PubHawk
Physiol Rev January 2019 PMID 30565508

Brain Glucose Metabolism: Integration of Energetics with Function.

Gerald A Dienel

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Mentions

31
Peak: 8 in Aug 2023
across 4 sources since Feb 2019

Extended reach

507,094
potential audience

Total likes

15,476

Video views

362,244

Mentions per month

Feb 2019 – Mar 2025

Where it's discussed

  • X / Twitter22 posts
  • News4 articles
  • YouTube3 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall discussion reflects curiosity and some back-and-forth on the scientific points, with mentions of specific mechanisms like glycolysis and lactate transport, as well as criticisms about outdated evidence, indicating moderate interest and engagement but uncertain impact. Words like 'interesting,' 'bizarre logic,' and references to scientific details demonstrate varied attitudes—from curiosity to skepticism.

AgreementNeither agree nor disagree

Posts show mixed opinions; some support the scientific discussion, while others dismiss or criticize it.

InterestModerate interest

Most posts demonstrate curiosity or engagement with the topic, especially regarding brain glucose metabolism, but few show deep excitement.

EngagementModerate engagement

Several discussions reference complex mechanisms and scientific debates, indicating moderate to high engagement.

ImpactNeutral impact

While some posts raise questions or critique, there is limited evidence of the discourse leading to broad or transformative implications.

Abstract in brief

  • Brain glucose is essential for critical functions such as ATP production, managing oxidative stress, and synthesizing neurotransmitters and structural components.
  • Neurotransmission increases glucose metabolism in both neurons and astrocytes, with glycolysis being preferentially upregulated during brain activation, even when oxygen is sufficient.
  • The roles of glucose and lactate, as well as the process of shuttling between astrocytes and neurons during brain activity, are still debated, with implications for understanding brain energy use and potential treatments for brain disorders.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Veganella
@Veganella_ · X

The brain alone uses almost 5x that amount of glucose. https://t.co/zBVtchv05R https://t.co/XTabEutJCU https://t.co/uZsVa2aPhr

Mar 12, 2025 · 32 likes · 5 shares · 58,233 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

Interesting: „Curiously, the brain does not use its high capacity for oxidative metabolism during functional activation. Instead, glycolysis is preferentially upregulated more than oxygen consumption to sustain functions that include signaling,….“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 7 likes · 1,182 followers View post →
Daniel Kane
@mitokanedria · X

“An important, unresolved issue in these studies is that the carbohydrate taken up in excess of oxygen during exhaustive exercise does not accumulate in brain (2)...” – G. Dienal, 2019 (1)   1. https://t.co/6TTuFCzI38 2. https://t.co/wkjUFSz5zr https://t.co/RINPKCWDtH https://t.co/oHZrpKXqAZ

May 24, 2023 · 5 likes · 1,006 followers View post →
Jennifer Madrigal
@jenchemfolife · X

@laurenancona Depending on your idea of fun, here's a fun, thorough, and recent review: https://t.co/hbIiLze89E

Aug 26, 2022 · 5 likes · 442 followers View post →
Veganella
@Veganella_ · X

@CGTCFA @tobyzapf @DrEenfeldt It does indeed. Nice misuse of the term “fallacies” btw. https://t.co/jwdilQb8iv

Feb 13, 2025 · 4 likes · 58,233 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

Where lactate goes: „However, an advantage of glycolysis is fast production of ATP at subcellular sites with high ATP turnover (e.g., plasma membrane ion pumps) and lactate released to blood can be used by other organs as fuel or for gluconeogenesis.“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 4 likes · 1,182 followers View post →

All mentions

stinkiemonkie
@stinkiemonkie · X

RT @Veganella_: The brain alone uses almost 5x that amount of glucose. https://t.co/zBVtchv05R https://t.co/XTabEutJCU

Mar 12, 2025 · 5 shares · 43 followers View post →
BlueByrd (Vegan)
@NigelCo14798581 · X

RT @Veganella_: The brain alone uses almost 5x that amount of glucose. https://t.co/zBVtchv05R https://t.co/XTabEutJCU

Mar 12, 2025 · 5 shares · 5,826 followers View post →
©anines tho™ ᕕ( ᐛ )ᕗ
@ShortnBluntTho · X

RT @Veganella_: The brain alone uses almost 5x that amount of glucose. https://t.co/zBVtchv05R https://t.co/XTabEutJCU

Mar 12, 2025 · 5 shares · 5,673 followers View post →
Veganella
@Veganella_ · X

The brain alone uses almost 5x that amount of glucose. https://t.co/zBVtchv05R https://t.co/XTabEutJCU https://t.co/uZsVa2aPhr

Mar 12, 2025 · 32 likes · 5 shares · 58,233 followers View post →
Veganella
@Veganella_ · X

@CGTCFA @tobyzapf @DrEenfeldt It does indeed. Nice misuse of the term “fallacies” btw. https://t.co/jwdilQb8iv

