Nat Med January 2019 PMID 30617325

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

Mychael V Lourenco, Rudimar L Frozza, Guilherme B de Freitas, Hong Zhang, Grasielle C Kincheski, Felipe C Ribeiro, Rafaella A Gonçalves, Julia R Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A Guerra, Letícia Forny-Germano, Shelby Meier, Donna M Wilcock

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Mentions

182

Peak: 31 in Jan 2019

across 5 sources since Jan 2019

Extended reach

98,410

potential audience

Total likes

Video views

741

Mentions per month

Jan 2019 – Oct 2022

Where it's discussed

News90 articles
X / Twitter46 posts
Facebook22 posts
Blogs22 articles
YouTube2 videos

AI synopsis

What people are saying

Posts show strong support for the research, with many emphasizing the promise of irisin as a treatment for Alzheimer's, using words like 'very interesting,' 'parar la progresión del Alzheimer,' and 'revert loss of memory.' The tone is optimistic and engaged, with some sharing personal motivations like starting CrossFit or discussing scientific details, indicating both high interest and perceived impact.

AgreementStrong agreement

Most discussions explicitly support the findings, citing the therapeutic potential of irisin in AD and emphasizing its positive role, indicating strong agreement.

InterestHigh interest

The posts highlight curiosity about exercise's benefits and potential for preventing or reversing AD, reflecting high interest.

EngagementHigh engagement

Several comments reference specific mechanisms, implications, or personal experiences, demonstrating deep engagement with the research.

ImpactHigh impact

The widespread praise and mention of possible clinical applications suggest that these discussions see the research as highly impactful for future health strategies.

Abstract in brief

The study finds that the levels of FNDC5/irisin, a hormone released during exercise, are decreased in the brains and cerebrospinal fluid of Alzheimer's disease (AD) patients and models, and this reduction is linked to memory and synaptic deficits.
Enhancing FNDC5/irisin levels in the brain or periphery improves synaptic plasticity and memory in AD mice, while blocking it worsens these impairments, highlighting its protective role.
The research suggests that FNDC5/irisin mediates the positive effects of exercise on brain health in AD, positioning it as a potential therapeutic target for combating memory loss and synapse failure in the disease.]

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All mentions

Exercise's Role in Preventing Memory Loss

This educational video discusses the latest studies on how exercise can improve memory and prevent memory loss. Highlighting research that shows exercise-linked FNDC5/irisin can rescue synaptic plasticity and memory…

Diseases Simplified · Apr 4, 2021 705 views

Exercise-Linked Irisin and Its Effects on Alzheimer's Models

This video explores the role of exercise-linked FNDC5/irisin in rescuing synaptic plasticity and memory defects in Alzheimer's models, highlighting key research findings. It serves as a scientific resource for…

Camila Freitas · Sep 2, 2020 36 views

Dr. Hernández-Reyes, A. RD, MSc, PhD

@albertohdez · X

Los niveles d irisina (hormona que aumenta durante el ejercicio y posee la capacidad de generar calor, debido a que puede convertir tejido adiposo blanco en TA marrón) están⬇️tanto en el hipocampo y el líquido cefalorraquídeo, en Alzheimer doi: 10.1038/s41591-018-0275-4 https://t.co/dFXI7lTvmp

Oct 16, 2022 · 1 like · 2,027 followers View post →

Fitness Therapy: Neuroscience Professional Learner

@LaCourCouture · X

(Lourenco et al., 2019). Exercise as an intervention mediator of cognitive degeneration is beneficial for the aging population, inclusive of those already impaired (i.e., alzheimer's disease, parkinson's, and TBI). https://t.co/KMSUOWIigS

Aug 26, 2021 · 446 followers View post →

土橋祥平 Shohei Dobashi

@shoheidobashi · X

となると、脳機能を含めた多臓器連関に期待したいところ。 https://t.co/z2Ik7plqTw

Jul 18, 2020 · 1 like · 793 followers View post →

John Gordon (@jgordon@appdot.net)

@jgordonshare · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s MOUSE models. https://t.co/A3sYfJzDOt. Mice are a lousy AD model. But, this is why I started CrossFit 7y ago. (Exercise addiction is bigger driver now.)

