Gut August 2019 PMID 31076401

Leaky gut: mechanisms, measurement and clinical implications in humans.

Michael Camilleri

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Mentions

Peak: 10 in May 2019

across 5 sources since May 2019

Extended reach

233,700

potential audience

Total likes

Video views

642

Mentions per month

May 2019 – Aug 2025

Where it's discussed

News44 articles
X / Twitter32 posts
Facebook5 posts
Blogs5 articles
YouTube3 videos

AI synopsis

What people are saying

Many discussions focus on querying the validity of the concept, such as one post asking if it is pseudoscience, reflecting skepticism or critical engagement. Others mention specific authors and emphasize the clinical implications, like references to gut barrier function and metabolic conditions, which shows that users are aware of its potential relevance but also recognize that research is ongoing and not conclusive. The tone varies from doubtful to intrigued, contributing to a cautious but interested overall perception.

AgreementNeither agree nor disagree

The range of posts suggests mixed opinions, with some expressing skepticism (e.g., questioning pseudoscience) and others referencing clinical implications, reflecting a neutral overall stance.

InterestModerate interest

Most discussion indicates moderate curiosity, as many posts highlight the article's relevance and mention its key topics, but few show deep analysis or strong emotional engagement.

EngagementNeutral engagement

Posts mostly reference the publication's content and authors without detailed critique or extensive debate, indicating surface-level engagement rather than in-depth discussion.

ImpactNeutral impact

The discussions seem to acknowledge the publication's potential significance but also emphasize uncertainties and limitations, suggesting a perception of moderate rather than high impact.

Abstract in brief

The review explains that the intestinal barrier is made up of mucus, epithelial cells, and immune defenses, and its permeability can increase due to stress, certain drugs, or dietary factors, which may lead to "leaky gut."
Measurement of intestinal permeability can be done through in vivo tests with probe molecules or in vitro tests using biopsies, and various factors like exercise, medications, pregnancy, and diets can influence gut permeability.
While some dietary and probiotic interventions can potentially repair or improve gut barrier function, existing evidence is not yet strong enough to confirm that normalizing barrier function can treat or cure GI diseases; clinicians should recognize the role of barrier dysfunction but understand that more research is needed for effective therapies.

Read the full abstract

All mentions

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Understanding Leaky Gut: Mechanisms and Clinical Implications

The intestinal barrier comprises mucus, epithelial cells, and immune defenses. Its permeability can increase due to stress, drugs, or diet, leading to leaky gut. Measurement techniques and potential interventions are…

Shayna L. Powell, ND · Aug 8, 2025 60 views

Understanding Your Lymphatic System's Essential Role

The lymphatic system is more than a drainage system; it's your body's cleanup crew and immune hub. This video explores how factors like leaky gut, hormones, and chronic infections impact lymphatic function, along with…

IBD Well Women · Aug 25, 2025 0 views

Philotherapeute

@philotherapeute · X

@dr_andrealove Is that pseudoscience? https://t.co/ChrLzfPXmn

Sep 25, 2024 · 4 likes · 31 followers View post →

TwoDogs ∞

@Steph2Dogs · X

@jonathanstea The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans https://t.co/53YnvITRYM

Nov 3, 2023 · 1,924 followers View post →

Si its easier

@SimonTurton10 · X

@jonathanstea https://t.co/W01azleFj0

Nov 2, 2023 · 286 followers View post →

sunflwr

@sunflwr971 · X

The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans https://t.co/v0yRkhh4lR

May 12, 2023 · 464 followers View post →

TH@疫学

@pon144 · X

確かにリンクは胡散臭いけど、leaky gut自体は概念としてはまあまあ確立されてるかなぁと。（疾患との関連や臨床応用は別として） https://t.co/wEMV6Uush4 https://t.co/aj64bMyJW3 副腎疲労は知らん。 https://t.co/A6AiR8zqWS

Oct 2, 2021 · 1 like · 442 followers View post →

わくたよしのぶ【超敏感肌のくすり屋さん】

@wakunobu · X

参考 https://t.co/6EKrwy54fc

Aug 18, 2021 · 20,972 followers View post →

Cecilia Giron

@mceciliagiron · X

RT @DanielJDrucker: Targeting gut barrier function ameliorates metabolic inflammation #obesity #T2D #NASH in animals. As Prof Camilleri has…

Apr 17, 2021 · 1 share · 309 followers View post →

Daniel J Drucker

@DanielJDrucker · X

Apr 17, 2021 · 6 likes · 1 share · 34,095 followers View post →

Massimo Barberi

@masbarberi · X

Leaky gut: mechanisms, measurement and clinical implications in humans | Gut https://t.co/5PiC01iIJ1

Dec 23, 2020 · 1 like · 3,823 followers View post →

LowFodmap

@gidoc111 · X

https://t.co/v1JjMF0c80 https://t.co/ZbFd7UC0aq #histamin #SIBO #ibs #leaky gut #glutenfree

Sep 1, 2020 · 207 followers View post →

Fathimath Naseer RD

@Fathimath_N · X

RT @DanielJDrucker: And while we are pondering metabolic endotoxemia, is the ‘Leaky Gut’ while important for sepsis & gastrointestinal diso…

Aug 31, 2019 · 2 shares · 185 followers View post →

Yoni Freedhoff

@YoniFreedhoff · X

RT @DanielJDrucker: And while we are pondering metabolic endotoxemia, is the ‘Leaky Gut’ while important for sepsis & gastrointestinal diso…

Aug 30, 2019 · 2 shares · 62,285 followers View post →

Daniel J Drucker

@DanielJDrucker · X

Aug 30, 2019 · 5 likes · 2 shares · 34,095 followers View post →

Ashish Chogle

@ashish_chogle · X

Nice article by Dr. Camilleri! Leaky gut: mechanisms, measurement and clinical implications in humans | Gut https://t.co/t4OQhIJFBC

Jul 7, 2019 · 462 followers View post →

SlaintePeace

@ojad71 · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 6, 2019 · 6 shares · 850 followers View post →

Cahuilla Nicole

@QandAMamma · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 6, 2019 · 6 shares · 661 followers View post →

katie wright

@katiewr31413491 · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 6, 2019 · 6 shares · 12,910 followers View post →

Lianne Campbell MSc

@health_fuel · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 6, 2019 · 6 shares · 3,978 followers View post →

Thinking Autism

@TweetingAutism · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 6, 2019 · 6 shares · 14,335 followers View post →

Stacey Auger

@staceyauger1 · X

RT @PaulWhiteleyPhD: Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LS…

Jul 5, 2019 · 6 shares · 1,028 followers View post →

Paul Whiteley

@PaulWhiteleyPhD · X

Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/G6bgvrozWJ Indeed: https://t.co/LSZkIOHL4f

Jul 5, 2019 · 14 likes · 6 shares · 4,930 followers View post →

Darmtag

@darmtag · X

Leaky gut: mechanisms, measurement and clinical implications in humans https://t.co/7kdnAy8Fy3 https://t.co/Qf8eqE3FPT

Jul 5, 2019 · 60 followers View post →

Dr Celestino Gutiérrez González MD

@CelestinoGutirr · X