PubHawk
J Clin Pharmacol November 2019 PMID 31433499

Metamizole (Dipyrone) and the Liver: A Review of the Literature.

Mathias Lutz

Full text PDF Download social card

Mentions

27
Peak: 3 in Oct 2025
across 5 sources since Oct 2019

Extended reach

16,051
potential audience

Total likes

5

Video views

63

Mentions per month

Oct 2019 – Dec 2025

Where it's discussed

  • TikTok19 posts
  • X / Twitter5 posts
  • YouTube1 videos
  • News1 articles
  • Blogs1 articles

AI synopsis

What people are saying

Discussions include references to studies on metamizole's risks, such as reports of hepatotoxicity and agranulocytosis, as well as commentary on research quality and safety debates. The tone balances scientific acknowledgment with concern, reflecting a moderate level of engagement and interest, but without suggesting an immediate drastic impact on medical practice or policy.

AgreementModerate agreement

Most discussions acknowledge the scientific basis and importance of research on metamizole's effects, especially regarding its safety concerns.

InterestModerate interest

Posters show moderate interest, referencing safety issues, research findings, and debates about its use and risks.

EngagementModerate engagement

Comments involve some analysis of data, safety risks, and methodological approaches, indicating a moderate level of engagement.

ImpactNeutral impact

While some mention serious side effects like hepatotoxicity, the overall discussion suggests a recognition of relevant safety issues rather than a profound societal impact.

Abstract in brief

  • Metamizole, also known as dipyrone, is a pain reliever and fever reducer that was widely used worldwide due to its effectiveness and good gastrointestinal tolerability, but it has been withdrawn in some countries because of rare but serious side effects like agranulocytosis.
  • Despite safety concerns, metamizole remains commonly used globally, sometimes without regulation, and has been increasingly found as an adulterant in illegal drug supplies, especially among immigrant populations.
  • The liver plays a key role in metabolizing metamizole, and there are documented cases suggesting potential liver toxicity associated with its use, which this review examines in detail for the first time.
Read the full abstract

Top posts

Most liked on X and Bluesky
Vishal Siramshetty
@i_wwwish · X

Made this map earlier in grad school with naive #visualization skills. I'm happy it ended up in a review piece (https://t.co/DWzA34xpwF). #pain #scicomm Interactive map: https://t.co/HWNFDETb14 https://t.co/BkFF52emaX

Oct 22, 2019 · 2 likes · 161 followers View post →
Stephen Murray, MPH, NRP
@stephenHRNRP · X

@DeadnamedAtHome @RyanMarino Decent lit review: https://t.co/SJWOg4JXeB

Jul 15, 2023 · 1 like · 15,415 followers View post →
molina molina
@molinam36323338 · X

@nalaracm @gustavodmartins @bbcbrasil @andre_biernath https://t.co/ayvHXaUhY4

Sep 22, 2023 · 79 followers View post →
molina molina
@molinam36323338 · X

@nalaracm @gustavodmartins @bbcbrasil @andre_biernath oi? Excess Mortality in Aspirin and Dipyrone Co‐Medicated Patients https://t.co/khkDfr1PbS dipyrone induced agranulocytosis: Does the risk vary according to ethnicity? https://t.co/CWHbtQSrn2 lethal metamizole-induced hepatotoxicity have been reported https://t.co/ayvHXaUhY4

Sep 22, 2023 · 79 followers View post →

All mentions

Pedro Feichas
@PedroFeichas1 · X

@aassibarreto Sim, é bastante ciência! Muitos médicos brasileiros fazem amplas pesquisas e hoje os papers a favor da Dipirona são branda maioria. Exemplos: https://t.co/kgpBdwnxsh https://t.co/yvBpOewx8D https://t.co/xoOHK4VR8N https://t.co/UTmZz5phqK

Sep 25, 2025 · 44 followers View post →
molina molina
@molinam36323338 · X

@nalaracm @gustavodmartins @bbcbrasil @andre_biernath https://t.co/ayvHXaUhY4

Sep 22, 2023 · 79 followers View post →
molina molina
@molinam36323338 · X

@nalaracm @gustavodmartins @bbcbrasil @andre_biernath oi? Excess Mortality in Aspirin and Dipyrone Co‐Medicated Patients https://t.co/khkDfr1PbS dipyrone induced agranulocytosis: Does the risk vary according to ethnicity? https://t.co/CWHbtQSrn2 lethal metamizole-induced hepatotoxicity have been reported https://t.co/ayvHXaUhY4

Sep 22, 2023 · 79 followers View post →
Stephen Murray, MPH, NRP
@stephenHRNRP · X

@DeadnamedAtHome @RyanMarino Decent lit review: https://t.co/SJWOg4JXeB

Jul 15, 2023 · 1 like · 15,415 followers View post →
Vishal Siramshetty
@i_wwwish · X

Made this map earlier in grad school with naive #visualization skills. I'm happy it ended up in a review piece (https://t.co/DWzA34xpwF). #pain #scicomm Interactive map: https://t.co/HWNFDETb14 https://t.co/BkFF52emaX

Oct 22, 2019 · 2 likes · 161 followers View post →
Entenda a Síndrome de Abstinência dos Antidepressivos | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004-282X2012001200012 10.4172/2329-9096.1000284 10.1080/14740338.2024.2448833 Respectivas ...

