Aging Cell June 2019 PMID 30916479

Glycine supplementation extends lifespan of male and female mice.

Richard A Miller, David E Harrison, C Michael Astle, Molly A Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns

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Mentions

Peak: 9 in Mar 2019

across 6 sources since Mar 2019

Extended reach

1,382,103

potential audience

Total likes

4,849

Video views

138,761

Mentions per month

Mar 2019 – Jun 2025

Where it's discussed

X / Twitter75 posts
Facebook5 posts
Reddit5 posts
YouTube4 videos
News4 articles
Blogs2 articles

AI synopsis

What people are saying

The collection of digital discussions features various perspectives on the glycine study, with multiple posts citing its potential to extend lifespan, such as the remark that 'Glycine also extends lifespan in mice, but only by about 5%.' The tone throughout shows excitement and exploration, using terms like 'lifespan extender' and 'seems to have effects' which convey a mix of caution and intrigue. Many participants also discuss the broader implications of glycine compared to other dietary factors, indicating a desire to understand its role in longevity research.

AgreementModerate agreement

Many discussions express general support for the findings regarding glycine's potential benefits on lifespan.

InterestHigh interest

Participants show a strong curiosity about the implications and methods of the study, suggesting ongoing relevance.

EngagementModerate engagement

While discussions often touch on details of the research, some posts reflect superficial engagement without deep analysis.

ImpactHigh impact

The majority of participants believe this research could lead to significant advancements in understanding longevity.

Abstract in brief

Glycine supplementation increased the lifespan of both male and female mice, with a statistically significant lifespan extension observed across multiple testing sites.
The study found that glycine-treated females weighed less than control females, but there was no significant weight change in male mice.
Additionally, mice on the glycine diet showed a reduced likelihood of dying from pulmonary adenocarcinoma, indicating potential health benefits linked to dietary amino acid modulation for aging research.

Read the full abstract

All mentions

Glycine's Role in Longevity and Aging Mechanisms

Glycine has been shown to boost longevity in various model organisms. This video discusses its role as a prolongevity molecule, including its interaction with enzymes like glycine N-methyltransferase and effects on…

Physionic · Oct 23, 2024 58,400 views

Glycine's Impact on Lifespan in Mice: A Scientific Review

Glycine supplementation increased the lifespan of both male and female mice, with significant lifespan extension observed. The study indicates potential health benefits linked to dietary amino acid modulation.

Physionic · Jul 5, 2024 50,060 views

Lessons from the Interventions Testing Program on Lifespan

The Interventions Testing Program funded by the National Institute on Aging investigates various compounds to prevent disease and extend lifespan in mice. This video explores key findings and principles from the ITP…

The Sheekey Science Show · Mar 12, 2021 22,677 views

Understanding the Role of High Protein Diets in Health

This video will explain how protein is the foundation of a healthy diet, especially for those looking to build muscle or lose fat. We analyze the effects of a very high protein diet on body composition in…

Analyze & Optimize · Jul 29, 2020 7,625 views

Mr T.

@Mr_T____1776 · X

@NHAunleashed Also here are a couple vitamins I buy that are proven to extend lifespan: Vitamin #1: Glycine https://t.co/yFG4sDnH2N

Jun 18, 2025 · 1,103 followers View post →

@ja_apple1284 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Feb 22, 2025 · 11 shares · 191 followers View post →

Taylor Thompson

@TJThomps · X

https://t.co/3alzZGxR5c.

Nov 21, 2024 · 258 followers View post →

Bryce Hanna

@photobiogenesis · X

Methionine restriction and longevity https://t.co/EJ7z2bKBtx Iron restriction and longevity https://t.co/cD3vpbPOza Glycine and longevity https://t.co/eUEqtuLxGV

Jun 26, 2024 · 5 likes · 34,215 followers View post →

Chris Tuttle

@chrisintroy · X

@OptispanPodcast @mkaeberlein @mkaeberlein I noticed in this podcast that you identified the successful ITP interventions to date. What was it about the glycine result from 2014 that got it excluded? https://t.co/kDnvB8kce2

