First talk by Eamonn Kelly on "Clarity or confusion in the field of biased agonism at opioid receptors?" (https://t.co/U96ld5jwox), aiming to generate analgesic w/o side-effects associated w/ conventional μOR agonists & screens for real ligand bias (https://t.co/8WDj79k3UD)
Fentanyl depression of respiration: Comparison with heroin and morphine.
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Jun 2019 – Jul 2025Where it's discussed
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X / Twitter18 posts
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YouTube2 videos
AI synopsis
What people are saying
The overall tone and word choices reflect a high level of interest and engagement, with users referencing the drug's faster onset and more severe respiratory depression, citing the article's significance as it is ranked highly in bioRxiv, and emphasizing its potential impact on treatment approaches and public health discussions.
Most discussions recognize the significance of the publication, especially regarding fentanyl's potency and respiratory depression effects, showing general support for the research findings.
Users display high curiosity about the topic, with many referencing the comparison between fentanyl, heroin, and morphine, and discussing implications for overdose and addiction.
Some posts delve into detailed considerations of the pharmacological mechanisms and treatment challenges, indicating active engagement with the material.
The widespread sharing of the article's prominence, mentions of its ranking, and discussion of clinical implications suggest that the publication has a notable influence on ongoing conversations around opioid safety and treatment.
Abstract in brief
- Fentanyl causes faster and more severe respiratory depression than heroin and morphine, largely contributing to its high overdose death rate in North America.
- The study finds that fentanyl's effects are directly related to its potency, rapid onset, and lipophilicity, making it harder for traditional overdose treatments like naloxone to reverse its effects fully.
- Factors such as lower cross-tolerance and the nature of its antagonists suggest that lipophilic drugs like diprenorphine could be more effective than naloxone in treating fentanyl overdoses.
Top posts
Most liked on X and Blueskywhy might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine Fentanyl depression of respiration: comparison with heroin and morphine https://t.co/GNABLe8nac (ps sorry for no link this morning, computer playing up)
@jpusanes @honjio69 @28sai_masuikai 動物実験モデルですが… https://t.co/Ks783766Sn
why might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine Fentanyl depression of respiration: comparison with heroin and morphine
@humanedrug @julianbuchanan (2019) "Fentanyl depression of respiration: Comparison with heroin and morphine" says Fentanyl has a faster onset. Which would make it more addictive. Faster your homeostasis changes the more powerful the high https://t.co/8xgRTXNRTY
@ContraculturaGT Fentanilo, causa insuficiencia respiratoria aun en dosis pequeñas. https://t.co/mZRbsuMUYr https://t.co/3iAJLcvxSU
All mentions
Understanding Fentanyl Overdose Risks and Prevention Strategies
Resources used include guidelines on opioid prescribing for children, molecular aspects of fentanyl, receptor pharmacology, overdose characteristics, and comparison with heroin and morphine. The videos provide insights…
Understanding Fentanyl's Impact on Breathing and Overdose Risks
Fentanyl causes faster and more severe respiratory depression than heroin and morphine, largely contributing to its high overdose death rate in North America. The study highlights the drug’s potency, rapid onset, and…
@ContraculturaGT Fentanilo, causa insuficiencia respiratoria aun en dosis pequeñas. https://t.co/mZRbsuMUYr https://t.co/3iAJLcvxSU
@humanedrug @julianbuchanan (2019) "Fentanyl depression of respiration: Comparison with heroin and morphine" says Fentanyl has a faster onset. Which would make it more addictive. Faster your homeostasis changes the more powerful the high https://t.co/8xgRTXNRTY
Fentanyl depression of respiration: Comparison with heroin and morphine - Hill - 2020 - British Journal of Pharmacology - Wiley Online Library https://t.co/ODSFPTppQP
@jpusanes @honjio69 @28sai_masuikai 動物実験モデルですが… https://t.co/Ks783766Sn
#GeorgeFloyd https://t.co/7VKiKN0eSN
@douglasxtaylor @ReliantNCC1864 @Footincrease99 @benshapiro https://t.co/7VKiKN0eSN
@wanderer_jasnah https://t.co/4h6uYHUt32 I don't claim to know what sort of dose had taken nor should you. Given that the drug of course gets metabolised we still wouldn't know how much he took or exactly when he took it. But it was found in his system.
RT @j0kaso: First talk by Eamonn Kelly on "Clarity or confusion in the field of biased agonism at opioid receptors?" (https://t.co/U96ld5jw…
RT @j0kaso: First talk by Eamonn Kelly on "Clarity or confusion in the field of biased agonism at opioid receptors?" (https://t.co/U96ld5jw…
RT @j0kaso: First talk by Eamonn Kelly on "Clarity or confusion in the field of biased agonism at opioid receptors?" (https://t.co/U96ld5jw…
First talk by Eamonn Kelly on "Clarity or confusion in the field of biased agonism at opioid receptors?" (https://t.co/U96ld5jwox), aiming to generate analgesic w/o side-effects associated w/ conventional μOR agonists & screens for real ligand bias (https://t.co/8WDj79k3UD)
BPS Publications https://t.co/15BkD8zvxy
RT @kyletsp: why might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine…
why might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine Fentanyl depression of respiration: comparison with heroin and morphine https://t.co/GNABLe8nac (ps sorry for no link this morning, computer playing up)
RT @kyletsp: why might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine…
why might different #opioids depress breathing differently? Interesting paper comparing fentanyl with heroin and morphine Fentanyl depression of respiration: comparison with heroin and morphine
"Fentanyl depression of respiration: comparison with heroin and morphine" is the #1 paper on bioRxiv today in pharmacology and toxicology. Congrats @RobHillSr @0rwell. See it at -> https://t.co/ABnUMecKqT and https://t.co/TAmCzGPzMa. Please retweet.
Fentanyl depression of respiration: comparison with heroin and morphine https://t.co/lOzBte7I78 #bioRxiv
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