The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synthesis by the lab of Ang Li and compare it to recent syntheses completed by the Sarpong and Qin labs. #chemtwitter https://t.co/7rn1SGKy1a https://t.co/5Ka9yjyhMq
Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine.
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Jul 2019 – Sep 2022Where it's discussed
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X / Twitter19 posts
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YouTube2 videos
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The discussions demonstrate strong interest and engagement through mentions of podcasts, analyses, and comparisons of the synthesis by Ang Li's group with other laboratories, indicating a lively and attentive community focused on the significance and methods of this complex chemical synthesis.
Most discussions acknowledge the significance of the synthesis work, reflecting general agreement on its importance in organic chemistry.
Posts show high interest, especially with mentions of podcasts, analyses, and comparisons with other labs, indicating curiosity and engagement.
Posts include references to detailed discussions, such as analyses on YouTube and podcasts, suggesting active engagement with the research.
The focus on comparing synthesis methods and highlighting its significance in the field shows recognition of the research’s influence.
Abstract in brief
- The researchers successfully carried out the asymmetric total synthesis of three arcutine-type C20 diterpenoid alkaloids—arcutinidine, arcutinine, and arcutine—using a series of strategic reactions.
- They constructed a pentacyclic intermediate efficiently via two Diels-Alder reactions and developed a cascade sequence involving Prins cyclization and Wagner-Meerwein rearrangement to form the core structure of arcutinidine, which was further elaborated into a more complex oxygenated pentacycle through a scalable process.
- The synthesis included a chemoselective reductive amination step that produced a pyrroline motif, and the structure of arcutine was confirmed by chemical synthesis and crystallography, clarifying the configuration around the acyl group's carbon.]
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Most liked on X and BlueskyOur next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of Organic Chemistry. Stay tuned for our release tomorrow, Monday, July 22nd! @J_A_C_S https://t.co/3AbAVfKmkv
Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine https://t.co/1eaSm0c80g https://t.co/mqdakLNcib
Ang Li新作。不斉全合成。かなり初段階の段階でtBuLiつかってしかもホルミル化っていうのが少し課題に思えました。 #学ぶの論文紹介 Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine https://t.co/9oF3Ay9ze3
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
All mentions
Total Synthesis of Arcutinidine and Related Alkaloids Explained
This video details the asymmetric total synthesis of three arcutine-type alkaloids—arcutinidine, arcutinine, and arcutine—using strategic reactions including Diels-Alder, Prins cyclization, and Wagner-Meerwein…
Mukaiyama Hydration: Mechanism and Applications in Organic Synthesis
The Mukaiyama hydration transforms olefins into alcohols with Markovnikov selectivity. It involves a metal hydride mechanism, radical formation, and oxygen trapping, providing a versatile method for selective hydration…
Ang Li新作。不斉全合成。かなり初段階の段階でtBuLiつかってしかもホルミル化っていうのが少し課題に思えました。 #学ぶの論文紹介 Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine https://t.co/9oF3Ay9ze3
Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine https://t.co/1eaSm0c80g https://t.co/mqdakLNcib
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: Episode 4 discusses the synthesis of arcutinidine by the group of Ang Li. Within the last few months, this molecule wa…
RT @TheCycloEdition: The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synt…
RT @TheCycloEdition: The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synt…
RT @TheCycloEdition: The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synt…
RT @TheCycloEdition: The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synt…
RT @TheCycloEdition: The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synt…
The Cyclo Edition episode #4 is out on Youtube, Spotify, and Apple Podcasts! In this episode we analyze the total synthesis by the lab of Ang Li and compare it to recent syntheses completed by the Sarpong and Qin labs. #chemtwitter https://t.co/7rn1SGKy1a https://t.co/5Ka9yjyhMq
RT @TheCycloEdition: Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of O…
RT @TheCycloEdition: Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of O…
RT @TheCycloEdition: Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of O…
RT @TheCycloEdition: Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of O…
RT @TheCycloEdition: Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of O…
Our next podcast is covering the total synthesis of arcutinidine by the group of Ang Li at the Shanghai Institute of Organic Chemistry. Stay tuned for our release tomorrow, Monday, July 22nd! @J_A_C_S https://t.co/3AbAVfKmkv