Cell Metab November 2019 PMID 31523009

Mediation of the Acute Stress Response by the Skeleton.

Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L Horvath, Ana I Domingos, Anna L Marsland, Vijay Kumar Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty

Mentions

178
Peak: 42 in Sep 2019
across 6 sources since Sep 2019

Extended reach

772,304
potential audience

Total likes

760

Video views

22,944

Mentions per month

Sep 2019 – Mar 2025

Where it's discussed

  • X / Twitter73 posts
  • News63 articles
  • Facebook16 posts
  • Blogs15 articles
  • Reddit8 posts
  • YouTube3 videos

AI synopsis

What people are saying

The discussions reflect a strong intrigue about the novel role of bones in stress responses, with posts noting how osteocalcin secretion during stress impacts the body's reaction. For instance, phrases like "Never Mind the Adrenals" and "Physiology just turned over its head" evoke a sense of revelation and excitement, suggesting that users find the research groundbreaking. This choice of positive language and the analytical depth of the discussions indicate a collective enthusiasm for the implications of this study.

AgreementModerate agreement

Many posts express agreement with the ideas presented in the publication, highlighting the significance of osteocalcin in the stress response.

InterestHigh interest

There is a strong level of interest as participants are discussing and referencing the publication frequently.

EngagementHigh engagement

Several posts delve deeply into methods, findings, and implications, indicating a high level of engagement with the content.

ImpactHigh impact

Users perceive the publication as having high impact, reflecting a belief that it changes our understanding of stress response mechanisms.

Abstract in brief

  • The study suggests that bones may have evolved to help vertebrates better escape dangers by influencing the acute stress response (ASR).
  • Exposure to stress causes a spike in osteocalcin, a hormone from bones, which impacts how the body reacts to stress.
  • Even without adrenal glands, certain animals and patients can still exhibit an ASR due to high levels of osteocalcin, indicating its crucial role in this process.

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic nervous system activation is not primarily mediated by the adrenals, but bones or CALCIUM-GLUTAMATE.

May 18, 2021 · 22 likes · 5 shares · 134,042 followers View post →
Atanas G. Atanasov
@_atanas_ · X

Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co/BCxDDzHrES

Sep 16, 2019 · 14 likes · 11 shares · 123,667 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 12 likes · 6 shares · 53,670 followers View post →
BryanRoth
@zenbrainest · X

Mediation of the Acute Stress Response by the Skeleton--interesting use of chemogenetics here https://t.co/Y66tvN4zs0

Sep 12, 2019 · 9 likes · 1 share · 17,008 followers View post →
nextdoormartian
@nextdoormartian · X

Physiology just turned over its head... osteocalcin from bone, not adrenaline, is the primary driver of the acute stress response, fight or flight! "Mediation of the acute stress response by the skeleton," Cell Metabolism (2019). DOI: 10.1016/j.cmet.2019.08.012

Sep 13, 2019 · 7 likes · 1 share · 5,314 followers View post →
George Dawson
@dawso007 · X

Very interesting work: "We propose that osteocalcin defines a bony-vertebrate-specific endocrine mediation of the ASR." Mediation of the Acute Stress Response by the Skeleton https://t.co/aygazzXNWX

Sep 16, 2020 · 5 likes · 1 share · 7,823 followers View post →

All mentions

The Role of Bones in the Fight or Flight Response

A new study from Columbia researchers reveals that bony vertebrates rely on their skeletons for the fight or flight response. Upon recognizing danger, the brain directs the skeleton to release osteocalcin, a hormone…

VHFILM · Sep 18, 2019 1,559 views
Duong Van Hiep
@hiep2016 · X

RT @felipehelf: Mediation of the Acute Stress Response by the Skeleton https://t.co/EWAROEOgeQ

Mar 4, 2025 · 1 share · 21,670 followers View post →
Consciousness & The Brain
@NeurobiologyOf · X

RT @NatalieGeld: Mediation of the Acute Stress Response by the Skeleton (Berger et al., 2024)

Nov 7, 2024 · 1 share · 15 followers View post →
Natalie Geld
@NatalieGeld · X

Mediation of the Acute Stress Response by the Skeleton (Berger et al., 2024)

Nov 6, 2024 · 1 like · 1 share · 1,770 followers View post →
Saber Atualizado
@AtualizadoSaber · X

@MarlintonW @Sceo__ @crfpolonio Dá tempo para você apagar seu comentário... Se você tivesse lido o artigo (ATUALIZADO), veria que os resultados desse estudo continuam firmes: Berger et al. (2019). Mediation of the acute stress response by the skeleton. Cell Metabolism 30:890–902.e8. https://t.co/xjt5Yun7B6

Jan 13, 2024 · 1 like · 30,168 followers View post →
The Roaring Mouse
@emmiellifluous · X

