Mol Metab May 2019 PMID 30876866

A role for foregut tyrosine metabolism in glucose tolerance.

Judith Korner, Gary W Cline, Mark Slifstein, Pasquale Barba, Gina R Rayat, Gerardo Febres, Rudolph L Leibel, Antonella Maffei, Paul E Harris

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Mentions

Peak: 2 in Mar 2019

across 3 sources since Feb 2019

Extended reach

42,396

potential audience

Total likes

294

Video views

28,130

Mentions per month

Feb 2019 – Nov 2020

Where it's discussed

X / Twitter4 posts
Facebook2 posts
YouTube1 videos

AI synopsis

What people are saying

The collective discussions express strong interest in the novel postprandial circuit involving foregut tyrosine metabolism, with phrases like 'proof-of-principle' and 'role for foregut tyrosine'. The tone reflects curiosity and optimism about potential implications for glucose tolerance and metabolic health, though some comments remain surface-level without elaborating on mechanisms.

AgreementModerate agreement

Most posts support the significance of the research, emphasizing the discovery of a new circuit involved in glucose regulation.

InterestHigh interest

The posts demonstrate high interest by highlighting novel mechanisms and using enthusiastic language like 'proof-of-principle' and 'novel circuit'.

EngagementModerate engagement

Posts show some depth by referencing specific concepts such as dopamine and beta cells, but lack detailed critique or expanded discussion.

ImpactModerate impact

The discussions suggest that this research could pave the way for new therapeutic approaches, indicating an expectation of moderate to high impact.

Abstract in brief

The study explores how tyrosine metabolism in the foregut influences glucose regulation by examining the pathway where tyrosine is converted to dopamine (DA) and LDOPA in the gut and pancreas, affecting insulin secretion and glucose tolerance.
Key experiments included mapping enzyme expression in gut tissues, measuring DA and LDOPA levels after meals with different tyrosine content, and analyzing how these levels impact plasma insulin and glucose in rodents and human patients.
The findings suggest that meal-derived tyrosine increases intestinal and circulatory DA and LDOPA, which can influence beta cell activity by secreting and binding DA, thereby playing a role in glucose regulation and metabolic responses.

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All mentions

Tyrosine Metabolism's Role in Glucose Regulation and Insulin Response

This video explores how foregut tyrosine metabolism influences glucose tolerance by affecting dopamine and LDOPA levels, which impact insulin secretion and glucose regulation based on recent research in molecular…

AJE Video Bytes · Apr 22, 2019 28,130 views

the(sugar)science

@thesugarscience · X

Novel Postprandial circuit ! A role for foregut tyrosine metabolism in glucose tolerance https://t.co/vI7Vx9RtWd #betacells#dopamine

Nov 7, 2020 · 1 like · 2,241 followers View post →

Adam J Rose

@DrAJRose · X

RT @MolMetab: Proof-of-principle evidence for the existence of a novel #postprandial circuit of glucose #homeostasis dependent on #nutritio…

Mar 1, 2019 · 1 share · 810 followers View post →

Molecular Metabolism

@MolMetab · X

Mar 1, 2019 · 11 likes · 1 share · 9,959 followers View post →

Gavin Bewick

@GavBew · X

A role for foregut tyrosine metabolism in glucose tolerance https://t.co/XtCvPEUv1P

Feb 27, 2019 · 2 likes · 1,253 followers View post →