PubHawk
November 2019 PMID 31717265

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

Andrea G Izquierdo, Ana B Crujeiras, Felipe F Casanueva, Marcos C Carreira

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Mentions

40
Peak: 11 in Nov 2019
across 5 sources since Nov 2019

Extended reach

860,421
potential audience

Total likes

9,405

Video views

417,977

Mentions per month

Nov 2019 – Oct 2025

Where it's discussed

  • X / Twitter28 posts
  • News5 articles
  • Facebook3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Several discussions highlight ongoing debates about leptin therapy's ineffectiveness and uncertain mechanisms, such as the question of whether resistance is due to CNS factors or leptin’s physiological limits. The tone varies from technical to appreciative, with comments like 'great paper' and references to recent research, indicating both interest and recognition of its significance for understanding obesity. The tone and content reflect engagement that balances curiosity with scientific curiosity, suggesting respect for the article's insights without overestimating its immediate impact.

AgreementModerate agreement

Most discussions acknowledge the ongoing challenges with leptin resistance and the incomplete understanding of its mechanisms, reflecting partial agreement with the article's points.

InterestHigh interest

The posts show curiosity about recent developments and therapies, indicating high interest, especially with mentions of new research and strategies.

EngagementModerate engagement

Some posts reference specific concepts like CNS resistance and the effectiveness of leptin replacement, demonstrating moderate deeper engagement with the scientific content.

ImpactModerate impact

The discussions suggest recognition of the article’s importance in shaping future research directions, though they do not explicitly mention immediate practical impacts.

Abstract in brief

  • Leptin, a hormone that can reduce food intake and body weight, was once considered a promising treatment for obesity. However, obese individuals often have high leptin levels but do not respond to it, a condition known as leptin resistance, which remains poorly understood.
  • For leptin to work, it must cross the blood-brain barrier to affect the hypothalamus, but the mechanisms of this transport are not fully understood, complicating its use as a therapy.
  • Recently, new strategies have been developed to enhance leptin sensitivity in obese individuals, and ongoing research aims to unravel the molecular causes of leptin resistance to improve obesity treatments.
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Top posts

Most liked on X and Bluesky
Atanas G. Atanasov
@_atanas_ · X

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 36 likes · 13 shares · 124,315 followers View post →
Cristina Tejera
@cristinatejerap · X

#mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCzFFuD8l @acrujeirasm enhorabuena equipazo por este paper! https://t.co/HBCyKLxCZg

Dec 24, 2019 · 12 likes · 8 shares · 11,543 followers View post →
Saúl Sánchez
@SaulNutri · X

Feb 16, 2023 · 9 likes · 1 share · 108,041 followers View post →
Clayton Camargos
@DrCamargosCN · X

Cérebro e obesidade

Dec 22, 2023 · 1 like · 213 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Dec 25, 2019 · 13 shares · 124,315 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

@sguyenet @StephenORahilly Leptin replacement in people with common obesity is ineffective. Why do we assume this is 2/2 to CNS resistance vs. a limitation of leptin’s physiologic effects in common Ob as discussed in these reviews? https://t.co/lgyEzqkUbg https://t.co/Sxf4O6yuS7

Apr 15, 2022 · 16,091 followers View post →

All mentions

Clayton Camargos
@DrCamargosCN · X

Cérebro e obesidade

Dec 22, 2023 · 1 like · 213 followers View post →
Rafael Radaeli
@rfradaeli · X

RT @SaulNutri:

Feb 16, 2023 · 1 share · 382 followers View post →
Saúl Sánchez
@SaulNutri · X

Feb 16, 2023 · 9 likes · 1 share · 108,041 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

@sguyenet @StephenORahilly Leptin replacement in people with common obesity is ineffective. Why do we assume this is 2/2 to CNS resistance vs. a limitation of leptin’s physiologic effects in common Ob as discussed in these reviews? https://t.co/lgyEzqkUbg https://t.co/Sxf4O6yuS7

Apr 15, 2022 · 16,091 followers View post →
Nutrients MDPI
@Nutrients_MDPI · X

#mdpinutrients Read the High Cited Paper from Dr. Andrea Gonzalez-Izquierdo et al. #Leptin, #Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/3U82OYiM01 https://t.co/DrNlLQpS7U

Feb 28, 2022 · 11,317 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?" https://t.co/XokTMo0oVG

Apr 28, 2020 · 621 followers View post →
Lilia Andrea
@LiliaAndreataf1 · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Jan 1, 2020 · 8 shares · 377 followers View post →
Lynne Evans
@levaly2 · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Dec 25, 2019 · 13 shares · 933 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Dec 25, 2019 · 13 shares · 10,292 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Dec 25, 2019 · 13 shares · 124,315 followers View post →
Agelvis Martínez MD
@agelvisr · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Dec 24, 2019 · 8 shares · 279 followers View post →
SEEDO
@SociedadSeedo · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Dec 24, 2019 · 8 shares · 10,589 followers View post →
Catalina Ramírez-Contreras
@cataramirezc · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Dec 24, 2019 · 8 shares · 446 followers View post →
fausto heredia z.
@drfherediaz · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Dec 24, 2019 · 8 shares · 4,376 followers View post →
SEDCA
@sedcadietetica · X

RT @cristinatejerap: #mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCz…

Dec 24, 2019 · 8 shares · 6,835 followers View post →
Cristina Tejera
@cristinatejerap · X

#mdpinutrients Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? @Nutrients_MDPI https://t.co/EOCzFFuD8l @acrujeirasm enhorabuena equipazo por este paper! https://t.co/HBCyKLxCZg

Dec 24, 2019 · 12 likes · 8 shares · 11,543 followers View post →
Bibliosaude
@Bibliosaude · X

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? - PubMed - NCBI https://t.co/r9Ww0Mghl5 #PublicaSergas #CHUS

Dec 12, 2019 · 1,878 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?" https://t.co/XokTMo0oVG

Nov 14, 2019 · 621 followers View post →
12Alice Lee
@PepperPell · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 10, 2019 · 13 shares · 3,161 followers View post →
Hidetaka Hamasaki
@hhamasaki78 · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 10, 2019 · 13 shares · 123 followers View post →
Apollonaught
@Apollonaught1 · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 10, 2019 · 13 shares · 266 followers View post →
Dr. Alex Chisholm, PhD
@DrAlexChisholm · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 901 followers View post →
Elliot Siemon
@sci_tek · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 751 followers View post →
Tod Fullston
@Tod_Fullston · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 376 followers View post →
Dora C.
@DoraQetesh · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 2,241 followers View post →
Michael Carmody
@m_carmody · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 185 followers View post →
Diego Morales
@diegomoralesvit · X

RT @_atanas_: Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 13 shares · 523 followers View post →
Atanas G. Atanasov
@_atanas_ · X

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? https://t.co/uovJBPE8SX

Nov 9, 2019 · 36 likes · 13 shares · 124,315 followers View post →