“Bone, not adrenaline, drives fight or flight response“ https://t.co/8FY6CFTOeH Study Referenced in the above Article: “Mediation of the Acute Stress Response by the Skeleton” https://t.co/dL7FyEOhsa #ActuallyAutistic

Feb 14, 2023 · 4 likes · 679 followers View post →
Maitreya
@Mithreu · X

RT @Grimhood: Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic n…

Sep 30, 2021 · 5 shares · 1,263 followers View post →
Scott Bauman
@STHMBauman · X

RT @Grimhood: Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic n…

Sep 28, 2021 · 5 shares · 421 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @Grimhood: Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic n…

Sep 28, 2021 · 5 shares · 134,042 followers View post →
DP
@Pimpodauniverse · X

RT @Grimhood: Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic n…

Sep 28, 2021 · 5 shares · 489 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell Metabolism paper "Mediation of the Acute Stress Response by the Skel…" (https://t.co/oDhxdnLFKt). Thank you for making your #methodsmatter. #OpenScience

Sep 2, 2021 · 161 followers View post →
RRID Robot
@RobotRrid · X

.#EnCor Biotechnology, https://t.co/GpSWVmhJqX was used by the authors of the Cell Metabolism paper "Mediation of the Acute Stress Response by the Skel…": https://t.co/TqLkUgFZbf (https://t.co/oDhxdnLFKt). Thank you for making your #methodsmatter.

Aug 17, 2021 · 161 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/kEOKkmFrdf The fight-or-flight response or sympathetic nervous system activation is not primarily mediated by the adrenals, but bones or CALCIUM-GLUTAMATE.

May 18, 2021 · 22 likes · 5 shares · 134,042 followers View post →
サカト
@Sakato0 · X

骨による急性ストレス反応の媒介。 オステオカルシンは副交感神経を抑制する。 副腎不全では、オステオカルシン上昇により急性ストレス反応が発生する。 「骨」という内分泌器官によるストレス反応

May 5, 2021 · 4 likes · 2,504 followers View post →
Wbond
@MrWBond · X

RT @dawso007: Very interesting work: "We propose that osteocalcin defines a bony-vertebrate-specific endocrine mediation of the ASR." Med…

Sep 16, 2020 · 1 share · 1,372 followers View post →
George Dawson
@dawso007 · X

Very interesting work: "We propose that osteocalcin defines a bony-vertebrate-specific endocrine mediation of the ASR." Mediation of the Acute Stress Response by the Skeleton https://t.co/aygazzXNWX

Sep 16, 2020 · 5 likes · 1 share · 7,823 followers View post →
Christopher James
@body_elektric · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/kfA3PJYlPO

Aug 13, 2020 · 10 followers View post →
UltimApe
@ultimape · X

@NgoloTesla @Grimhood Ah, I need to test it against the full body. I suspect the hair/skin/bones themselves are being impacted by sound. https://t.co/XAJ8CpvpTU

Jul 20, 2020 · 2 likes · 6,452 followers View post →
هاشتاقـك ترنـد ↗️
@filipelanglois · X

Essa é novidade! Novas funções do osso sobre outros órgãos. Sistema musculoesquelético pode ser considerado o maior órgão/sistema endócrino do corpo humano? https://t.co/qSOb1KgCDl

May 18, 2020 · 120 followers View post →
wolodya
@wolodya · X

@traependergrast yeah, I had trouble staying awake for that. I might have kept it more together if I'd known about how bones themselves participate in threat response - Mediation of the Acute Stress Response by the Skeleton, inspired by the gif https://t.co/TDnvTDwAoW

Apr 5, 2020 · 1 like · 1,073 followers View post →
Chiropractic STL
@ChiropracticSTL · X

Did you know that your BONES can secrete a hormone? It’s called osteocalcin, and during stressful situations it contributes to the body’s flight-or-fight mechanism. https://t.co/E6KYkNPo3V

Dec 16, 2019 · 1 like · 2,180 followers View post →
Julia B.
@JuliaB_fitness · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 7, 2019 · 6 shares · 2,272 followers View post →
Johnny Laupsa-Borge
@healthmacangel · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 7, 2019 · 6 shares · 361 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 6 shares · 1,007 followers View post →
Adam J Rose
@DrAJRose · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 6 shares · 810 followers View post →
Violeta Echevarria
@gabomikimom · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 6 shares · 346 followers View post →
Dipsikha Biswas
@itsmedipsikha · X

RT @Cell_Metabolism: Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 6 shares · 905 followers View post →
Cell Metabolism
@Cell_Metabolism · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/dZGIrC0K8e

Nov 6, 2019 · 12 likes · 6 shares · 53,670 followers View post →
KarsentyLab
@KarsentyLab · X

RT @KarsentyLab: Mediation of the Acute Stress Response by the Skeleton https://t.co/CONcPR4Gvc

