Genome Res November 2019 PMID 31649059

Identification and dynamic quantification of regulatory elements using total RNA.

Sascha H Duttke, Max W Chang, Sven Heinz, Christopher Benner

Mentions

14
Peak: 6 in Nov 2019
across 3 sources since Oct 2019

Extended reach

68,143
potential audience

Total likes

30

Video views

918

Mentions per month

Oct 2019 – Mar 2021

Where it's discussed

  • X / Twitter10 posts
  • Facebook3 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions exhibit strong support, with posts describing the csRNA-seq method as a breakthrough using words like 'new' and 'free open access,' reflecting excitement and value. The tone emphasizes significance and potential, such as references to the method's ability to detect transcription start sites at single-nucleotide resolution, suggesting the study's substantial impact on gene regulation research.

AgreementModerate agreement

Most discussions express strong support and enthusiasm for the research, highlighting its innovative methods and significance.

InterestHigh interest

Posts demonstrate high interest by emphasizing the novelty of csRNA-seq and its potential applications.

EngagementModerate engagement

Responses show moderate engagement, with some posts elaborating on the methodology and potential impact, but few deep discussions.

ImpactModerate impact

Participants widely believe that the study could influence future research and techniques, indicating perceived high impact.

Abstract in brief

  • The study introduces csRNAseq, a method using total RNA to precisely identify transcription start sites (TSSs) of both stable and unstable RNAs, revealing many more regulated transcripts than traditional RNA sequencing.
  • Researchers found that unstable transcripts, similar to enhancer RNAs and antisense transcripts, are conserved across many eukaryotic species and evolutionary time, highlighting their importance in gene regulation.
  • Integration with epigenomic data showed that histone modifications like H3K4me3 are linked to stable transcripts' TSSs, while H3K27ac marks active regions downstream, suggesting that histone modifications play a key role in controlling transcription across evolution.]

Top posts

Most liked on X and Bluesky
Genome Research
@genomeresearch · X

NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA as starting material to detect transcription start sites of stable and unstable RNAs at single-nucleotide resolution. FREE #GRopenaccess https://t.co/2LXrBxKvDC https://t.co/fNmNTXsHfF

Nov 21, 2019 · 25 likes · 8 shares · 54,032 followers View post →
Nucleosome papers
@Nucleosome_Bot · X

Identification and dynamic quantification of regulatory elements using total RNA. https://t.co/PWyxR8mi0Z

Oct 28, 2019 · 1 like · 1 share · 4,707 followers View post →
Andrea Branda-Sica
@AndreaBranda8 · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 4,280 followers View post →
Stefan A. Rensing
@RensingStefan · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 2,077 followers View post →
Small RNA papers
@sRNAPapers · X

Identification and dynamic quantification of regulatory elements using total RNA. https://t.co/9d5eDYeONj

Oct 28, 2019 · 1,087 followers View post →
Irina Ćalić Fiebig
@calic_irina · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 469 followers View post →

All mentions

Dreamgbutterfly
@dreamgbutterfly · X

Identification and dynamic quantification of regulatory elements using total RNA https://t.co/VDCSJ4PoHU

Mar 4, 2020 · 82 followers View post →
Irina Ćalić Fiebig
@calic_irina · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 469 followers View post →
Tito
@tito_tasks · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 115 followers View post →
Stefan A. Rensing
@RensingStefan · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 2,077 followers View post →
Peter szovenyi
@peter_szovenyi · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 260 followers View post →
Andrea Branda-Sica
@AndreaBranda8 · X

RT @genomeresearch: NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA…

Nov 21, 2019 · 8 shares · 4,280 followers View post →
Genome Research
@genomeresearch · X

NEW research from @UCSanDiego! @genomeresearch publishes capped-small RNA-seq (csRNA-seq), a method that uses total RNA as starting material to detect transcription start sites of stable and unstable RNAs at single-nucleotide resolution. FREE #GRopenaccess https://t.co/2LXrBxKvDC https://t.co/fNmNTXsHfF

Nov 21, 2019 · 25 likes · 8 shares · 54,032 followers View post →
Small RNA papers
@sRNAPapers · X

Identification and dynamic quantification of regulatory elements using total RNA. https://t.co/9d5eDYeONj

Oct 28, 2019 · 1,087 followers View post →
Nucleosome papers
@Nucleosome_Bot · X

Identification and dynamic quantification of regulatory elements using total RNA. https://t.co/PWyxR8mi0Z

Oct 28, 2019 · 1 like · 1 share · 4,707 followers View post →
Meng
@wang__meng · X

Identification and dynamic quantification of regulatory elements using total RNA. https://t.co/0sxU7AydK8

Oct 28, 2019 · 18 followers View post →