Nat Biomed Eng January 2020 PMID 31844155

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.

Zhaogang Yang, Junfeng Shi, Jing Xie, Yifan Wang, Jingyao Sun, Tongzheng Liu, Yarong Zhao, Xiuting Zhao, Xinmei Wang, Yifan Ma, Veysi Malkoc, Chiling Chiang, Weiye Deng, Yuanxin Chen, Yuan Fu

Mentions

78
Peak: 18 in Dec 2019
across 5 sources since Dec 2019

Extended reach

224,183
potential audience

Total likes

796

Video views

16,629

Mentions per month

Dec 2019 – Jul 2023

Where it's discussed

  • X / Twitter55 posts
  • News14 articles
  • Facebook4 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions reference specific aspects of the research, such as its application in skin biology and the effective delivery of mRNA for reversing skin aging. Phrases like 'cool work' and 'this is significant' indicate enthusiasm and a positive outlook on the research's applicability, contributing to an overall optimistic sentiment regarding its impact on future developments.

AgreementModerate agreement

Most discussions reflect a general support for the findings presented in the publication, with many comments highlighting its relevance.

InterestHigh interest

The posts demonstrate strong curiosity and intrigue about the research, particularly in its potential applications.

EngagementModerate engagement

Some posts indicate a moderate level of engagement, discussing related topics but mostly quoting or referencing the original research without deep dives.

ImpactHigh impact

The perceived significance of the publication is high, as many users convey that its findings could lead to advancements in the field.

Abstract in brief

  • Exosomes are effective carriers for nucleic acids due to their biocompatibility and ability to cross barriers that traditional drug-delivery systems can't.
  • The study introduces a method called cellular nanoporation, which significantly increases the yield of therapeutic mRNAs and targeting peptides in exosomes.
  • In mouse models of glioma, these mRNA-loaded exosomes demonstrated restored tumor-suppressor function, slowed tumor growth, and improved survival outcomes.

Top posts

Most liked on X and Bluesky
Eleanor Sheekey
@EleanorSheekey · X

Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellular vesicles vs. lipid nanoparticle gene delivery systms. Cool work by @BettyKimLab @wenjiang_nano & more! --> https://t.co/bu3EjF0LA9 #scicomm #AcademicYouTube https://t.co/QfL6B2wzvX

Feb 11, 2023 · 85 likes · 11 shares · 4,875 followers View post →
Nature Biomedical Engineering
@natBME · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co/uHFmHqXrOW

Dec 16, 2019 · 66 likes · 22 shares · 52,518 followers View post →
Kenneth W Witwer (he/him)
@KennethWWitwer · X

Cellular #nanoporation for scalable #EV production and #mRNA loading? Check out this #EVJournalClub paper @natBME https://t.co/TUHgNAK3pD with Michael Paulatis @HopkinsMedNews: Wed April 6, 12 noon (GMT-4) to join, see your email invitation or sign up at https://t.co/9sKDU43mcO https://t.co/z1LPWCnSeF

May 4, 2020 · 14 likes · 6 shares · 4,988 followers View post →
Kenneth W Witwer (he/him)
@KennethWWitwer · X

If you missed the #EVJournalClub with Michael Paulaitis @JohnsHopkins @HopkinsMedicine on cellular nanoporation for production and #RNA loading of #ExtracellularVesicles, it's up on our @YouTube channel now. Enjoy and please subscribe! @IsevComms @exRNA https://t.co/W9DfnePnT7

May 20, 2020 · 13 likes · 1 share · 4,987 followers View post →
J Controlled Release
@JCRnEDITORS · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. | Nature Biomedical Engineering | https://t.co/cZ7rHSlq7d

Feb 17, 2020 · 8 likes · 2 shares · 7,796 followers View post →
Swedish EV Network
@SweEVnet · X

This afternoon we will be listening to Loes Teeuwen, @SusanneGab group, KI, presenting a @NaturePortfolio (Biomedical Engineering) paper: https://t.co/ff3XMmEaFp in #ExoZoom https://t.co/OG58TAeeyT

Mar 29, 2023 · 7 likes · 2 shares · 309 followers View post →

All mentions

Marengo
@tacticalluddite · X

@sphengolipid there's this yt channel that I've been following lately the format is very reddit but she's always updating about longevity science so it might interest you https://t.co/TkLBto5ZKo

Jul 21, 2023 · 679 followers View post →
exRNA
@exRNA · X

#ERCC19 @ReateguiLab @OhioState Yang Nat Bio Eng 2020 Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/NeXEf32EId

