Front Endocrinol (Lausanne) November 2019 PMID 31824415

Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway.

Jiameng Liu, Chaoming Mao, Liyang Dong, Ping Kang, Chao Ding, Tingting Zheng, Xuefeng Wang, Yichuan Xiao

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Mentions

16
Peak: 5 in Nov 2019
across 2 sources since Nov 2019

Extended reach

49,601
potential audience

Total likes

225

Video views

7,887

Mentions per month

Nov 2019 – May 2025

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos

AI synopsis

What people are saying

The social discussions mainly revolve around confirming the harmful effects of excess iodine on thyroid cells with references to pathways like pyroptosis and inflammation, exemplified by comments such as 'Pyroptosis is 'died suddenly' to thyroid cells,' and mentions of the pathways involved. The tone varies from cautious concern to curiosity, reflecting a moderate level of engagement and a recognition of the research’s significance without deep technical analysis.

AgreementModerate agreement

Most discussions acknowledge the study’s findings that excess iodine can promote inflammatory cell death in the thyroid, indicating partial to full agreement.

InterestModerate interest

Participants show a moderate level of curiosity, especially those mentioning implications for Hashimoto’s and thyroid health, but some dismissive or unrelated posts lower overall interest.

EngagementNeutral engagement

The reactions are somewhat surface-level; some users reference specific pathways like ROS-NF-κB-NLRP3, but many posts are brief, lacking deep analysis or detailed engagement.

ImpactModerate impact

The discussion suggests that the research could influence thyroid health awareness and medical approaches, but the overall tone indicates that it’s not seen as a groundbreaking breakthrough by all participants.

Abstract in brief

  • Excessive iodine intake is linked to increased pyroptosis (a form of inflammatory cell death) in thyroid follicular cells, which may contribute to Hashimoto's thyroiditis (HT), an autoimmune thyroid disease.
  • The study found that high iodine levels activate the ROS (reactive oxygen species) and NF-κB pathways, as well as the NLRP3 inflammasome, promoting pyroptosis and the release of inflammatory cytokines like IL-1 in thyroid cells.
  • These findings suggest that iodine excess might trigger abnormal cell death processes in the thyroid, potentially playing a key role in the development of HT.]

Top posts

Most liked on X and Bluesky
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway: Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease. In recent… https://t.co/nRXqArpWSb #Endocrinology #Endo

Nov 22, 2019 · 5 likes · 4 shares · 5,052 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 22, 2019 · 4 shares · 11,327 followers View post →
EurekaMag
@EurekaMag · X

Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway https://t.co/PCOmOaW8oK

May 7, 2020 · 2 shares · 6,543 followers View post →
@swallowsgroup
@swallowsgroup · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 22, 2019 · 4 shares · 5,331 followers View post →
POPLINE
@POPLINE_org · X

RT @EurekaMag: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB…

May 7, 2020 · 2 shares · 5,238 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Commentary: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway https://t.co/iOQWsz2XYs #Endocrinology #Endo

Aug 28, 2020 · 5,052 followers View post →

All mentions

Anny Ants Hashimotaki™
@anny_ants · X

Να υπενθυμίσω #hashimotaki https://t.co/MhV3lYGkfM #bbgr #BigBrotherGR #Eurovision2025 #eurovisiongr #Eurovision #MasterChefGR https://t.co/yhuFLgKfNl

May 15, 2025 · 122 followers View post →
Anny Ants Hashimotaki™
@anny_ants · X

Προβλήματα με τον Θυρεοειδή! Γιατί μπορεί να αρρωστήσει κάποιος; Ποιοι είναι οι παράγοντες κινδύνου; Πάτησε απλά τον σύνδεσμο εδώ https://t.co/MhV3lYGkfM #hashimotaki #survivorGR #ΕΣΥ_για_ολους #Ελλάδα #eurovision2024 https://t.co/mh2oJScCGT

May 15, 2024 · 122 followers View post →
Ari Kaihola
@aricarbins · X

@RobinJCaston1 @Marion436842126 Iodine. It depends. If your thyroid problems stem from Hashimoto's, then it's absolute NO. https://t.co/E5Ml94SxI9

Apr 25, 2024 · 349 followers View post →
Ari Kaihola
@aricarbins · X

@drkohilathas 80% of hypothyroids are inflammatory, like Hashimoto. For them excess iodine kills their thyroids. Must be cautious: https://t.co/1XV4ONUmhv

Apr 14, 2023 · 349 followers View post →
Ari Kaihola
@aricarbins · X

@NestLucy @uTobian Pyroptosis is 'died suddenly' to thyroid cells: https://t.co/1XV4ONUU73

Mar 30, 2023 · 349 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Commentary: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway https://t.co/iOQWsz2XYs #Endocrinology #Endo

Aug 28, 2020 · 5,052 followers View post →
POPLINE
@POPLINE_org · X

RT @EurekaMag: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB…

May 7, 2020 · 2 shares · 5,238 followers View post →
Science Alerts
@Science_Alerts · X

RT @EurekaMag: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB…

May 7, 2020 · 2 shares · 1,234 followers View post →
EurekaMag
@EurekaMag · X

Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway https://t.co/PCOmOaW8oK

May 7, 2020 · 2 shares · 6,543 followers View post →
Science Socks
@SocksScience · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 24, 2019 · 4 shares · 452 followers View post →
Cesar
@elcesarinsabe · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 22, 2019 · 4 shares · 142 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 22, 2019 · 4 shares · 11,327 followers View post →
@swallowsgroup
@swallowsgroup · X

RT @FrontEndocrinol: New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis T…

Nov 22, 2019 · 4 shares · 5,331 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway: Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease. In recent… https://t.co/nRXqArpWSb #Endocrinology #Endo

Nov 22, 2019 · 5 likes · 4 shares · 5,052 followers View post →