Jun 11, 2024 · 253 followers View post →

奎圓

@TheatreQ · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 11 shares · 1,002 followers View post →

Oui

@Oui_0705 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 11 shares · 3 followers View post →

开云体育百家乐欧冠五大联赛西甲英超百家乐开云足球推荐

@kanggyoungsuk · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 11 shares · 1,160 followers View post →

☦︎ₚₛycₕₒₚₐₜₕᵢcᵣₐᵢₙ☦︎

@Psychopathicra3 · X

RT @IchorGrad: Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 8, 2023 · 6 shares · 816 followers View post →

John Best

@noobestjohn · X

RT @IchorGrad: Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 8, 2023 · 6 shares · 452 followers View post →

Cancel-Aging

@Cancel_Aging · X

RT @IchorGrad: Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 8, 2023 · 6 shares · 1,012 followers View post →

GMERICANITE

@gmericanite · X

RT @IchorGrad: Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 8, 2023 · 6 shares · 1,090 followers View post →

Andy Scott

@AndyJScott · X

RT @IchorGrad: Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 7, 2023 · 6 shares · 4,572 followers View post →

Ichor Grad Student

@IchorGrad · X

https://t.co/njADUxTziz

Dec 7, 2023 · 3 likes · 2,740 followers View post →

Ichor Grad Student

@IchorGrad · X

Glycine supplementation extends lifespan of male and female mice. https://t.co/xQYpaVWbrB

Dec 7, 2023 · 83 likes · 6 shares · 2,740 followers View post →

Vladimir Heiskanen

@ValtsuH · X

@stephensmithPN @NanciGuestRDPhD @EatsleepfitJeff I'll start with preclinical research. First, collagen has shown increased lifespan in rats: https://t.co/udQe2NcKyT Glycine (abuntant in collagen) has shown increased lifespan in mice: https://t.co/ZvgB0FW15e

Sep 25, 2023 · 797 followers View post →

Siim Land

@siimland · X

On the other hand, glycine supplementation in rats leads to a lifespan extension of 30-40% A diet consisting of 8% glycine has been found to extend the lifespan of mice (2% in females and 6% in males https://t.co/J3zjfBkOMb https://t.co/tgxdtWBkze

Aug 2, 2023 · 1 like · 26,393 followers View post →

Vitalholis

@vitalholis · X

@christophewyns C'est plutôt quel joue le rôle de la glycine dans les processus physiologiques.

Jul 27, 2023 · 19,109 followers View post →

kike

@FUENTESMANZULLI · X

RT @Mangan150: Glycine also extends lifespan in mice, but only by about 5%. https://t.co/6uvqy5kyK4

Jun 26, 2023 · 3 shares · 249 followers View post →

kike

@FUENTESMANZULLI · X

RT @Mangan150: Glycine also extends lifespan in mice, but only by about 5%. https://t.co/6uvqy5kyK4

May 15, 2023 · 3 shares · 249 followers View post →

Joe B

@JBianco215 · X

@WeightInnovate Thoughts on glycine neutralizing the need for methionine restriction? https://t.co/rWLiZfpsqo Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction https://t.co/L3FfjufhtY Glycine supplementation extends lifespan of male and female mice

Jan 26, 2023 · 4,593 followers View post →

5대수

@AprilMay454545 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Jan 21, 2023 · 11 shares · 285 followers View post →

타히티꿈의바다

@luckystrongrab8 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Jan 21, 2023 · 11 shares · 83 followers View post →

Heewon Jung

@DrEcsta · X

Jan 21, 2023 · 31 likes · 11 shares · 130,171 followers View post →

kike

@FUENTESMANZULLI · X

RT @Mangan150: Glycine also extends lifespan in mice, but only by about 5%. https://t.co/6uvqy5kyK4

Jan 11, 2023 · 3 shares · 249 followers View post →

P.D. Mangan Health & Freedom Maximalist

@Mangan150 · X

Glycine also extends lifespan in mice, but only by about 5%. https://t.co/6uvqy5kyK4

Jan 11, 2023 · 63 likes · 3 shares · 291,307 followers View post →

alephh

@alephh · X

Glycine supplementation extends lifespan of male and female mice – Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). https://t.co/hLH9YsE5eR

