Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.

ChangDong Lin, YouHua Zhang, Kun Zhang, YaJuan Zheng, Ling Lu, HaiShuang Chang, Hui Yang, YanRong Yang, YaoYing Wan, ShiHui Wang, MengYa Yuan, ZhanJun Yan, RongGuang Zhang, YongNing He, GaoXiang Ge

January 2019

Synopsis of Social media discussions

Numerous discussions explore the role of fever in boosting the immune system, with users stating that 'fever powers up our immune cells' and discussing the potential dangers of overusing fever reducers. Phrases like 'important role in boosting your immune system' and 'fantastic study' reflect a positive and intrigued tone that contributes to a comprehensive understanding of the article's significance.

A
Agreement
 Strong agreement

The overall sentiment strongly aligns with the findings of the publication, as most discussions express clear support and validation of the research.

I
Interest
 High level of interest

There is a high level of curiosity about the mechanisms behind fever and immune response, with many users expressing eagerness to learn more.

E
Engagement
 High engagement

Several users engage deeply with the content, referencing specific findings and their implications for health practices, particularly regarding fever management.

I
Impact
 High level of impact

Participants perceive significant implications for clinical practices related to fever treatment, suggesting that the findings could influence medical guidelines.

Social Mentions

YouTube

2 Videos

Facebook

10 Posts

Twitter

80 Posts

Blogs

8 Articles

News

26 Articles

Reddit

3 Posts

Metrics

Video Views

7,169

Total Likes

490

Extended Reach

211,824

Social Features

129

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Understanding Fever's Role in Immune Response Mechanisms

Understanding Fever's Role in Immune Response Mechanisms

Fever is not as detrimental as many believe. It activates T lymphocytes by enhancing interactions between heat shock protein 90 and α4 integrins, which promotes their movement to infected tissues. This vital mechanism underscores fever's importance in bolstering immune defense against infections.

Daniel Pugge

January 21, 2019

6,207 views

Exploring Herbal Remedies for Fever in Children and Adults

Exploring Herbal Remedies for Fever in Children and Adults

In this session, we discuss herbal alternatives for treating fever, focusing on their efficacy in children and adults. Recent studies highlight the role of fever in activating T lymphocytes, emphasizing immune response and the importance of herbal interventions in managing fever.

Silvy and Sigit

November 13, 2022

962 views

  • Honey Honey
    @msWV0NUFrgFuLp0 (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
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  • Devon Y
    @devonJ32130301 (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
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    August 24, 2021

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  • DDD
    @DDD15460845 (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
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    August 22, 2021

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  • shiye
    @dongfangdeyun (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
    view full post

    August 22, 2021

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  • lulu
    @LuluLuluparis20 (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
    view full post

    August 22, 2021

    6

  • john
    @Golffanzz (Twitter)

    RT @CPAJim2021: 在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫…
    view full post

    August 22, 2021

    6

  • CPA Jim
    @CPAJim2021 (Twitter)

    在国家自然科学基金项目资助下，陈剑峰成果：通过构建α4整合素R985A突变基因敲入小鼠在体内破坏Hsp90-α4整合素结合后，导致细菌感染的小鼠快速死亡。适用于发热调控其它α4整合素表达阳性的免疫细胞的定向迁移，说明适用于多种固有免疫与适应性免疫细胞https://t.co/T34cSJ9TWO
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    August 22, 2021

    7

    6

  • RRID Robot
    @RobotRrid (Twitter)

    RRIDs were included in the Immunity paper "untitled" (https://t.co/Uxevyp5KxN). Thank you for making your #methodsmatter. #STMpublishing
    view full post

    August 5, 2021

  • BiologyJ
    @BiologyJ3 (Twitter)

    #Fever Promotes #T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock #Protein 90 and α4 Integrins explore more @ https://t.co/uh5I2K2oM7
    view full post

    January 27, 2021

  • BiologyJ
    @BiologyJ3 (Twitter)

    #Fever Promotes #T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock #Protein 90 and α4 Integrins explore more #https://www.longdom.org/cell-developmental-biology.html#
    view full post

    December 29, 2020

  • Antonio Aracil
    @Aracil81 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 26, 2020

    36

  • Juan Manuel Marín
    @Marin_gine (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 25, 2020

    36

  • Jaime Raúl Molina
    @jaimeraulmolina (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 24, 2020

