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The discussions highlight the pathway's importance, with participants referencing the foundational role of mTORC1 in aging and senescence, using supportive language like 'target' and 'drive,' while also noting gaps such as the lack of direct evidence; this mixture of support and skepticism demonstrates moderate engagement with the research's potential impact.
Most discussions acknowledge the importance of the mTORC1-autophagy pathway in targeting senescent cells, showing general support for the research's significance.
Participants express curiosity about the topic, with some referencing the pathway's role in aging and cellular processes.
Comments include references to previous studies and critical evaluation, indicating moderate deep engagement.
The collective tone suggests that the discussions recognize the potential therapeutic implications, though some call for further evidence.
@cryptoxds @BioProtocol Skin is just another tissue - and senescent cells are ruining it. While the mTORC1-autophagy axis clearly drives senescent cell clearance (DOI: 10.1007/s10522-019-09802-9), we lack direct evidence for your triple combination. But the logic is sound: ceramides maintain barriers,
The mTORC1-autophagy pathway is a target for senescent cell elimination (2019) https://t.co/i6uBEu12BN
The mTORC1 pathway plays a crucial role in cellular senescence, a key factor in aging. Recent research shows that targeting mTORC1 can help eliminate senescent cells, potentially reducing aging-related tissue damage and…
This video summarizes key factors for healthy longevity and disease reduction. It provides insights into how lifestyle choices impact aging and offers a detailed look at scientific research on cellular senescence and…
@cryptoxds @BioProtocol Skin is just another tissue - and senescent cells are ruining it. While the mTORC1-autophagy axis clearly drives senescent cell clearance (DOI: 10.1007/s10522-019-09802-9), we lack direct evidence for your triple combination. But the logic is sound: ceramides maintain barriers,
RT @agingdoc1: The mTORC1-autophagy pathway is a target for senescent cell elimination (2019) https://t.co/i6uBEu12BN
The mTORC1-autophagy pathway is a target for senescent cell elimination (2019) https://t.co/i6uBEu12BN
DOI: 10.1007/s10522-019-09802-9. Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 (opens in new window). Author(s): ...
... 10.1007/s10522-019-09802-9. Ενώ έχω δει μερικές ουλές να ξεθωριάζουν, δεν είμαι σίγουρος τι οφείλεται απλά στην ηλικία και τι είναι το ...
... 10.1007/s10522-019-09802-9. Embora algumas das minhas cicatrizes tenham atenuado, não tenho a certeza do que é só a idade e o que é o efeito ...
... 10.1007/s10522-019-09802-9. Хотя у меня некоторые шрамы стали менее заметными, я не уверен, что это просто возраст, а что эффект от СГ ...
... 10.1007/s10522-019-09802-9. Obwohl einige meiner Narben verblasst sind, bin ich mir nicht sicher, was nur Alter und was die Wirkung von DF ...
... 10.1007/s10522-019-09802-9. Embora algumas das minhas cicatrizes tenham diminuído, não sei o que é apenas idade e o que é o efeito do DF. Não ...
... 10.1007/s10522-019-09802-9. Bazı yara izlerim solsa da, bunun sadece yaşlanma mı yoksa DF'nin etkisi mi olduğundan emin değilim. Denemekten ...
... 10.1007/s10522-019-09802-9. Walaupun parut aku ada pudar sikit, aku tak pasti mana satu sebab umur, mana satu kesan DF. Tak salah kalau nak ...
... 10.1007/s10522-019-09802-9. Deși unele cicatrici s-au estompat, nu sunt sigur ce se datorează doar vârstei și ce este efectul postului negru ...
... 10.1007/s10522-019-09802-9. Vaikka mulla on joitain arpia haalistunut, en oo varma, mikä on vaan ikää ja mikä on kuivapaaston vaikutusta. Ei ...
com/article/10.1007/s10522-019-09802-9. いくつか傷跡が薄くなったけど、年齢的なものなのか、DFの効果なのかはよくわからないんだよね。試してみる ...
... 10.1007/s10522-019-09802-9. Mặc dù tôi đã thấy một số vết sẹo mờ đi, nhưng tôi không chắc đó là do tuổi tác hay do hiệu quả của DF (viết tắt ...
... 10.1007/s10522-019-09802-9. Selv om jeg har sett noen arr blekne, er jeg ikke sikker på hva som bare er alder og hva som er effekten av DF ...
com/article/10.1007/s10522-019-09802-9. 雖然我的一些疤痕淡化了，但我不確定哪些是單純的年齡因素，哪些是DF 的效果。試試也無妨，而且我很想聽聽你 ...
com/article/10.1007/s10522-019-09802-9. 흉터가 좀 옅어지긴 했는데, 이게 그냥 나이가 들어서 그런 건지, 아니면 건식 단식의 효과인지는 잘 ...
... 10.1007/s10522-019-09802-9. Bár néhány heg elhalványult, nem vagyok biztos benne, hogy mi csak az idő, és mi a száraz böjt hatása. Nem árthat ...
... 10.1007/s10522-019-09802-9. While I've had some scars fade, I'm not sure what is just age and what is the effect of DF. Can't hurt to try and ...
com/article/10.1007/s10522-019-09802-9. 虽然我的一些疤痕淡化了，但我不太确定这只是年龄的因素，还是DF 的效果。 试试也无妨，我很想听听你的结果。
... 10.1007/s10522-019-09802-9. Chociaż niektóre moje blizny zbladły, nie jestem pewien, co jest efektem wieku, a co efektem DF. Próba nie ...
... 10.1007/s10522-019-09802-9 La senescenza cellulare è un potente meccanismo soppressore del tumore che svolge anche un ruolo importante nella ...
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