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The discussions reflect a strong consensus on the importance of immune evasion in disease progression, exemplified by references to PD-L1's role in tumor escape, the regulation of MHC proteins, and new insights into viral mechanisms. The tone is technical and optimistic, highlighting the potential for these findings to inform innovative therapies, which underscores their high impact and interest levels.
Most discussions agree on the significance of immune evasion mechanisms in cancer and viral infections, emphasizing their role in therapy resistance and disease progression.
The posts demonstrate high interest by sharing detailed insights, study results, and academic publications about immune evasion strategies and potential therapeutic targets.
Many discussions reference specific molecular pathways, such as PD-L1, MHC-I, and cyclic oligonucleotides, indicating deep engagement and analysis of underlying mechanisms.
The collective tone suggests these studies have high potential impact for advancing medical treatments, with mentions of novel targets and approaches for overcoming immune evasion in cancer and infectious diseases.
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/rBaLoR8ivH Original https://t.co/fizLOtBJzk
طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتفادى دفاعات الجسم. 1. إنتاج مستضدات (Antigens) متعددة عادةً الجهاز المناعي يكوّن أجسام مضادة (Antibodies) ضد المستضدات الفيروسية. بعض الفيروسات تغيّر أو تنتج
Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/oFS38qZd3K
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:
Excited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residing nucleoporins drive #ProstateCancer progression & immune evasion by switching on oncogenic signaling from deep within the nucleus! https://t.co/99Kmakz161 https://t.co/T1PkbL2Tz9
This video introduces Staphylococcus aureus, one of the most clinically significant bacteria. Discover its general characteristics, morphology, and habitat. Continue learning about this pathogen through our dedicated…
This video provides an overview of how Staphylococcus aureus exploits its virulence factors and the contextual opportunities it encounters to cause harm to the human body. It discusses the mechanisms of infection and…
This video clarifies that teichoic acids are not proteins but components of the bacterial cell wall that aid in adhesion. Explore the virulence factors and strategies used by Staphylococcus aureus for infections and…
This video explores when and how Staphylococcus aureus colonizes the human body, highlighting its clinical significance. Topics include microbiology, infections such as MRSA, and references to key scientific literature…
This video explains the action mechanism of toxins causing food poisoning. It emphasizes ongoing research suggesting that submucosal mast cells or enteric neurons are the cells stimulated by the toxin. Discover the…
They are vital for preventing excessive immune activation, but in chronic diseases, they can contribute to immune evasion by tumours & pathogens. This makes them critical for both normal immune function & potential therapeutic targets.
@Scorcher78 @jsm2334 PD-L1 primarily enables immune evasion by binding PD-1 on T-cells, suppressing their activation and allowing cancer escape. It also promotes proliferation via pathways like PI3K/AKT and MAPK (e.g., in colorectal and breast cancers, per NIH and Nature studies). For spread, PD-L1
@Scorcher78 @jsm2334 IgG4 antibodies can contribute to cancer immune evasion by inhibiting ADCC/CDC through Fc-Fc interactions with IgG1, competing for Fc receptors, and promoting tolerance via Treg activation, potentially suppressing anti-tumor immunity (e.g., in melanoma, pancreatic cancers).
@BorgerPieter @karelpopper The PD-L1 mechanism indeed permits immune evasion by microtumors, potentially allowing outgrowth if unchecked. However, global surveillance data from sources like VAERS, EudraVigilance, and cohort studies (e.g., NEJM 2025 updates) reveal no causal cancer surge post-mRNA
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSXSH
Excited to share that my article was published today in Viruses! It explores how NSs evades the host immune response. Immune Evasion by the NSs Protein of Rift Valley Fever Virus: A Viral Houdini Act https://t.co/UVUffe8UTG #mdpiviruses via @VirusesMDPI @MDPIOpenAccess
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSXSH
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSXSH
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSq39
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSq39
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes pubmed.ncbi.nlm.nih.gov/41083534/ #cryoEM
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSq39
A mouthful×recap: Neutralizing soluble tumor necrosis factor alpha overcomes trastuzumab-resistant breast cancer immune evasion by downregulating mucin 4, improving NK cell function and decreasing myeloid-derived suppressor cells in tumor microenvironment. https://t.co/EJWW7Cqnyd
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSXSH
Cell-based experiments demonstrated that the absence or loss of mCpol-produced cyclic oligonucleotides triggers cell death, preventing the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. www.nature.com/articles/s41...
