrJohnBarbieri · X

Oral #isotretinoin for #acne is a unique treatment in that it consistently provides a durable remission, even after stopping the medication. I think of it as an “acne modifying” treatment since often the acne never comes back. And if it does, it’s usually much easier to manage. https://t.co/SEpldfVvIL

Dec 2, 2019 · 13 likes · 7,062 followers View post →
León Waxtein M.
@leowaxmderm · X

Oral Isotretinoin for Acne Increases Plasma Homocysteine and Decreases Folic Acid https://t.co/N1nXxo6QA6

Aug 9, 2019 · 63 followers View post →
dermatologyf
@dermatologyf · X

Oral isotretinoin for acne. https://t.co/iCqEqwbRyx

Mar 23, 2019 · 88 followers View post →
Dominique du Crest
@ducrest · X

RT @ducrest: Oral isotretinoin for acne - Cochrane Systematic Reviews https://t.co/w5zSnGehue 31 RCTs, involving 3836 participants (12 to 5…

Mar 1, 2019 · 2 shares · 8,016 followers View post →
Cassandra Bankson
@CassandraBank · X

RT @ducrest: Oral isotretinoin for acne - Cochrane Systematic Reviews https://t.co/w5zSnGehue 31 RCTs, involving 3836 participants (12 to 5…

Jan 24, 2019 · 2 shares · 14,406 followers View post →