Br J Clin Pharmacol September 2019 PMID 31222854

A systematic review of cannabidiol dosing in clinical populations.

S A Millar, N L Stone, Z D Bellman, A S Yates, T J England, S E O'Sullivan

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Mentions

64
Peak: 29 in Jun 2019
across 5 sources since Jun 2019

Extended reach

155,296
potential audience

Total likes

237

Video views

5,894

Mentions per month

Jun 2019 – Nov 2025

Where it's discussed

  • X / Twitter49 posts
  • Reddit6 posts
  • News5 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The group shows strong interest in the systematic review, with posts discussing specific doses like 600 mg for anxiety, and critical perspectives questioning the safety of high doses, such as the 21x dosage linked to eye pressure issues. The tone varies from supportive to skeptical, reflecting engagement with the article’s implications and ongoing debates about CBD’s safety and efficacy.

AgreementModerate agreement

Most discussions acknowledge the review's comprehensive analysis and generally support its findings, with some posts emphasizing the need for further research.

InterestHigh interest

Posts demonstrate high interest by sharing detailed insights and calling attention to the importance of the study, indicating active engagement.

EngagementModerate engagement

Many discussions include references to specific studies, doses, and research gaps, showing a moderate level of engagement and critical thinking.

ImpactModerate impact

While some posts highlight the relevance for clinical practice and future research, others are more informational, suggesting a modest overall impact.

Abstract in brief

  • This systematic review analyzed 35 studies to determine the effective doses of cannabidiol (CBD) used in treating various health conditions, finding that doses ranged from 1 to 50 mg/kg and mainly showed positive results in epilepsy and other mental health issues.
  • While CBD was generally well-tolerated across studies, there was a lack of plasma concentration data, and the research showed no significant benefits for conditions like diabetes, Crohn's disease, ocular hypertension, fatty liver disease, or chronic pain at low doses.
  • The review emphasizes that more pharmacokinetic studies and conclusive phase III trials are needed to better understand the optimal plasma levels and effective doses of CBD for different medical conditions.

Top posts

Most liked on X and Bluesky
Saoirse E.O'Sullivan
@ScienceSaoirse · X

delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial data https://t.co/uG9MeUCLH6

Jun 21, 2019 · 24 likes · 8 shares · 2,254 followers View post →
Julio Ponce
@jasonptodd · X

@luizacaires3 Tem sim. Para ansiedade, tem estudo RCT com 600 mg que indica efeito positivo em redução. Esse artigo aqui tem um bom apanhado do que se sabe e das doses avaliadas. https://t.co/RT5UipJSZX

Oct 11, 2023 · 17 likes · 21,487 followers View post →
Steve Alexander
@mqzspa · X

A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/GrIGF9v4eA

Jun 21, 2019 · 15 likes · 11 shares · 943 followers View post →
British Journal of Clinical Pharmacology (BJCP)
@BritJClinPharm · X

A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Jul 22, 2020 · 7 likes · 4 shares · 3,766 followers View post →
Denise A. Valenti
@ROADSIDE_IMMAD · X

CBD dose is 21X that which was shown to develop elevated eye pressure in both animal and human study. Are these patients slowly going blind? Why is there no additional research on this? Shame to Sen Paul Rand for pushing CBD as food additive https://t.co/xJNZUelVQe

Aug 21, 2021 · 4 likes · 1 share · 283 followers View post →
Patrick Lockwood
@AlobhaPatrick · X

Neat article on #CBD. A systematic review of cannabidiol dosing in clinical populations. https://t.co/Tz3dBJojfE #ReadByQxMD

Aug 4, 2019 · 2 likes · 2 shares · 4,998 followers View post →

All mentions

Julio Ponce
@jasonptodd · X

@luizacaires3 Tem sim. Para ansiedade, tem estudo RCT com 600 mg que indica efeito positivo em redução. Esse artigo aqui tem um bom apanhado do que se sabe e das doses avaliadas. https://t.co/RT5UipJSZX

Oct 11, 2023 · 17 likes · 21,487 followers View post →
Denise A. Valenti
@ROADSIDE_IMMAD · X

CBD dose is 21X that which was shown to develop elevated eye pressure in both animal and human study. Are these patients slowly going blind? Why is there no additional research on this? Shame to Sen Paul Rand for pushing CBD as food additive https://t.co/xJNZUelVQe

Aug 21, 2021 · 4 likes · 1 share · 283 followers View post →
TheFarmacyUs
@FarmacyUs · X

