Front Immunol October 2019 PMID 30555458

HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy.

Diana P Saraiva, António Jacinto, Paula Borralho, Sofia Braga, M Guadalupe Cabral

Mentions

7
Peak: 2 in Feb 2019
across 2 sources since Feb 2019

Extended reach

36,355
potential audience

Total likes

17

Video views

620

Mentions per month

Feb 2019 – Jun 2020

Where it's discussed

  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions underscore the importance of the study, citing its recognition with the Pfizer prize and its role in predicting treatment response, with language like 'promising marker' and 'correlates with better outcomes', which reflect a strong endorsement and curiosity about clinical relevance and future applications.

AgreementStrong agreement

All discussions recognize the significance of HLA-DR as a predictor for chemotherapy response, showing strong consensus.

InterestHigh interest

The posts are highly engaged with the topic, highlighting the clinical implications and potential for improving treatment outcomes.

EngagementHigh engagement

Multiple messages reference the original research findings and its awards, indicating deep interest and understanding.

ImpactHigh impact

The emphasis on the potential for personalizing breast cancer treatment and the recognition through awards underscore the high impact of the research.

Abstract in brief

  • The study finds that the activation state of cytotoxic T lymphocytes (CTLs), indicated by HLADR expression, is a better predictor of breast cancer patients' response to neoadjuvant chemotherapy (NACT) than just the presence of CTLs themselves.
  • Patients without axillary lymph node metastasis who have high HLADR levels in their tumor CTLs tend to respond better to NACT, and these HLADR levels in tumor CTLs are also reflected systemically, which could allow for easier blood tests.
  • HLADR-positive CTLs produce immune molecules like IFN and Granzyme B, indicating they are actively fighting the tumor, and higher HLADR in CTLs is associated with lower levels of immunosuppressive cells, making HLADR a promising marker for personalizing breast cancer treatment.

Top posts

Most liked on X and Bluesky
Immunicom
@immunicom · X

The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemotherapy https://t.co/3utFeSvFk6 #immunology #Immunotherapy

Feb 25, 2019 · 4 likes · 3 shares · 598 followers View post →
Tissue Repair and Inflammation Lab
@The_TRI_Lab · X

Saraiva et al 2018, ‘HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy’ was distinguished with @pfizer prize 2019.

Nov 14, 2019 · 2 likes · 103 followers View post →
Dr. Thomas Ichim
@exosome · X

RT @immunicom: The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemother…

Mar 1, 2019 · 3 shares · 33,102 followers View post →
Immune Advisors
@Immuneadvisors · X

RT @immunicom: The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemother…

Feb 26, 2019 · 3 shares · 1,744 followers View post →

All mentions

Tissue Repair and Inflammation Lab
@The_TRI_Lab · X

Saraiva et al 2018, ‘HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy’ was distinguished with @pfizer prize 2019.

Nov 14, 2019 · 2 likes · 103 followers View post →
PregnancyProbiotic
@PregnancyProbio · X

RT @immunicom: The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemother…

Mar 7, 2019 · 3 shares · 165 followers View post →
Dr. Thomas Ichim
@exosome · X

RT @immunicom: The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemother…

Mar 1, 2019 · 3 shares · 33,102 followers View post →
Immune Advisors
@Immuneadvisors · X

RT @immunicom: The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemother…

Feb 26, 2019 · 3 shares · 1,744 followers View post →
Immunicom
@immunicom · X

The presence of HLA-DR on T cells of patients with #breastcancer correlates with better outcome after neoadjuvant #chemotherapy https://t.co/3utFeSvFk6 #immunology #Immunotherapy

Feb 25, 2019 · 4 likes · 3 shares · 598 followers View post →