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Acta Crystallogr D Struct Biol December 2019 PMID 31793901

Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin.

Andreas Naschberger, Pauline Juyoux, Jill von Velsen, Bernhard Rupp, Matthew W Bowler

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Mentions

35
Peak: 15 in Dec 2019
across 2 sources since Jun 2019

Extended reach

248,761
potential audience

Total likes

56

Video views

218

Mentions per month

Jun 2019 – Mar 2022

Where it's discussed

  • X / Twitter33 posts
  • YouTube2 videos

AI synopsis

What people are saying

The posts highlight the significance of the research by emphasizing the novel use of controlled dehydration to stabilize protein structures and the discovery of afamin's capacity for multi-site ligand binding. Words like 'exciting,' 'innovative,' and phrases referencing 'methodology' and 'potential biological implications' demonstrate a tone of interest and perceived importance, especially among the scientific community engaged in structural biology and medical imaging.

AgreementModerate agreement

Most discussions recognize the significance of the research, with some explicitly praising its contribution to structural biology, indicating general consensus on its importance.

InterestNeutral interest
EngagementNeutral engagement
ImpactNeutral impact

Abstract in brief

  • The study investigates the structural challenges of determining afamin's crystal structure due to its variable packing, glycosylation, and conformational flexibility and demonstrates that controlled dehydration can stabilize a specific crystal form and alter protein conformation.
  • Utilizing automated experiments on MASSIF1, researchers established an efficient method to induce phase transitions, with insights suggesting that relying on a single structural model may lead to interpretative biases, especially regarding ligand binding sites.
  • Afamin, a multifunctional transporter, can bind gadoteridol, a contrast agent used in MRI, at multiple sites, including near the Sudlow site of albumin, highlighting its promiscuous ligand-binding capacity which may influence its biological and imaging functions.]
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Top posts

Most liked on X and Bluesky
Matthew Bowler
@moncourvoisier · X

Our preprint @biorxivpreprint with @ruppweb describing dehydration of afamin and how it binds the MRI contrast agent gadolinium is now published @ActaCrystD congrats to @PaulineJYX and @jvonvelsen ! Data collection @ID30_MASSIF1 @esrfsynchrotron @embl

Nov 27, 2019 · 20 likes · 3 shares · 693 followers View post →
MASSIF1
@ID30_MASSIF1 · X

New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin https://t.co/Ztm2yuJaD5 https://t.co/wbTEsIPdm1

Nov 26, 2019 · 11 likes · 6 shares · 857 followers View post →
Matthew Bowler
@moncourvoisier · X

Pleased to see our X-ray methods paper

Dec 4, 2019 · 10 likes · 7 shares · 693 followers View post →
Structural Biology
@ActaCrystD · X

Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin #IUCr https://t.co/utB0Q33c3t

Nov 19, 2019 · 5 likes · 4 shares · 3,020 followers View post →
bioRxiv
@biorxivpreprint · X

Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin https://t.co/g4X8eGXXWi #bioRxiv

Jun 18, 2019 · 2 likes · 1 share · 137,616 followers View post →
African Synchrotron
@AfSynchrotron · X

Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin https://t.co/o0Z4xXVOoB via @ActaCrystD https://t.co/X5HhJtEuWN

Dec 2, 2019 · 2 likes · 2 shares · 2,923 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin published as: https://t.co/rbB70PUO2A #Acta_Crystallographica_Section_D_Structural_Biology #biorxiv

Mar 15, 2022 · 2,909 followers View post →
Analio Dugarte
@analioj · X

RT @ActaCrystD: Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the huma…

Dec 11, 2019 · 4 shares · 2,182 followers View post →
Analio Dugarte
@analioj · X

RT @ID30_MASSIF1: New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility…

Dec 11, 2019 · 6 shares · 2,182 followers View post →
Analio Dugarte
@analioj · X

RT @moncourvoisier: Our preprint @biorxivpreprint with @ruppweb describing dehydration of afamin and how it binds the MRI contrast agent ga…

Dec 11, 2019 · 3 shares · 2,182 followers View post →
Veronica KaneDickson
@vkd002 · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 5, 2019 · 7 shares · 166 followers View post →
Analio Dugarte
@analioj · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 4, 2019 · 7 shares · 2,182 followers View post →
Helen Gavaghan. UK. Photo+Digital Art by me.
@HelenGavaghan · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 4, 2019 · 7 shares · 1,208 followers View post →
MASSIF1
@ID30_MASSIF1 · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 4, 2019 · 7 shares · 857 followers View post →
David Bowler
@MillionAtomMan · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 4, 2019 · 7 shares · 1,128 followers View post →
Structural Biology
@ActaCrystD · X

RT @moncourvoisier: Pleased to see our X-ray methods paper

Dec 4, 2019 · 7 shares · 3,020 followers View post →
Matthew Bowler
@moncourvoisier · X

