August 2019 PMID 31339001

Protein Leverage: Theoretical Foundations and Ten Points of Clarification.

David Raubenheimer, Stephen J Simpson

Mentions

73
Peak: 18 in Apr 2020
across 5 sources since Jul 2019

Extended reach

671,212
potential audience

Total likes

324

Video views

7,085

Mentions per month

Jul 2019 – Jan 2025

Where it's discussed

  • X / Twitter57 posts
  • News9 articles
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions reflect a high level of interest, as seen in references to multiple studies and figures, with posts noting the paper's potential to clarify misconceptions and deepen understanding, such as comments about the 'theoretical foundations' and effects like 'fat leverage.' The tone is analytical and respectful, emphasizing the scientific importance of the publication rather than dismissiveness or superficial remarks.

AgreementModerate agreement

Most social discussions acknowledge the validity and significance of the protein leverage hypothesis, often referencing its experimental and epidemiological support.

InterestHigh interest

The majority of posts show high interest, with many sharing articles, studies, and deep reflections on the topic.

EngagementModerate engagement

Posts involve thoughtful responses to research points, suggesting moderate engagement through clarifications and discussions, though mostly in a surface-to-moderate depth.

ImpactModerate impact

While discussions highlight the importance of understanding protein leverage, the influence on practical dietary behaviors or policies remains limited, indicating moderate impact.

Top posts

Most liked on X and Bluesky
L. Amber O'Hearn
@KetoCarnivore · X

Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting last year: "fat leverage" could come into play as a mirror image of protein leverage when protein is beyond sufficient. (my idea here: https://t.co/Vw3Qy0vsUK) https://t.co/Qg5Tj9csNk

Apr 6, 2020 · 52 likes · 6 shares · 60,014 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just wanted to say some of the questions you raised are answered here: https://t.co/x9GtzU0vhu Happy to discuss further

Apr 6, 2020 · 26 likes · 7 shares · 3,273 followers View post →
KOJI@プライマルコーチ
@kojija · X

【プロティンレバレッジ仮説 (PLH )】 PLH:P量がFやC摂取量を支配する https://t.co/LOk2w9ZpVy 〇 動物はPをどの栄養素よりも優先して食事量を調整する 〇 Pの需要を満たすまで食欲は持続する 〇 P摂取が少ないと摂取カロリーが多くなる Y: 総Kcal X: 総Kcalに占めるP(%) https://t.co/1UKpptHXLL

Nov 11, 2020 · 14 likes · 3 shares · 2,309 followers View post →
Marty Kendall
@martykendall2 · X

@richcollins @FrogHarmless @DrEenfeldt @DietDoctor https://t.co/9LBd3ItWHS https://t.co/QNxrIceDRn

Mar 9, 2023 · 5 likes · 2 shares · 11,023 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@KetoCarnivore also evidence for fat leverage (involving also carbs) in humans on high P diets - see Fig 9 in https://t.co/x9GtzU0vhu. Exactly what we would predict from interacting appetites https://t.co/XPvJTZWJ0g

Apr 6, 2020 · 5 likes · 1 share · 3,273 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

Nice overview of the protein leverage hypothesis in humans by @eatlikeanimals Also think these are wise caveats of not jumping to premature conclusions that high protein diets are a generalized antidote to our ills. https://t.co/QQELc1Wbhq https://t.co/jOCo1B3PGc

Sep 15, 2021 · 4 likes · 9,798 followers View post →

All mentions

Carnal Dancer
@CarnalDancer · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

Jan 20, 2025 · 6 shares · 1,391 followers View post →
CambridgePT
@cambridge_pt · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

Jan 20, 2025 · 6 shares · 2,307 followers View post →
exfatloss
@exfatloss · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

May 9, 2024 · 6 shares · 6,736 followers View post →
Carnivore Augustus
@CarnivoreAugust · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

May 9, 2024 · 6 shares · 828 followers View post →
Marty Kendall
@martykendall2 · X

@ErasmasFigaro @TuckerGoodrich @tednaiman @DoctorTro And here. https://t.co/dB5fgesbtm

Jun 12, 2023 · 1 like · 11,023 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@JohnSpeakman4 @tednaiman @eatlikeanimals Yes, have been working through this: "Protein Leverage: Theoretical Foundations and Ten Points of Clarification" https://t.co/wfXchwS1zP https://t.co/zT6VdkZb0y

Jun 12, 2023 · 1 like · 28,290 followers View post →
Seraphim Angels
@SeraphimAngels1 · X

RT @martykendall2: @richcollins @FrogHarmless @DrEenfeldt @DietDoctor https://t.co/9LBd3ItWHS https://t.co/QNxrIceDRn

Mar 10, 2023 · 2 shares · 326 followers View post →
RD, Ph.D.
@RRDDDDDDDDDD · X

RT @martykendall2: @richcollins @FrogHarmless @DrEenfeldt @DietDoctor https://t.co/9LBd3ItWHS https://t.co/QNxrIceDRn

Mar 10, 2023 · 2 shares · 8,947 followers View post →
Marty Kendall
@martykendall2 · X

@richcollins @FrogHarmless @DrEenfeldt @DietDoctor https://t.co/9LBd3ItWHS https://t.co/QNxrIceDRn

Mar 9, 2023 · 5 likes · 2 shares · 11,023 followers View post →
DYLΛN
@fysiologik · X

How we chase Protein and therefore over eat fat and cho?