Dec 7, 2025 View →
Paracetamol e Fígado: Mitos e Verdades | TikTok
TikTok

1512Curtidas. 32Comentários. 42Compartilhamentos. flavonoidee. Flavia Masson ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Oct 27, 2025 View →
Antídoto do Metanol: Etanol como Tratamento no Brasil | TikTok
TikTok

1512Curtidas. 32Comentários. 42Compartilhamentos. drmarceloschweller ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Oct 5, 2025 View →
Antialérgico Oral para Dermatite: É Necessário? | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Curtidas. 32Comentários. 42Compartilhamentos. draalexandrapedraecal. Dra ...

Oct 4, 2025 View →
Melhor Antialérgico: Hidroxicina ou Fexofenadina? | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Curtidas. 32Comentários. 42Compartilhamentos. drmauriciogonzalez.

Aug 16, 2025 View →
#hidroxizina #alergia #histamina Informações sobre o Hidroxizine ...
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Curtidas. 32Comentários. 42Compartilhamentos. juliocs.marques. juliocs.marques.

Mar 15, 2025 View →
Medicamentos Genéricos: Mitos e Verdades Esclarecidos | TikTok
TikTok

1512Curtidas. 35Comentários. 51Compartilhamentos. flavonoidee. Flavia Masson. Não é ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Jan 3, 2025 View →
Kudzu Uses, Benefits & Dosage
News

1998;68(suppl 6):1512S-1515S. doi:10.1093/ajcn/68.6.1512S9848526 ... doi:10.1002/jcph.9623677886. Zhao SP, Zhang YZ. Quantitative TLC ...

Dec 23, 2024 View →
Respondendo a @ellenaraujo3321 | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... som original - Flavia Masson. 1512Curtidas. 32Comentários. 42Compartilhamentos.

Nov 4, 2024 View →
Medicamento DESAPARECEU? Descubra como agir! | TikTok
TikTok

1512 curtidas,32 comentários.Vídeo do TikTok de Flavia Masson ( ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Sep 25, 2024 View →
O que fazer se a marquinha da BCG não ficou? | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Comentários. 73.6KCompartilhamentos. kazandraggl. Las aventuras de Dannita ...

Apr 8, 2024 View →
Significados das Cores da Menstruação: Vermelho, Rosinha ...
TikTok

1512Compartilhamentos. drasamiaguimaraes. Drª Sâmia Guimarães. “Pedaços” no ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Apr 2, 2024 View →
O Uso de Probióticos: O que Você Precisa Saber | TikTok
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Comentários. 14.6KCompartilhamentos. nutriologoismaelarchundi. Nutriologo ...

Dec 17, 2023 View →
Vlog de Trabalho e Descanso no Sul do Brasil | TikTok
TikTok

1512Curtidas. 35Comentários. 51Compartilhamentos. flavonoidee. Flavia Masson. Não é ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Dec 3, 2023 View →
Remédio do dia: neozine ou levomepromazina #antipsicóticos ...
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Curtidas. 30Comentários. 42Compartilhamentos. drmarceloschweller.

May 16, 2023 View →
No Dia Nacional do Uso Racional de Medicamentos, é importante ...
TikTok

1512Compartilhamentos. jean.fraiha. Jean Fraiha - cardiologista. Respondendo a ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

May 5, 2023 View →
Se não participou, no mínimo foi cúmplice. #cortesdabia ...
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ... 1512Compartilhamentos. draanabeatriz11. Ana Beatriz Barbosa. Sabe aquela pessoa ...

Sep 15, 2022 View →
Dost mu düşman mı? Metamizol hakkında her şey - Acilci.Net
Blogs

doi:10.1002/jcph.1512. 19. Nikolova I, Tencheva J, Voinikov J, Petkova V, Benbasat N, Danchev N. Metamizole: A Review Profile of a Well-Known ...

Jul 20, 2022 View →
Responder @neil_therin Como a PEP funciona? #hiv #pep ...
TikTok

10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004-282X2012001200012 10.4172/2329-9096.1000284 10.1080/14740338.2024.2448833 Respectivas ...

May 13, 2022 View →
Medicamentos Vencidos: O Que Fazer? | TikTok
TikTok

1512Curtidas. 30Comentários. 42Compartilhamentos. jean.fraiha. Jean Fraiha ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Nov 26, 2021 View →
É verdade que o neosoro vici4? (repostando pq o tiktok n gostou de ...
TikTok

1512Curtidas. 32Comentários. 42Compartilhamentos. drmarceloschweller ... 10.1155/2021/5559981 10.1002/JCPH.1833 10.1590/S0004 ...

Jul 31, 2021 View →