PubHawk
Bone November 2019 PMID 31442676

The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling.

Celso Martins Queiroz-Junior, Anna Clara Paiva Menezes Santos, Izabela Galvão, Giovanna Ribeiro Souto, Ricardo Alves Mesquita, Marcos Augusto Sá, Anderson José Ferreira

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Mentions

4
Peak: 1 in Mar 2020
across 3 sources since Mar 2020

Extended reach

6,525
potential audience

Total likes

0

Video views

174

Mentions per month

Mar 2020 – Apr 2021

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos
  • News1 articles

AI synopsis

What people are saying

The discourse reflects casual references to the role of ACE receptors in COVID and hypertension, with comments like questioning the choice of proteins for vaccines, indicating some awareness but limited engagement with the specific research about bone remodeling. This tone and focus demonstrate a general curiosity but not deeply invested or impactful discussions.

AgreementNeither agree nor disagree

The discussions show mixed opinions, with some skepticism about the research focus and its broader implications.

InterestModerate interest

There is some curiosity about the topic, especially regarding the biological mechanisms and potential health applications, but overall interest remains moderate.

EngagementNeutral engagement

Most comments are brief and somewhat superficial, with limited in-depth analysis or detailed discussion of the research findings.

ImpactNeutral impact

The discussions do not suggest significant influence or transformative potential, mostly touching on related yet somewhat tangential themes such as COVID and hypertension.

Abstract in brief

  • The study explores how the ACE2-Ang17-MasR axis, part of the renin-angiotensin system, influences bone remodeling, particularly in alveolar bone, and finds that activating this axis promotes bone formation and reduces inflammation in bone cells.
  • Researchers detected ACE2 and MasR proteins in bone cells both in lab cultures and in rat models, showing that stimulating these receptors enhances osteoblast activity (bone formation) and decreases osteoclast differentiation (bone resorption), especially under inflammatory conditions.
  • The findings also highlight that in human gum tissue, ACE2 and MasR are present, and their levels decrease during periodontal disease, suggesting this pathway could be targeted to help manage inflammatory bone loss in conditions like periodontitis.]
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Top posts

Most liked on X and Bluesky
Trevor Sutcliffe
@TrevorSutcliffe · X

RT @TrevorSutcliffe: Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal Programing, Sex Differences,…

Mar 30, 2020 · 1 share · 6,308 followers View post →
Dr. Yasir Tashkandi
@yasnota · X

@ISICEM @bhwords The covid spike protein binds to ACE receptors. The ACE/Ang II/AT1 axis play a role in the progression of hypertension and is involved in thrombogenic processes. Did they choose the wrong protein as a taget for vaccines?!! https://t.co/omv4spimu9

Apr 22, 2021 · 31 followers View post →

All mentions

Dr. Yasir Tashkandi
@yasnota · X

@ISICEM @bhwords The covid spike protein binds to ACE receptors. The ACE/Ang II/AT1 axis play a role in the progression of hypertension and is involved in thrombogenic processes. Did they choose the wrong protein as a taget for vaccines?!! https://t.co/omv4spimu9

Apr 22, 2021 · 31 followers View post →
Trevor Sutcliffe
@TrevorSutcliffe · X

RT @TrevorSutcliffe: Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal Programing, Sex Differences,…

Mar 30, 2020 · 1 share · 6,308 followers View post →
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