Feb 22, 2023 · 1 like · 1,692 followers View post →
Marty Kendall
@martykendall2 · X

@guido_vogel @DarinDenman @tednaiman @bendormiki @KetoCarnivore @raphaels7 this chart shows R&S's compilation of human studies. https://t.co/UdBpFr10pp https://t.co/ZwwuJ2P7nc

Jun 28, 2022 · 11,023 followers View post →
Marty Kendall
@martykendall2 · X

@guido_vogel @DarinDenman @tednaiman it's not really a claim. @tednaiman and I are just pointing to R&S's #proteinleverage data. https://t.co/MEJvv8RtUN https://t.co/hZqnpS2qZX

Jun 27, 2022 · 1 like · 11,023 followers View post →
Dr. E
@DrEenfeldt · X

@garytaubes @venture_guru @Nickle1011 @tanyanashphoto @lowcarbGP @PHCukorg @bigfatsurprise @drjasonfung @DoctorTro @LoCarbFreshwell @DrAseemMalhotra @lowcarb_aus @AnnChildersMD There are many articles about the evidence behind the PLH, I’m sure you’re not asking me to reinvent the wheel here? Just one example: https://t.co/xZWAllno0S

May 29, 2022 · 62,926 followers View post →
Harmless Frog
@FrogHarmless · X

@mold_time @eatlikeanimals TL;DR: Humans strive to eat a somewhat inflexible amount of protein. Protein in food got "diluted" and this caused the recent obesity spike. It aligns well with the "causal non-correlate" idea. https://t.co/wGRznGkqDt https://t.co/h961kI9Wsc

Mar 15, 2022 · 1 like · 503 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@DrEades @richcollins @raphaels7 @kevinnbass @tednaiman @bendormiki Not true. Many studies have been done since the undergrad pilot study - which was essential for convincing funders something discovered in locust research is worth pursuing in humans. Read the evidence then happy to discuss. https://t.co/1VRY7Bf3Cp https://t.co/TSVifvrsHk

Mar 10, 2022 · 3,273 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

Nice overview of the protein leverage hypothesis in humans by @eatlikeanimals Also think these are wise caveats of not jumping to premature conclusions that high protein diets are a generalized antidote to our ills. https://t.co/QQELc1Wbhq https://t.co/jOCo1B3PGc

Sep 15, 2021 · 4 likes · 9,798 followers View post →
Marty Kendall
@martykendall2 · X

@KevinH_PhD @tednaiman @eatlikeanimals these 'problems' are addressed by @eatlikeanimals here. https://t.co/dB5fgea2fe

Jul 24, 2021 · 11,023 followers View post →
Marty Kendall
@martykendall2 · X

@KevinH_PhD @tednaiman the chart is from https://t.co/dB5fgea2fe by @eatlikeanimals based on the compilation of clinical trials.

Jul 24, 2021 · 1 like · 11,023 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@kevinnbass @tednaiman We have addressed several of those points here: https://t.co/x9GtzU0vhu

Jun 17, 2021 · 2 likes · 3,273 followers View post →
ちゃんの助
@piyomarck · X

RT @kojija: 【プロティンレバレッジ仮説 (PLH )】 PLH:P量がFやC摂取量を支配する https://t.co/LOk2w9ZpVy 〇 動物はPをどの栄養素よりも優先して食事量を調整する 〇 Pの需要を満たすまで食欲は持続する 〇 P摂取が少ないと摂取…

Apr 26, 2021 · 3 shares · 351 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@raphaels7 @tednaiman @gerdosi Are you referring to the PL (protein leverage) hypothesis? That's been demonstrated in several human studies, both experimental and epidemiological most recently reviewed in: https://t.co/1VRY7AWUoh

Apr 19, 2021 · 2 likes · 3,273 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@whsource @JohnSpeakman4 1/2 Please do read this: https://t.co/x9GtzU0vhu i. PLH is about humans not mice ii. PL is a pattern of MN regulation – which like all things biological varies between species iii. And possibly within species (age/sex class etc.) iv. And circumstances (e.g. diets)

Mar 5, 2021 · 3 likes · 3,273 followers View post →
Agingdoc
@agingdoc1 · X

@JohnSpeakman4 @KetoCarnivore @LogicalLynx @FrogHarmless @whsource That’s right, as discussed @ https://t.co/qJL05UCiZL (Simpson / @eatlikeanimals ) which agrees with you John: PL not 100%, and as you correctly pointed out strongest effects apply to a limited range of %P above your primary effects tested thresholds this study.

