@JHochgesang @headdock Oxycodone works for neuropathic pain. Excerpt from "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" https://t.co/kzTsBQ0WJk
Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone.
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Mar 2021 – Feb 2023Where it's discussed
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What people are saying
The discussions demonstrate high interest, with users frequently mentioning the article as a key source for understanding oxycodone's effects, safety, and applications, using words like 'informative,' 'bible,' and 'valuable.' The tone suggests respect for the research, but some users also express frustration regarding medical knowledge gaps, indicating a potential gap between research and practice.
Most discussions acknowledge the publication as a valuable resource and agree with its importance for understanding oxycodone's pharmacology.
The discussions highlight high interest, with users referencing the article for specific pain management insights and safety considerations.
Posts show moderate engagement, with users sharing personal experiences, citing specific sections, and discussing implications for self-care and clinical practice.
While some posts emphasize the article’s relevance for safe medication use, the overall perceived impact is moderate, affecting individual and clinical perspectives more than broader policy.
Abstract in brief
- The global consumption of oxycodone has increased significantly over the past two decades, surpassing morphine in 2008, but much of the existing pharmacokinetic (PK) data is from the 1990s, with recent research providing new insights, especially related to special populations like neonates, children, pregnant women, and the elderly.
- The review emphasizes the importance of understanding drug interactions, particularly with substances affecting cytochrome P450 enzymes (CYP 3A and CYP 2D6), which can alter oxycodone's effectiveness and safety when used together with certain inducers or inhibitors.
- Additionally, recent data has focused on abused-deterrent formulations of oxycodone, as well as pharmacokinetics associated with alternative routes of administration such as transmucosal and epidural delivery systems.
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Most liked on X and Bluesky@JustWinks @LelenaPeacock ...papers saying bupe AND oxy both don't effect the immune system, & my personal "bible", "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" that outlines pain types it is EFFECTIVE on & how to rx it SAFELY in different patient groups.
@Wanita1 @AlaskanNative49 Oxycodone is known to help with neuro pain, but the drs don't know it since they don't keep up with opioid research & didnt learn it in school, unfortunately. Part 12 covers neuro pain: https://t.co/dIY1P5NBCX
@FireIsBorn3 @headdock @kris_lovaas @sky_dvr ...(though I lost research that said that...) & it's a delta & kappa agonist @ higher doses (which I've found is 20mg as it reduces redness from inflammation at that dose). This is a very informative paper you can use:... https://t.co/sNN6iM15b9
@HR4peopleinpain @kris_lovaas @headdock @carrie4502 @Elianok10 @SpicyPurritos @lakeparkcpl @JustWinks @ThomasKlineMD @russell90367011 @Technovore1 @KimmMathiesen @JSG_54 @Chronic_FLKeys @NitaGhei @secondchances09 @DebM01279692 @GEugenics @hope411adcock @SarahSaysHi2U @EbCummings1 @sky_dvr @dau1776 @CContrarus @OpioidHysteria @wittywax1 @ChadDKollas @process_x @ibdgirl76 @docroland @WriterMera @onnaroll66 @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @aander1987 @life_is_art___ @fightpaindaily @Kazeself FYI, alcohol does seem to be able to reverse tolerance to oxycodone & other opioids I think. Don't take at same time, take a day off of opioids & doesn't even take enough to get drunk. "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodon
@HR4peopleinpain @ThomasKlineMD @serendipitousP @Annemarie55USA @hope411adcock @headdock @Cyanytlas @EbCummings1 @CContrarus @Technovore1 @life_is_art___ @docroland @WriterMera @onnaroll66 @SpicyPurritos @OpioidHysteria @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @Chronic_FLKeys @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @soofriends @DebM01279692 @russell90367011 @aander1987 @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 @CDCgov @CDCDirector ...It's kinda terrifying that my pcps don't know how medications work. Really grateful for free access to med journal articles like: https://t.co/Np5qz6dCX8 It has been far more helpful than my lemming pcps. It's like drs are being hired based on gullibility & bigote
All mentions
Updated Pharmacokinetics and Safety of Oxycodone Use
The global consumption of oxycodone has increased significantly over the past two decades, surpassing morphine in 2008. Recent research provides new insights into pharmacokinetics, drug interactions, special…
@Wanita1 @AlaskanNative49 Oxycodone is known to help with neuro pain, but the drs don't know it since they don't keep up with opioid research & didnt learn it in school, unfortunately. Part 12 covers neuro pain: https://t.co/dIY1P5NBCX
@JustWinks @LelenaPeacock ...papers saying bupe AND oxy both don't effect the immune system, & my personal "bible", "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" that outlines pain types it is EFFECTIVE on & how to rx it SAFELY in different patient groups.
@FireIsBorn3 @headdock @kris_lovaas @sky_dvr ...(though I lost research that said that...) & it's a delta & kappa agonist @ higher doses (which I've found is 20mg as it reduces redness from inflammation at that dose). This is a very informative paper you can use:... https://t.co/sNN6iM15b9
@JHochgesang @headdock Oxycodone works for neuropathic pain. Excerpt from "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" https://t.co/kzTsBQ0WJk
@HR4peopleinpain @kris_lovaas @headdock @carrie4502 @Elianok10 @SpicyPurritos @lakeparkcpl @JustWinks @ThomasKlineMD @russell90367011 @Technovore1 @KimmMathiesen @JSG_54 @Chronic_FLKeys @NitaGhei @secondchances09 @DebM01279692 @GEugenics @hope411adcock @SarahSaysHi2U @EbCummings1 @sky_dvr @dau1776 @CContrarus @OpioidHysteria @wittywax1 @ChadDKollas @process_x @ibdgirl76 @docroland @WriterMera @onnaroll66 @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @aander1987 @life_is_art___ @fightpaindaily @Kazeself FYI, alcohol does seem to be able to reverse tolerance to oxycodone & other opioids I think. Don't take at same time, take a day off of opioids & doesn't even take enough to get drunk. "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodon
@HR4peopleinpain @ThomasKlineMD @serendipitousP @Annemarie55USA @hope411adcock @headdock @Cyanytlas @EbCummings1 @CContrarus @Technovore1 @life_is_art___ @docroland @WriterMera @onnaroll66 @SpicyPurritos @OpioidHysteria @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @Chronic_FLKeys @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @soofriends @DebM01279692 @russell90367011 @aander1987 @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 @CDCgov @CDCDirector ...It's kinda terrifying that my pcps don't know how medications work. Really grateful for free access to med journal articles like: https://t.co/Np5qz6dCX8 It has been far more helpful than my lemming pcps. It's like drs are being hired based on gullibility & bigote