Am J Hematol April 2019 PMID 30697803

White matter has impaired resting oxygen delivery in sickle cell patients.

Yaqiong Chai, Adam M Bush, Julie Coloigner, Aart J Nederveen, Benita Tamrazi, Chau Vu, Soyoung Choi, Thomas D Coates, Natasha Lepore, John C Wood

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Peak: 10 in Mar 2019

across 4 sources since Feb 2019

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Feb 2019 – Aug 2019

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What people are saying

Discussions emphasize the significance of the study by mentioning its role in understanding subtle cognitive changes in sickle cell patients, illustrated by comments about supporting brain health and MRI research; the tone suggests curiosity and recognition of its potential impact without overly technical jargon, indicating moderate engagement and interest.

AgreementModerate agreement

Most discussions recognize the importance of the research, with some explicitly supporting its significance for understanding sickle cell disease.

InterestModerate interest

Participants show moderate interest, highlighting the study's relevance to brain function and possible cognitive effects.

EngagementModerate engagement

Several comments delve into the implications for patient care and the broader understanding of cerebrovascular issues.

ImpactModerate impact

There is a consensus that these findings could influence future research directions and clinical approaches.

Abstract in brief

White matter in sickle cell disease patients shows impaired oxygen delivery at rest, despite overall increases in cerebral blood flow that aim to compensate for anemia.
While gray matter oxygen delivery remains normal, white matter oxygen delivery is approximately 35% lower than in healthy controls, and this reduction is linked to regions showing signs of damage such as white matter hyperintensities.
Age and hematocrit levels are key factors influencing white matter blood flow and oxygen delivery, suggesting that these variables are critical in understanding white matter injury risk in sickle cell patients.]

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All mentions

Impacts of Sickle Cell Disease on White Matter Oxygen Delivery and Brain Health

Recent research explains how silent strokes caused by Sickle Cell Disease affect bodily functions. Despite increased cerebral blood flow, white matter in patients shows around 35% reduced oxygen delivery, which…

TomoNews Indonesia · Feb 12, 2019 6,306 views

White Matter Impaired Oxygen Delivery in Sickle Cell Disease

White matter in sickle cell disease patients shows impaired oxygen delivery at rest, despite increased cerebral blood flow. This reduction is linked to white matter damage, influenced by age and hematocrit levels…

TomoNews US · Feb 8, 2019 6,204 views

Impacts of Silent Strokes and Oxygen Delivery in Sickle Cell Disease

New research highlights how silent strokes caused by sickle cell disease affect brain regions, particularly white matter, which shows impaired oxygen delivery despite increased blood flow due to anemia.

News Direct · Mar 10, 2019 1,395 views

Siegfried Treitner

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