PubHawk
June 2019 PMID 31168091

De novo protein design by citizen scientists.

Brian Koepnick, Jeff Flatten, Tamir Husain, Alex Ford, Daniel-Adriano Silva, Matthew J Bick, Aaron Bauer, Gaohua Liu, Yojiro Ishida, Alexander Boykov, Roger D Estep, Susan Kleinfelter, Toke Nørgård-Solano, Linda Wei, Foldit Players

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Mentions

105
Peak: 53 in Jun 2019
across 6 sources since Jun 2019

Extended reach

207,639
potential audience

Total likes

133

Video views

498

Mentions per month

Jun 2019 – Feb 2022

Where it's discussed

  • X / Twitter62 posts
  • News21 articles
  • Blogs9 articles
  • Facebook8 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions prominently feature phrases like 'this is great' and 'awesome', indicating high regard for the innovative approach of involving citizen scientists. Comments reflect on the fun and creativity inherent in the Foldit game, which suggests a sense of community and collaborative spirit. This positive language and enthusiastic tone contribute to the overall sentiment of excitement and approval regarding the publication's findings.

AgreementStrong agreement

Most discussions reflect a strong approval of the publication's ideas and findings.

InterestHigh interest

There is notable enthusiasm and curiosity surrounding the potential of citizen scientists in protein design.

EngagementModerate engagement

While many posts express excitement, few dive deeply into specific methodologies or implications discussed in the article.

ImpactHigh impact

Participants perceive the research as having substantial implications for the field of protein design and science as a whole.

Abstract in brief

  • De novo protein design has been successfully tackled by citizen scientists using the online game Foldit, where players craft protein structures from a basic peptide chain, showcasing their creativity beyond mere pattern recognition.
  • Players designed a diverse range of protein structures, with 146 unique designs synthesized, and 56 were confirmed to be functional and stable when expressed in E. coli, including a new protein fold not seen in nature.
  • The success of the Foldit project highlights the potential of citizen science to contribute valuable insights into protein design, demonstrating that collective human creativity can solve complex scientific challenges.
Read the full abstract

Top posts

Most liked on X and Bluesky
南 慎太朗
@shintaro_minami · X

De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co/pcu4tIGvM5

Jun 6, 2019 · 31 likes · 9 shares · 584 followers View post →
M. Eugenio Vázquez
@ChemBioUSC · X

This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert citizen scientists, playing the online computer game Foldit, can accurately design completely new protein structures from scratch" https://t.co/vlNEX9OOTq

Jun 24, 2019 · 20 likes · 7 shares · 3,209 followers View post →
Hideaki E. Kato
@emeKato · X

De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 19 likes · 4 shares · 5,755 followers View post →
ShorterLab
@ShorterLab · X

De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 10 likes · 7 shares · 12,059 followers View post →
NobuoMaita
@nob_mai · X

De novo protein design by citizen scientists | Nature https://t.co/EJ3YbSUNFh

Jun 5, 2019 · 9 likes · 1,071 followers View post →
とりさん
@biochem_fan · X

"De novo protein design by citizen scientists" https://t.co/ZNvqtEwS06 https://t.co/1bImapoiN3 FoldIt のやつ。設計された蛋白質自体よりも、いかに gamification するかという点を焦点にした論文という印象を受けた。

Jun 28, 2019 · 7 likes · 4 shares · 6,039 followers View post →

All mentions

Ran_Zalk_BGU_Cryo_EM
@zalk_r · X

@omriwu @OdedRechavi foldit gamers are on his author's lists :^) this is the best but there are more. https://t.co/xtOSDlSKPD

Oct 1, 2021 · 532 followers View post →
Arkadiy Garber
@theironark · X

This is great: "De novo protein design by citizen scientists" https://t.co/82iMLxzprH Sounds like a fun game indeed! https://t.co/8tM14dPOVZ

Jul 2, 2020 · 1 like · 675 followers View post →
吳冠廷tinger wu
@tingerwu · X

De novo protein design by citizen scientists https://t.co/1i73ayKFgd

May 25, 2020 · 492 followers View post →
Sean Aubin
@voyageur_techno · X

RT @voyageur_techno: Human protein design follows a much different path than automatic design. From https://t.co/1vbEbMak4B https://t.co/q8…

May 22, 2020 · 1 share · 357 followers View post →
Sean Aubin
@voyageur_techno · X

Human protein design follows a much different path than automatic design. From https://t.co/1vbEbMak4B https://t.co/q8nl9X6OsW

Dec 11, 2019 · 1 share · 357 followers View post →
Rosario Strano
@Rosario_Strano · X

De novo protein design by citizen scientists https://t.co/o1Vvr3VHja

Nov 12, 2019 · 6,985 followers View post →
Calvin Cheung
@CheungCalvinCL · X

Imagine the quantity and quality of information we could have harness from essentially everyone, just by visuallzng the core of a problem as a simple game. De novo protein design by citizen scientists https://t.co/ok9QwrPDLr

