Biomolecules August 2019 PMID 31450809

Creatine for the Treatment of Depression.

Brent M Kious, Douglas G Kondo, Perry F Renshaw

Mentions

113
Peak: 13 in Nov 2025
across 8 sources since Sep 2020

Extended reach

237,319
potential audience

Total likes

130

Video views

483

Mentions per month

Sep 2020 – Dec 2025

Where it's discussed

  • X / Twitter47 posts
  • TikTok38 posts
  • Facebook10 posts
  • Reddit9 posts
  • Instagram3 posts
  • News3 articles
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

Overall, these discussions demonstrate a high level of support and curiosity, with many posters referencing scientific studies and expressing enthusiasm about creatine's potential to treat depression, as seen in phrases such as 'incredible compound' and mentions of its 'antidepressant-like properties,' which highlight both positive tone and serious scientific interest.

AgreementStrong agreement

Most discussions strongly support the potential of creatine as a treatment for depression, citing empirical studies and promising benefits.

InterestHigh interest

There is high interest, with users referencing recent reviews, scientific studies, and the broader implications for mental health and dietary choices.

EngagementHigh engagement

Many posts involve active engagement, including sharing personal opinions, referencing scientific data, and contributing to social discussions about mental health and treatment options.

ImpactHigh impact

The discussions suggest that the article's findings could significantly influence how depression is understood and treated, with users emphasizing the potential for creatine to improve mental health outcomes.

Abstract in brief

  • Depressed mood is a serious health issue linked to various mental health disorders, and current treatments don't work for everyone, highlighting the need for new strategies.
  • Research suggests that problems with how the brain produces and uses energy may contribute to depression, pointing to new targets for treatment.
  • Creatine, a common supplement, shows promise as a potential antidepressant because it can help improve brain energy function, with early studies indicating it may be effective.

Top posts

Most liked on X and Bluesky
Creatine For Health
@Creatine4Health · X

#CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 27, 2024 · 31 likes · 12 shares · 1,285 followers View post →
Rene Sugar
@renesugar · X

Creatine for the Treatment of Depression #MECFS #LongCovid https://t.co/hGMP7f7jx1

Aug 14, 2024 · 16 likes · 3 shares · 3,987 followers View post →
Amons - Holistic health
@AlphaAmons · X

@AlpacaAurelius Creatine is such an incredible compound Get stronger, smarter, less depressed & more swole Yes please https://t.co/a9ov4xSz44

Apr 27, 2024 · 14 likes · 3 shares · 2,852 followers View post →
doctorcypher
@doctorcypher · X

@JoeAratari Also evidence for creatine to have positive impacts on mood: https://t.co/FY9sTGH0Kn

Nov 3, 2021 · 9 likes · 1 share · 1,089 followers View post →
junglehoney
@KruseYouri · X

"Together, they suggest that compounds that might enhance brain energy storage, like creatine, could contribute to the treatment of depression" https://t.co/5uJJT8Q7Ea

Aug 1, 2022 · 7 likes · 2 shares · 13,351 followers View post →
CulturadeGym
@CulturadeGym · X

https://t.co/e2dO4N1IAh

Mar 29, 2023 · 7 likes · 1 share · 11,144 followers View post →

All mentions

Sean Manion
@TheUnjournaling · X

@NTFabiano A starting contextual point might be this 2019 review that looked at 112 studies relating to creatine and depression, "Creatine for the Treatment of Depression" https://t.co/Qm4GRVTNLu https://t.co/EyfCLVtWO6

May 21, 2025 · 637 followers View post →
Український нічний месник
@NichnyjMesnyk · X

@TishakovaDi Чесно кажучи, стаття автора - це... позор, а не стаття. Дві сторінки, 5 посилань. Це дайджест, сильно натянутий. Єдиний плюс- посилання на великий аналіз https://t.co/DvNDr0vVuq. Пункт 2.6 про емпіричне дослідження впливу креатиніну разом з АД. Висновок: 50/50 (краще літнім) https://t.co/TSBWS9HpAQ

Apr 29, 2025 · 4 likes · 291 followers View post →
Prof Marios Adamou OBE
@DrMariosAdamou · X

Creatine for the Treatment of Depression https://t.co/HL9O1Ymm8f

Apr 18, 2025 · 1,010 followers View post →
Angelos Antonatos
@A_Antonatos · X

@NTFabiano @szerby I also found a nice recent review that includes this study: https://t.co/tO85WRJWFn

Jan 28, 2025 · 1 like · 241 followers View post →
P123
@P1231032850 · X

RT @renesugar: Creatine for the Treatment of Depression #MECFS #LongCovid https://t.co/hGMP7f7jx1

Aug 14, 2024 · 3 shares · 3,419 followers View post →
Sam Disabled Man #CareNotCuts
@CounsellingSam · X

RT @renesugar: Creatine for the Treatment of Depression #MECFS #LongCovid https://t.co/hGMP7f7jx1

Aug 14, 2024 · 3 shares · 63,018 followers View post →
Hope
@hopestardust20 · X

RT @renesugar: Creatine for the Treatment of Depression #MECFS #LongCovid https://t.co/hGMP7f7jx1

