Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.

Zhaogang Yang, Junfeng Shi, Jing Xie, Yifan Wang, Jingyao Sun, Tongzheng Liu, Yarong Zhao, Xiuting Zhao, Xinmei Wang, Yifan Ma, Veysi Malkoc, Chiling Chiang, Weiye Deng, Yuanxin Chen, Yuan Fu

January 2020 Nat Biomed Eng

Synopsis of Social media discussions

Several discussions reference specific aspects of the research, such as its application in skin biology and the effective delivery of mRNA for reversing skin aging. Phrases like 'cool work' and 'this is significant' indicate enthusiasm and a positive outlook on the research's applicability, contributing to an overall optimistic sentiment regarding its impact on future developments.

A
Agreement
 Moderate agreement

Most discussions reflect a general support for the findings presented in the publication, with many comments highlighting its relevance.

I
Interest
 High level of interest

The posts demonstrate strong curiosity and intrigue about the research, particularly in its potential applications.

E
Engagement
 Moderate level of engagement

Some posts indicate a moderate level of engagement, discussing related topics but mostly quoting or referencing the original research without deep dives.

I
Impact
 High level of impact

The perceived significance of the publication is high, as many users convey that its findings could lead to advancements in the field.

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Facebook

4 Posts

Twitter

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Top Social Media Posts

Posts referencing the article

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Abstract Synopsis

  • Exosomes are effective carriers for nucleic acids due to their biocompatibility and ability to cross barriers that traditional drug-delivery systems can't.
  • The study introduces a method called cellular nanoporation, which significantly increases the yield of therapeutic mRNAs and targeting peptides in exosomes.
  • In mouse models of glioma, these mRNA-loaded exosomes demonstrated restored tumor-suppressor function, slowed tumor growth, and improved survival outcomes.