Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis.

Alexandre de Souza E Silva, Adriana Pertille, Carolina Gabriela Reis Barbosa, Jasiele Aparecida de Oliveira Silva, Diego Vilela de Jesus, Anna Gabriela Silva Vilela Ribeiro, Ronaldo Júlio Baganha, José Jonas de Oliveira

November 2019 J Ren Nutr

Synopsis of Social media discussions

Several discussions highlight the findings of the meta-analysis, with comments like 'creatine doesn’t damage healthy kidneys, it just raises creatinine,' which showcases a clear understanding of the article's conclusions. Others reference the long history of safety data, using phrases like '30+ years of RCTs show no renal harm,' indicating a strong reliance on scientific literature. The tone of reassurance in these discussions contributes positively to the perception that creatine supplementation is both safe and effective.

A
Agreement
 Strong agreement

The majority of discussions strongly align with the findings of the publication, emphasizing the safety of creatine for healthy individuals.

I
Interest
 High level of interest

Conversations display significant curiosity and are driven by the relevance of the topic to both athletic and health communities.

E
Engagement
 Moderate level of engagement

While many comments refer to the findings, some users engage more deeply by discussing specifics of the studies or clinical implications.

I
Impact
 High level of impact

Many discussions reflect a belief that this research has substantial implications for public health and exercise nutrition.

Social Mentions

YouTube

2 Videos

Bluesky

1 Posts

Facebook

6 Posts

Twitter

115 Posts

Blogs

4 Articles

News

23 Articles

Reddit

2 Posts

Metrics

Video Views

1,592

Total Likes

663

Extended Reach

892,606

Social Features

153

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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174 views

  • Ana Oliva
    @AnaOliva31 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    October 19, 2025

    57

  • Maegan Laporte unacceptable independent
    @maegan_laporte (Twitter)

    RT @IntegralAnswers: 7/ ⚕️ Safety: 30+ years of RCTs show no renal harm in healthy people. Serum creatinine rises slightly (biochemical, n…
    view full post

    October 14, 2025

    1

  • IntegralAnswers
    @IntegralAnswers (Twitter)

    7/ ⚕️ Safety: 30+ years of RCTs show no renal harm in healthy people. Serum creatinine rises slightly (biochemical, not pathologic). Quality = HIGH for healthy; insufficient for CKD. (J Ren Nutr 2019 doi: 10.1053/j.jrn.2019.05.004)
    view full post

    October 14, 2025

    2

    1

  • LongTermSubstituteDictator
    @YSburneraccount (Twitter)

    RT @Monique510: Creatine doesn’t damage healthy kidneys, it just raises creatinine on labs, which people confuse. Studies show no harm at n…
    view full post

    October 9, 2025

    1

  • From Oakland With ❤️
    @Monique510 (Twitter)

    Creatine doesn’t damage healthy kidneys, it just raises creatinine on labs, which people confuse. Studies show no harm at normal doses (3–5g/day).
    view full post

    October 9, 2025

    2

    1

  • Δέσποτας Ο ΠΙΛΟΤΟΣ ✈ Ο ΠΟΘΗΤΟΣ
    @JudgeJury7 (Twitter)

    Η κρεατίνη στην πράξη: Τι λένε 1000+ επιστημονικές μελέτες (2025) | Efi ... https://t.co/rQrMCXoAMD via @YouTube
    view full post

    October 6, 2025

  • Find something that isnt Rigged and HODL
    @LordBadjujus (Twitter)

    @jaxon9470 @Wendi_Irlbeck The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels Source Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis - ScienceDirect https://t.co/MzQX1zS5Wo
    view full post

    August 7, 2025

  • Caleb Mahlen
    @cmahlen.bsky.social (Bluesky)

    This meta analysis shows there is no change in serum urea or creatinine, which you would expect to see if creatine were causing renal damage. I haven't read this literature as carefully because I don't have kidney disease, but it seems like the wsj article is right pubmed.ncbi.nlm.nih.gov/31375416/
    view full post

    May 14, 2025

    1

  • Nicholas Fabiano, MD
    @NTFabiano (Twitter)

    @tshepo_sr Read up on renal function https://t.co/VEx6A2bTVC And not sure what you're getting at re: dizziness
    view full post

    April 26, 2025

  • Miloslav Šindelář
    @Milosval1 (Twitter)

    @DanielHruby_ @mikesjak Neni problem. Zde meta-analýza studii: https://t.co/EbfaZLobI9 https://t.co/LbypSg6q0y
    view full post