Feb 13, 2025 · 4 likes · 58,233 followers View post →
Earthling
@_earthling74 · X

@KenDBerryMD For the benefit of your audience, would you be willing to provide a direct rebuttal (with references to support your stance) to the points made by this former carnivore diet eater? https://t.co/ruf8rhT8bU

Aug 4, 2024 · 1 like · 427 followers View post →
Earthling
@_earthling74 · X

@KenDBerryMD I bet you won’t watch this and guarantee you won’t have good rebuttals for it (or his book). https://t.co/F3y7OV6V11

Apr 8, 2024 · 427 followers View post →
Steven Quartz PhD
@StevenQuartz · X

@janellison @AmDiabetesAssn Ignoring that this is a sales pitch for a company whose key piece of evidence is from 1972!, this is bizarre logic. The brain does not need ketones and for its preferred substrate needs carbohydrate. Here's some actual contemporary science: https://t.co/8Cyft0PNav

Mar 26, 2024 · 2,940 followers View post →
Anna@ Miss-Information
@gsl_anna · X

So interesting: https://t.co/5PsthQ3Ckc

Feb 13, 2024 · 156 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

@j_theriault @LFeldmanBarrett Wow, that was a ride! Very intense information. Thanx! https://t.co/wmpgDWhZj1

Aug 31, 2023 · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

„Review of the extensive older literature (151) revealed that the vagus nerve has β2-receptors and can transmit signals from blood to the brainstem, activate the locus coeruleus, and stimulate NE release throughout the brain..“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 1 like · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

„The lactate/pyruvate ratio would also rise if glycolytic rate outstripped pyruvate oxidation or if the MAS could not match glycolytic rate because of the competition of the MAS and TCA cycle for αKG.“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 1 like · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

Excitotoxicity: „Another component of the MAS, the aspartate–glutamate carrier (AGC1 or Aralar; FIGURE 1) that is the regulatory step in the NADH shuttle into mitochondria is required for rescue of cultured neurons from glutamate excitotoxicity (377).“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 1 like · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

„However, MAS inhibition has a huge impact on brain glucose oxidation providing strong evidence against predominant lactate uptake into brain mitochondria, followed by its oxidation.“ Wouldn’t MAS then be the primary intervention target? https://t.co/wmpgDWhrtt

Aug 30, 2023 · 1 like · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

Where lactate goes: „However, an advantage of glycolysis is fast production of ATP at subcellular sites with high ATP turnover (e.g., plasma membrane ion pumps) and lactate released to blood can be used by other organs as fuel or for gluconeogenesis.“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 4 likes · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

Interesting: „Curiously, the brain does not use its high capacity for oxidative metabolism during functional activation. Instead, glycolysis is preferentially upregulated more than oxygen consumption to sustain functions that include signaling,….“ https://t.co/wmpgDWhrtt

Aug 30, 2023 · 7 likes · 1,182 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

„…after weaning, the level of monocarboxylic acid transporters in the brain's vasculature falls markedly, and β-hydroxybutyrate dehydrogenase activity also falls to the much lower adult levels…“ I wonder how ketosis still helps? ⁦⁦@ChrisPalmerMD https://t.co/wmpgDWhrtt

Aug 30, 2023 · 3 likes · 1,182 followers View post →
Aled Zachary
@aled_zachary · X

@CarnivoreIs @Pseudome17 @AFreshLitBeacon @OliverCramon @BrianCPT @AlexBulnes1 @BioLayne Diabetics can come off insulin on low carb? Lol, tell that to all the type 1 diabetics! Under normal dietary conditions the brain oxidises glucose. Fact, read this: https://t.co/u73pypfbkA

Jul 18, 2023 · 1 like · 76 followers View post →
Daniel Kane
@mitokanedria · X

“An important, unresolved issue in these studies is that the carbohydrate taken up in excess of oxygen during exhaustive exercise does not accumulate in brain (2)...” – G. Dienal, 2019 (1)   1. https://t.co/6TTuFCzI38 2. https://t.co/wkjUFSz5zr https://t.co/RINPKCWDtH https://t.co/oHZrpKXqAZ

May 24, 2023 · 5 likes · 1,006 followers View post →
Jennifer Madrigal
@jenchemfolife · X

@laurenancona Depending on your idea of fun, here's a fun, thorough, and recent review: https://t.co/hbIiLze89E

Aug 26, 2022 · 5 likes · 442 followers View post →
Red Pill Vegan
@RedPillVegan · X

@zhusu Oh, No. Don’t bring this quack shit into the crypto space. https://t.co/LBRSl6eAXz

May 16, 2021 · 2 likes · 1,865 followers View post →
Ansh Goel
@AnshGoel_Pro · X

#Brain #Glucose #Metabolism: #Integration of #Energetics with #Function. https://t.co/ueRQirFXeS https://t.co/8oo0Oio26f

Feb 24, 2019 · 1 like · 8 followers View post →