Dec 30, 2019 · 418 followers View post →

Joe Gordon

@josephwgordon · X

RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…

Oct 16, 2019 · 4 shares · 2,107 followers View post →

Marina García Macia

@Juanaloca2002 · X

RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…

Oct 16, 2019 · 4 shares · 2,810 followers View post →

Ruben QC

@RubenQC_Lab · X

RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…

Oct 16, 2019 · 4 shares · 2,556 followers View post →

Andrea Armani

@AndreaArmani4 · X

RT @MauroCorradoBio: Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plas…

Oct 15, 2019 · 4 shares · 788 followers View post →

Mauro Corrado

@MauroCorradoBio · X

Get fit! #Irisin might help you reduce risk of #AlzheimersDisease | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/yUHEfWkJzW

Oct 15, 2019 · 3 likes · 4 shares · 2,003 followers View post →

Vendetta

@Vendett34414357 · X

@Mangan150 . That's from Brazil: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/d9a6msSqNW

Jun 29, 2019 · 349 followers View post →

松原　守

@matsubara_m · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/XfmL3xJ2VA

Feb 15, 2019 · 1 like · 2,156 followers View post →

DocMendizabal

@DocMendizabal · X

Dr. Oscar Mendizabal Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s modelsEjercicio aeróbico para prevenir demencias. Es gratis y si funciona, no como las aplicaciones de "gimnasia cerebral" que solo entretienen. https://t.co/iwuUMrHnti

Feb 14, 2019 · 145 followers View post →

@fm_tsukuba · X

Feb 13, 2019 · 15 likes · 2,432 followers View post →

Ariakas Enoreth

@Aenoreth · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/ybMRQmFW58

Feb 10, 2019 · 1,008 followers View post →

Spinal Healthcare

@SpinalHealthPM · X

Irisin is a protective factor in cancer (e.g., spinal metastasis & breast cancer), protective against insulin resistance, diabetes, etc. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects https://t.co/f9Dck8zz4S

Feb 9, 2019 · 1 like · 21 followers View post →

Marita Ostos

@MaritaOstos · X

RT @jfcryan: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | ⁦@NatureMedicine⁩ https:/…

Jan 22, 2019 · 1 share · 158 followers View post →

redglial

@redglial · X

RT @JLTrejo2: El bloqueo de FNDC5 / irisin (periférico o cerebral) atenúa los efectos del ejercicio físico sobre plasticidad y memoria en r…

Jan 20, 2019 · 2 shares · 768 followers View post →

John F. Cryan

@jfcryan · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | ⁦@NatureMedicine⁩ https://t.co/8PdqQfeZ7G

Jan 19, 2019 · 10 likes · 1 share · 22,442 followers View post →

Mercè Pallàs

@PallasMerce · X

RT @JLTrejo2: El bloqueo de FNDC5 / irisin (periférico o cerebral) atenúa los efectos del ejercicio físico sobre plasticidad y memoria en r…

Jan 19, 2019 · 2 shares · 423 followers View post →

José Luis Trejo

@JLTrejo2 · X

Jan 19, 2019 · 3 likes · 2 shares · 2,307 followers View post →

Gonzalo Marquez

@gmarquez_11 · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/iXuL5ZgD8l

Jan 17, 2019 · 3 likes · 970 followers View post →

Michael Vine

@mpvine · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/OGUXv4KNtO

Jan 17, 2019 · 1 like · 3,693 followers View post →

Damián Rangel

@roque976 · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/JHvRSASBqG

Jan 15, 2019 · 68 followers View post →

‍‍‍‍ ‍‍‍‍ ‍‍‍‍يِ DB LeConte-Sp̜̮ink ็็้้ܝܵܢ‍‍‍‍

@LeConteSpink · X

"Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models" Mychael V. Lourenco, et al. (2019) Full text: https://t.co/viMIlfqWBQ https://t.co/OgqZGweCZ0

Jan 13, 2019 · 1 like · 672 followers View post →

the paper link

@the_paper_link · X

[trend] up+2: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u

Jan 13, 2019 · 136 followers View post →

the paper link

@the_paper_link · X

[trend] up+1: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u

Jan 10, 2019 · 136 followers View post →

Yu-Kai Chang

@chang_yukai · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/Y3zvJWPMDB

Jan 10, 2019 · 3 likes · 150 followers View post →

V.S.P. Sotiras

@ptolemy_soter · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/EWz3swpDPh

Jan 10, 2019 · 433 followers View post →

the paper link

@the_paper_link · X

[trend] new: *Lourenco MV* et al (Nat Med) **Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.** https://t.co/fAb4FQ0C6u

