Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.
Mychael V Lourenco, Rudimar L Frozza, Guilherme B de Freitas, Hong Zhang, Grasielle C Kincheski, Felipe C Ribeiro, Rafaella A Gonçalves, Julia R Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A Guerra, Letícia Forny-Germano, Shelby Meier, Donna M Wilcock
January 2019 Nat MedSynopsis of Social media discussions
Posts show strong support for the research, with many emphasizing the promise of irisin as a treatment for Alzheimer's, using words like 'very interesting,' 'parar la progresión del Alzheimer,' and 'revert loss of memory.' The tone is optimistic and engaged, with some sharing personal motivations like starting CrossFit or discussing scientific details, indicating both high interest and perceived impact.
Agreement
Strong agreementMost discussions explicitly support the findings, citing the therapeutic potential of irisin in AD and emphasizing its positive role, indicating strong agreement.
Interest
High level of interestThe posts highlight curiosity about exercise's benefits and potential for preventing or reversing AD, reflecting high interest.
Engagement
High engagementSeveral comments reference specific mechanisms, implications, or personal experiences, demonstrating deep engagement with the research.
Impact
High level of impactThe widespread praise and mention of possible clinical applications suggest that these discussions see the research as highly impactful for future health strategies.
Social Mentions
YouTube
2 Videos
22 Posts
46 Posts
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22 Articles
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90 Articles
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741
Total Likes
80
Extended Reach
98,410
Social Features
182
Timeline: Posts about article
Top Social Media Posts
fm
運動に伴い筋肉から分泌されるIrisinと呼ばれるホルモンが骨・脳の健康維持に重要との研究が、昨年末〜今年初旬にかけて複数報告されていて、寿命と運動の関係もこのあたりからつながっているのかなと思ったり。https://t.co/uq2EVJS2ke https://t.co/eG4cAgxpN8
view full post
John F. Cryan
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | @NatureMedicine https://t.co/8PdqQfeZ7G
view full post
O Atrito
O link para o artigo "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models", mencionado nas matérias e publicado na Nature Medicine, volume 25, páginas 165–175 (2019) , pode ser encontrado no link abaixo:
https://t.co/I6EL8y9IYG
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Reinaldo dos Santos
Congrats to my friends @IBqMUFRJ.
#exercise #irisin #memory #Alzheimer
"Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models"
https://t.co/1msHjftk02
view full post
Dan Tyrrell
Nice paper out in @NatureMedicine:
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/Mbj2JCVzme
view full post
Posts referencing the article
Exercise's Role in Preventing Memory Loss
This educational video discusses the latest studies on how exercise can improve memory and prevent memory loss. Highlighting research that shows exercise-linked FNDC5/irisin can rescue synaptic plasticity and memory defects in Alzheimer's models, we explore significant findings on brain health.
April 4, 2021
705 views
Exercise-Linked Irisin and Its Effects on Alzheimer's Models
This video explores the role of exercise-linked FNDC5/irisin in rescuing synaptic plasticity and memory defects in Alzheimer's models, highlighting key research findings. It serves as a scientific resource for understanding the implications of irisin in metabolic diseases.
September 2, 2020
36 views
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Los niveles d irisina (hormona que aumenta durante el ejercicio y posee la capacidad de generar calor, debido a que puede convertir tejido adiposo blanco en TA marrón) están⬇️tanto en el hipocampo y el líquido cefalorraquídeo, en Alzheimer doi: 10.1038/s41591-018-0275-4 https://t.co/dFXI7lTvmp
view full postOctober 16, 2022
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Fitness Therapy: Neuroscience Professional Learner
@LaCourCouture (Twitter)(Lourenco et al., 2019). Exercise as an intervention mediator of cognitive degeneration is beneficial for the aging population, inclusive of those already impaired (i.e., alzheimer's disease, parkinson's, and TBI). https://t.co/KMSUOWIigS
view full postAugust 26, 2021
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土橋祥平 Shohei Dobashi
@shoheidobashi (Twitter)となると、脳機能を含めた多臓器連関に期待したいところ。 https://t.co/z2Ik7plqTw
view full postJuly 18, 2020
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John Gordon (@jgordon@appdot.net)
@jgordonshare (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s MOUSE models. https://t.co/A3sYfJzDOt. Mice are a lousy AD model. But, this is why I started CrossFit 7y ago. (Exercise addiction is bigger driver now.)
