Clin Pharmacokinet June 2019 PMID 30652261

Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone.

Mari Kinnunen, Panu Piirainen, Hannu Kokki, Pauliina Lammi, Merja Kokki

Mentions

7
Peak: 3 in Apr 2021
across 2 sources since Mar 2021

Extended reach

3,967
potential audience

Total likes

44

Video views

2,312

Mentions per month

Mar 2021 – Feb 2023

Where it's discussed

  • X / Twitter6 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate high interest, with users frequently mentioning the article as a key source for understanding oxycodone's effects, safety, and applications, using words like 'informative,' 'bible,' and 'valuable.' The tone suggests respect for the research, but some users also express frustration regarding medical knowledge gaps, indicating a potential gap between research and practice.

AgreementModerate agreement

Most discussions acknowledge the publication as a valuable resource and agree with its importance for understanding oxycodone's pharmacology.

InterestHigh interest

The discussions highlight high interest, with users referencing the article for specific pain management insights and safety considerations.

EngagementModerate engagement

Posts show moderate engagement, with users sharing personal experiences, citing specific sections, and discussing implications for self-care and clinical practice.

ImpactModerate impact

While some posts emphasize the article’s relevance for safe medication use, the overall perceived impact is moderate, affecting individual and clinical perspectives more than broader policy.

Abstract in brief

  • The global consumption of oxycodone has increased significantly over the past two decades, surpassing morphine in 2008, but much of the existing pharmacokinetic (PK) data is from the 1990s, with recent research providing new insights, especially related to special populations like neonates, children, pregnant women, and the elderly.
  • The review emphasizes the importance of understanding drug interactions, particularly with substances affecting cytochrome P450 enzymes (CYP 3A and CYP 2D6), which can alter oxycodone's effectiveness and safety when used together with certain inducers or inhibitors.
  • Additionally, recent data has focused on abused-deterrent formulations of oxycodone, as well as pharmacokinetics associated with alternative routes of administration such as transmucosal and epidural delivery systems.

Top posts

Most liked on X and Bluesky
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@JHochgesang @headdock Oxycodone works for neuropathic pain. Excerpt from "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" https://t.co/kzTsBQ0WJk

Apr 30, 2021 · 8 likes · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@JustWinks @LelenaPeacock ...papers saying bupe AND oxy both don't effect the immune system, & my personal "bible", "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" that outlines pain types it is EFFECTIVE on & how to rx it SAFELY in different patient groups.

Jun 9, 2021 · 2 likes · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@Wanita1 @AlaskanNative49 Oxycodone is known to help with neuro pain, but the drs don't know it since they don't keep up with opioid research & didnt learn it in school, unfortunately. Part 12 covers neuro pain: https://t.co/dIY1P5NBCX

Feb 15, 2023 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@FireIsBorn3 @headdock @kris_lovaas @sky_dvr ...(though I lost research that said that...) & it's a delta & kappa agonist @ higher doses (which I've found is 20mg as it reduces redness from inflammation at that dose). This is a very informative paper you can use:... https://t.co/sNN6iM15b9

May 30, 2021 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@HR4peopleinpain @kris_lovaas @headdock @carrie4502 @Elianok10 @SpicyPurritos @lakeparkcpl @JustWinks @ThomasKlineMD @russell90367011 @Technovore1 @KimmMathiesen @JSG_54 @Chronic_FLKeys @NitaGhei @secondchances09 @DebM01279692 @GEugenics @hope411adcock @SarahSaysHi2U @EbCummings1 @sky_dvr @dau1776 @CContrarus @OpioidHysteria @wittywax1 @ChadDKollas @process_x @ibdgirl76 @docroland @WriterMera @onnaroll66 @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @aander1987 @life_is_art___ @fightpaindaily @Kazeself FYI, alcohol does seem to be able to reverse tolerance to oxycodone & other opioids I think. Don't take at same time, take a day off of opioids & doesn't even take enough to get drunk. "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodon

