PubHawk
May 2019 PMID 30765332

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.

Federica Laudisi, Davide Di Fusco, Vincenzo Dinallo, Carmine Stolfi, Antonio Di Grazia, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Claudia Alteri, Francesca Guerrieri, Maria Mavilio, Francesca Ceccherini-Silberstein, Massimo Federici, Thomas Thornton MacDonald, Ivan Monteleone

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Mentions

22
Peak: 3 in Feb 2019
across 5 sources since Feb 2019

Extended reach

30,560
potential audience

Total likes

94

Video views

2,939

Mentions per month

Feb 2019 – Jul 2025

Where it's discussed

  • X / Twitter11 posts
  • YouTube3 videos
  • Facebook3 posts
  • News3 articles
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect a high level of agreement on the harmful effects of maltodextrin, with users advocating for bans and switching to natural alternatives, as seen in messages like 'Can we get Maltodextrin banned?' and references to replacing ingredients with FOS. The tone combines concern and urgency, emphasizing both scientific details and practical implications, contributing to a sense of impact and engagement.

AgreementStrong agreement

Most postings strongly endorse the findings, emphasizing that maltodextrin negatively affects gut health and should be reconsidered or banned.

InterestModerate interest

Discussions show moderate interest, with some users expressing concern and calling for action, though not all are deeply engaged with the science.

EngagementHigh engagement

Many discussions reference specific mechanisms like ER stress and mucus depletion, indicating a desire to understand and deliberate on the implications.

ImpactHigh impact

The posts suggest the research could have significant influence on consumer choices and policy debates, especially regarding food additive regulation.

Abstract in brief

  • Maltodextrin (MDX), a common food additive, worsens intestinal inflammation by causing stress in the cells’ endoplasmic reticulum, leading to a decrease in protective mucus and increased gut inflammation in mice.
  • The study found that MDX triggers ER stress by activating specific cellular pathways (like inositol requiring protein 1 and p38 MAP kinase), which results in less mucin2, a key mucus protein, without significantly changing gut microbiota.
  • Using an ER stress inhibitor (TUDCA) in mice reduced mucus depletion and inflammation, suggesting that MDX’s harmful effects are linked to ER stress pathways in gut cells, making it a potential target to lessen diet-related intestinal issues.]
Read the full abstract

Top posts

Most liked on X and Bluesky
BANT
@BANTonline · X

@thelowcarb_rd @MaritKolby https://t.co/dKDsXvgH9J

Apr 10, 2024 · 2 likes · 7,664 followers View post →
✨Reina Nakamoto✨
@mindstatex · X

Food additives chronically messing with Ur gut. I avoid this in supplements/powders. https://t.co/2m3mxeCE7Z https://t.co/DpThy5oHkb

Jul 25, 2025 · 1 like · 6,951 followers View post →
Joe B
@JBianco215 · X

https://t.co/UsZdeNXHeH Food additive Maltodextrin increases Endoplasmic Reticulum stress in gut epithelial cells with the downstream effect of reducing mucus production and enhancing colitis susceptibility.

Jan 22, 2023 · 1 like · 4,593 followers View post →
Steven M. Weil
@smweilhermes · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation https://t.co/68PRuvFMpq

Feb 16, 2019 · 1 like · 303 followers View post →
Dr. Suzana Mantovani
@Tweet_Nutrition · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation https://t.co/7pNwLBG30W

Mar 4, 2019 · 4,575 followers View post →
DrDawnSherling
@dharrissherling · X

@england_cy @KevinH_PhD Laudisi F, Di Fusco D, Dinallo V, et al. The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7(2):457-473. doi: 10.1016/j.jcmgh.2018.09.002. Epub 2018 Sep 11.

Sep 8, 2023 · 1,557 followers View post →

All mentions

✨Reina Nakamoto✨
@mindstatex · X

Food additives chronically messing with Ur gut. I avoid this in supplements/powders. https://t.co/2m3mxeCE7Z https://t.co/DpThy5oHkb

Jul 25, 2025 · 1 like · 6,951 followers View post →
Type4_Nickel_Sensitivity
@type4_nickel · X

@TeamTrump @RobertKennedyJr Can we get Maltodextrin banned? https://t.co/wmyjkUygfR

Dec 24, 2024 · 158 followers View post →
Type4_Nickel_Sensitivity
@type4_nickel · X

@solarayvitamins Your Baby Me Now Bifidobacterium longum powder contains maltodextrin, which causes gut inflammation https://t.co/wmyjkUygfR Please go back to FOS. I'm pretty sure that's what you guys wete using 10 years ago.

Dec 24, 2024 · 158 followers View post →
BANT
@BANTonline · X

@thelowcarb_rd @MaritKolby https://t.co/dKDsXvgH9J

Apr 10, 2024 · 2 likes · 7,664 followers View post →
DrDawnSherling
@dharrissherling · X

@england_cy @KevinH_PhD Laudisi F, Di Fusco D, Dinallo V, et al. The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019;7(2):457-473. doi: 10.1016/j.jcmgh.2018.09.002. Epub 2018 Sep 11.

Sep 8, 2023 · 1,557 followers View post →
Joe B
@JBianco215 · X

https://t.co/UsZdeNXHeH Food additive Maltodextrin increases Endoplasmic Reticulum stress in gut epithelial cells with the downstream effect of reducing mucus production and enhancing colitis susceptibility.

Jan 22, 2023 · 1 like · 4,593 followers View post →
Jerome Craig, CHPC, CFMP, DC
@CHPCJeromeCraig · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. https://t.co/TSV4HIwZCb

Feb 26, 2020 · 510 followers View post →
Dr. Suzana Mantovani
@Tweet_Nutrition · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation https://t.co/7pNwLBG30W

Mar 4, 2019 · 4,575 followers View post →
Mucus papers
@mucuspapers · X

Pubmed: The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. https://t.co/n0vpMUvb9y

Feb 16, 2019 · 42 followers View post →
Steven M. Weil
@smweilhermes · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation https://t.co/68PRuvFMpq

Feb 16, 2019 · 1 like · 303 followers View post →
Symbiosis papers
@Symbiosispapers · X

The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation. https://t.co/FDYB24yr9c

Feb 16, 2019 · 1,111 followers View post →