Dec 23, 2022 · 388 followers View post →

Scott Schlegel

@ImScottSchlegel · X

@TheCodyAngeli @Cernovich Glycine supplementation extends lifespan of male and female mice https://t.co/YODnqcGATX Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats https://t.co/Ya0rxl6BNJ

Dec 22, 2022 · 398 followers View post →

Longevity Explorer

@LongevityExplor · X

RT @Orlando_uy: Glycine supplementation extends lifespan of male and female mice https://t.co/Cwv8PtzdAn

Dec 3, 2022 · 2 shares · 1,678 followers View post →

Orlando_uy

@Orlando_uy · X

Glycine supplementation extends lifespan of male and female mice https://t.co/Cwv8PtzdAn

Dec 3, 2022 · 12 likes · 2 shares · 690 followers View post →

alephh

@alephh · X

Glycine extends lifespan of male/female mice — Diets low in methionine extend lifespan: Glycine mitigates methionine toxicity — #Glycine led to small (4%–6%) but significant (maximum) lifespan increase — In parallel analyses:no benefits from inulin/aspirin https://t.co/ajVKscuwnf

Nov 5, 2022 · 388 followers View post →

Orlando_uy

@Orlando_uy · X

Glycine supplementation extends lifespan of male and female mice. https://t.co/1wWiZEm2dq

Jul 24, 2022 · 1 like · 690 followers View post →

Maitreya

@Mithreu · X

Its been stated before, but its important to know the longevity enhancing effects of methionine restriction is probably just from having enough glycine to match it https://t.co/syLYSp9cwQ

Jun 17, 2022 · 4 likes · 1,262 followers View post →

Agingdoc

@agingdoc1 · X

Glycine supplementation extends lifespan of male and female mice (2019) https://t.co/5lf0Rr7i7C

Mar 6, 2022 · 5 likes · 41,315 followers View post →

✨Reina Nakamoto✨

@mindstatex · X

RT @Grimhood: Glycine supplementation extends lifespan of male and female mice https://t.co/KT5C7sPmAt (mouse model) The importance of eat…

Apr 8, 2021 · 1 share · 6,937 followers View post →

⚡️

@SolBrah · X

Study here: https://t.co/QQKa2SvkfL

Apr 8, 2021 · 9 likes · 236,571 followers View post →

Mg2+ Papi, the BowTied Mg2+

@Grimhood · X

Glycine supplementation extends lifespan of male and female mice https://t.co/KT5C7sPmAt (mouse model) The importance of eating nose-to-tail. https://t.co/ncYJsVr1ok

Apr 8, 2021 · 30 likes · 1 share · 134,155 followers View post →

jordi de Haro

@zazen71 · X

Glicina y la extensión de la vida útil https://t.co/rMV9Y7l8Ue

Mar 25, 2021 · 626 followers View post →

Orlando_uy

@Orlando_uy · X

Glycine supplementation extends lifespan of male and female mice https://t.co/hyhyvK4tjI

Mar 14, 2021 · 2 likes · 690 followers View post →

Agingdoc

@agingdoc1 · X

@MartinGTobias @PeterAttiaMD Innocuous at worst, with few exceptions. Unlike sugar alcohols better tolerated as a rule (GI). In mice, beneficial at very high doses: https://t.co/vCtCBPRpSi Distinctive flavor may limit adoption rates.

Dec 8, 2020 · 41,315 followers View post →

Agingdoc

@agingdoc1 · X

RT @agingdoc1: @StartupYou @DanielJDrucker @UMich @ScienceTM It did @StartupYou. Relative to other +ITP pubs, the MLE effect was small (6%…

Dec 3, 2020 · 1 share · 41,315 followers View post →

Agingdoc

@agingdoc1 · X

@StartupYou @DanielJDrucker @UMich @ScienceTM It did @StartupYou. Relative to other +ITP pubs, the MLE effect was small (6% males 2% females[ns]) & required very high dosing (8%). It is the only acceptor for CH3 groups via GNMT & thus⬇️effective methionine levels akin to mild methionine restriction. https://t.co/vCtCBPRpSi