    36


  • @canal_salud (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Carlos J V
    @carlosjvp111 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Osapig
    @Osapig13 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Juanillo
    @juanillowe (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Marc C.
    @NaturMarc (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Alejandro Barrios
    @alexbarrios14 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Adriakin ✝️
    @RastyKiba (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Andrés Mora
    @AndrsEMG (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Rodri Atienza
    @RodriAtienza (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Rosa Tomás
    @rosa_tomas (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/KHnVyBorA1
    view full post

    March 23, 2020

  • alan pedraza
    @AlanPeM (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • humberto_gmr
    @gmr_humberto (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • sete7ber
    @narber21 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Pedro
    @Zirculovizioso (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Raul Barea
    @raul7barea (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • โชคดี
    @Mr_Lopesito (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Paco
    @PacoBernalll (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • erika jimenez
    @etjimenezr (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Jose Angel Mena
    @joseangelmena (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Zyo
    @zyo73 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • HarmoniaIntegral
    @AbrahamPerezGo2 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Charly
    @guantutri92007 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Fede de Novales
    @Fede_Novales (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • De verdad
    @DeVerdad15 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Georgia Mendoza Castañeda
    @GeoMenC12 (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • MIGUEL❤️‍
    @mmolinae (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • ★WallMapuLibre★
    @MalditaCronopia (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • Néstor
    @senoner_ (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • JDolan
    @SyDolan (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36


  • @_Benengeli (Twitter)

    RT @mitokondriac: En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error a…
    view full post

    March 23, 2020

    36

  • ☀️MitoHacker☀️
    @mitokondriac (Twitter)

    En la sociedad actual la palabra FIEBRE es sinónimo de "tengo que tomar algo". Es posible que estés cometiendo un error al bloquear la respuesta innata del organismo frente a infecciones externas. Utiliza los antipiréticos con cabeza. https://t.co/mXOf0M6zLp https://t.co/UEjWoN0YQq
    view full post

    March 23, 2020

    109

    36


  • @jb0x_ (Twitter)

    https://t.co/dNFRVxwFGN is the synopsis of https://t.co/HMfXp4cKPO And now I have an incomplete, rather than incorrect, understanding of the role fevers play in the body. Internet points for anyone willing to synthesize and regurgitate that cell paper for a sick dog..
    view full post

    January 23, 2020

  • New Scientist Zone
    @NewScientistZon (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins (and enhances immune surveillance during infection.) https://t.co/pfCUy8zm43
    view full post

    May 8, 2019

  • Torben L. Sørensen
    @tlsophtha (Twitter)

    Nice study on how Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins: Immunity ⁦@ImmunityCP⁩ https://t.co/5q40g7cF18
    view full post

    May 4, 2019

    4

  • Maria Rickert Hong
    @mariarickert (Twitter)

    Fever powers up our immune cells, which is why using fever reducers such as Tylenol or ibuprofen may be harmful to the immune system in the long run. https://t.co/dYA1SitMMk
    view full post

    February 15, 2019

  • Almost Autism
    @almostautism (Twitter)

    Fever powers up our immune cells, which is why using fever reducers such as Tylenol or ibuprofen may be harmful to the immune system in the long run. https://t.co/LyDOM8XTmG
    view full post

    February 15, 2019

  • andes de aragua
    @andesdearagua (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 27, 2019

    13

  • Dragons Medical
    @DragonsMedical (Twitter)

    This is why you don't want to suppress a fever in most situations. It has an important role in boosting your immune system. https://t.co/wPFnwxDzhx
    view full post

    January 25, 2019

  • Science Furs
    @Sci_Furs (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/cKtioigUcH
    view full post

    January 25, 2019

  • Shivendra K Sinha
    @ShivendraKSinh1 (Twitter)

    RT @EFHPAeu: via NHPF:Studie bekrefter betydningen av feber ved bekjempelse av sykdom. Her undertrykker man kroppens forsvar med uante kon…
    view full post

    January 24, 2019

    1

  • EFHPA
    @EFHPAeu (Twitter)

    via NHPF:Studie bekrefter betydningen av feber ved bekjempelse av sykdom. Her undertrykker man kroppens forsvar med uante konsekvenser!https://t.co/CFJPMcxoWF https://t.co/FLKr09r5VL
    view full post