Apr 29, 2021 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@HR4peopleinpain @ThomasKlineMD @serendipitousP @Annemarie55USA @hope411adcock @headdock @Cyanytlas @EbCummings1 @CContrarus @Technovore1 @life_is_art___ @docroland @WriterMera @onnaroll66 @SpicyPurritos @OpioidHysteria @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @Chronic_FLKeys @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @soofriends @DebM01279692 @russell90367011 @aander1987 @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 @CDCgov @CDCDirector ...It's kinda terrifying that my pcps don't know how medications work. Really grateful for free access to med journal articles like: https://t.co/Np5qz6dCX8 It has been far more helpful than my lemming pcps. It's like drs are being hired based on gullibility & bigote

Apr 7, 2021 · 1 like · 276 followers View post →

All mentions

Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@Wanita1 @AlaskanNative49 Oxycodone is known to help with neuro pain, but the drs don't know it since they don't keep up with opioid research & didnt learn it in school, unfortunately. Part 12 covers neuro pain: https://t.co/dIY1P5NBCX

Feb 15, 2023 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@JustWinks @LelenaPeacock ...papers saying bupe AND oxy both don't effect the immune system, & my personal "bible", "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" that outlines pain types it is EFFECTIVE on & how to rx it SAFELY in different patient groups.

Jun 9, 2021 · 2 likes · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@FireIsBorn3 @headdock @kris_lovaas @sky_dvr ...(though I lost research that said that...) & it's a delta & kappa agonist @ higher doses (which I've found is 20mg as it reduces redness from inflammation at that dose). This is a very informative paper you can use:... https://t.co/sNN6iM15b9

May 30, 2021 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@JHochgesang @headdock Oxycodone works for neuropathic pain. Excerpt from "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone 2019" https://t.co/kzTsBQ0WJk

Apr 30, 2021 · 8 likes · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@HR4peopleinpain @kris_lovaas @headdock @carrie4502 @Elianok10 @SpicyPurritos @lakeparkcpl @JustWinks @ThomasKlineMD @russell90367011 @Technovore1 @KimmMathiesen @JSG_54 @Chronic_FLKeys @NitaGhei @secondchances09 @DebM01279692 @GEugenics @hope411adcock @SarahSaysHi2U @EbCummings1 @sky_dvr @dau1776 @CContrarus @OpioidHysteria @wittywax1 @ChadDKollas @process_x @ibdgirl76 @docroland @WriterMera @onnaroll66 @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @Royalacresrod @soofriends @aander1987 @life_is_art___ @fightpaindaily @Kazeself FYI, alcohol does seem to be able to reverse tolerance to oxycodone & other opioids I think. Don't take at same time, take a day off of opioids & doesn't even take enough to get drunk. "Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodon

Apr 29, 2021 · 1 like · 276 followers View post →
Meowing 'Deny Defend Depose' #disabled free
@NAbleism · X

@HR4peopleinpain @ThomasKlineMD @serendipitousP @Annemarie55USA @hope411adcock @headdock @Cyanytlas @EbCummings1 @CContrarus @Technovore1 @life_is_art___ @docroland @WriterMera @onnaroll66 @SpicyPurritos @OpioidHysteria @bluelilly40 @Nashkitty66 @TheDarkGift_ @eullrich11 @StopBadDocs @Chronic_FLKeys @lockedoutofvenu @Deeenst @Canada_NV @chattyknana @maryann19711 @Vlynx5 @SweetDeals16 @secondchances09 @Royalacresrod @soofriends @DebM01279692 @russell90367011 @aander1987 @fightpaindaily @Kazeself @JustWinks @JoshBloomACSH @RepKatiePorter @NPR @NPRHealth @JeffreyFudin @drcarlhart @BethDarnall @twebber02 @CDCgov @CDCDirector ...It's kinda terrifying that my pcps don't know how medications work. Really grateful for free access to med journal articles like: https://t.co/Np5qz6dCX8 It has been far more helpful than my lemming pcps. It's like drs are being hired based on gullibility & bigote

Apr 7, 2021 · 1 like · 276 followers View post →