PubHawk
Headache May 2019 PMID 30982963

CGRP and the Trigeminal System in Migraine.

Smriti Iyengar, Kirk W Johnson, Michael H Ossipov, Sheena K Aurora

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Mentions

28
Peak: 13 in Apr 2019
across 3 sources since Apr 2019

Extended reach

53,950
potential audience

Total likes

28

Video views

8,589

Mentions per month

Apr 2019 – Mar 2024

Where it's discussed

  • X / Twitter18 posts
  • News8 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall sentiment reflects strong support and curiosity about the research, with posts highlighting the success of CGRP-targeted therapies as exemplified by the mention of monoclonal antibodies and the 'bench-to-bedside' success story, while the tone conveys excitement about future potential in managing migraines.

AgreementModerate agreement

Most discussions recognize the significance of CGRP research and its potential for migraine treatment, showing general support.

InterestHigh interest

Participants demonstrate high curiosity, often referencing recent advances and therapeutic implications.

EngagementModerate engagement

Many posts cite specific research findings, mention medications, or discuss the broader implications, indicating active involvement.

ImpactModerate impact

The discussions highlight that knowledge about CGRP could lead to improved treatments, emphasizing its practical importance.

Abstract in brief

  • The article discusses how migraine is a common and debilitating neurological condition characterized by intense, often one-sided headaches, and emphasizes the importance of understanding its underlying mechanisms, especially the role of the peptide CGRP within the trigeminovascular system.
  • It highlights recent research (from 2016-2018) that explores the role of CGRP in migraine, focusing on how it is released from trigeminal ganglion neurons, leading to increased nitric oxide production and nerve sensitization, which contribute to migraine symptoms.
  • The review also notes that new medications targeting CGRP signaling have shown early promise in migraine treatment, reflecting a growing interest in this pathway as a potential therapeutic avenue.
Read the full abstract

Top posts

Most liked on X and Bluesky
Christoph Burch
@ChristophBurch · X

CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBlvIc https://t.co/d0zxayPJ6q

Apr 19, 2019 · 20 likes · 7 shares · 15,484 followers View post →
Neudrawlogy
@neudrawlogy · X

Jan 7, 2023 · 5 likes · 1 share · 8,148 followers View post →
Headache Journal
@HeadacheJournal · X

#CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDMFPi

Apr 15, 2019 · 3 likes · 5 shares · 7,603 followers View post →
Nina Riggins, MD, PhD, FAAN, FAHS, UCNS Diplomate
@NinaRiggins · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 15, 2019 · 5 shares · 3,430 followers View post →
ACPSEMdance
@ACPSEMdance · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 2,970 followers View post →
FNDConnect
@ConnectFnd · X

CGRP and the Trigeminal System in Migraine https://t.co/pY9r9gvF70

May 19, 2021 · 2,513 followers View post →

All mentions

Neurdle - Neurology Word Game
@Neurdle · X

...it's a monoclonal antibody that decreases migraine by binding calcitonin-gene related protein. The CGRP story is a rare triumph of the "bench-to-bedside" model of medicine development. Read more about CGRP inhibition here: https://t.co/ApJi3yhuAY...

Mar 17, 2024 · 1,429 followers View post →
Sol
@ArualSogar · X

RT @neudrawlogy:

Jun 8, 2023 · 1 share · 798 followers View post →
Neudrawlogy
@neudrawlogy · X

Jan 7, 2023 · 5 likes · 1 share · 8,148 followers View post →
Yazawa @ よもぎ栽培系鍼灸師
@94javelin7 · X

#頑張れGoogle先生 https://t.co/AaBogebcBi

Nov 22, 2021 · 957 followers View post →
FNDConnect
@ConnectFnd · X

CGRP and the Trigeminal System in Migraine https://t.co/pY9r9gvF70

May 19, 2021 · 2,513 followers View post →
Juan Joost
@JuanJoost · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 20, 2019 · 7 shares · 134 followers View post →
Antonello Viceconti
@Anto_Viceconti · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 493 followers View post →
ACPSEMdance
@ACPSEMdance · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 2,970 followers View post →
Christian Jiménez Arranz
@arranz_jimenez · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 437 followers View post →
Javier Asensio Ruiz
@JaviAsensio_PT · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 32 followers View post →
EskeleThor
@EskeleThor · X

RT @ChristophBurch: CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBl…

Apr 19, 2019 · 7 shares · 405 followers View post →
Christoph Burch
@ChristophBurch · X

CGRP and the Trigeminal System in Migraine | Review Iyengar S, et al. Headache. 2019 #OpenAccess https://t.co/tXptrBlvIc https://t.co/d0zxayPJ6q

Apr 19, 2019 · 20 likes · 7 shares · 15,484 followers View post →
Joshua.xlsx
@owoyemi_joshua · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 16, 2019 · 5 shares · 88 followers View post →
Nina Riggins, MD, PhD, FAAN, FAHS, UCNS Diplomate
@NinaRiggins · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 15, 2019 · 5 shares · 3,430 followers View post →
@CoreThermal - Next Generation Migraine Therapy
@CorethermalT · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 15, 2019 · 5 shares · 16 followers View post →
Mark Swyer - Rutgers Medical School
@MarkSwyer1 · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 15, 2019 · 5 shares · 36 followers View post →
Marja Hassinen
@m_hassinen · X

RT @HeadacheJournal: #CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDM…

Apr 15, 2019 · 5 shares · 226 followers View post →
Headache Journal
@HeadacheJournal · X

#CGRP and the trigeminal system in #migraine Smriti Iyengar @sheaur et al https://t.co/Jjx7LMaVWM https://t.co/MJjkpDMFPi

Apr 15, 2019 · 3 likes · 5 shares · 7,603 followers View post →