Dec 3, 2020 · 4 likes · 1 share · 41,315 followers View post →

Matt Donne

@Matt_Donne · X

On a glycine kick for better sleep, but now... Glycine supplementation extends lifespan of male and female mice - Miller - 2019 - Aging Cell - Wiley Online Library https://t.co/wYianhS03x

Nov 28, 2020 · 439 followers View post →

Fit-Drive

@salama_sohaib · X

The reasson why human get issue from #eating too much #meat is because the lack of glycine and high level of methionine and then arterial dysfunction bit hear me out on this still meat not all end all be all when we comes to #Health problems https://t.co/uwFbjQaL2s

Sep 22, 2020 · 26 followers View post →

Republican-Justicialist (He/Him/The God Of F*ck)

@JRClark14591150 · X

@LiaColombo1 @veganfuture Sorry I meant extends mouse & rat lifespan, lol. I meant to put average lifespan & typed human

Sep 19, 2020 · 174 followers View post →

Republican-Justicialist (He/Him/The God Of F*ck)

@JRClark14591150 · X

RT @JRClark14591150: @indusidler @Mangan150 https://t.co/CPHd7vzLaa

Jun 27, 2020 · 2 shares · 174 followers View post →

Republican-Justicialist (He/Him/The God Of F*ck)

@JRClark14591150 · X

@indusidler @Mangan150 https://t.co/CPHd7vzLaa

Jun 27, 2020 · 2 shares · 174 followers View post →

Mel Chen

@wintel_tw · X

https://t.co/ag0TpPTVok (最「小」的胺基酸，對健康... https://t.co/oSvo13F7go

Mar 20, 2020 · 4 followers View post →

TechNews 科技新報

@technews_tw · X

最「小」的胺基酸，對健康卻「大」有幫助 https://t.co/UNUyeeWaGL https://t.co/mFjiJmeeRu

Mar 20, 2020 · 1 like · 3,533 followers View post →

IberianCitizen

@IberianCitizen · X

"La suplementación con glicina extiende la vida útil de ratones machos y hembras" https://t.co/eM0g8kzEkl https://t.co/DNwAH7rqTq

Feb 27, 2020 · 5 likes · 12,923 followers View post →

Republican-Justicialist (He/Him/The God Of F*ck)

@JRClark14591150 · X

Glycine is a lifespan extender. https://t.co/QGivvGqUlT

Feb 26, 2020 · 174 followers View post →

LIVE!

@Hapivit · X

RT @americanaging: New from AGE member Dr. Randy Strong and colleagues, "Glycine supplementation extends lifespan of male and female mice"…

Dec 21, 2019 · 3 shares · 21,886 followers View post →

Julianne Taylor, Nutritionist

@juliannejtaylor · X

RT @mike_lustgarten: Glycine supplementation extends lifespan of male and female mice. - PubMed - NCBI https://t.co/Z0t2MXk5XO

Nov 15, 2019 · 1 share · 5,315 followers View post →

Mike Lustgarten, PhD

@mike_lustgarten · X

Glycine supplementation extends lifespan of male and female mice. - PubMed - NCBI https://t.co/Z0t2MXk5XO

Nov 15, 2019 · 6 likes · 1 share · 9,722 followers View post →

JRA

@odisa_ra · X

Glycine supplementation extends lifespan of male and female mice https://t.co/UwT8rUhWuI

Nov 8, 2019 · 8 followers View post →

Sergio Ferrero

@calotonterias · X

@MartianOtter @NutriRebel @Froscas Aumentar la ingesta de glicina, incluso sin reducir la de metionina, parece tener efectos positivos https://t.co/BTnHhh4WOf https://t.co/kbnvBjTwz3 Lo que sugiere q ingerirla en apropiadas proporciones es la clave (sigo)

Oct 16, 2019 · 17,296 followers View post →

Shared Nutrition ❣️

@sharednutrition · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

May 15, 2019 · 6 shares · 100 followers View post →

Ali Macdonald

@resilient_ali · X

RT @humanOS_me: Glycine supplementation extends lifespan of male and female mice. Elevated #glycine led to a small (4%–6%) but statistical…

