J Inherit Metab Dis July 2019 PMID 30671974

Disorders affecting vitamin B metabolism.

Matthew P Wilson, Barbara Plecko, Philippa B Mills, Peter T Clayton

Mentions

19
Peak: 5 in Feb 2020
across 2 sources since Dec 2019

Extended reach

39,905
potential audience

Total likes

88

Video views

2,862

Mentions per month

Dec 2019 – Nov 2024

Where it's discussed

  • X / Twitter17 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect strong agreement and interest by repeatedly highlighting the paper's popularity, such as labeling it as one of the most downloaded articles and referencing special issues dedicated to B vitamins. The tone conveys admiration and recognition of the article's importance, with examples like phrases 'most downloaded paper' and 'popular discussion', which show the community values this research highly and considers it impactful for advancing understanding of vitamin B6-related disorders.

AgreementStrong agreement

Most discussions emphasize the importance and relevance of the publication, with some calling it a 'most downloaded' and 'popular' paper, indicating strong agreement.

InterestHigh interest

Participants show high interest by referencing special issues, notable authors, and comprehensive reviews, demonstrating engagement with the topic.

EngagementModerate engagement

Some posts include multiple mentions and efforts to highlight the study’s significance, reflecting a moderate level of deep engagement.

ImpactHigh impact

The emphasis on the paper being highly downloaded and part of special issues suggests the publication has significant influence within the scientific community.

Abstract in brief

  • Vitamin B, particularly pyridoxal 5-phosphate (PLP), is essential for various metabolic processes including amino acid, neurotransmitter, folate, carbohydrate, lipid metabolism, and mitochondrial function, with roles extending beyond enzyme cofactor activity to cellular regulation and immune function.
  • Disorders affecting PLP metabolism, such as genetic deficiencies in synthesis, recycling, transport, or inactivation of PLP, often manifest as early-onset epilepsy that responds to treatment with vitamin B6 derivatives like pyridoxine or PLP, requiring lifelong supplementation in some cases.
  • These inborn errors include conditions like pyridoxamine phosphate oxidase deficiency, hypophosphatasia, and GPI anchor synthesis defects, with clinical features and management strategies detailed in the review to highlight their impact on neurodevelopment and seizure control.

Top posts

Most liked on X and Bluesky
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton #openaccess https://t.co/Rmi7V9McDG Join us tomorrow for a look at the most popular papers in JIMD Reports. https://t.co/DM9JOp1sa2

Feb 26, 2020 · 10 likes · 5 shares · 3,517 followers View post →
James Nurse
@DrJNurse · X

Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalka57RS https://t.co/GLErZdBAHe

May 16, 2024 · 6 likes · 2 shares · 1,487 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehensive review of disorders affecting vitamin B6 metabolism. https://t.co/Rmi7V9McDG https://t.co/y0cxHb4R4c

Dec 28, 2019 · 4 likes · 2 shares · 3,517 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton https://t.co/Rmi7Va3Nve https://t.co/LJyZUZLcu6

Apr 2, 2020 · 3 likes · 2 shares · 3,517 followers View post →
サカト
@Sakato0 · X

”高用量のPLPを服用している小児の中には、肝硬変62や肝細胞癌へと進行するトランスアミナーゼの持続的な上昇を示すものがいる(未発表の観察)。原因は不明のままであり、PLPとピリドキサールによるアルデヒドストレス、またはPLP光分解生成物の毒性などが考えられる。” https://t.co/E15sebIjV4

Feb 28, 2021 · 2 likes · 2,502 followers View post →
サカト
@Sakato0 · X

”細胞内フリーPLP濃度は、不適切な反応("アルデヒドストレス "または "カルボニルストレス")を防ぐために、約1μM13で維持されています。” お〜、やはりアルデヒド基を持つということはそういうことか

Feb 28, 2021 · 2 likes · 2,502 followers View post →

All mentions

Maria Quelhas
@quelhas_maria · X

RT @DrJNurse: Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalk…

May 16, 2024 · 2 shares · 64 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @DrJNurse: Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalk…