RT @BritJClinPharm: A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Aug 13, 2020 · 4 shares · 145 followers View post →
TheFarmacyUs
@FarmacyUs · X

Science must be approached holistically, just like our bodies. One study concluding one thing, doesn't necessarily make it a universal truth. Research is crucial. A systematic review of cannabidiol dosing in clinical populations: https://t.co/AsyOpaprPH #cannabidiol #CBD #dosing https://t.co/bw84IXYiD2

Aug 13, 2020 · 145 followers View post →
⬡:: troy/farah
@filth_filler · X

@judymdotcom @madras_bertha not true? that's just contradiction, if you want to discuss this further, cite something. again, not recommending anyone take cbd for covid! i'm not insane, but it warrants investigation. here's more on its 'favourable toxicity and side effect profile' https://t.co/mZyYgYyQZa

Aug 12, 2020 · 4,126 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @BritJClinPharm: A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Jul 22, 2020 · 4 shares · 10,856 followers View post →
British Pharmacological Society
@BritPharmSoc · X

RT @BritJClinPharm: A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Jul 22, 2020 · 4 shares · 12,864 followers View post →
Jen Smith
@jensmithmi · X

RT @BritJClinPharm: A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Jul 22, 2020 · 4 shares · 433 followers View post →
British Journal of Clinical Pharmacology (BJCP)
@BritJClinPharm · X

A systematic review of #cannabidiol dosing in clinical populations https://t.co/wr0d19gdun https://t.co/bmqgJiQWRV

Jul 22, 2020 · 7 likes · 4 shares · 3,766 followers View post →
Kim Lawson
@KimLawson4 · X

Positive effects of CBD on reducing seizure frequency or severity, but no positive activity in randomised controlled trials assessing diabetes, Crohn's disease, ocular hypertension, fatty liver disease or chronic pain https://t.co/Okz4ii1xZB

Jul 9, 2020 · 254 followers View post →
The Natural Health Blogger
@naturalhealthbl · X

@tompollak @WalkKD @ProfValCurran "Twenty‐three studies reported a significantimprovement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), withdoses ranging between <1 and 50 mg/kg/d. " https://t.co/2IPu35C4BV

Mar 7, 2020 · 2,288 followers View post →
m M
@mitch2you80 · X

@BigCheds @CanteringClark We may find out that's true. But that's not what current clinical research has tested. Here's a meta-analysis if you have time/interest in getting into the weeds about dose response. https://t.co/5iFZThMFKl

Jan 24, 2020 · 1 like · 178 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @EuropePMC: New from #BBSRC https://t.co/LggAtdkmSs A systematic review of cannabidiol dosing in clinical populations

Aug 30, 2019 · 1 share · 6,704 followers View post →
Europe PMC articles
@EuropePMC · X

New from #BBSRC https://t.co/LggAtdkmSs A systematic review of cannabidiol dosing in clinical populations

Aug 29, 2019 · 1 share · 1,549 followers View post →
Lukas Brandon
@LukasBrandon · X

RT @PsychPLockwood: Neat article on #CBD. A systematic review of cannabidiol dosing in clinical populations. https://t.co/Tz3dBJojfE #Read…

Aug 5, 2019 · 2 shares · 291 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @PsychPLockwood: Neat article on #CBD. A systematic review of cannabidiol dosing in clinical populations. https://t.co/Tz3dBJojfE #Read…

Aug 4, 2019 · 2 shares · 6,704 followers View post →
Patrick Lockwood
@AlobhaPatrick · X

Neat article on #CBD. A systematic review of cannabidiol dosing in clinical populations. https://t.co/Tz3dBJojfE #ReadByQxMD

Aug 4, 2019 · 2 likes · 2 shares · 4,998 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @jensmithmi: "A systematic review of #cannabidiol dosing in clinical populations" - What do we know? Not as much as we'd like... A usefu…

Jul 23, 2019 · 1 share · 6,704 followers View post →
Jen Smith
@jensmithmi · X

"A systematic review of #cannabidiol dosing in clinical populations" - What do we know? Not as much as we'd like... A useful article - and free #fulltext! #EBM https://t.co/BUn27L1u4r https://t.co/6Cjcdlh5ac

Jul 23, 2019 · 1 share · 433 followers View post →
IRCCMH
@irccmh · X

CBD RESEARCH: Just how much #cannabidiol is enough for a given condition? A team of researchers analyzed all the current clinical trial data. https://t.co/umII58xdxz #pschtwitter #cannatwitterverse #CBDresearch #CBDproducts https://t.co/60LXLYYTzN

