PubHawk
Endocrinology May 2019 PMID 30822352

A Modifying Autoantigen in Graves' Disease.

Rauf Latif, Mihaly Mezei, Syed A Morshed, Risheng Ma, Rachel Ehrlich, Terry F Davies

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Mentions

21
Peak: 2 in Apr 2019
across 5 sources since Mar 2019

Extended reach

39,553
potential audience

Total likes

152

Video views

6,734

Mentions per month

Mar 2019 – Dec 2025

Where it's discussed

  • Facebook10 posts
  • X / Twitter4 posts
  • TikTok3 posts
  • YouTube2 videos
  • Instagram2 posts

AI synopsis

What people are saying

The discussions reflect a strong interest in the research, with comments praising the study's focus on the TSH receptor as a key autoantigen in Graves' disease and its clinical relevance. Words like 'update' and 'important' convey enthusiasm, while references to immune responses and antibody mechanisms indicate moderate deep engagement with the scientific content.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, highlighting its focus on the TSH receptor's role in Graves' disease and its potential implications.

InterestHigh interest

Posts demonstrate high interest, with mentions of updates on Graves' disease and the importance of the research, indicating active engagement with the topic.

EngagementModerate engagement

Participants reference specific aspects of the publication, such as the autoantigen role and immune responses, showing moderate in-depth discussion.

ImpactModerate impact

The emphasis on new understanding in autoimmunity and potential for advancing treatment suggests a perception of meaningful impact.

Abstract in brief

  • The study explores a variant of the TSH receptor called TSHRv13, which is generated through alternative splicing and found in various tissues, including the thyroid, bone marrow, thymus, and adipose tissue, suggesting it could play a role in Graves disease.
  • Experiments show that TSHRv13 can bind to TSH and stimulating autoantibodies, potentially altering TSHR activity by inhibiting TSH-induced signaling, and it may act as an autoantigen in Graves disease.
  • The research also demonstrates that under cell stress or apoptosis, the intracellular TSHRv13 can be released from cells, supporting its potential role in disease modulation and autoimmunity in Graves disease.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Icahn School of Medicine at Mount Sinai
@IcahnMountSinai · X

The receptor for #thyroid stimulating hormone is a major antigen for Graves’ disease and patients have unique antibodies to the #TSHR which stimulate excessive #thyroid hormone secretion, said Dr. Terry Davies: https://t.co/w3GxQuFPTO

Apr 5, 2019 · 2 likes · 1 share · 30,879 followers View post →
ja is ra eL
@I4yJaJa · X

RT @IcahnMountSinai: The receptor for #thyroid stimulating hormone is a major antigen for Graves’ disease and patients have unique antibodi…

Apr 5, 2019 · 1 share · 1,275 followers View post →
Thyroid4patients
@Thyroid4patient · X

Graves' disease update! #hyperthyroidism A Modifying Autoantigen in Graves' Disease. https://t.co/4wnH7QqzVH

Mar 2, 2019 · 351 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Endocrinology paper "A Modifying Autoantigen in Graves’ Disease" (https://t.co/XD5NeK0H1D). Thank you for making your #methodsmatter. #accelerateopenscience

Sep 7, 2021 · 161 followers View post →

All mentions

RRID Robot
@RobotRrid · X

RRIDs were included in the Endocrinology paper "A Modifying Autoantigen in Graves’ Disease" (https://t.co/XD5NeK0H1D). Thank you for making your #methodsmatter. #accelerateopenscience

Sep 7, 2021 · 161 followers View post →
ja is ra eL
@I4yJaJa · X

RT @IcahnMountSinai: The receptor for #thyroid stimulating hormone is a major antigen for Graves’ disease and patients have unique antibodi…

Apr 5, 2019 · 1 share · 1,275 followers View post →
Icahn School of Medicine at Mount Sinai
@IcahnMountSinai · X

The receptor for #thyroid stimulating hormone is a major antigen for Graves’ disease and patients have unique antibodies to the #TSHR which stimulate excessive #thyroid hormone secretion, said Dr. Terry Davies: https://t.co/w3GxQuFPTO

Apr 5, 2019 · 2 likes · 1 share · 30,879 followers View post →
Thyroid4patients
@Thyroid4patient · X

Graves' disease update! #hyperthyroidism A Modifying Autoantigen in Graves' Disease. https://t.co/4wnH7QqzVH

Mar 2, 2019 · 351 followers View post →
Desodorante Sin Disruptores Endocrinos Santa Cruz | TikTok
TikTok

DOI: 10.1210/en.2018-01048) ⚠️ Claro: ninguém vai ganhar 20 quilos só por causa do desodorante. Mas na menopausa, quando o metabolismo já está mais lento ...

Dec 13, 2025 View →
What causes Graves' disease pathophysiology?
Facebook

pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Dec 3, 2025 View →
These are my recent results. Been hyperthyroid for 10 years. Can ...
Facebook

pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Sep 24, 2025 View →
O desodorante que você usa todo dia pode estar sabotando seu ...
TikTok

... 10.1210/en.2018-01048) ⚠️ Claro que não é o desodorante que faz ninguém engordar 20 quilos sozinho... Mas quando seu metabolismo já está ...

Jun 22, 2025 View →
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Facebook

pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Apr 3, 2025 View →
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DOI: 10.1210/en.2018-01048) ⚠️ Claro que não é o desodorante que faz ninguém engordar 20 quilos sozinho… Mas quando seu metabolismo já ...

Aug 22, 2024 View →
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TikTok

DOI: 10.1210/en.2018-01048) ⚠️ Claro: ninguém vai ganhar 20 quilos só por causa do desodorante. Mas na menopausa, quando o metabolismo já ...

Dec 2, 2023 View →
**"Thyroid hormones and thyroid antibodies are possibly involved in ...
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Jan 21, 2023 View →
In Graves' disease, the presence of auto antibodies against which ...
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Apr 2, 2021 View →
The thyroid gland is a strong regulator of the body's metabolism ...
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Feb 18, 2021 View →
## Thyroid autoantibodies The authors do not generally recommend ...
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Apr 21, 2019 View →
Study finds a TSH Receptor variant in people with Graves and Hashi ...
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Apr 2, 2019 View →
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

Aug 17, 2018 View →
Which one of the following is most likely to be found in a patient with ...
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pii: en.2018-01048. doi: 10.1210/en.2018-01048. [ Epub ahead of print] A Modifying Autoantigen in Graves' Disease. https://medicalresearch ...

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