May 16, 2024 · 2 shares · 3,517 followers View post →
James Nurse
@DrJNurse · X

Dr Champion hi-lights this paper from @JIMD_Editors, one of the most downloaded JIMD papers of all time. https://t.co/zMalka57RS https://t.co/GLErZdBAHe

May 16, 2024 · 6 likes · 2 shares · 1,487 followers View post →
Metacademy
@metacademy2 · X

Bugün laboratuvar köşemizde Prof. Dr. Özlem Gülbahar ile birlikte B6 vitamini ölçümü üzerine konuşuyoruz. Moderatör: Dr. Ekin Özsaydı Aktaşoğlu İlgili kaynaklar: https://t.co/fZoBCYQNqK https://t.co/3fJdfJLVjV Instagram: metacademymetabolism metacademymetabolism@gmail.com https://t.co/1Znfn5B0A3

Sep 24, 2021 · 2 likes · 15 followers View post →
サカト
@Sakato0 · X

”高用量のPLPを服用している小児の中には、肝硬変62や肝細胞癌へと進行するトランスアミナーゼの持続的な上昇を示すものがいる(未発表の観察)。原因は不明のままであり、PLPとピリドキサールによるアルデヒドストレス、またはPLP光分解生成物の毒性などが考えられる。” https://t.co/E15sebIjV4

Feb 28, 2021 · 2 likes · 2,502 followers View post →
サカト
@Sakato0 · X

”細胞内フリーPLP濃度は、不適切な反応("アルデヒドストレス "または "カルボニルストレス")を防ぐために、約1μM13で維持されています。” お〜、やはりアルデヒド基を持つということはそういうことか

Feb 28, 2021 · 2 likes · 2,502 followers View post →
サカト
@Sakato0 · X

”PLPに依存する経路には、アミノ酸および神経伝達物質代謝、葉酸および1-炭素代謝、タンパク質およびポリアミン合成、炭水化物および脂質代謝、ミトコンドリア機能および赤血球造血が含まれます。” 覚えました?

Feb 27, 2021 · 1 like · 2,502 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @JIMD_Editors: In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders af…

Apr 2, 2020 · 2 shares · 3,517 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

In case you missed it, July 2019 was a B vitamin special issue, including this popular #openaccess piece on: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton https://t.co/Rmi7Va3Nve https://t.co/LJyZUZLcu6

Apr 2, 2020 · 3 likes · 2 shares · 3,517 followers View post →
Matthew Wilson
@MattWilson4 · X

RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…

Feb 28, 2020 · 5 shares · 112 followers View post →
HCU Network America
@HCUAmerica · X

RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…

Feb 26, 2020 · 5 shares · 728 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…

Feb 26, 2020 · 5 shares · 3,517 followers View post →
BIMDG
@BIMDG · X

RT @JIMD_Editors: The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Pleck…

Feb 26, 2020 · 5 shares · 1,215 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

The unassailable, incontrovertable most downloaded paper of 2019: Disorders affecting vitamin B6 metabolism Wilson, Plecko, Mills & Clayton #openaccess https://t.co/Rmi7V9McDG Join us tomorrow for a look at the most popular papers in JIMD Reports. https://t.co/DM9JOp1sa2

Feb 26, 2020 · 10 likes · 5 shares · 3,517 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

RT @JIMD_Editors: In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehen…

Dec 28, 2019 · 2 shares · 3,517 followers View post →
BIMDG
@BIMDG · X

RT @JIMD_Editors: In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehen…

Dec 28, 2019 · 2 shares · 1,215 followers View post →
The Journal of Inherited Metabolic Disease
@JIMD_Editors · X

In another #openaccess paper, Matthew P. Wilson, Barbara Plecko, Philippa B. Mills & Peter T. Clayton provide a comprehensive review of disorders affecting vitamin B6 metabolism. https://t.co/Rmi7V9McDG https://t.co/y0cxHb4R4c

Dec 28, 2019 · 4 likes · 2 shares · 3,517 followers View post →