October 2019 PMID 30487791

Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.

Jie Liang, Beate Jahraus, Emre Balta, Jacqueline D Ziegler, Katrin Hübner, Norbert Blank, Beate Niesler, Guido H Wabnitz, Yvonne Samstag

Mentions

32
Peak: 2 in Jul 2023
across 3 sources since Jun 2020

Extended reach

184,105
potential audience

Total likes

581

Video views

36,957

Mentions per month

Jun 2020 – Jun 2025

Where it's discussed

  • X / Twitter27 posts
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

This collection of discussions highlights skepticism about the purported health benefits of sulforaphane, with users pointing out that it depletes glutathione rather than increasing it, such as mentioning that NAC can negates SFN effects. The tone is analytical, referencing scientific studies and using technical language that reflects a serious engagement with the research findings.

AgreementLow agreement

Most discussions challenge the positive perception of sulforaphane's benefits, emphasizing its pro-oxidative and depleting effects on glutathione, which suggests skepticism about its health claims.

InterestModerate interest

Posts demonstrate curiosity about mechanisms and effects, especially regarding antioxidant levels and how compounds like NAC and GSH interact with sulforaphane.

EngagementModerate engagement

Users actively reference scientific concepts, studies, and expert opinions, showing a moderate level of detailed engagement.

ImpactNeutral impact

Discussions are largely focused on clarifying scientific details rather than proposing broad real-world impacts, resulting in neutral impact scoring.

Abstract in brief

  • Sulforaphane (SFN), a plant-derived compound, induces oxidative stress in human T cells by increasing reactive oxygen species (ROS) and decreasing glutathione (GSH), which affects T cell activity and function.
  • SFN targets the transcription factor STAT3, leading to reduced activation of T cells and downregulation of T17-related genes and cytokines such as IL-17A, IL-17F, and IL-22, which are involved in autoimmune diseases like rheumatoid arthritis.
  • The immunosuppressive effects of SFN can be reversed by GSH or antioxidants like N-acetylcysteine (NAC), indicating that SFN’s action depends on redox changes, and it may offer new treatment options for T17-driven chronic inflammatory autoimmune conditions.

Top posts

Most liked on X and Bluesky
Nick | Gut Health
@theholisticnick · X

There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below). https://t.co/GtGaIrZ452

Oct 5, 2022 · 2 likes · 54,169 followers View post →
Eve.S.
@yeeseak · X

https://t.co/QLezuY7BI2

Jun 30, 2023 · 2 likes · 870 followers View post →
The GUT CLUB
@club_gut · X

@chydorina @remissionbiome NAC negates SFN: “The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).” https://t.co/M6AKfry3sC

Feb 7, 2023 · 1 like · 2,310 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jul 28, 2024 · 1 like · 1,669 followers View post →
Ronen Pinko
@ronenpinko · X

@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM

Sep 17, 2021 · 1 like · 161 followers View post →
Nick | Gut Health
@theholisticnick · X

of the body, but only after oxidative stress from the Sulforaphane The study below shows it doesn't raise antioxidant levels & actually depletes glutathione levels in parts of the body so that it can be used to address the stress caused by Sulforaphane https://t.co/GtGaIrZ452

Mar 23, 2023 · 54,169 followers View post →

All mentions

T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jun 14, 2025 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Apr 11, 2025 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Feb 21, 2025 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jan 11, 2025 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Nov 10, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Aug 31, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jul 28, 2024 · 1 like · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jun 22, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

May 20, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Apr 24, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Mar 31, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Mar 14, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Feb 19, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jan 28, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Jan 6, 2024 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Dec 8, 2023 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Nov 3, 2023 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Sep 25, 2023 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVkFw

Aug 24, 2023 · 1,669 followers View post →
T.C. Hale
@kickitinthenuts · X

Addressing Ulcers Naturally: https://t.co/7MKHDtVSv4

Jul 25, 2023 · 1,669 followers View post →
Eve.S.
@yeeseak · X

https://t.co/QLezuY7BI2

Jun 30, 2023 · 2 likes · 870 followers View post →
Lee Stevenson
@bashuser · X

Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione https://t.co/p3WPP9qFbS

May 17, 2023 · 1,702 followers View post →
Nick | Gut Health
@theholisticnick · X

of the body, but only after oxidative stress from the Sulforaphane The study below shows it doesn't raise antioxidant levels & actually depletes glutathione levels in parts of the body so that it can be used to address the stress caused by Sulforaphane https://t.co/GtGaIrZ452

Mar 23, 2023 · 54,169 followers View post →
The GUT CLUB
@club_gut · X

@chydorina @remissionbiome NAC negates SFN: “The inhibitory effects of SFN could be abolished by exogenously supplied GSH and by the GSH replenishing antioxidant N-acetylcysteine (NAC).” https://t.co/M6AKfry3sC

Feb 7, 2023 · 1 like · 2,310 followers View post →
Nick | Gut Health
@theholisticnick · X

There's also a belief that this chemical boosts your body's normal base levels of glutathione. That's also not true. As studies have shown, it can boost the presence in certain areas, but depletes other areas leaving cells vulnerable (study below). https://t.co/GtGaIrZ452

Oct 5, 2022 · 2 likes · 54,169 followers View post →
Ronen Pinko
@ronenpinko · X

@BradStanfieldMD Doesn’t NAC counter some of SFN benefits?, as described here https://t.co/TALyl0TBQM

Sep 17, 2021 · 1 like · 161 followers View post →
alephh
@alephh · X

Sulforaphane has a pro-oxidative effect on human T-cells leading to an increase of reactive oxygen species (ROS) levels & severe depletion of ROS-scavenger glutathione pools accompanied by increased oxidation of proteins at redox active cysteine residues. https://t.co/CPJFlGnWeA

Jun 25, 2020 · 388 followers View post →