view full postDecember 30, 2019
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Joe Gordon
@josephwgordon (Twitter)RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…
view full postOctober 16, 2019
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Marina García Macia
@Juanaloca2002 (Twitter)RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…
view full postOctober 16, 2019
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Ruben QC
@RubenQC_Lab (Twitter)RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…
view full postOctober 16, 2019
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Andrea Armani
@AndreaArmani4 (Twitter)RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…
view full postOctober 15, 2019
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Mauro Corrado
@MauroCorradoBio (Twitter)Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/yUHEfWkJzW
view full postOctober 15, 2019
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Vendetta
@Vendett34414357 (Twitter)@Mangan150 . That's from Brazil: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/d9a6msSqNW
view full postJune 29, 2019
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松原 守
@matsubara_m (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/XfmL3xJ2VA
view full postFebruary 15, 2019
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@DocMendizabal (Twitter)Dr. Oscar Mendizabal Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s modelsEjercicio aeróbico para prevenir demencias. Es gratis y si funciona, no como las aplicaciones de "gimnasia cerebral" que solo entretienen. https://t.co/iwuUMrHnti
view full postFebruary 14, 2019
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fm
@fm_tsukuba (Twitter)運動に伴い筋肉から分泌されるIrisinと呼ばれるホルモンが骨・脳の健康維持に重要との研究が、昨年末〜今年初旬にかけて複数報告されていて、寿命と運動の関係もこのあたりからつながっているのかなと思ったり。https://t.co/uq2EVJS2ke https://t.co/eG4cAgxpN8
view full postFebruary 13, 2019
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Ariakas Enoreth
@Aenoreth (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/ybMRQmFW58
view full postFebruary 10, 2019
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Spinal Healthcare
@SpinalHealthPM (Twitter)Irisin is a protective factor in cancer (e.g., spinal metastasis & breast cancer), protective against insulin resistance, diabetes, etc. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects https://t.co/f9Dck8zz4S
view full postFebruary 9, 2019
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Marita Ostos
@MaritaOstos (Twitter)RT @jfcryan: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | @NatureMedicine https:/…
view full postJanuary 22, 2019
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redglial
@redglial (Twitter)RT @JLTrejo2: El bloqueo de FNDC5 / irisin (periférico o cerebral) atenúa los efectos del ejercicio físico sobre plasticidad y memoria en r…
view full postJanuary 20, 2019
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John F. Cryan
@jfcryan (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | @NatureMedicine https://t.co/8PdqQfeZ7G
view full postJanuary 19, 2019
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Mercè Pallàs
@PallasMerce (Twitter)RT @JLTrejo2: El bloqueo de FNDC5 / irisin (periférico o cerebral) atenúa los efectos del ejercicio físico sobre plasticidad y memoria en r…
view full postJanuary 19, 2019
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José Luis Trejo
@JLTrejo2 (Twitter)El bloqueo de FNDC5 / irisin (periférico o cerebral) atenúa los efectos del ejercicio físico sobre plasticidad y memoria en ratones con AD. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/dxzsnJIZpb
view full postJanuary 19, 2019
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Gonzalo Marquez
@gmarquez_11 (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/iXuL5ZgD8l
view full postJanuary 17, 2019
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Michael Vine
@mpvine (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/OGUXv4KNtO
view full postJanuary 17, 2019
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Damián Rangel
@roque976 (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/JHvRSASBqG
view full postJanuary 15, 2019
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يِ DB LeConte-Sp̜̮ink ็็้้ܝܵܢ
@LeConteSpink (Twitter)"Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models" Mychael V. Lourenco, et al. (2019) Full text: https://t.co/viMIlfqWBQ https://t.co/OgqZGweCZ0
view full postJanuary 13, 2019
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the paper link
@the_paper_link (Twitter)[trend] up+2: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u
view full postJanuary 13, 2019
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the paper link
@the_paper_link (Twitter)[trend] up+1: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u
view full postJanuary 10, 2019
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Yu-Kai Chang
@chang_yukai (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/Y3zvJWPMDB
view full postJanuary 10, 2019
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V.S.P. Sotiras