Immune activation upon cyclic oligonucleotide depletion prevents the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
Special Issue - Regulation of innate immunity and immune evasion by microbes, including viruses - https://t.co/kz294fSXSH
Field outbreak investigation and immunoinformatic analysis suggest potential immune evasion by Newcastle disease virus Sub-Genotype XIV.2 in Nigeria ->Nature | #Health #Disease #Virus | More from BigEarthData.ai
RT @jitcancer: New #JITC article: LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorect…
cont: 3) Immune evasion by tumour = Bureaucratic opacity, gaslighting or procedural obfuscation that prevents accountability cont...
RT @jitcancer: New #JITC article: LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorect…
RT @jitcancer: New #JITC article: LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorect…
RT @STITCHESMed: G3BP1 emerges as a pivotal biomarker for cancer diagnostics and prognosis, linked to poor outcomes and immune evasion. by…
New #JITC article: LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorectal cancer https://t.co/0e0z68YQFM https://t.co/xqBgM2mM0v
G3BP1 emerges as a pivotal biomarker for cancer diagnostics and prognosis, linked to poor outcomes and immune evasion. by Lu S, Du T (...) Liu W et 4 al. in Hum Mol Genet https://t.co/k2dqTkSzYX #MedX #MedResearch
@HarrySpoelstra @fitterhappierAJ While the concept of SARS-CoV-2 disrupting immune function is compelling, it’s crucial to validate these claims with peer-reviewed research. The transformation of neutrophils into suppressive cells adds a fascinating layer to understanding immune evasion by pathogens. Have you
Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation published as: https://t.co/utHpxwX2nk #Cancer_Immunology_Research #biorxiv
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @AndrewEwing11: 19/ May 20 2022, Title: SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly ”…
ChREBP drives choline-induced reprogramming in tumor-associated macrophages, fostering immunosuppression and promoting cancer immune evasion. by Zhao J, Chen B (...) Jiang C et 12 al. in Cancer Res https://t.co/5ZLloXQNz8 #MedX #MedResearch
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
RT @NEJM: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression…
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/rBaLoR8ivH Original https://t.co/fizLOtBJzk
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
RT @mole_biology: طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتف…
طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتفادى دفاعات الجسم. 1. إنتاج مستضدات (Antigens) متعددة عادةً الجهاز المناعي يكوّن أجسام مضادة (Antibodies) ضد المستضدات الفيروسية. بعض الفيروسات تغيّر أو تنتج
طرق هروب الفيروسات من جهاز المناعة (Immune evasion by viruses). الفيروسات ليست فقط أجسام خاملة، بل طوّرت آليات ذكية لتتفادى دفاعات الجسم. 1. إنتاج مستضدات (Antigens) متعددة عادةً الجهاز المناعي يكوّن أجسام مضادة (Antibodies) ضد المستضدات الفيروسية. بعض الفيروسات تغيّر أو تنتج
Mitochondria indirectly support immune evasion by modulating nuclear gene expression.