Pleased to see our X-ray methods paper

Dec 4, 2019 · 10 likes · 7 shares · 693 followers View post →
MASSIF1
@ID30_MASSIF1 · X

RT @AfSynchrotron: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycopro…

Dec 3, 2019 · 2 shares · 857 followers View post →
Matthew Bowler
@moncourvoisier · X

RT @AfSynchrotron: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycopro…

Dec 3, 2019 · 2 shares · 693 followers View post →
African Synchrotron
@AfSynchrotron · X

Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin https://t.co/o0Z4xXVOoB via @ActaCrystD https://t.co/X5HhJtEuWN

Dec 2, 2019 · 2 likes · 2 shares · 2,923 followers View post →
Life & Health Science Cluster Tirol
@lhsct_at · X

RT @ID30_MASSIF1: New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility…

Nov 28, 2019 · 6 shares · 223 followers View post →
Structural Biology
@ActaCrystD · X

RT @moncourvoisier: Our preprint @biorxivpreprint with @ruppweb describing dehydration of afamin and how it binds the MRI contrast agent ga…

Nov 27, 2019 · 3 shares · 3,020 followers View post →
MASSIF1
@ID30_MASSIF1 · X

RT @moncourvoisier: Our preprint @biorxivpreprint with @ruppweb describing dehydration of afamin and how it binds the MRI contrast agent ga…

Nov 27, 2019 · 3 shares · 857 followers View post →
Matthew Bowler
@moncourvoisier · X

Our preprint @biorxivpreprint with @ruppweb describing dehydration of afamin and how it binds the MRI contrast agent gadolinium is now published @ActaCrystD congrats to @PaulineJYX and @jvonvelsen ! Data collection @ID30_MASSIF1 @esrfsynchrotron @embl

Nov 27, 2019 · 20 likes · 3 shares · 693 followers View post →
Structural Biology
@ActaCrystD · X

RT @ID30_MASSIF1: New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility…

Nov 26, 2019 · 6 shares · 3,020 followers View post →
Matthew Bowler
@moncourvoisier · X

RT @ID30_MASSIF1: New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility…

Nov 26, 2019 · 6 shares · 693 followers View post →
EMBL
@embl · X

RT @ID30_MASSIF1: New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility…

Nov 26, 2019 · 6 shares · 67,064 followers View post →
MASSIF1
@ID30_MASSIF1 · X

New pub @ID30_MASSIF1 in @ActaCrystD from @embl Grenoble and @imed_tweets Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin https://t.co/Ztm2yuJaD5 https://t.co/wbTEsIPdm1

Nov 26, 2019 · 11 likes · 6 shares · 857 followers View post →
Molecular Dimensions
@molecularD · X

RT @ActaCrystD: Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the huma…

Nov 20, 2019 · 4 shares · 1,486 followers View post →
MASSIF1
@ID30_MASSIF1 · X

RT @ActaCrystD: Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the huma…

Nov 20, 2019 · 4 shares · 857 followers View post →
Matthew Bowler
@moncourvoisier · X

RT @ActaCrystD: Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the huma…

Nov 20, 2019 · 4 shares · 693 followers View post →
Structural Biology
@ActaCrystD · X

Naschberger et al.: Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin #IUCr https://t.co/utB0Q33c3t

Nov 19, 2019 · 5 likes · 4 shares · 3,020 followers View post →
MASSIF1
@ID30_MASSIF1 · X

RT @glycopreprint: Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotei…

Jul 1, 2019 · 1 share · 857 followers View post →
Matthew Bowler
@moncourvoisier · X

RT @assert_pub: "Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in.." is the #1 paper on bioR…

Jun 20, 2019 · 1 share · 693 followers View post →
Assert Biorxiv
@assert_pub · X

"Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in.." is the #1 paper on bioRxiv today in biochemistry. Congrats @PaulineJYX @CaptainRupp. See it at -> https://t.co/dIWIj60FNO and https://t.co/N2ULy4JB4n. Please retweet.

Jun 20, 2019 · 2 likes · 1 share · 848 followers View post →
Matthew Bowler
@moncourvoisier · X

RT @biorxivpreprint: Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprot…

Jun 19, 2019 · 1 share · 693 followers View post →
glycopreprint
@glycopreprint · X

Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin https://t.co/Nw47HZYlKC #glycotime

Jun 18, 2019 · 1 like · 1 share · 1,352 followers View post →
bxv_biochem
@bxv_biochem · X

Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin https://t.co/pAocKWIpHt

Jun 18, 2019 · 2 likes · 562 followers View post →
bioRxiv
@biorxivpreprint · X

Controlled dehydration, structural flexibility, and Gadolinium MRI contrast compound binding in human plasma glycoprotein afamin https://t.co/g4X8eGXXWi #bioRxiv

Jun 18, 2019 · 2 likes · 1 share · 137,616 followers View post →