Jul 2, 2019 · 1 like · 115 followers View post →
DdC
@DendeCannabist · X

BPS Publications https://t.co/4zNAba5IZy

Jun 26, 2019 · 1,357 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @the_paper_link: trend up+1: *Millar SA* et al (Br J Clin Pharmacol) __A systematic review of cannabidiol dosing in clinical populations…

Jun 25, 2019 · 1 share · 6,704 followers View post →
the paper link
@the_paper_link · X

trend up+1: *Millar SA* et al (Br J Clin Pharmacol) __A systematic review of cannabidiol dosing in clinical populations.__ https://t.co/7OVw6kGspc

Jun 25, 2019 · 1 share · 136 followers View post →
Justin Prince
@TacomaHempfest · X

https://t.co/7sSCADForY

Jun 24, 2019 · 2,186 followers View post →
CBD Breaks
@CBDbreaks · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 24, 2019 · 8 shares · 2,633 followers View post →
Tim Montrief
@EMinMiami · X

#FOAMed #FOAMtox @acmt @ToxNow @toxstagram https://t.co/xdWwOBOBVo

Jun 24, 2019 · 3,918 followers View post →
Isla
@mamaduza · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 24, 2019 · 8 shares · 1,441 followers View post →
Enrique Faria
@enriquefaria08 · X

RT @CannabisBelge: A systematic review of cannabidiol dosing in clinical populations. https://t.co/u8pFPYYklH

Jun 23, 2019 · 2 shares · 335 followers View post →
Julia Garcia-Fuster
@GarciaFusterLab · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 22, 2019 · 11 shares · 544 followers View post →
Cannify
@CannifyUS · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 22, 2019 · 11 shares · 356 followers View post →
Jonathon Arnold
@JonathonCArnold · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 22, 2019 · 11 shares · 1,723 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @cbdmedbot: A systematic review of cannabidiol dosing in clinical populations. https://t.co/eKRDFsx84K

Jun 22, 2019 · 1 share · 6,704 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @CannabisBelge: A systematic review of cannabidiol dosing in clinical populations. https://t.co/u8pFPYYklH

Jun 22, 2019 · 2 shares · 6,704 followers View post →
cbdmedbot
@cbdmedbot · X

A systematic review of cannabidiol dosing in clinical populations. https://t.co/eKRDFsx84K

Jun 22, 2019 · 1 share · 157 followers View post →
Cannabis Belgique
@CannabisBelge · X

A systematic review of cannabidiol dosing in clinical populations. https://t.co/u8pFPYYklH

Jun 22, 2019 · 1 like · 2 shares · 650 followers View post →
Jorge Herrera
@Georgeudea · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 929 followers View post →
SEAN
@Oebs1 · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 21, 2019 · 8 shares · 1,314 followers View post →
Cece Hillard
@HillardCece · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 468 followers View post →
Dr Karen Wright
@iamkarenwright · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 21, 2019 · 8 shares · 639 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @DeanAcee: https://t.co/znfS7p6asE A systematic review of #CBD dosing on clinical population! #cannabis #Cannabinoids

Jun 21, 2019 · 1 share · 6,704 followers View post →
Dinesh Thapa
@DeanAcee · X

https://t.co/znfS7p6asE A systematic review of #CBD dosing on clinical population! #cannabis #Cannabinoids

Jun 21, 2019 · 1 like · 1 share · 356 followers View post →
New Hemp Times
@NewHempTimes · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 21, 2019 · 8 shares · 53 followers View post →
Owen Bowden-Jones
@OwenBowdenJones · X

RT @ScienceSaoirse: delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial…

Jun 21, 2019 · 8 shares · 2,400 followers View post →
gavin stewart
@metanutter · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 796 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 3,170 followers View post →
Saoirse E.O'Sullivan
@ScienceSaoirse · X

delighted to have this in press! How much #CBD #cannabidiol is enough? we analysed all the relevant #clinical #trial data https://t.co/uG9MeUCLH6

Jun 21, 2019 · 24 likes · 8 shares · 2,254 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 6,704 followers View post →
Saoirse E.O'Sullivan
@ScienceSaoirse · X

RT @mqzspa: A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/Gr…

Jun 21, 2019 · 11 shares · 2,254 followers View post →
Steve Alexander
@mqzspa · X

A systematic review of cannabidiol dosing in clinical populations @millar_sophie @ScienceSaoirse and colleagues https://t.co/GrIGF9v4eA

Jun 21, 2019 · 15 likes · 11 shares · 943 followers View post →
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