Mar 5, 2021 · 3 likes · 42,032 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@kevinnbass @agingdoc1 Thanks all for discussion on our work. @kevinbass, lots of misunderstanding around #proteinleverage. Suggest you read https://t.co/x9GtzU0vhu to be sure your view is solidly founded. Happy to discuss then. Eat Like the Animals provides the broader context.

Jan 21, 2021 · 1 like · 3,273 followers View post →
Agingdoc
@agingdoc1 · X

@Aging_Scientist @LammingLab @S_SolonBiet @eatlikeanimals @davidasinclair @JohnSpeakman4 Of interest, more recent NG updates https://t.co/YMa3OxN35y &https://t.co/P0AqvpXLVh & WRT the matter of EAAR w/ protein dilution, https://t.co/nWOaSE4esQ. No model is perfect (dilution vs restricting) & while progress made https://t.co/5yvxs2LS9e there’s still much to work out.

Jan 16, 2021 · 42,031 followers View post →
KOJI@プライマルコーチ
@kojija · X

【PLH レバレッジの上限】 PLHの提唱者による最近のPLHの理解に対する警笛で 「PLHは高P食が最適とは意味しない」 - レバレッジは低P食では強いが、高P食では弱い - 過剰なP摂取は老化を促進→寿命減少 - 人生後期における心疾患、腸内細菌叢へ負の影響 とありました https://t.co/LOk2w9ZpVy https://t.co/AFLaTiga2R

Nov 11, 2020 · 3 likes · 2,309 followers View post →
katsu@金森式ダイエット
@katsusa7 · X

RT @kojija: 【プロティンレバレッジ仮説 (PLH )】 PLH:P量がFやC摂取量を支配する https://t.co/LOk2w9ZpVy 〇 動物はPをどの栄養素よりも優先して食事量を調整する 〇 Pの需要を満たすまで食欲は持続する 〇 P摂取が少ないと摂取…

Nov 11, 2020 · 3 shares · 31 followers View post →
金森重樹@ダイエットonlineサロン
@ShigekiKanamori · X

RT @kojija: 【プロティンレバレッジ仮説 (PLH )】 PLH:P量がFやC摂取量を支配する https://t.co/LOk2w9ZpVy 〇 動物はPをどの栄養素よりも優先して食事量を調整する 〇 Pの需要を満たすまで食欲は持続する 〇 P摂取が少ないと摂取…

Nov 11, 2020 · 3 shares · 125,199 followers View post →
KOJI@プライマルコーチ
@kojija · X

【プロティンレバレッジ仮説 (PLH )】 PLH:P量がFやC摂取量を支配する https://t.co/LOk2w9ZpVy 〇 動物はPをどの栄養素よりも優先して食事量を調整する 〇 Pの需要を満たすまで食欲は持続する 〇 P摂取が少ないと摂取カロリーが多くなる Y: 総Kcal X: 総Kcalに占めるP(%) https://t.co/1UKpptHXLL

Nov 11, 2020 · 14 likes · 3 shares · 2,309 followers View post →
Agingdoc
@agingdoc1 · X

Written by the two researchers who developed the Protein Leverage Hypothesis conclude “PL does not imply that high‐protein diets are optimal” ( the title of section 10).... https://t.co/RYXRvgxAc0

Oct 22, 2020 · 1 like · 42,032 followers View post →
Rob Hanna
@PurestVitality · X

@tednaiman have you seen this one, it's prolly in your library: https://t.co/03A4GfP3ez

Oct 11, 2020 · 1 like · 1,183 followers View post →
Agingdoc
@agingdoc1 · X

Protein Leverage: Theoretical Foundations and Ten Points of Clarification - Raubenheimer - Obesity https://t.co/RYXRvgxAc0

Oct 11, 2020 · 42,032 followers View post →
Institute for Optimum Nutrition
@ion_nutrition · X

@dawnwaldron @tednaiman You might enjoy this paper https://t.co/CsC2cxZph0

Sep 11, 2020 · 1 like · 5,755 followers View post →
Harmless Frog
@FrogHarmless · X

@TheBhupiThakur @FoodFirst_Ty The graphs are my own hastily assembled work. For where I get these ideas, check out: https://t.co/8mOpXcWx4l https://t.co/8pPFP662Uu https://t.co/2NuRHlHTxL In general also the works of @eatlikeanimals, @whsource, @GardnerPhD, @JoseAntonioPhD and @KevinH_PhD.