@SitSilver @53v3n0fn1n3 @Pinzie @coreyum @Rebecca21951651 @xai @DeptofDefense @CharlesRixey Viruses mimicking toxins can gain advantages like enhanced host cell entry (e.g., via receptor binding), immune evasion by modulating responses (as in α7 nAChR interactions per your study), increased virulence for better spread, and potential host adaptation. This is seen in
Excited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
RT @exosome: Want to cure cancer? think about targeting this.... $NWBO $CLDI #Cancer innervation by nociceptive neurons promotes immune…
RT @exosome: Want to cure cancer? think about targeting this.... $NWBO $CLDI #Cancer innervation by nociceptive neurons promotes immune…
RT @exosome: Want to cure cancer? think about targeting this.... $NWBO $CLDI #Cancer innervation by nociceptive neurons promotes immune…
Want to cure cancer? think about targeting this.... $NWBO $CLDI #Cancer innervation by nociceptive neurons promotes immune evasion by increasing number of myeloid derived suppressor cells. https://t.co/Ozpk9WzXUj
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
RT @NEJM: Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells w…
Today at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp @ttsorg.bsky.social
Presented at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/oFS38qZd3K
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
Prostate cancer cells enhance immune evasion by secreting PD-1 in exosomes, boosting myeloid-derived suppressor cells' activity. by Zhang J, Chen W (...) Chen Y et 20 al. in Cancer Res https://t.co/zLdQKjSP8W #MedX #MedResearch
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
RT @MayoUrology: Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residi…
Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residing nucleoporins drive #ProstateCancer progression & immune evasion by switching on oncogenic signaling from deep within the nucleus! https://t.co/99Kmakz161 https://t.co/T1PkbL2Tz9
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan | PNAS www.pnas.org/doi/abs/10.1...
However, the added N30 glycan contributes to immune evasion by disrupting the binding of a neutralizing antibody targeting the NTD.
RT @ThailandMedicaX: -Facilitate epithelial–mesenchymal transition (EMT), a process linked to metastasis -Support immune evasion by reshapi…
-Facilitate epithelial–mesenchymal transition (EMT), a process linked to metastasis -Support immune evasion by reshaping the tumor microenvironment
Understanding basic features of cancer cells, including tumorigenicity, pluripotency, immune evasion...by understanding neural stemness. https://t.co/jRsZpccJ5Z https://t.co/wvpF9STA2j https://t.co/1RVGDoWz0m
Enhanced reverse zoonotic potential and immune evasion by omicron JN.1 variant. https://t.co/2liGHysbn4 https://t.co/WorYrLMUvr
@AIpubmed Immune evasion by latent herpesviruses is a fascinating area of study! The viral proteins' ability to block MHC class I and II presentation is crucial for virus survival and persistence in the host. How do you think these findings could influence future therapeutic strategies
I've been on a bsky hiatus but I'm back to tell you to read this very cool paper if you're interested in IFNs & host-pathogen interactions! Our fav constitutively-expressed IFN, IFN-epsilon, facilitates immune evasion by Neisseria gonorrhoeae via modulation of sialic acid metabolism #immunosky
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan | PNAS www.pnas.org/doi/10.1073/...
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines https://www.biorxiv.org/content/10.1101/2025.05.29.656815v1
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines https://www.biorxiv.org/content/10.1101/2025.05.29.656815v1
circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome bioRxivpreprint
circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome bioRxivpreprint
circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome https://www.biorxiv.org/content/10.1101/2025.05.05.652247v1
circEPSTI1 Enables Dengue Innate Immune Evasion by Sponging miR-942-5p, a Repressor of AKT1 and the Viral Genome https://www.biorxiv.org/content/10.1101/2025.05.05.652247v1
From figure 3 in the Nature review. “Host immune evasion by SARS-CoV-2 proteins. SARS-CoV-2 triggers IFN signaling pathway after being recognized by RIG-1 and MDA5. Different SARS-CoV-2 proteins interfere with these pathways in different ways.” The last sentence is what I am talking about.
The inverse signaling logic suggested that disruption of immune signaling could trigger 2TMβ-induced cell death. Using cell-based assays we found that phage-encoded proteins that attempt immune evasion by depleting host cyclic oligonucleotides were both necessary and sufficient to activate MISS.
Preprint alert! ✨ In this project that I co-led with @benadler.bsky.social, we show that a miniature CRISPR-Cas10-like enzyme, mCpol, uses a novel inverse signaling mechanism to prevent the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides. Check it out:
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes www.biorxiv.org/content/10.1101/2025.03.22.644518v1 #cryoEM
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes https://www.biorxiv.org/content/10.1101/2025.03.22.644518v1
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes https://www.biorxiv.org/content/10.1101/2025.03.22.644518v1
Abcam's resource, RRID:AB_3068617, was just reported to be used in "SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint that Enables Tumor Immune Evasion by Impairing T Cell Cytotoxicity". We appreciate the author's support of reproducibility. #methodsmatter #reproducibility
Long-read RNA sequencing uncovered novel genes and transcripts linked to ccRCC recurrence and immune evasion by analyzing 12 archival tumors and validating in 20 patients. PMID:39284687, Genome Res 2024 @nanoporetech.com doi.org/10.1101/gr.2...
