PubHawk
October 2019 PMID 31619571

Proteostasis collapse is a driver of cell aging and death.

Mantu Santra, Ken A Dill, Adam M R de Graff

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Mentions

64
Peak: 20 in Oct 2019
across 5 sources since Oct 2019

Extended reach

115,275
potential audience

Total likes

1,194

Video views

37,223

Mentions per month

Oct 2019 – Mar 2025

Where it's discussed

  • X / Twitter36 posts
  • YouTube18 videos
  • News5 articles
  • Blogs3 articles
  • Reddit2 posts

AI synopsis

What people are saying

The discussions show a mostly positive and curious attitude towards the article's implications, with many posts sharing the core idea that proteostasis collapse drives aging, exemplified by repeated mentions of 'cell aging and death.' Phrases like 'The End Of Aging' and questions about whether defeating aging would be a miracle reflect a tone of intrigue and anticipation, while some users express interest by sharing related scientific content and raising broader philosophical questions.

AgreementModerate agreement

Most discussions recognize the significance of proteostasis in aging, with some emphasizing its potential as a fundamental driver of cell death.

InterestModerate interest

Participants appear reasonably interested, focusing on the possibility of ending aging and questions about its broader implications.

EngagementModerate engagement

Posts involve sharing of content, references to scientific findings, and some personal reflections, indicating moderate engagement.

ImpactModerate impact

There is a sense that this topic could reshape views on aging and health, though the discussions remain somewhat preliminary or speculative.

Abstract in brief

  • Proteostasis collapse, driven by slow translation and oxidative damage, leads to the accumulation of damaged proteins, which distracts chaperones and disrupts cell function, ultimately causing cell aging and death.
  • The model aligns with experimental data showing that lifespan decreases nonlinearly with higher temperature and oxidative stress, but can be extended in mutants with more chaperones or proteasomes that maintain protein quality.
  • It explains the age-related increase in oxidative damage and the Gompertz-like pattern of mortality, emphasizing how protein instability accelerates damage accumulation and disrupts cellular balance over time.]
Read the full abstract

Top posts

Most liked on X and Bluesky
ShorterLab
@ShorterLab · X

Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 32 likes · 12 shares · 12,012 followers View post →
Help Defeat Aging
@HelpDefeatAging · X

The End Of Aging https://t.co/PEWcrC8caj

Feb 27, 2024 · 4 likes · 3 shares · 1,964 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

Proteostasis collapse is a driver of cell aging and death https://t.co/ILAOxajTIT

Oct 22, 2019 · 2 likes · 1 share · 3,218 followers View post →
Fund anti-aging research ∞
@NoToaging · X

Over 3h long video of quality about the end of aging, share and retweet. The End Of Aging https://t.co/caVc52jYhO via @YouTube

Dec 1, 2023 · 2 likes · 1,449 followers View post →
Fund anti-aging research ∞
@NoToaging · X

@CharlesMBrenner https://t.co/5ILj3Lsbpc

Mar 8, 2025 · 2 likes · 1,449 followers View post →
Qigong Aikido Judo Taichi
@QigongAikido · X

Would defeating aging be a sort of life energy cultivation? Qigong The End of Aging https://t.co/N1CzHwuxI8

Feb 27, 2024 · 2 likes · 74 followers View post →

All mentions

Genomic Instability and Its Role in Aging Processes

This video explores the role of genomic instability in aging, highlighting cellular reprogramming and epigenetic rejuvenation as potential strategies to slow or reverse aging processes without losing cell identity.

Tuldun · Dec 11, 2023 1,520 views

Understanding the Role of Proteostasis Loss in Aging

This video explores how the loss of proteostasis influences aging, highlighting current research, limitations of telomere length as a biomarker, and the importance of combining multiple indicators for accurate…

Tuldun · Dec 15, 2023 776 views

Deregulated Nutrient Sensing and Its Role in Aging

This video explores how deregulated nutrient sensing impacts aging, emphasizing telomere length and other biomarkers to improve biological age assessments. It discusses current research and future perspectives on aging…

Tuldun · Dec 20, 2023 668 views

Cellular Senescence and the Future of Aging Research

This video explores cellular senescence and examines telomere length as a marker of biological age, highlighting limitations and the importance of combining multiple indicators for more accurate aging assessments.

Tuldun · Dec 22, 2023 377 views
Fund anti-aging research ∞
@NoToaging · X

@CharlesMBrenner https://t.co/5ILj3Lsbpc

Mar 8, 2025 · 2 likes · 1,449 followers View post →
homer60
@homer604 · X

The End Of Aging https://t.co/DfRtUs8Ivn via @YouTube

Mar 1, 2024 · 114 followers View post →
Sanath Janaka Gunawardena
@5anath666 · X

RT @HelpDefeatAging: The End Of Aging https://t.co/PEWcrC8caj

Feb 28, 2024 · 3 shares · 686 followers View post →
observer137
@aeonhermit · X

RT @HelpDefeatAging: The End Of Aging https://t.co/PEWcrC8caj

Feb 27, 2024 · 3 shares · 430 followers View post →
Andrew Choi
@choi_andre56958 · X