Oct 29, 2019 · 1 share · 314 followers View post →
KarsentyLab
@KarsentyLab · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/CONcPR4Gvc

Oct 25, 2019 · 2 likes · 1 share · 314 followers View post →
Heather Edgell
@heather_edgell · X

Interesting...bone can cause parasympathetic withdrawal/"fight or flight response" Mediation of the Acute Stress Response by the Skeleton https://t.co/Bzc5E1uQ6J

Oct 23, 2019 · 3 likes · 296 followers View post →
Osteoporosis-NL @osteoporosis-nl.bsky.social
@Osteoporosis_NL · X

Mediation of the Acute Stress Response by the Skeleton. Berger JM et al. Cell Metab. 2019 Sep 12 https://t.co/bH4Bgf9mnK with comment Alan Morris in Nat Rev Endocrinol 15 (627) doi:10.1038/s41574-019-0269-4: osteocalcin linked to stress response https://t.co/fJDwAeOi9Z

Oct 16, 2019 · 2 likes · 3,378 followers View post →
NIAMS
@NIH_NIAMS · X

#NIAMSResearch in mice @ColumbiaMed: “Mediation of the Acute Stress Response by the Skeleton” https://t.co/x1fVzQTAdn #OpenAccess paper @Cell_Metabolism https://t.co/cXSbhWS7ES

Oct 2, 2019 · 13,779 followers View post →
matiere*
@matiere · X

(2019/09/12) Mediation of the Acute Stress Response by the Skeleton: Cell Metabolism https://t.co/bkqpG7f76Q https://t.co/okDO7qgceY

Sep 27, 2019 · 2,835 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Mediation of the Acute Stress Response by the Skeleton - ScienceDirect https://t.co/tkCDmpJcJA

Sep 21, 2019 · 253 followers View post →
Ralph Turchiano
@RalphTurchiano · X

Bone, not adrenaline, drives fight or flight response https://t.co/3Nl4V5GjhC https://t.co/7AzdSJ8nyE

Sep 18, 2019 · 128 followers View post →
ryo694
@ryo694 · X

Mediation of the Acute Stress Response by the Skeleton - ScienceDirect https://t.co/Y6QhKpNndE

Sep 18, 2019 · 1,389 followers View post →
maxwell singler
@SinglerMaxwell · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/d0IebYwDMn

Sep 18, 2019 View post →
Alessandro Bartolomucci Lab
@BartolomucciLab · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/MR6H3QH8N4

Sep 17, 2019 · 1 like · 1,521 followers View post →
Denis A
@Merckxcycling · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 17, 2019 · 11 shares · 1,896 followers View post →
Mayuresh
@brainsinacup · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 17, 2019 · 11 shares · 104 followers View post →
Nature's Medicines
@NatMed_Research · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 17, 2019 · 11 shares · 2,955 followers View post →
طارق بن سعود بن حمد الجابري
@nomadarab · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 17, 2019 · 11 shares · 2,893 followers View post →
Dr. Máté
@milena_mate · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 1,068 followers View post →
Emilia Andrade Belitardo
@MilaBelitardo · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 1,082 followers View post →
Jennifer Depew, RD
@deNutrients · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 28,488 followers View post →
Klinger Neves
@Kli_Nev · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 3,791 followers View post →
M Shafi Kuchay
@drshafikuchay · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 19,892 followers View post →
Saraswanto Setiawan
@saraswantos · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 2,491 followers View post →
Nature Watcher
@av693 · X

RT @_atanas_: Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co…

Sep 16, 2019 · 11 shares · 24,718 followers View post →
Atanas G. Atanasov
@_atanas_ · X

Mediation of the Acute Stress Response by the Skeleton (Cell Metabolism, September 12, 2019, full text link) https://t.co/BCxDDzHrES

Sep 16, 2019 · 14 likes · 11 shares · 123,667 followers View post →
강아지 온도좋은날
@Goldendoodle_on · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/IhtADKQFec

Sep 16, 2019 · 1 followers View post →
joel seidemann
@JoelSeidemann · X

Mediation of the Acute Stress Response by the Skeleton: Cell Metabolism https://t.co/1OJIg5KLA0

Sep 15, 2019 · 1 like · 3 followers View post →
BB
@BatboldChuluun · X

RT @art_radnaa: Стрессийн гормон остеокальцин......... Mediation of the Acute Stress Response by the Skeleton https://t.co/qXqUrH9eMb

Sep 15, 2019 · 3 shares · 1,274 followers View post →
Dr.Siddharth
@SiddBits · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/GQ1fDUM3JY

Sep 15, 2019 · 190 followers View post →
Бүтээгч
@bayarkhu · X

RT @art_radnaa: Стрессийн гормон остеокальцин......... Mediation of the Acute Stress Response by the Skeleton https://t.co/qXqUrH9eMb