Apr 24, 2019 · 2 shares · 196 followers View post →

Gut Builder@GutBuilder

@Scott2987 · X

RT @humanOS_me: Glycine supplementation extends lifespan of male and female mice. Elevated #glycine led to a small (4%–6%) but statistical…

Apr 23, 2019 · 2 shares · 55 followers View post →

humanOS.me

@humanOS_me · X

Apr 23, 2019 · 11 likes · 2 shares · 9,669 followers View post →

Lindsay Wu

@LindsayWu_UNSW · X

Interesting that glycine, a fairly benign nutrient, extends lifespan - in this case by acting as a "sink" to remove excess methionine - but keep in mind that this was enough glycine to comprise an heroic eight per cent of the entire diet. Eight per cent! https://t.co/cf0v2uo0EH

Apr 9, 2019 · 2,361 followers View post →

Nathan Shock Centers

@NathanShockCtrs · X

RT @americanaging: New from AGE member Dr. Randy Strong and colleagues, "Glycine supplementation extends lifespan of male and female mice"…

Apr 3, 2019 · 3 shares · 1,172 followers View post →

Lamming Lab

@LammingLab · X

RT @americanaging: New from AGE member Dr. Randy Strong and colleagues, "Glycine supplementation extends lifespan of male and female mice"…

Apr 2, 2019 · 3 shares · 5,839 followers View post →

American Aging Association

@americanaging · X

New from AGE member Dr. Randy Strong and colleagues, "Glycine supplementation extends lifespan of male and female mice" https://t.co/o7Hf8ubFNe

Apr 2, 2019 · 2 likes · 3 shares · 6,736 followers View post →

Julia B.

@JuliaB_fitness · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Apr 1, 2019 · 6 shares · 2,273 followers View post →

Mimi_ Cardio

@mimi_cardio · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Apr 1, 2019 · 6 shares · 188 followers View post →

Daniele Cohen

@DanieleCohenWA · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Mar 31, 2019 · 6 shares · 414 followers View post →

SNZK

@shinopp · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Mar 31, 2019 · 6 shares · 721 followers View post →

Sheila Shin

@scshinyahoo · X

RT @AgingBiology: Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Mar 31, 2019 · 6 shares · 3,560 followers View post →

Aging Science News

@AgingBiology · X

Glycine supplementation extends lifespan of male and female mice https://t.co/zeSeTWyLPV

Mar 31, 2019 · 8 likes · 6 shares · 30,530 followers View post →

NootropicReddit

@NootropicReddit · X

Glycine Supplementation Extends Lifespan of Male and Female Mice (2019) via /r/Nootropics https://t.co/MtbVsGbJnm

Mar 30, 2019 · 787 followers View post →

MedCobra

@medcobracom · X

Glycine Supplementation Extends Lifespan of Male and Female Mice (2019) https://t.co/LyJlxvwhC5

Mar 30, 2019 · 931 followers View post →

NZT Social Network

@nzt48nootropics · X

Glycine Supplementation Extends Lifespan of Male and Female Mice (2019) https://t.co/0LbAmMXyVV

Mar 30, 2019 · 2,046 followers View post →

Nick Krontiris

@nick_krontiris · X

Glycine supplementation extends lifespan of male and female mice (open access) https://t.co/DHBX3whwL0 #nutrition #protein

Mar 29, 2019 · 1 like · 18,973 followers View post →

Mike Lustgarten, PhD

@mike_lustgarten · X

Glycine supplementation extends lifespan of male and female mice - Miller - - Aging Cell - Wiley Online Library https://t.co/zWzQXuDaUy

Mar 28, 2019 · 8 likes · 9,722 followers View post →

Glycine supplementation extends lifespan of male and female mice.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Glycine's Role in Longevity and Aging Mechanisms

Glycine's Impact on Lifespan in Mice: A Scientific Review

Lessons from the Interventions Testing Program on Lifespan

Understanding the Role of High Protein Diets in Health