Aug 28, 2020 · 2 likes · 503 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@melanocortins For a deeper dig into protein leverage, see https://t.co/x9GtzU0vhu https://t.co/QxFrZReayZ

Jun 12, 2020 · 3,273 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@fleurmeddens ii. The higher the protein intake target, the more pronounced the protein leverage effect hence more vulnerable to obesity (Chapter 13 in #EatLikeTheAnimals and Fig. 6 in https://t.co/x9GtzU0vhu) /2 https://t.co/xeSr0Pcx8X

May 14, 2020 · 1 like · 3,273 followers View post →
Sean C. Lucan, MD
@SeanLucan · X

Protein Leverage: Theoretical Foundations & 10 Points of Clarification https://t.co/RmYvPqp0ps via @ObesitySociety #fat #carbs #protein #diet #weight https://t.co/0Iti55OFNn

May 11, 2020 · 1,497 followers View post →
James Gilbert - find me on BlueSky, link in bio!
@james_gilbert · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

Apr 16, 2020 · 6 shares · 2,162 followers View post →
Travis Statham
@Travis_Statham · X

I just posted "Protein Leverage: Theoretical Foundations and Ten Points of Clarification — Professors David Raubenheimer Stephen J. Simpson ASK ME ANYTHING" on Reddit https://t.co/9NE3EzEZdw

Apr 8, 2020 · 1 like · 12,706 followers View post →
XaviSo
@overpeter_ · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 7, 2020 · 7 shares · 540 followers View post →
Tristan Haggard, PhD*, BiGT
@TristanHaggard · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 7, 2020 · 7 shares · 9,328 followers View post →
Shaun Scott
@upyrbike · X

@DiscoStew66 See Fat v Protein leverage discussion by @eatlikeanimals https://t.co/oS1Vb8xYIF by

Apr 7, 2020 · 1,437 followers View post →
eleanorina
@_eleanorina · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

Apr 7, 2020 · 6 shares · 3,180 followers View post →
Sarah Ellen
@Living_LCHF · X

"In contrast...on low‐protein diets...there is no way to convert ingested nonprotein energy into limiting protein." https://t.co/4sGfdkgUdx

Apr 7, 2020 · 3 likes · 639 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

RT @eatlikeanimals: @KetoCarnivore also evidence for fat leverage (involving also carbs) in humans on high P diets - see Fig 9 in https://t…

Apr 6, 2020 · 1 share · 3,273 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

@KetoCarnivore also evidence for fat leverage (involving also carbs) in humans on high P diets - see Fig 9 in https://t.co/x9GtzU0vhu. Exactly what we would predict from interacting appetites https://t.co/XPvJTZWJ0g

Apr 6, 2020 · 5 likes · 1 share · 3,273 followers View post →
Lakey Farm
@RayMondeDeux · X

RT @KetoCarnivore: Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting…

Apr 6, 2020 · 6 shares · 2,732 followers View post →
L. Amber O'Hearn
@KetoCarnivore · X

Cool. The new paper from @eatlikeanimals (https://t.co/92vQCGdKZS) has a nice representation of an idea I was promoting last year: "fat leverage" could come into play as a mirror image of protein leverage when protein is beyond sufficient. (my idea here: https://t.co/Vw3Qy0vsUK) https://t.co/Qg5Tj9csNk

Apr 6, 2020 · 52 likes · 6 shares · 60,014 followers View post →
Agnes Ayton
@AgnesAyton · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 7,404 followers View post →
Lakey Farm
@RayMondeDeux · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 2,732 followers View post →
RD, Ph.D.
@RRDDDDDDDDDD · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 8,947 followers View post →
Travis Statham
@Travis_Statham · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 12,706 followers View post →
eleanorina
@_eleanorina · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 3,180 followers View post →
Melchior Meijer
@PolderPaleo · X

RT @eatlikeanimals: Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just…

Apr 6, 2020 · 7 shares · 5,169 followers View post →
Prof David Raubenheimer & Prof Stephen Simpson
@eatlikeanimals · X

Listened to the great interview @KetoCarnivore @TristanHaggard - good to see deep thought around protein leverage. Just wanted to say some of the questions you raised are answered here: https://t.co/x9GtzU0vhu Happy to discuss further

Apr 6, 2020 · 26 likes · 7 shares · 3,273 followers View post →
Harmless Frog
@FrogHarmless · X

@PeleOgunseye @DietHeartNews Regarding protein being low for obesity prevention: https://t.co/2NuRHlHTxL

Jan 25, 2020 · 1 like · 503 followers View post →
Karageorgos
@Karageorgos15 · X

"Over recent years, however, several misconceptions about protein leverage have arisen. Our aim in this paper is to briefly outline some key aspects of the underlying theory and clarify 10 points of misunderstanding... https://t.co/eP0fZNlqh3

Jul 25, 2019 · 2 likes · 611 followers View post →