    January 24, 2019

    2

    1

  • Moreno Marcellini, PhD in Physics
    @moreno8691 (Twitter)

    Dr Ing @gd_roger ce l'hai DOI: https://t.co/HjOTWNtGGe ?
    view full post

    January 24, 2019

  • Erin
    @emmunologie (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Marianela Castés
    @MarianelaCastes (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Chucho
    @Chuch012 (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • jaimevquiroga
    @jaimevquiroga (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Herena Eixarch
    @EixarchHerena (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Martín González-Rodríguez
    @immuno_martin (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Sjögrens Forum
    @SjogrensForum (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 23, 2019

    13

  • Russell Jones
    @DrRGJonesLab (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 22, 2019

    13

  • Christeayo TTV
    @christeayo (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 22, 2019

    13

  • Immunity
    @ImmunityCP (Twitter)

    RT @AnnaOhradanova: Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins.…
    view full post

    January 22, 2019

    13

  • VK Ulaganathan
    @VK_Ulaganathan (Twitter)

    Fever helps immune cells crawl along blood-vessel walls by? Membrane-proximal recruitment of heat-shock proteins via "ENRRDSWSY" motif in the a4 integrin cytoplasmic tail. --new finding https://t.co/iCNFWKHhsq #MembraneProximalSignaling @ImmunityCP #integrin @NatureNews https://t.co/8IcVtDxBxK
    view full post

    January 22, 2019

  • Shweta Tikoo
    @Shwetatikoo29 (Twitter)

    Fantastic study! Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway ... https://t.co/cBA1uGLQUF @Cell @ImmunityCP @CellPressNews
    view full post

    January 21, 2019

    7

  • Jon Humphries
    @JDHL18 (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. https://t.co/YuX0Lab7jo
    view full post

    January 21, 2019

  • Anna Ohradanova-Repic
    @AnnaOhradanova (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. A nice paper showing that our T cells actually need fever to get to the site of infection. https://t.co/ONC2umICxt
    view full post

    January 21, 2019

    40

    13

  • Kenyan Posts
    @TafakariYaBabu (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/Lk1TS817io https://t.co/TGQl6pqSsY
    view full post

    January 19, 2019

  • Pit Tobkins
    @SEOPit (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/AYCL93AV7g #science
    view full post

    January 19, 2019

  • Azzam D. Alotaibi
    @azzamalotaibi (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/2A3pg2GjBk
    view full post

    January 19, 2019

  • New Scientist Zone
    @NewScientistZon (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Prot... https://t.co/IOkZVrUdxS
    view full post

    January 18, 2019

  • Will Wompoto
    @WompotoWill (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/NdqW2HCulQ
    view full post

    January 18, 2019

  • Deep Adhya, PhD
    @DeepAdhyaPhD (Twitter)

    How fever helps our body to search and destroy infection https://t.co/WmjNrcTYAr
    view full post

    January 18, 2019

    3

  • Kristin Knouse
    @kristinknouse (Twitter)

    Hot study showing that #fever promotes #lymphocyte trafficking via an Hsp90-dependent mechanism. Far more mechanistically satisfying than the cooking pathogens hypothesis drilled home in grade school. https://t.co/Rz179qBE8c
    view full post

    January 18, 2019

    21

  • Immune Regulation News
    @Immune_News (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/VviYZyztwV https://t.co/O16NjM4s7E
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    January 17, 2019

    1

  • Akshay Sharma MD
    @AkshaySharmaMD (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins
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    January 16, 2019

  • Ariakas Enoreth
    @Aenoreth (Twitter)

    Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/V6InWPozRr
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    January 16, 2019

  • Richard Burchmore
    @Thetoadwork (Twitter)

    How fever helps to control infection. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins https://t.co/i9kp4IqGZG
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    January 15, 2019

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Abstract Synopsis

  • Fever is an important survival mechanism during infection, but how it works at a cellular level wasn't fully understood until now.
  • The study found that fever activates T lymphocytes by enhancing the interaction between heat shock protein 90 (Hsp90) and α4 integrins, which helps T cells move and adhere effectively to inflamed tissues.
  • Disrupting this interaction can hinder T cell movement to lymph nodes and reduce the body's ability to fight off bacterial infections, highlighting the crucial role of the Hsp90-α4-integrin pathway in immune response.