Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in @Cell_Metabolism Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: https://t.co/6Lkz0VjzDO
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
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Aug 2019 – Oct 2025Where it's discussed
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X / Twitter21 posts
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Blogs3 articles
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YouTube2 videos
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Facebook2 posts
AI synopsis
What people are saying
The discussions strongly support the article's significance, with comments like 'Great findings by the Susztak lab' and mentions of the pathway's role in renal inflammation. The tone reflects enthusiasm and recognition of the study's potential for future therapies, highlighted by phrases like 'important in the kidney' and 'molecular damage leading to fibrosis,' which signal high engagement and perceived impact.
Most discussions acknowledge the importance of the research, emphasizing its relevance to kidney inflammation and the role of the STING pathway, which indicates strong agreement with the article's findings.
The excitement about the discovery and its potential implications show a high level of interest, with many participants highlighting the significance of these findings in the context of kidney disease.
Participants engage by referencing prior studies, emphasizing reproducibility, and commenting on the biological mechanisms, demonstrating thoughtful involvement, though some responses are more enthusiastic than deeply analytical.
The widespread acknowledgment of the study's potential for advancing therapeutic strategies and its importance in understanding kidney fibrosis suggest a high perceived impact of the publication.
Abstract in brief
- Mitochondrial damage, particularly the loss of the mitochondrial transcription factor TFAM, is linked to kidney fibrosis and inflammation, as seen in both patient and animal studies.
- In mice with tubule-specific TFAM deletion, mitochondrial dysfunction led to the release of mtDNA into the cytoplasm, activating the STING pathway and promoting immune responses that contribute to fibrosis.
- Blocking STING activity in these models reduced kidney fibrosis, highlighting its role in inflammation-driven kidney damage and suggesting potential therapeutic targets for chronic kidney disease.]
Top posts
Most liked on X and BlueskyMitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/I8pzaaR9QH
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t.co/SEMspNZiEt
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/GJcktwywRy
COMMENTARY | Type I Interferon Chung, K.W. et al., 2019. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metabolism, 30: 784-799. #Health #Interferon #Mitochondria https://t.co/jIqSdPiDCM
RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…
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Preventing Kidney Damage by Repairing Mitochondria and Reducing Inflammation
Mitochondrial damage, especially loss of TFAM, is linked to kidney fibrosis and inflammation. The release of mtDNA activates the STING pathway, promoting immune responses that cause tissue damage. Blocking STING can…
Protecting Kidney Health by Supporting Mitochondrial Function and TFAM
Can your kidneys start failing silently before any symptoms show up? A hidden culprit is the mitochondrial protein TFAM. Low TFAM leads to reduced energy, inflammation, and kidney damage. Learn science-backed steps to…
RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…
RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…
RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…
RT @KSusztak: Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in…
Today's Lasker for Cytosolic nucleotide sensors (cGAS) This is clearly important in the kidney. Our first paper from 2019 in @Cell_Metabolism Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: https://t.co/6Lkz0VjzDO
RRIDs were included in the Cell Metabolism paper "Mitochondrial Damage and Activation of the STING P…" (https://t.co/2CWmXoKHav). RRIDs like this improve reproducibility in scientific research. #reproducibility #ReproducibleResearch
COMMENTARY | Type I Interferon Chung, K.W. et al., 2019. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metabolism, 30: 784-799. #Health #Interferon #Mitochondria https://t.co/jIqSdPiDCM
Released mitochondrial DNA induces inflammatory response... What a STING! Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/bQhfYWjj1c
RT @rhodophila: Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t…
RT @rhodophila: Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t…
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis: Cell Metabolism https://t.co/SEMspNZiEt
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis. - PubMed - NCBI https://t.co/qfkDrYcV2g
Trend up+2: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF
Trend up+1: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF
Trend new: *Chung KW* et al (Cell Metab) __Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.__ https://t.co/cUgLWaVsGF
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/KL1nMoKHwn #nor論文 STING経路も色々出るね、炎症免疫関連だから当然か 別の話でモデルの特性は気になる。ヒトの末期腎不全に外挿できるとは思わないけど特徴知りたい(読んでない
Great findings by the Susztak lab @KSusztak Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/VaJuc7Q43v
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/GJcktwywRy
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis https://t.co/I8pzaaR9QH
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