RT @HelpDefeatAging: The End Of Aging https://t.co/PEWcrC8caj

Feb 27, 2024 · 3 shares · 40 followers View post →
Qigong Aikido Judo Taichi
@QigongAikido · X

Would defeating aging be a sort of life energy cultivation? Qigong The End of Aging https://t.co/N1CzHwuxI8

Feb 27, 2024 · 2 likes · 74 followers View post →
ACIMHeaven
@ACIMHeaven · X

Would Earth be more heaven like if aging were defeated? Would defeating aging potentially be a miracle? The End Of Aging https://t.co/hlxK4YW6N2

Feb 27, 2024 · 198 followers View post →
Help Defeat Aging
@HelpDefeatAging · X

The End Of Aging https://t.co/PEWcrC8caj

Feb 27, 2024 · 4 likes · 3 shares · 1,964 followers View post →
Crukih
@Crukih221502 · X

@TeamYouTube I appreciate the fact that you are busy. I contacted you a week ago in relation to my video becoming age restricted and it being unsearchable. I would like to know what changes / edits I can make to have this removed. https://t.co/S9PlnJ8Lvj

Dec 11, 2023 View post →
Crukih
@Crukih221502 · X

@TeamYouTube My 3.5 hour medical science documentary has been age restricted for allegedly showing 'minors in a sexual way'. https://t.co/S9PlnJ8Lvj

Dec 4, 2023 View post →
Fund anti-aging research ∞
@NoToaging · X

Over 3h long video of quality about the end of aging, share and retweet. The End Of Aging https://t.co/caVc52jYhO via @YouTube

Dec 1, 2023 · 2 likes · 1,449 followers View post →
baaskelabs
@baaskelabs · X

The End Of Aging https://t.co/BY5Rz7GeIw via @YouTube

Nov 30, 2023 · 3,127 followers View post →
Paola De Gennaro
@PaolaDeGennar10 · X

https://t.co/5GxjIFUszn

Nov 29, 2023 · 198 followers View post →
BobThom23923239
@BobThom23923239 · X

The End Of Aging? https://t.co/UdMsm4ekHz

Nov 26, 2023 · 439 followers View post →
biotech archives
@bot_biotech · X

Proteostasis collapse is a driver of cell aging and death https://t.co/2TgWRVJyq1

Jun 15, 2022 · 162 followers View post →
YE_lab
@YE_lab · X

Proteostasis collapse is a driver of cell aging and death https://t.co/Jjr0B20Xyv

Jun 25, 2021 · 74 followers View post →
Rhonda Little, MD
@BenefitVBurden · X

RT @BlackPhysicists: Proteostasis collapse is a driver of cell aging and death [Biophysics and Computational Biology] https://t.co/QX0w3KOx…

Oct 30, 2019 · 2,545 followers View post →
BlackPhysicists
@BlackPhysicists · X

Proteostasis collapse is a driver of cell aging and death [Biophysics and Computational Biology] https://t.co/QX0w3KOxH8 #biophysics https://t.co/iRScELrjxq

Oct 30, 2019 · 1 like · 25,148 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @ShorterLabGroup: Proteostasis collapse is a driver of cell aging and death https://t.co/ILAOxajTIT

Oct 23, 2019 · 1 share · 3,645 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

Proteostasis collapse is a driver of cell aging and death https://t.co/ILAOxajTIT

Oct 22, 2019 · 2 likes · 1 share · 3,218 followers View post →
Ariakas Enoreth
@Aenoreth · X

Proteostasis collapse is a driver of cell aging and death https://t.co/sslnt5gWgh

Oct 22, 2019 · 1,013 followers View post →
the paper link
@the_paper_link · X

Trend new: *Santra M* et al (Proc Natl Acad Sci U S A) __Proteostasis collapse is a driver of cell aging and death.__ https://t.co/RUoluaa1Tt

Oct 19, 2019 · 136 followers View post →
mcmullanlab_papers
@mcmullan_papers · X

Proteostasis collapse is a driver of cell aging and death. https://t.co/wDRNH1xHQu

Oct 18, 2019 · 24 followers View post →
Abdul Hye
@HiAbs · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 266 followers View post →
Pastel BioScience
@PastelBio · X

Proteostasis collapse is a driver of cell aging and death | https://t.co/4Yayq9muTE #proteomics https://t.co/50hE19ZehC

Oct 17, 2019 · 1 like · 5,376 followers View post →
P. Binder.
@pbinders · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 600 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 2,053 followers View post →
Patricia Rosewell
@stormpetrel · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 1,233 followers View post →
Dougan Lab
@DouganLab · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 936 followers View post →
Dr. Candace Strang
@Nscience4ever · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 17, 2019 · 12 shares · 696 followers View post →
Xiaojing Sui
@Xiaojing_Sui · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 12 shares · 451 followers View post →
Toyota_Group_Komaba
@KomaToug · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 12 shares · 671 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 12 shares · 3,645 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 12 shares · 3,218 followers View post →
Claes Andréasson
@ClaesAndreasson · X

RT @ShorterLab: Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 12 shares · 452 followers View post →
ShorterLab
@ShorterLab · X

Proteostasis collapse is a driver of cell aging and death: https://t.co/AZUU6EUs97

Oct 16, 2019 · 32 likes · 12 shares · 12,012 followers View post →