    April 25, 2025

  • ORSID
    @OrsiD (Twitter)

    @adalozzo Doctor y la evidencia para cuando? , llevo 2 meta-analysis qué dicen que usted miente, o esta desinformado sobre la creatina. Ahí le dejo para que lea y se informe https://t.co/zGZQvfjBtj
    view full post

    March 15, 2025

  • Beto Romero
    @betto_93 (Twitter)

    @adalozzo Un médico como vos?? Te recomiendo un poco de lectura. https://t.co/V41e94Slh2
    view full post

    March 15, 2025

  • Aldrin
    @ArturoEcho (Twitter)

    @adalozzo Que tal este? https://t.co/t7T0c6FnOD
    view full post

    March 15, 2025

  • LondonJoy
    @JoyLondonCol (Twitter)

    @adalozzo No lo sé dr., no estoy segura sobre lo de la creatina. Probablemente tenía marcadores de enfermedad renal subyacentes. La creatina ha sido estudiada ampliamente https://t.co/Oj1u58csll
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    March 15, 2025

  • Damian
    @DammIsHere (Twitter)

    @adalozzo Considerando que sos un medico y que tu tweet es 50% desinformacion, no le estarias haciendo un favor a la tesis de asesorarse siempre primero con el medico. El cuerpo de evidencia a favor de la suplementacion con creatina y su seguridad es enorme. https://t.co/gQyWk4Cb6i
    view full post

    March 14, 2025

    2

  • Alex Leaf
    @AlexJLeaf (Twitter)

    @jmwhit72 I've never seen data suggesting it to. Here's a meta-analysis suggesting no negative effect when looking at blood markers. https://t.co/d8DFmKUZKs
    view full post

    December 9, 2024

  • Victor Manoel
    @_vitas28_ (Twitter)

    Toda vez que vejo gente falando que creatina causa pedra nos rins, eu fico me remoendo por dentro, uma simples olhada no pubmed e vc tira as conclusões que vc está errado https://t.co/fnkc0Nhoi2
    view full post

    November 3, 2024

    2

  • Joey Stich, CSCS, TSAC-F
    @jstich310 (Twitter)

    @Jude01638018 @vstyles17 Creatinine, not CK. My bad. https://t.co/KQs8BGUncn
    view full post

    November 3, 2024

    1

  • Daniel Berglind, PhD
    @DanielBerglind (Twitter)

    @Jafar2561 And >35 is not = kidney disease + meta-analysis data show that creatine is safe: https://t.co/nrxXmj3VDi
    view full post

    September 22, 2024

  • fer cortes
    @feeercortes (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    August 28, 2024

    57

  • Saúl Sánchez
    @SaulNutri (Twitter)

    @osmarbonino Falacia de autoridad. Te dejo metanalisis https://t.co/WsB2rFjGjI
    view full post

    July 30, 2024

    5

  • Stefan Nikolic
    @stevcho91 (Twitter)

    @neinspirativan Kreatinin nije baš dobar za merilo rada bubrega kod ljudi koji vežbaju. I sama mišićna masa ga podiže a ne samo kreatin. Meri cystatin C pa vidi da li ima oštećenja bubrega. https://t.co/hqsqig164z
    view full post

    July 25, 2024

    4

  • NU PW
    @NUPW628515 (Twitter)

    @Adaximandro https://t.co/QL3y8T645R
    view full post

    July 19, 2024

  • werita flowrockstar
    @alellanesc (Twitter)

    https://t.co/P8bP0dByo5 todo depende del contexto del paciente, reducirlo a una causa es tonto y provoca desinformación
    view full post

    July 18, 2024

  • Leonardo Rocha
    @Leo_Fit (Twitter)

    @PamelaForeroB @Adaximandro No causa daño renal https://t.co/h0cAyxEjOy
    view full post

    July 18, 2024

    305

  • Leonardo Rocha
    @Leo_Fit (Twitter)

    @FXearn @andressEduardo @Adaximandro Bueno pero comparar el cigarrillo con la creatina no tiene mucho sentido, teniendo en cuenta que esta última ha sido super estudiada por décadas e incluso se ha demostrado que no causa problemas renales. https://t.co/h0cAyxEjOy
    view full post

    July 18, 2024

    40

  • Jamie Timmons
    @metapredict (Twitter)