Sep 15, 2019 · 3 shares · 3,655 followers View post →
batsukh.ts
@TsBatsukh · X

RT @art_radnaa: Стрессийн гормон остеокальцин......... Mediation of the Acute Stress Response by the Skeleton https://t.co/qXqUrH9eMb

Sep 15, 2019 · 3 shares · 3,495 followers View post →
Ч. Раднаа
@art_radnaa · X

Стрессийн гормон остеокальцин......... Mediation of the Acute Stress Response by the Skeleton https://t.co/qXqUrH9eMb

Sep 15, 2019 · 2 likes · 3 shares · 9,416 followers View post →
Glasgow Watch
@Glasgow_Watch · X

RT @LewisSteell: Mediation of the Acute Stress Response by the Skeleton https://t.co/jTRmiffBE1

Sep 15, 2019 · 1 share · 9,846 followers View post →
Lewis Steell
@DrLewisSteell · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/jTRmiffBE1

Sep 15, 2019 · 3 likes · 1 share · 160 followers View post →
Sarah Perez Berger
@_sarahantonia · X

RT @DanielJDrucker: Never Mind the Adrenals. It is Osteocalcin and Mediation of the Acute Stress Response by the Skeleton @Cell_Metabolism…

Sep 14, 2019 · 2 shares · 4 followers View post →
Brain and Sleep Research Laboratory
@bsrlaboratory · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/FqaQBbWGGn

Sep 14, 2019 · 2 likes · 675 followers View post →
JXG
@JohnXGaspar · X

Mediation of the Acute Stress Response by the Skeleton: •ASR stimulates osteocalcin release from bone •Glutamate uptake into osteoblasts is required for osteocalcin release •Osteocalcin inhibits the parasympathetic tone during an ASR #fightorflight https://t.co/5djxuw249M

Sep 14, 2019 · 576 followers View post →
Marek Paul
@mp_1963 · X

Mediation of the Acute Stress Response by the Skeleton - ScienceDirect ⁦@PainCPsych⁩ https://t.co/nQczK8NxCG

Sep 14, 2019 · 22 followers View post →
DrM
@WildernessEMC · X

https://t.co/ibymVGUqJA Mediation of the Acute Stress Response by the Skeleton This is the article which inspired the thread above, thanks to @evolutionarypsy @LaraBriden @juliannejtaylor Answer to you Q might be @ElementalPopie might be in the tweet before this one

Sep 13, 2019 · 3 likes · 1,503 followers View post →
Felipe Helfenstein
@felipehelf · X

Mediation of the Acute Stress Response by the Skeleton https://t.co/EWAROEOgeQ

Sep 13, 2019 · 1 share · 13 followers View post →
dawessner
@dawessner · X

Great article in @Cell_Metabolism re: #bio111 #biology #fightorflight Mediation of the Acute Stress Response by the Skeleton https://t.co/1lUM7pmkph Thnx @heyyitsyara ! I see you!

Sep 13, 2019 · 818 followers View post →
UltimApe
@ultimape · X

oww oof my bones. https://t.co/lGpDklplbd

Sep 13, 2019 · 1 like · 6,452 followers View post →
nextdoormartian
@nextdoormartian · X

Physiology just turned over its head... osteocalcin from bone, not adrenaline, is the primary driver of the acute stress response, fight or flight! "Mediation of the acute stress response by the skeleton," Cell Metabolism (2019). DOI: 10.1016/j.cmet.2019.08.012

Sep 13, 2019 · 7 likes · 1 share · 5,314 followers View post →
Scott Hannah
@Scott_Hannah_ · X

Mediation of the Acute Stress Response by the Skeleton - ScienceDirect https://t.co/ZOCnw5OgIH

Sep 12, 2019 · 1 like · 433 followers View post →
lbgbox
@lbgbox · X

RT @DanielJDrucker: Never Mind the Adrenals. It is Osteocalcin and Mediation of the Acute Stress Response by the Skeleton @Cell_Metabolism…

Sep 12, 2019 · 2 shares · 52 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @zenbrainest: Mediation of the Acute Stress Response by the Skeleton--interesting use of chemogenetics here https://t.co/Y66tvN4zs0

Sep 12, 2019 · 1 share · 10,774 followers View post →
BryanRoth
@zenbrainest · X

Mediation of the Acute Stress Response by the Skeleton--interesting use of chemogenetics here https://t.co/Y66tvN4zs0

Sep 12, 2019 · 9 likes · 1 share · 17,008 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Never Mind the Adrenals. It is Osteocalcin and Mediation of the Acute Stress Response by the Skeleton @Cell_Metabolism https://t.co/g87CyRVIOK

Sep 12, 2019 · 3 likes · 2 shares · 34,179 followers View post →