Resveratrol as a Multifunctional Topical Hypopigmenting Agent.

Abstract in brief

• Resveratrol is a promising topical agent for reducing skin pigmentation because it directly and indirectly inhibits tyrosinase, an enzyme involved in melanin production, and also influences keratinocytes that regulate melanocyte activity.
• It helps prevent skin discoloration not only by reducing melanin synthesis but also by protecting keratinocytes from oxidative damage and inflammation, which in turn decreases their stimulation of melanocytes.
• Additionally, resveratrol may aid in repairing skin damage caused by photoaging in conditions like melasma, making it a multifunctional option with potentially fewer adverse effects compared to current treatments like hydroquinone.