There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below). https://t.co/GtGaIrZ452
Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.
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Jun 2020 – Jun 2025Where it's discussed
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X / Twitter27 posts
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YouTube3 videos
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Facebook2 posts
AI synopsis
What people are saying
This collection of discussions highlights skepticism about the purported health benefits of sulforaphane, with users pointing out that it depletes glutathione rather than increasing it, such as mentioning that NAC can negates SFN effects. The tone is analytical, referencing scientific studies and using technical language that reflects a serious engagement with the research findings.
Most discussions challenge the positive perception of sulforaphane's benefits, emphasizing its pro-oxidative and depleting effects on glutathione, which suggests skepticism about its health claims.
Posts demonstrate curiosity about mechanisms and effects, especially regarding antioxidant levels and how compounds like NAC and GSH interact with sulforaphane.
Users actively reference scientific concepts, studies, and expert opinions, showing a moderate level of detailed engagement.
Discussions are largely focused on clarifying scientific details rather than proposing broad real-world impacts, resulting in neutral impact scoring.
Abstract in brief
- Sulforaphane (SFN), a plant-derived compound, induces oxidative stress in human T cells by increasing reactive oxygen species (ROS) and decreasing glutathione (GSH), which affects T cell activity and function.
- SFN targets the transcription factor STAT3, leading to reduced activation of T cells and downregulation of T17-related genes and cytokines such as IL-17A, IL-17F, and IL-22, which are involved in autoimmune diseases like rheumatoid arthritis.
- The immunosuppressive effects of SFN can be reversed by GSH or antioxidants like N-acetylcysteine (NAC), indicating that SFN’s action depends on redox changes, and it may offer new treatment options for T17-driven chronic inflammatory autoimmune conditions.
Top posts
Most liked on X and Blueskyhttps://t.co/QLezuY7BI2
@chydorina @remissionbiome NAC negates SFN: “The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).” https://t.co/M6AKfry3sC
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM
of the body, but only after oxidative stress from the Sulforaphane The study below shows it doesn't raise antioxidant levels & actually depletes glutathione levels in parts of the body so that it can be used to address the stress caused by Sulforaphane https://t.co/GtGaIrZ452
All mentions
Sulforaphane Modulates T-Cell Inflammatory Responses via Oxidative Stress
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Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw
Addressing Ulcers Naturally: https://t.co/7MKHDtVSv4
https://t.co/QLezuY7BI2
Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione https://t.co/p3WPP9qFbS
of the body, but only after oxidative stress from the Sulforaphane The study below shows it doesn't raise antioxidant levels & actually depletes glutathione levels in parts of the body so that it can be used to address the stress caused by Sulforaphane https://t.co/GtGaIrZ452
@chydorina @remissionbiome NAC negates SFN: “The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).” https://t.co/M6AKfry3sC
There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below). https://t.co/GtGaIrZ452
@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM
Sulforaphane has a pro-oxidative effect on human T-cells leading to an increase of reactive oxygen species (ROS) levels & severe depletion of ROS-scavenger glutathione pools accompanied by increased oxidation of proteins at redox active cysteine residues. https://t.co/CPJFlGnWeA