Aug 14, 2024 · 3 shares · 2,356 followers View post →
Rene Sugar
@renesugar · X

Creatine for the Treatment of Depression #MECFS #LongCovid https://t.co/hGMP7f7jx1

Aug 14, 2024 · 16 likes · 3 shares · 3,987 followers View post →
Koushik
@koushikphysio · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

May 6, 2024 · 12 shares · 519 followers View post →
TheHopeGardener
@TheHopeGardener · X

RT @AlphaAmons: @AlpacaAurelius Creatine is such an incredible compound Get stronger, smarter, less depressed & more swole Yes please…

Apr 29, 2024 · 3 shares · 1,924 followers View post →
KatieFLultra7
@rezfreed · X

RT @AlphaAmons: @AlpacaAurelius Creatine is such an incredible compound Get stronger, smarter, less depressed & more swole Yes please…

Apr 29, 2024 · 3 shares · 17,671 followers View post →
Teena Marie
@scoops1819 · X

RT @AlphaAmons: @Scavacini777 @AlpacaAurelius @BTCYN Yes brother https://t.co/a9ov4xSz44 https://t.co/HoT7RQYBiy

Apr 28, 2024 · 1 share · 164 followers View post →
Amons - Holistic health
@AlphaAmons · X

@AlpacaAurelius Creatine is such an incredible compound Get stronger, smarter, less depressed & more swole Yes please https://t.co/a9ov4xSz44

Apr 27, 2024 · 14 likes · 3 shares · 2,852 followers View post →
Amons - Holistic health
@AlphaAmons · X

@Scavacini777 @AlpacaAurelius @BTCYN Yes brother https://t.co/a9ov4xSz44 https://t.co/HoT7RQYBiy

Apr 27, 2024 · 2 likes · 1 share · 2,852 followers View post →
Noemi Cuenca (Dietista-Nutricionista)
@noemicuencaq · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 536 followers View post →
YURI PAUCAR
@ypaucar · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 1,205 followers View post →
SHIFTED
@ShiftedStrong · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 884 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 2,459 followers View post →
Tarik Fehmi
@Tarik_Fehmi · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 815 followers View post →
MarcoAntonioMedeiros
@professormarcoa · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 709 followers View post →
Leorex
@LeorexMufasa · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 28, 2024 · 12 shares · 9 followers View post →
Mind Your Science!
@MindYourSci · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 27, 2024 · 12 shares · 131 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 27, 2024 · 12 shares · 6,741 followers View post →
DBSS International
@TeamDBSS · X

RT @Creatine4Health: #CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 27, 2024 · 12 shares · 238 followers View post →
Creatine For Health
@Creatine4Health · X

#CreatineForHealth Creatine for the Treatment of Depression Continue reading here

Feb 27, 2024 · 31 likes · 12 shares · 1,285 followers View post →
Heron Carlos
@HeronCarlo30795 · X

Creatine for the Treatment of Depression https://t.co/6R9tgCllin

Feb 20, 2024 · 1 followers View post →
Hudek1
@Hudek110 · X

https://t.co/XiDl86oQmM

Dec 3, 2023 · 3,626 followers View post →
VileAlligator
@VileAlligator · X

@_neanderthsmall SSRIs do not work, please don't listen to him. You're better off taking creatine and working out. Also do not fall for the pill. https://t.co/UiZiC9dJL7 https://t.co/lXg3HKlMD9 https://t.co/tLgKl2WpSF https://t.co/xPHRF2DEtD

Sep 11, 2023 · 1 like · 590 followers View post →
Sebastian ◇ Web Designer
@LocalSociall · X

Creatine has an extraordinary impact on the brain The antidepressant properties of creatine have been tested using the highly reliable tail suspension test. Turns out it has.. antidepressant-like properties and a synergistic interaction with dopamine. https://t.co/t8ozTaFxkw https://t.co/vYlBDaH0xE

Jul 13, 2023 · 113 followers View post →
CulturadeGym
@CulturadeGym · X

https://t.co/e2dO4N1IAh

Mar 29, 2023 · 7 likes · 1 share · 11,144 followers View post →
Debbie Ford
@debbieford14 · X

RT @zaptrapped: Creatine for the Treatment of Depression https://t.co/erkshNo9lI

Mar 18, 2023 · 3,421 followers View post →
Ice Princess³³º¹
@zaptrapped · X

Creatine for the Treatment of Depression https://t.co/erkshNo9lI

Mar 17, 2023 · 4 likes · 9,085 followers View post →
Jason Heard
@jmheard15 · X

Creatine for the Treatment of Depression https://t.co/ANlJseELT6

Mar 14, 2023 · 836 followers View post →
McOwl Who
@wubalubb · X

@ScepticalDoctor @krosenque Nice. Peep these in reference to impact on mental health too - https://t.co/CKdNXwTor3 https://t.co/SdZk6hlypD Might help to explain why there is a consistent observed correlation between vegetarian/ vegan diets and depression