    @MichaelMindrum @hjluks I’m afraid both are probably talking nonsense tbh. If your kidneys are fine, you won’t get much change in Creatinine with Creatine supplementation. https://t.co/TT9KPmnzGb (my qualification? I read the literature)
    view full post

    May 26, 2024

    1

  • clorazene
    @clorazene (Twitter)

    @Patriot4Lyfe74 @AlpacaAurelius "The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations" https://t.co/tTOcamfmzG
    view full post

    April 5, 2024

  • Mg2+ Papi, the BowTied Mg2+
    @Grimhood (Twitter)

    @Shane_Hunter @BowTiedYukon @AbudBakri Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/LUZng9jElV
    view full post

    December 31, 2023

    6

  • Mr. Teen Crypto 2015 — e/acc⏩
    @elonconomy (Twitter)

    @Elons_Tapeworm https://t.co/8OnOQmldNB
    view full post

    October 19, 2023

  • Froggo
    @FroggoGobbo (Twitter)

    @crossplanecrank @safetyth1rd Any reputable paper shows that creatine is safe for your kidneys https://t.co/zHbnbscGDN
    view full post

    August 2, 2023

    2

  • POP_PAPP
    @Pop_papp_osk (Twitter)

    ขอแปะ ref แบบไม่เป็นแบบฟอร์ม ขี้เกียจ : Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis -July 2019Journal of Renal Nutrition 29(6)
    view full post

    July 13, 2023

    2

  • Doug of Chaos
    @d_freires (Twitter)

    @FooooiMal Procurei aqui mais a fundo e realmente não tem relação: https://t.co/nGi0ysVByV Mas foi o que a médica disse pra ele
    view full post

    May 3, 2023

  • Bader alshatti Ms
    @alshatti_fit (Twitter)

    سلامة الكرياتين مراجعة منهجية مع تحليل تلوي لـ 15 دراسة: آثار مكملات الكرياتين على وظائف الكلى أظهرت النتائج : أن الكرياتين لم يزيد بشكل كبير من تركيز الكرياتينين واليوريا وهي علامات مهمة لخطر إصابة بامراض الكلى. مكمل #الكرياتين آمن https://t.co/qEKGSEBJQM
    view full post

    February 17, 2023

    9

  • Berserker
    @unpincheMG (Twitter)

    @Doctor__wheels @la_euforia_soy @ferparraless 1) doi: 10.1053/j.jrn.2019.05.004. 2) doi: 10.1080/17461391.2018.1500644. 3) doi: 10.3390/biom9110642 4)Incluso ESPEN la avala mi dog Te va a poner más fuerte la creatina si haces las cosas bien si, es necesaria pues rotundamente NO. Ya es decisión propia de cada quien https://t.co/kY20BR7Ski
    view full post

    January 19, 2023

    4

  • *h₂ŕ̥tḱos
    @machadoemrusso_ (Twitter)

    @Tadeu_2806 Para vc ter uma ideia, já estudaram o efeito da creatina em várias pessoas tomando de 5-20g/d por 5 anos. Não deu problema renal https://t.co/DdzpcG9blP https://t.co/wjTx9S9Wdk Tem esses dois artigos que falam sobre isso
    view full post

    December 29, 2022

  • Sudha Garimella MD FAAP
    @sugarkro (Twitter)

    Ingested Creatine does not seem to raise serum creatinine levels
    view full post

    November 2, 2022

    1

  • No Heart Feelings
    @frenddie (Twitter)

    @MwendaChris https://t.co/YZBifzfynu
    view full post

    December 27, 2020


  • @DrHorwitz (Twitter)

    @Neurophysik @fakeMonish @antihritik Oh my ... https://t.co/hQnqJaogCR https://t.co/d25064UeYF
    view full post

    December 21, 2020

  • C. Guillamón, Dr.
    @Guillamon_ (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 29, 2020

    7

  • Natalia Velázquez.
    @holisticament (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 29, 2020

    7

  • JEC
    @Conan_1987_ (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    7

  • Little Chicken
    @Rey_Nikochan (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    7

  • IberianCitizen
    @IberianCitizen (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    7

  • Bader alshatti Ms
    @alshatti_fit (Twitter)

    من 15 في تحليل النوعي : تشير النتائج إلى أن مكملات #الكرياتين لم تغير بشكل كبير مستويات الكرياتينين في المصل ولم تغير اليوريا في البلازما بمعنى : لا تسبب التلف الكلوي بالكميات المعقولة في الدراسات https://t.co/qEKGSEBc1e
    view full post