@ptolemy_soter (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/EWz3swpDPh
view full postJanuary 10, 2019
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the paper link
@the_paper_link (Twitter)[trend] new: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u
view full postJanuary 10, 2019
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Cris Ordieres
@cris_ordieres (Twitter)RT @carlosminguez: La irisina podría parar la progresión del alzheimer (esta hormona se segrega con la práctica de AF) | Exercise-linked FN…
view full postJanuary 10, 2019
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Carlos Mínguez
@carlosminguez (Twitter)La irisina podría parar la progresión del alzheimer (esta hormona se segrega con la práctica de AF) | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/HO7DpvrL2A
view full postJanuary 9, 2019
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Dr. Ilene Naomi Rusk
@inrneuro (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/lOeHsVIB2M
view full postJanuary 9, 2019
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Dityatev Lab
@DityatevL (Twitter)Very interesting! Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models - https://t.co/TNPyG3uRQE
view full postJanuary 9, 2019
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Jose F. Ruiz
@josefra1975 (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/QhMuk38dfe
view full postJanuary 9, 2019
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AurelG
@AurelG7 (Twitter)Exercise-linked #FNDC5/#irisin rescues #synaptic #plasticity and #memory defects in Alzheimer’s models | #alzheimer #cognition #exercise #hippocampus #neuroscience https://t.co/iBMj7TJ7bP
view full postJanuary 9, 2019
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Malcolm Brown, Ph.D.
@MalBrown7 (Twitter)RT @dantyrr: Nice paper out in @NatureMedicine: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer…
view full postJanuary 8, 2019
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Nirav Dhanesha
@Nirav_Dhanesha (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/HVWc1JEUvA
view full postJanuary 8, 2019
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Dan Tyrrell
@danis1337 (Twitter)Nice paper out in @NatureMedicine: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/Mbj2JCVzme
view full postJanuary 8, 2019
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Reinaldo dos Santos
@rsdossantos13 (Twitter)Congrats to my friends @IBqMUFRJ. #exercise #irisin #memory #Alzheimer "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models" https://t.co/1msHjftk02
view full postJanuary 8, 2019
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Toru Ishihara
@toru_ishihara (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/EJNN9ftToU
view full postJanuary 7, 2019
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CLaE
@leafs_s (Twitter)Alzheimer’s disease FNDC5/irisin Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/RxqQc65eaz
view full postJanuary 7, 2019
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Damião Pereira
@dpspersonal01 (Twitter)Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/XVMOjA6HLF
view full postJanuary 7, 2019
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マーキュリー２世
@uranus_2 (Twitter)末梢でのFNDC5/イリシン過発現は記憶障害を弱める。末梢や脳でのFNDC5/イリシン阻害は、運動がシナプス可塑性や記憶を向上させる効果を弱める。Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/OEvO0GLRZu https://t.co/gwE9HR8xJ1
view full postJanuary 7, 2019
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Dr. Alexandre Cruzeiro
@DrCruzeiro (Twitter)Pesquisa liderada por brasileiros aponta que hormônio pode reverter perda de memória causada pelo #Alzheimer. #irisina #neurociência #neurologia #neuroscience #neurology https://t.co/FcdJ6yzHt9 https://t.co/oSjiqTgd9X
view full postJanuary 7, 2019
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Michelle Saul
@MichelleESaul (Twitter)RT @OAtrito: O link para o artigo "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models", menc…
view full postJanuary 7, 2019
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O Atrito
@OAtrito (Twitter)O link para o artigo "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models", mencionado nas matérias e publicado na Nature Medicine, volume 25, páginas 165–175 (2019) , pode ser encontrado no link abaixo: https://t.co/I6EL8y9IYG
view full postJanuary 7, 2019
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Abstract Synopsis
- The study finds that the levels of FNDC5/irisin, a hormone released during exercise, are decreased in the brains and cerebrospinal fluid of Alzheimer's disease (AD) patients and models, and this reduction is linked to memory and synaptic deficits.
- Enhancing FNDC5/irisin levels in the brain or periphery improves synaptic plasticity and memory in AD mice, while blocking it worsens these impairments, highlighting its protective role.
- The research suggests that FNDC5/irisin mediates the positive effects of exercise on brain health in AD, positioning it as a potential therapeutic target for combating memory loss and synapse failure in the disease.]
Dr. Hernández-Reyes, A. RD, MSc, PhD
@albertohdez (Twitter)