Sep 29, 2019 · 29 followers View post →
Dr. Marigo Raftopoulos
@marigo · X

De novo protein design by citizen scientists | Nature https://t.co/nu6B6IqypB

Aug 7, 2019 · 4,788 followers View post →
Michael Ristow, MD
@Prof_M_Ristow · X

De novo protein design by #citizen scientists. #citizenscience https://t.co/VTJH5kNpzX

Jul 1, 2019 · 6 likes · 6,992 followers View post →
K. Yam
@yam_cpp · X

RT @biochem_fan: "De novo protein design by citizen scientists" https://t.co/ZNvqtEwS06 https://t.co/1bImapoiN3 FoldIt のやつ。設計された蛋白質自体よりも、いか…

Jun 29, 2019 · 4 shares · 805 followers View post →
たかとー
@takatoh1 · X

RT @biochem_fan: "De novo protein design by citizen scientists" https://t.co/ZNvqtEwS06 https://t.co/1bImapoiN3 FoldIt のやつ。設計された蛋白質自体よりも、いか…

Jun 28, 2019 · 4 shares · 605 followers View post →
とりさん
@biochem_fan · X

"De novo protein design by citizen scientists" https://t.co/ZNvqtEwS06 https://t.co/1bImapoiN3 FoldIt のやつ。設計された蛋白質自体よりも、いかに gamification するかという点を焦点にした論文という印象を受けた。

Jun 28, 2019 · 7 likes · 4 shares · 6,039 followers View post →
Justin Benesch
@BeneschResearch · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 25, 2019 · 7 shares · 966 followers View post →
Cosimo Ducani
@CosimoDucani · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 24, 2019 · 7 shares · 78 followers View post →
Olalla Vázquez
@OlallaLab · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 24, 2019 · 7 shares · 7,455 followers View post →
Biosynth
@BiosynthGroup · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 24, 2019 · 7 shares · 2,237 followers View post →
Paola Laurino
@PaolaLaurino · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 24, 2019 · 7 shares · 1,615 followers View post →
Carlos Moreno-Yruela
@CarlosMYruela · X

RT @ChemBioUSC: This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert…

Jun 24, 2019 · 7 shares · 417 followers View post →
M. Eugenio Vázquez
@ChemBioUSC · X

This paper, De novo protein design by citizen scientists, is awesome. Not only nifty structures but check this: "non-expert citizen scientists, playing the online computer game Foldit, can accurately design completely new protein structures from scratch" https://t.co/vlNEX9OOTq

Jun 24, 2019 · 20 likes · 7 shares · 3,209 followers View post →
Gerd Moe-Behrens
@GerdMoeBehrens · X

De novo protein design by citizen scientists https://t.co/kCjIzbHLfX

Jun 20, 2019 · 2,448 followers View post →
bernard Maillere
@BernardMaillere · X

Seen in Nature this week. It is not needed to be an expert in protein engineering anymore ...De novo protein design by citizen scientists Proteins designed de novo by players of the online protein-folding game Foldit https://t.co/rXZEbkpPJd

Jun 20, 2019 · 114 followers View post →
Geraint Rees
@profgeraintrees · X

De novo protein design by citizen scientists https://t.co/3E4EUc75OQ

Jun 20, 2019 · 11,604 followers View post →
Pavlos Msaouel
@PavlosMsaouel · X

RT @weldeiry: De novo protein design by citizen scientists https://t.co/NCr6wvwrFW

Jun 19, 2019 · 1 share · 3,527 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

De novo protein design by citizen scientists https://t.co/NCr6wvwrFW

Jun 19, 2019 · 2 likes · 1 share · 18,421 followers View post →
Benjamin Good
@bgood · X

De novo protein design by citizen scientists https://t.co/lnvG5nLIZL

Jun 11, 2019 · 2 likes · 976 followers View post →
Lenny Moise
@gen2vax · X

De novo protein design by citizen scientists | Nature https://t.co/nCfwJtQqTi

Jun 11, 2019 · 112 followers View post →
マーキュリー２世
@uranus_2 · X

シチズン・サイエンスを活用したタンパク質のデザイン。ゲームで自然界にはない折り畳み構造を創造できる。De novo protein design by citizen scientists https://t.co/TFZ1UrSJXQ

Jun 9, 2019 · 5,546 followers View post →
Mohan K. Bavirisetty
@InnovArch · X

De novo protein design by citizen scientists #CitizenAI #Science https://t.co/GZLPtG3Sxh

Jun 7, 2019 · 1,293 followers View post →
Mac Jamil
@mac_jamil · X

De novo protein design by citizen scientists | Nature https://t.co/1WR7KqaLkL

Jun 7, 2019 · 359 followers View post →
MichaelMcMurraylab
@McMurraylab · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 7, 2019 · 7 shares · 918 followers View post →
Geraint Rees
@profgeraintrees · X