Mar 2, 2023 · 95 followers View post →
Christine Cockett
@Hcacockett · X

RT @alexsims101: @adampiore @markhoro @joannamoncrieff @eturnermd1 @And_Cipriani Appears that creatine can be used to treat depression - so…

Sep 22, 2022 · 1 share · 423 followers View post →
Alex Sims
@alexsims101 · X

@adampiore @markhoro @joannamoncrieff @eturnermd1 @And_Cipriani Appears that creatine can be used to treat depression - so why not just eat meat (who would have thought that diet effects mental health) https://t.co/krAqilRbGP

Sep 22, 2022 · 3 likes · 1 share · 377 followers View post →
Loofymectin aka Jan Masleid
@loofymectin · X

RT @DrPalmquist: Biomolecules | Free Full-Text | Creatine for the Treatment of Depression https://t.co/AxKojWlfUW

Sep 1, 2022 · 1 share · 1,179 followers View post →
DrRPalmquist
@DrPalmquist · X

Biomolecules | Free Full-Text | Creatine for the Treatment of Depression https://t.co/AxKojWlfUW

Sep 1, 2022 · 1 like · 1 share · 3,162 followers View post →
Gregg Huestis
@GreggHuestis67 · X

https://t.co/GNfIjuGSfk

Aug 31, 2022 · 2,494 followers View post →
Maitreya
@Mithreu · X

RT @KruseYouri: "Together, they suggest that compounds that might enhance brain energy storage, like creatine, could contribute to the trea…

Aug 4, 2022 · 2 shares · 1,258 followers View post →
junglehoney
@KruseYouri · X

"Together, they suggest that compounds that might enhance brain energy storage, like creatine, could contribute to the treatment of depression" https://t.co/5uJJT8Q7Ea

Aug 1, 2022 · 7 likes · 2 shares · 13,351 followers View post →
Ghaïs Guelaïa
@GeekNfit · X

@EpisteMax Impact positif sur la cognition, je t'ai envoyé une méta là-dessus. Etudié contre la démence, alzheimer : https://t.co/bGtfc2Vr5v Etudié contre la dépression : https://t.co/EN0ZVa2Agx Donc je réitère, ou est-ce que je mens ?

May 20, 2022 · 12,949 followers View post →
doctorcypher
@doctorcypher · X

@JoeAratari Also evidence for creatine to have positive impacts on mood: https://t.co/FY9sTGH0Kn

Nov 3, 2021 · 9 likes · 1 share · 1,089 followers View post →
L ❤ V E
@drkohilathas · X

@jerryteixeira Love creatine, super safe and effective. Great for the brain too. https://t.co/EOSSEg8nh7

Feb 19, 2021 · 1 like · 47,860 followers View post →
Biomolecules MDPI
@Biomol_MDPI · X

RT @Davidgomct: La disrupción energética durante la depresión es cada vez más estudiada una alteración en la producción, almacenamiento y u…

Nov 18, 2020 · 2 shares · 1,604 followers View post →
Carlos Colmenero
@colme99 · X

RT @Davidgomct: La disrupción energética durante la depresión es cada vez más estudiada una alteración en la producción, almacenamiento y u…

Nov 14, 2020 · 2 shares · 77 followers View post →
David Gómez
@Davidgomct · X

La disrupción energética durante la depresión es cada vez más estudiada una alteración en la producción, almacenamiento y utilización de la energía cerebral

Sep 16, 2020 · 4 likes · 2 shares · 5,143 followers View post →
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doi:10.3390/biom9090406. Kious BM, Kondo DG, Renshaw PF, et al. Vivere in alto e sentirsi giù: altitudine, suicidio e depressione. Harv Rev ...

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doi:10.3390/biom9090406. Kious BM, Kondo DG, Renshaw PF, et al. Living High and Feeling Low: Altitude, Suicide, and Depression. Harv Rev ...

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doi:10.3390/biom9090406. Kious BM, Kondo DG, Renshaw PF, et al. Vivendo no Alto e se Sentindo Mal: Altitude, Suicídio e Depressão. Harv Rev ...

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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions.

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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions ...

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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions ...

Jul 18, 2025 View →
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DOI: 10.3390/biom9090406 • Lyoo IK et al. Am J Psychiatry. 2012;169:937-945. DOI: 10.1176/appi.ajp.2012.12010009 • Bakian AV et al. Transl ...

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org/10.3390/nu13020586 & PMC1691485]. - prevention and treatment of depression [PMID: 30193988 & DOI: 10.3390/biom9090406] - enhanced ...

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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions.

Jun 22, 2024 View →
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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions ...

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doi: 10.3390/biom9090406 Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions.

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Além disso, existem inúmeros estudos mostrando que a creatina pode favorecer no tratamento de depressão (doi 10.3390/biom9090406), porque ela ...

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doi: 10.3390/biom9090406. 6. Escalante G, Gonzalez AM, St Mart D, Torres M, Echols J, Islas M, Schoenfeld BJ. Analysis of the efficacy ...

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