This provides opportunities and ample time for intervention. @MarcoGerlinger @cellpress.bsky.social www.sciencedirect.com/science/arti...
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots @natimmunol.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots www.nature.com/articles/s41...
Get ready for US with no further boosters. There is no simply any way who can maintain immune protections after ~4 months either through vaccines and/ or infections. Why? just our immune systems cannot induce long lasting plasma cells against SARS CoV2 infection - and immune evasion by variants (A)
Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...
NaNots clear pathogenic soluble factors in the blood that contribute to immune evasion by cancerous cells and drive hyperactive immune activity in sepsis and certain autoimmune disorders. Lou Hawthorne gave a great presentation at ARDD 2024: www.youtube.com/watch?v=9igL...
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation https://pubmed.ncbi.nlm.nih.gov/39753950/
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
and dissemination of tumor cells but also promote immune evasion by metabolically “educating” immune cells in the tumor microenvironment (TME)… @cellpress.bsky.social www.cell.com/cell-reports...
The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins https://www.biorxiv.org/content/10.1101/2024.11.29.626106v1
The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins https://www.biorxiv.org/content/10.1101/2024.11.29.626106v1
PTBP1 emerges as a #PanCancer #Biomarker, linking high expression to poor prognosis and immune evasion. By modulating Tregs and CD8+ T cells, PTBP1 shapes the tumor microenvironment and prognosis. Potential for targeted therapy unveiled. #CancerBiology journals.sagepub.com/doi/10.1177/...
Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling https://www.biorxiv.org/content/10.1101/2024.06.28.601139v1
Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling https://www.biorxiv.org/content/10.1101/2024.06.28.601139v1
To my colleagues: please be aware of your language. "These findings support a considerable immune evasion by JN.1, and that this immune evasion led to the observed rapid waning of the protection against JN.1" is incorrect and open to wrong speculation and misinterpretation. 5/7
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC‐I via PI3K/Akt Activation in Bladder Cancer
It also revealed a previously unrecognized strategy for E. tarda immune evasion by inducing CD8+ T cell tolerance to target Mϕ cells through eliciting the PD-L1/BTLA checkpoint pathway." #Immunology #zebrafish
Why Staph? Find out here! https://t.co/PRtd7ojXdv (3/4)
⏰Don´t miss to register for today´s DSSS online talk by Dr. Sara Clasen on how silent recognition of flagellins by Toll-like receptor 5 allows #immune evasion by human gut commensal #bacteria. It´s now or never, thus register here: presse-eb@tuebingen.mpg.de #guthealth #science
Curious to know what this receptor does? Then mark Friday 3:00 PM (CEST) and join our DSSS seminar by Dr. Sara Clasen on how silent recognition of flagellins by Toll-like receptor 5 allows immune evasion by human gut commensal bacteria.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 https://science.sciencemag.org/content/369/6508/1249
Here, a review on the immune properties of covid-19/SARS-CoV-2. These authors suggest that the long incubation period (2-11 days) compared with influenza (1-4 days) is likely to arise from immune evasion by the virus. http://apjai-journal.org/wp-content/uploads/2020/03/1.pdf#page=6
Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi https://www.frontiersin.org/article/10.3389/fimmu.2017.00012
Another new paper in Artur Scherf's Lab : Histamine releasing factor and elongation factor 1 alpha secreted via #malaria parasites extracellular vesicles promote #immune evasion by inhibiting specific T cell responses. @CellMicrobiol #science # research onlinelibrary.wiley.com/doi/abs/10.111…
#PLOSPathogens: Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase http://dx.plos.org/10.1371/journal.ppat.1006493
JCI - Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells https://www.jci.org/articles/view/120612#.XAYFSlZu0KM.twitter
#HPV2017 Martin Kast: part of immune evasion by HPVs is due to Langerhans cell suppression - and polyIC treatment reverses it?!
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