De novo protein design by citizen scientists https://t.co/3E4EUc75OQ

Jun 6, 2019 · 11,604 followers View post →
ShiyunF
@ShiyunF · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 6, 2019 · 7 shares View post →
know thyself（子豚のオリバー)
@thyself_know · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 1,223 followers View post →
K.I.
@genolib_19 · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 353 followers View post →
Serpell Lab Reads
@SerpellLabReads · X

De novo protein design by citizen scientists https://t.co/OnybzQbuNJ

Jun 6, 2019 · 1 like · 824 followers View post →
圧到的に成長したぬーとりあはかぴばらと区別できないですわ（極悪令嬢・圧ヌ一ちゃん）
@piyota0 · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 2,763 followers View post →
Open Science Feed
@OpenScienceR · X

De novo protein design by citizen scientists https://t.co/5xUHTv0Brq https://t.co/lW1NlhYPX3

Jun 6, 2019 · 2,648 followers View post →
りょしむ
@simularion · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 172 followers View post →
ねじ
@Longiland1313 · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 205 followers View post →
Ohue M/大上雅史
@tonets · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 12,718 followers View post →
Naoya KOBAYASHI
@kobnaoya · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 1,208 followers View post →
torusengoku
@torusengoku · X

RT @shintaro_minami: De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co…

Jun 6, 2019 · 9 shares · 3,063 followers View post →
南 慎太朗
@shintaro_minami · X

De novo protein design by citizen scientists, Nature (2019) の Extended Data Fig.5 には愛が感じられないので個人的にまとめました。 https://t.co/pcu4tIGvM5

Jun 6, 2019 · 31 likes · 9 shares · 584 followers View post →
Luis E. Valentín-Alvarado
@luisarchaeota · X

De novo protein design by citizen scientists | Nature https://t.co/Aw7U67c6eq

Jun 6, 2019 · 2,669 followers View post →
Jared Schrader
@schraderlab · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 6, 2019 · 7 shares · 775 followers View post →
Hejun Liu
@menchant_liu · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 7 shares · 84 followers View post →
Priya R. Banerjee
@BanerjeeLab_UB · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 7 shares · 1,877 followers View post →
sk
@geginegi · X

RT @emeKato: De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 4 shares · 907 followers View post →
torusengoku
@torusengoku · X

RT @emeKato: De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 4 shares · 3,063 followers View post →
epigenetist
@epigenetist · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 7 shares · 239 followers View post →
Johanna Tiemann
@j0kaso · X

RT @ramonguixxa: De novo protein design by citizen scientists https://t.co/YiZvRzgPqF

Jun 5, 2019 · 1 share · 799 followers View post →
Ramon Guixà-González
@ramonguixxa · X

De novo protein design by citizen scientists https://t.co/YiZvRzgPqF

Jun 5, 2019 · 3 likes · 1 share · 494 followers View post →
Toyota_Group_Komaba
@KomaToug · X

RT @emeKato: De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 4 shares · 667 followers View post →
NobuoMaita
@nob_mai · X

De novo protein design by citizen scientists | Nature https://t.co/EJ3YbSUNFh

Jun 5, 2019 · 9 likes · 1,071 followers View post →
Geoffrey Siwo
@gsiwo · X

De novo protein design by citizen scientists @UWproteindesign https://t.co/u9T5tBzRoH

Jun 5, 2019 · 946 followers View post →
VU Duc Duy
@duynth29 · X

De novo protein design by citizen scientists https://t.co/Y9gR8NkiH8

Jun 5, 2019 · 100 followers View post →
Francis Villatoro
@emulenews · X

De novo protein design by citizen scientists: online protein-folding game Foldit. Players were presented with a fully extended peptide chain and challenged to craft a folded protein structure and an amino acid sequence encoding that structure. https://t.co/ILmKPAGTz5 https://t.co/nR7Z6g0MbL

Jun 5, 2019 · 45,129 followers View post →
Jonny Walker
@JonnyWalker0806 · X

RT @emeKato: De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 4 shares · 48 followers View post →
Hideaki E. Kato
@emeKato · X

De novo protein design by citizen scientists https://t.co/ytCrPo5ILJ Baker研から。これも明日詳しく読む。

Jun 5, 2019 · 19 likes · 4 shares · 5,755 followers View post →
Castaneda Lab
@Castaneda_lab · X

RT @ShorterLab: De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 7 shares · 1,488 followers View post →
ShorterLab
@ShorterLab · X

De novo protein design by citizen scientists: https://t.co/rymNYH41TF

Jun 5, 2019 · 10 likes · 7 shares · 12,059 followers View post →
Naoya KOBAYASHI
@kobnaoya · X

De novo protein design by citizen scientists https://t.co/abOVkLWqKv

Jun 5, 2019 · 1 like · 1,208 followers View post →