Synopsis of Social media discussions
This collection of discussions highlights skepticism about the purported health benefits of sulforaphane, with users pointing out that it depletes glutathione rather than increasing it, such as mentioning that NAC can negates SFN effects. The tone is analytical, referencing scientific studies and using technical language that reflects a serious engagement with the research findings.
Agreement
Low agreementMost discussions challenge the positive perception of sulforaphane's benefits, emphasizing its pro-oxidative and depleting effects on glutathione, which suggests skepticism about its health claims.
Interest
Moderate level of interestPosts demonstrate curiosity about mechanisms and effects, especially regarding antioxidant levels and how compounds like NAC and GSH interact with sulforaphane.
Engagement
Moderate level of engagementUsers actively reference scientific concepts, studies, and expert opinions, showing a moderate level of detailed engagement.
Impact
Neutral impactDiscussions are largely focused on clarifying scientific details rather than proposing broad real-world impacts, resulting in neutral impact scoring.
Social Mentions
YouTube
3 Videos
2 Posts
27 Posts
Metrics
Video Views
36,957
Total Likes
581
Extended Reach
184,105
Social Features
32
Timeline: Posts about article
Top Social Media Posts
Nick | Gut Health
There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below).
https://t.co/GtGaIrZ452
view full post
Eve.S.
https://t.co/QLezuY7BI2
view full post
The GUT CLUB
@chydorina @remissionbiome NAC negates SFN:
“The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).”
https://t.co/M6AKfry3sC
view full post
T.C. Hale
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full post
Ronen Pinko
@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM
view full post
Posts referencing the article
Sulforaphane Modulates T-Cell Inflammatory Responses via Oxidative Stress
Sulforaphane, a plant compound, induces oxidative stress in human T cells by increasing ROS and depleting glutathione. It inhibits T cell activation by targeting STAT3 and reducing inflammatory cytokines, suggesting potential for autoimmune disease therapy.
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24,650 views
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November 28, 2023
14 views
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Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJune 14, 2025
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postApril 11, 2025
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postFebruary 21, 2025
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJanuary 11, 2025
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postNovember 10, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postAugust 31, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJuly 28, 2024
1
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJune 22, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postMay 20, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postApril 24, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postMarch 31, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postMarch 14, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postFebruary 19, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJanuary 28, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postJanuary 6, 2024
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postDecember 8, 2023
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postNovember 3, 2023
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postSeptember 25, 2023
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
view full postAugust 24, 2023
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T.C. Hale
@kickitinthenuts (Twitter)Addressing Ulcers Naturally: https://t.co/7MKHDtVSv4
view full postJuly 25, 2023
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Eve.S.
@yeeseak (Twitter)https://t.co/QLezuY7BI2
view full postJune 30, 2023
2
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Lee Stevenson
@bashuser (Twitter)Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione https://t.co/p3WPP9qFbS
view full postMay 17, 2023
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Nick | Gut Health
@theholisticnick (Twitter)of the body, but only after oxidative stress from the Sulforaphane The study below shows it doesn't raise antioxidant levels & actually depletes glutathione levels in parts of the body so that it can be used to address the stress caused by Sulforaphane https://t.co/GtGaIrZ452
view full postMarch 23, 2023
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The GUT CLUB
@club_gut (Twitter)@chydorina @remissionbiome NAC negates SFN: “The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).” https://t.co/M6AKfry3sC
view full postFebruary 7, 2023
1
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Nick | Gut Health
@theholisticnick (Twitter)There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below). https://t.co/GtGaIrZ452
view full postOctober 5, 2022
2
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Ronen Pinko
@ronenpinko (Twitter)@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM
view full postSeptember 17, 2021
1
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alephh
@alephh (Twitter)Sulforaphane has a pro-oxidative effect on human T-cells leading to an increase of reactive oxygen species (ROS) levels & severe depletion of ROS-scavenger glutathione pools accompanied by increased oxidation of proteins at redox active cysteine residues. https://t.co/CPJFlGnWeA
view full postJune 25, 2020
Abstract Synopsis
- Sulforaphane (SFN), a plant-derived compound, induces oxidative stress in human T cells by increasing reactive oxygen species (ROS) and decreasing glutathione (GSH), which affects T cell activity and function.
- SFN targets the transcription factor STAT3, leading to reduced activation of T cells and downregulation of T17-related genes and cytokines such as IL-17A, IL-17F, and IL-22, which are involved in autoimmune diseases like rheumatoid arthritis.
- The immunosuppressive effects of SFN can be reversed by GSH or antioxidants like N-acetylcysteine (NAC), indicating that SFN’s action depends on redox changes, and it may offer new treatment options for T17-driven chronic inflammatory autoimmune conditions.
T.C. Hale
@kickitinthenuts (Twitter)