Jan 10, 2019 · 136 followers View post →

Cris Ordieres

@cris_ordieres · X

RT @carlosminguez: La irisina podría parar la progresión del alzheimer (esta hormona se segrega con la práctica de AF) | Exercise-linked FN…

Jan 10, 2019 · 1 share · 130 followers View post →

Carlos Mínguez

@carlosminguez · X

La irisina podría parar la progresión del alzheimer (esta hormona se segrega con la práctica de AF) | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/HO7DpvrL2A

Jan 9, 2019 · 1 share · 2,589 followers View post →

Dr. Ilene Naomi Rusk

@inrneuro · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/lOeHsVIB2M

Jan 9, 2019 · 256 followers View post →

Dityatev Lab

@DityatevL · X

Very interesting! Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models - https://t.co/TNPyG3uRQE

Jan 9, 2019 · 3 likes · 562 followers View post →

Jose F. Ruiz

@josefra1975 · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/QhMuk38dfe

Jan 9, 2019 · 1 like · 1 share · 377 followers View post →

AurelG

@AurelG7 · X

Exercise-linked #FNDC5/#irisin rescues #synaptic #plasticity and #memory defects in Alzheimer’s models | #alzheimer #cognition #exercise #hippocampus #neuroscience https://t.co/iBMj7TJ7bP

Jan 9, 2019 · 3 likes · 30 followers View post →

Malcolm Brown, Ph.D.

@MalBrown7 · X

RT @dantyrr: Nice paper out in ⁦@NatureMedicine⁩: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer…

Jan 8, 2019 · 1 share · 278 followers View post →

Nirav Dhanesha

@Nirav_Dhanesha · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models | Nature Medicine https://t.co/HVWc1JEUvA

Jan 8, 2019 · 2 likes · 1,125 followers View post →

Dan Tyrrell

@danis1337 · X

Nice paper out in ⁦@NatureMedicine⁩: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/Mbj2JCVzme

Jan 8, 2019 · 3 likes · 1 share · 3,623 followers View post →

Reinaldo dos Santos

@rsdossantos13 · X

Congrats to my friends @IBqMUFRJ. #exercise #irisin #memory #Alzheimer "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models" https://t.co/1msHjftk02

Jan 8, 2019 · 4 likes · 383 followers View post →

Toru Ishihara

@toru_ishihara · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/EJNN9ftToU

Jan 7, 2019 · 89 followers View post →

CLaE

@leafs_s · X

Alzheimer’s disease FNDC5/irisin Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/RxqQc65eaz

Jan 7, 2019 · 28,112 followers View post →

Damião Pereira

@dpspersonal01 · X

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/XVMOjA6HLF

Jan 7, 2019 · 305 followers View post →

マーキュリー２世

@uranus_2 · X

末梢でのFNDC5/イリシン過発現は記憶障害を弱める。末梢や脳でのFNDC5/イリシン阻害は、運動がシナプス可塑性や記憶を向上させる効果を弱める。Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models https://t.co/OEvO0GLRZu https://t.co/gwE9HR8xJ1

Jan 7, 2019 · 1 like · 5,545 followers View post →

Dr. Alexandre Cruzeiro

@DrCruzeiro · X

Pesquisa liderada por brasileiros aponta que hormônio pode reverter perda de memória causada pelo #Alzheimer. #irisina #neurociência #neurologia #neuroscience #neurology https://t.co/FcdJ6yzHt9 https://t.co/oSjiqTgd9X

Jan 7, 2019 · 3 likes · 1,172 followers View post →

Michelle Saul

@MichelleESaul · X

RT @OAtrito: O link para o artigo "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models", menc…

Jan 7, 2019 · 1 share · 67 followers View post →

O Atrito

@OAtrito · X

Jan 7, 2019 · 5 likes · 1 share · 405 followers View post →

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Exercise's Role in Preventing Memory Loss

Exercise-Linked Irisin and Its Effects on Alzheimer's Models