    October 26, 2020

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    7

  • Joaquín San José
    @jsanjosea (Twitter)

    RT @DanielBerglind: Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    7

  • Daniel Berglind, PhD
    @DanielBerglind (Twitter)

    Meta-analysis: creatine supplementation does NOT induce renal damage: https://t.co/nrxXmj3VDi
    view full post

    October 26, 2020

    22

    7

  • Nick Krontiris
    @nick_krontiris (Twitter)

    RT @bioMioSoftware: https://t.co/p9trPMbNVk " did not significantly alter serum creatinine levels... & did not alter plasma urea values...…
    view full post

    October 26, 2020

    1

  • bioMioSoftware
    @bioMioSoftware (Twitter)

    https://t.co/p9trPMbNVk " did not significantly alter serum creatinine levels... & did not alter plasma urea values... Indicate that creatine supplementation does not induce renal damage in the studied amounts and durations" @nick_krontiris @nacho_zizou @HealthyFellow
    view full post

    October 25, 2020

    9

    1

  • Yasin Gaardo, PhD
    @YasinGaardo (Twitter)

    RT @kamkalantar: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 26, 2020

    6

  • Jeffery Heileson
    @jheilesonRD (Twitter)

    RT @kamkalantar: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 26, 2020

    6

  • Mostapha Habib Allah
    @NephroMostapha (Twitter)

    RT @kamkalantar: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 26, 2020

    6

  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @kamkalantar: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 25, 2020

    6

  • 若林秀隆 (Hidetaka Wakabayashi)
    @HideWakabayashi (Twitter)

    RT @kamkalantar: Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 25, 2020

    6

  • Kam Kalantar-Zadeh, MD, MPH, PhD
    @kamkalantar (Twitter)

    Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis https://t.co/8VuDMNG7IM
    view full post

    July 25, 2020

    18

    6

  • Emmanuel Cuevas
    @emmanuel_cr3 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    December 21, 2019

    57

  • Diana Dehesa
    @dehesa_diana (Twitter)

    Los efectos de la suplementación de #creatina en la función #renal, ¿y qué creen? Es revisión sistemática y metaanálisis... y no es por intrigar pero léanlo
    view full post

    November 8, 2019

    2

  • Carlos Daniel Jiménez
    @CarlosDrjimenez (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 4, 2019

    57

  • Julio Valencia, MD
    @jucevam (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 3, 2019

    57

  • Margarita Flo*
    @FloMarg_Ot (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 3, 2019

    57

  • Armando Vazquez
    @armandovaznefro (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 3, 2019

    57

  • Nelson Zamora R. MD
    @DrZamu13 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 3, 2019

    57

  • RicardoCabrera Nefro
    @drmarrocks (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Manuel Vazquez V
    @ManuelVVidaurre (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Alan Reyes-M.D
    @dralanreyesonco (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Sailor Kyupiter
    @Uisa_Michi (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Vicente Lozada-Balderrama
    @VicenteLozadaB (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Mayra et Lapeau
    @cano_maycv (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • MelChMauricio
    @Mauricio_Mel93 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Almaraz
    @mralewin (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • DraSwetty
    @Telomerasa0406 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Aprende Medicina Interna
    @aprendeminterna (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • NATALIA MALAVER
    @NATALIAMALAVER (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Favio varon suarez
    @faviomagno777 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • carlos camargo
    @ccamargo923 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Verner Venegas
    @Vernisartan (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • John Smith
    @Maurici50371192 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Ana Maria Matias
    @AMCMA6 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Bet Holeligan
    @ReumaMexAmer (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 2, 2019

    57

  • Navarro Zarza JE
    @JENavarrozarza (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 1, 2019

    57

  • luis alberto malaga
    @malaga1711 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
    view full post

    November 1, 2019

    57

  • David Domínguez G
    @davidando98 (Twitter)

    RT @JonathanNefro: Los suplementos de CREATINA no afectan la función RENAL; en metaanálisis de 15 estudios. Suplemento altamente utilizado…
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Abstract Synopsis

  • Creatine supplementation generally does not significantly affect kidney function, as shown by a systematic review of 290 studies that included 15 for qualitative and 6 for quantitative analysis.
  • The meta-analysis found no significant changes in serum creatinine and plasma urea levels, indicating that it doesn't impair renal function.
  • Overall, the research suggests that when taken within studied amounts and durations, creatine does not cause renal damage.