The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton #openaccess https://t.co/Rmi7V9McDG Join us tomorrow for a look at the most popular papers in JIMD Reports. https://t.co/DM9JOp1sa2
Disorders affecting vitamin B metabolism.
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Dec 2019 – Nov 2024Where it's discussed
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X / Twitter17 posts
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YouTube2 videos
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Discussions reflect strong agreement and interest by repeatedly highlighting the paper's popularity, such as labeling it as one of the most downloaded articles and referencing special issues dedicated to B vitamins. The tone conveys admiration and recognition of the article's importance, with examples like phrases 'most downloaded paper' and 'popular discussion', which show the community values this research highly and considers it impactful for advancing understanding of vitamin B6-related disorders.
Most discussions emphasize the importance and relevance of the publication, with some calling it a 'most downloaded' and 'popular' paper, indicating strong agreement.
Participants show high interest by referencing special issues, notable authors, and comprehensive reviews, demonstrating engagement with the topic.
Some posts include multiple mentions and efforts to highlight the study’s significance, reflecting a moderate level of deep engagement.
The emphasis on the paper being highly downloaded and part of special issues suggests the publication has significant influence within the scientific community.
Abstract in brief
- Vitamin B, particularly pyridoxal 5-phosphate (PLP), is essential for various metabolic processes including amino acid, neurotransmitter, folate, carbohydrate, lipid metabolism, and mitochondrial function, with roles extending beyond enzyme cofactor activity to cellular regulation and immune function.
- Disorders affecting PLP metabolism, such as genetic deficiencies in synthesis, recycling, transport, or inactivation of PLP, often manifest as early-onset epilepsy that responds to treatment with vitamin B6 derivatives like pyridoxine or PLP, requiring lifelong supplementation in some cases.
- These inborn errors include conditions like pyridoxamine phosphate oxidase deficiency, hypophosphatasia, and GPI anchor synthesis defects, with clinical features and management strategies detailed in the review to highlight their impact on neurodevelopment and seizure control.
Top posts
Most liked on X and BlueskyDr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalka57RS https://t.co/GLErZdBAHe
In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehensive review of disorders affecting vitamin B6 metabolism. https://t.co/Rmi7V9McDG https://t.co/y0cxHb4R4c
In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton https://t.co/Rmi7Va3Nve https://t.co/LJyZUZLcu6
”高用量のPLPを服用している小児の中には、肝硬変62や肝細胞癌へと進行するトランスアミナーゼの持続的な上昇を示すものがいる(未発表の観察)。原因は不明のままであり、PLPとピリドキサールによるアルデヒドストレス、またはPLP光分解生成物の毒性などが考えられる。” https://t.co/E15sebIjV4
”細胞内フリーPLP濃度は、不適切な反応("アルデヒドストレス "または "カルボニルストレス")を防ぐために、約1μM13で維持されています。” お〜、やはりアルデヒド基を持つということはそういうことか
All mentions
Avoid Harmful Forms of Supplements for Better Health
Join Nic and Steve as they discuss supplement forms to avoid, including folic acid, B12, B6, and iron, highlighting the importance of ingredient awareness. This episode urges you to check your supplements for…
Understanding Vitamin B Metabolism Disorders and Their Impact on Health
Join Nic and Steve as they discuss supplement forms to avoid, focusing on vitamin B metabolism disorders caused by PLP deficiencies, which can lead to early-onset epilepsy. Learn about diagnosis, treatment, and the…
RT @DrJNurse: Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalk…
RT @DrJNurse: Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalk…
Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalka57RS https://t.co/GLErZdBAHe
Bugün laboratuvar köşemizde Prof. Dr. Özlem Gülbahar ile birlikte B6 vitamini ölçümü üzerine konuşuyoruz. Moderatör: Dr. Ekin Özsaydı Aktaşoğlu İlgili kaynaklar: https://t.co/fZoBCYQNqK https://t.co/3fJdfJLVjV Instagram: metacademymetabolism metacademymetabolism@gmail.com https://t.co/1Znfn5B0A3
”高用量のPLPを服用している小児の中には、肝硬変62や肝細胞癌へと進行するトランスアミナーゼの持続的な上昇を示すものがいる(未発表の観察)。原因は不明のままであり、PLPとピリドキサールによるアルデヒドストレス、またはPLP光分解生成物の毒性などが考えられる。” https://t.co/E15sebIjV4
”細胞内フリーPLP濃度は、不適切な反応("アルデヒドストレス "または "カルボニルストレス")を防ぐために、約1μM13で維持されています。” お〜、やはりアルデヒド基を持つということはそういうことか
”PLPに依存する経路には、アミノ酸および神経伝達物質代謝、葉酸および1-炭素代謝、タンパク質およびポリアミン合成、炭水化物および脂質代謝、ミトコンドリア機能および赤血球造血が含まれます。” 覚えました?
RT @JIMD_Editors: In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders af…
In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton https://t.co/Rmi7Va3Nve https://t.co/LJyZUZLcu6
RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…
RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…
RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…
RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…
The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton #openaccess https://t.co/Rmi7V9McDG Join us tomorrow for a look at the most popular papers in JIMD Reports. https://t.co/DM9JOp1sa2
RT @JIMD_Editors: In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehen…
RT @JIMD_Editors: In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehen…
In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehensive review of disorders affecting vitamin B6 metabolism. https://t.co/Rmi7V9McDG https://t.co/y0cxHb4R4c
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