Cell Metab October 2019 PMID 31474566

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.

Ki Wung Chung, Poonam Dhillon, Shizheng Huang, Xin Sheng, Rojesh Shrestha, Chengxiang Qiu, Brett A Kaufman, Jihwan Park, Liming Pei, Joseph Baur, Matthew Palmer, Katalin Susztak

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Mentions

28
Peak: 7 in Sep 2019
across 4 sources since Aug 2019

Extended reach

153,614
potential audience

Total likes

2,354

Video views

51,560

Mentions per month

Aug 2019 – Oct 2025

Where it's discussed

  • X / Twitter21 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions strongly support the article's significance, with comments like 'Great findings by the Susztak lab' and mentions of the pathway's role in renal inflammation. The tone reflects enthusiasm and recognition of the study's potential for future therapies, highlighted by phrases like 'important in the kidney' and 'molecular damage leading to fibrosis,' which signal high engagement and perceived impact.

AgreementStrong agreement

Most discussions acknowledge the importance of the research, emphasizing its relevance to kidney inflammation and the role of the STING pathway, which indicates strong agreement with the article's findings.

InterestHigh interest

The excitement about the discovery and its potential implications show a high level of interest, with many participants highlighting the significance of these findings in the context of kidney disease.

EngagementModerate engagement

Participants engage by referencing prior studies, emphasizing reproducibility, and commenting on the biological mechanisms, demonstrating thoughtful involvement, though some responses are more enthusiastic than deeply analytical.

ImpactHigh impact

The widespread acknowledgment of the study's potential for advancing therapeutic strategies and its importance in understanding kidney fibrosis suggest a high perceived impact of the publication.

Abstract in brief

  • Mitochondrial damage, particularly the loss of the mitochondrial transcription factor TFAM, is linked to kidney fibrosis and inflammation, as seen in both patient and animal studies.
  • In mice with tubule-specific TFAM deletion, mitochondrial dysfunction led to the release of mtDNA into the cytoplasm, activating the STING pathway and promoting immune responses that contribute to fibrosis.
  • Blocking STING activity in these models reduced kidney fibrosis, highlighting its role in inflammation-driven kidney damage and suggesting potential therapeutic targets for chronic kidney disease.]

Top posts

Most liked on X and Bluesky
Katalin Susztak
@KSusztak · X

Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in @Cell_Metabolism Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: https://t.co/6Lkz0VjzDO

Sep 19, 2024 · 47 likes · 4 shares · 7,129 followers View post →
FrezzaLab
@FrezzaLab · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/I8pzaaR9QH

Aug 29, 2019 · 8 likes · 26,961 followers View post →
Dr Rhoda Stefanatos
@rhodophila · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t.co/SEMspNZiEt

Nov 2, 2019 · 7 likes · 2 shares · 1,278 followers View post →
George Vlasuk
@GVlasuk · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/GJcktwywRy

Aug 30, 2019 · 2 likes · 1,418 followers View post →
Aquela UK
@AquelaUK · X

COMMENTARY | Type I Interferon Chung, K.W. et al., 2019. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metabolism, 30: 784-799. #Health #Interferon #Mitochondria https://t.co/jIqSdPiDCM

May 12, 2020 · 1 like · 275 followers View post →
Cell Metabolism
@Cell_Metabolism · X

RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…

Sep 20, 2024 · 4 shares · 54,074 followers View post →

All mentions

Le Tran Phuc Khoa
@LeTranPhucKhoa1 · X

RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…

Sep 21, 2024 · 4 shares · 266 followers View post →
Afaf Saliba
@Afaf_Saliba · X

RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…

Sep 20, 2024 · 4 shares · 325 followers View post →
Cell Metabolism
@Cell_Metabolism · X

RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…

Sep 20, 2024 · 4 shares · 54,074 followers View post →
Jamie Privratsky MD/PhD
@JamiePrivratsky · X

RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…

Sep 20, 2024 · 4 shares · 831 followers View post →
Katalin Susztak
@KSusztak · X

Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in @Cell_Metabolism Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: https://t.co/6Lkz0VjzDO

Sep 19, 2024 · 47 likes · 4 shares · 7,129 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Metabolism paper "Mitochondrial Damage and Activation of the STING P…" (https://t.co/2CWmXoKHav). RRIDs like this improve reproducibility in scientific research. #reproducibility #ReproducibleResearch

Aug 17, 2021 · 161 followers View post →
Aquela UK
@AquelaUK · X

COMMENTARY | Type I Interferon Chung, K.W. et al., 2019. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metabolism, 30: 784-799. #Health #Interferon #Mitochondria https://t.co/jIqSdPiDCM

May 12, 2020 · 1 like · 275 followers View post →
BICEPS Lab
@BICEPS_Lab · X

Released mitochondrial DNA induces inflammatory response... What a STING! Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/bQhfYWjj1c

Dec 4, 2019 · 515 followers View post →
Hector Flores Romero
@floresromeroh · X

RT @rhodophila: Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t…

Nov 3, 2019 · 2 shares · 308 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @rhodophila: Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t…

Nov 3, 2019 · 2 shares · 2,814 followers View post →
Dr Rhoda Stefanatos
@rhodophila · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t.co/SEMspNZiEt

Nov 2, 2019 · 7 likes · 2 shares · 1,278 followers View post →
DrRPalmquist
@DrPalmquist · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis. - PubMed - NCBI https://t.co/qfkDrYcV2g

Sep 18, 2019 · 3,160 followers View post →
the paper link
@the_paper_link · X

Trend up+2: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF

Sep 10, 2019 · 137 followers View post →
Researchphilia
@researchphilia · X

Sep 6, 2019 · 480 followers View post →
Researchphilia
@researchphilia · X

Sep 5, 2019 · 480 followers View post →
the paper link
@the_paper_link · X

Trend up+1: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF

Sep 4, 2019 · 137 followers View post →
the paper link
@the_paper_link · X

Trend new: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF

Sep 4, 2019 · 137 followers View post →
nor
@noriji0 · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/KL1nMoKHwn #nor論文 STING経路も色々出るね、炎症免疫関連だから当然か 別の話でモデルの特性は気になる。ヒトの末期腎不全に外挿できるとは思わないけど特徴知りたい(読んでない

Sep 4, 2019 · 827 followers View post →
Shrey Kohli
@kohli_shrey · X

Great findings by the Susztak lab @KSusztak Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/VaJuc7Q43v

Aug 31, 2019 · 290 followers View post →
George Vlasuk
@GVlasuk · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/GJcktwywRy

Aug 30, 2019 · 2 likes · 1,418 followers View post →
FrezzaLab
@FrezzaLab · X

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/I8pzaaR9QH

Aug 29, 2019 · 8 likes · 26,961 followers View post →