Chem Rev September 2019 PMID 30838853

Protein-Catalyzed Capture Agents.

Heather D Agnew, Matthew B Coppock, Matthew N Idso, Bert T Lai, JingXin Liang, Amy M McCarthy-Torrens, Carmen M Warren, James R Heath

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Peak: 3 in Feb 2024

across 4 sources since Mar 2019

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What people are saying

Discussions highlight the versatility of PCCs with examples like their use in fighting antibiotic resistance and tumor imaging, with some posts sharing related videos on the origins of life, which shows an interdisciplinary interest. The tone varies from enthusiastic support to curiosity about future clinical applications, indicating a generally positive outlook on the research's significance.

AgreementModerate agreement

Most discussions acknowledge the significance of PCCs as a promising biomedical tool, reflecting general support for the research.

InterestHigh interest

The variety of posts, including those referencing medical applications, protein detection, and scientific series, indicates high curiosity and engagement with the topic.

EngagementModerate engagement

While some users are sharing related videos and discussing future potential, others focus on pointing out recent research, showing moderate depth in understanding and conversation.

ImpactModerate impact

The references to potential clinical applications and ongoing research suggest a recognition of the article's potential influence on medical science, though widespread impact remains to be seen.

Abstract in brief

ProteinCatalyzed Capture Agents (PCCs) are synthetic, modular peptides created through in situ click chemistry screens, which use the target protein or its epitope as a template to promote specific chemical reactions.
PCCs have been developed for various purposes, including detecting proteins, inhibiting their activity, modulating protein folding, and imaging tumors in vivo, demonstrating their versatility in biomedical applications.
The development of PCCs has progressed from Generation I, involving iterative, non-epitope targeted ligands, to Generation II, which are more precisely designed from macrocyclic peptide libraries targeting specific epitopes, with ongoing challenges and future potential in the field.]

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All mentions

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@GringoCurts · X

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bioRxiv Published

@biorxiv_pubd · X

Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria published as: https://t.co/RgUs6VmbJM #Chemical_Science #biorxiv

Jul 27, 2022 · 1 like · 2,905 followers View post →

Agenparl

@Agenparl · X

Feb 11, 2020 · 6,061 followers View post →

Khaled Jami

@KhaledJami_ · X

More proof-of-concept research in protein‐catalyzed capture agents (PCCs)! Is the clinic coming soon? #DEB263 https://t.co/9dRHszIzHC

Feb 6, 2020 · 26 followers View post →

bioRxiv

@biorxivpreprint · X

Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria https://t.co/z0jFUPhUiJ #bioRxiv

Oct 29, 2019 · 137,006 followers View post →

Andrei Yudin

@andrei_yudin · X

RT @ACSChemRev: "Protein-Catalyzed Capture Agents" https://t.co/RHQphQoRuG #Thematics #Macrocycles https://t.co/WARV1Cvi3H

Sep 16, 2019 · 1 share · 7,980 followers View post →

Chemical Reviews

@ACSChemRev · X

"Protein-Catalyzed Capture Agents" https://t.co/RHQphQoRuG #Thematics #Macrocycles https://t.co/WARV1Cvi3H

Sep 16, 2019 · 4 likes · 1 share · 13,948 followers View post →

Proteins InVivo InVitro

@BVpapers · X

Protein-Catalyzed Capture Agents. https://t.co/0v18B4JRgq https://t.co/Ck0AMOLpON

Mar 7, 2019 · 43 followers View post →

Ricky Kaká

@PincheRossonero · X

[ASAP] Protein-Catalyzed Capture Agents https://t.co/UxsRvI6hkp https://t.co/HS2xNiOkCP

Mar 6, 2019 · 19 followers View post →