May 2, 2023 · 2 likes · 2,149 followers View post →
Irma
@IrmaSchabussova · X

RT @SweEVnet: This afternoon we will be listening to Loes Teeuwen, @SusanneGab group, KI, presenting a @NaturePortfolio (Biomedical Enginee…

Mar 29, 2023 · 2 shares · 81 followers View post →
André Görgens
@andregorgens · X

RT @SweEVnet: This afternoon we will be listening to Loes Teeuwen, @SusanneGab group, KI, presenting a @NaturePortfolio (Biomedical Enginee…

Mar 29, 2023 · 2 shares · 875 followers View post →
Swedish EV Network
@SweEVnet · X

This afternoon we will be listening to Loes Teeuwen, @SusanneGab group, KI, presenting a @NaturePortfolio (Biomedical Engineering) paper: https://t.co/ff3XMmEaFp in #ExoZoom https://t.co/OG58TAeeyT

Mar 29, 2023 · 7 likes · 2 shares · 309 followers View post →
Patriot Boy Von Milky Way
@HelgerOun · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Mar 2, 2023 · 11 shares · 9,234 followers View post →
Betty Y.S. Kim, MD, PhD, FRCSC, FAIMBE
@BettyKimLab · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 16, 2023 · 11 shares · 1,871 followers View post →
Longevity Global
@LongevityGL · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 3,160 followers View post →
Alberto Sanz
@albertosanzmon1 · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 1,566 followers View post →
Nguyen An Hoang
@NguyenAnHoang4 · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 64 followers View post →
Matthew Van Norman
@mdvannorman · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 65 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 242 followers View post →
Gary Wang
@Wangg2017 · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 12, 2023 · 11 shares · 95 followers View post →
Jay
@jckellyinc · X

https://t.co/TiL1jW6z9o Skin reversal aging

Feb 11, 2023 · 19 followers View post →
hullpcfix
@hullpcfix · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 11, 2023 · 11 shares · 204 followers View post →
Mikołaj Idziok
@miki_edoc · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 11, 2023 · 11 shares · 92 followers View post →
ellie
@LyonsElisaveta · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 11, 2023 · 11 shares · 385 followers View post →
The Sheekey Science Show
@SheekeyScience · X

RT @EleanorSheekey: Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellula…

Feb 11, 2023 · 11 shares · 159 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Collagen mRNA delivery to reverse skin aging? This week, i stretched into skin biology and comparisons of extracellular vesicles vs. lipid nanoparticle gene delivery systms. Cool work by @BettyKimLab @wenjiang_nano & more! --> https://t.co/bu3EjF0LA9 #scicomm #AcademicYouTube https://t.co/QfL6B2wzvX

Feb 11, 2023 · 85 likes · 11 shares · 4,875 followers View post →
drchuckchan
@drchuckchan · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Aug 15, 2021 · 22 shares · 316 followers View post →
LUKMAN AFOLABI
@saintlukman · X

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/9T1O1qxRqG

Jun 15, 2021 · 921 followers View post →
Gary Beane
@pollinus66 · X

RT @nanotrac: Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/wR…

Jun 15, 2021 · 1 share · 2,024 followers View post →
NanoTrac Technologies
@nanotrac · X

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/wREicIy4V0 Nanoscience and technology @NatureNano #Nanoscience #Technology this is #Nature https://t.co/wKlZLZABjc

Jun 15, 2021 · 1 like · 1 share · 3,073 followers View post →
exRNA
@exRNA · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. https://t.co/jshs2xuBBu from @OhioState @UTSW_RadOnc #JilinUniversity @MSE_UJN @MayoClinic @IowaMed @PKU1898 @CellStanford @HMethodistMD @WeillCornell #SZBL https://t.co/D1K1SpYt6e

Aug 13, 2020 · 1 like · 2,149 followers View post →
exRNA
@exRNA · X

RT @KennethWWitwer: If you missed the #EVJournalClub with Michael Paulaitis @JohnsHopkins @HopkinsMedicine on cellular nanoporation for pro…

May 21, 2020 · 1 share · 2,152 followers View post →
Kenneth W Witwer (he/him)
@KennethWWitwer · X

If you missed the #EVJournalClub with Michael Paulaitis @JohnsHopkins @HopkinsMedicine on cellular nanoporation for production and #RNA loading of #ExtracellularVesicles, it's up on our @YouTube channel now. Enjoy and please subscribe! @IsevComms @exRNA https://t.co/W9DfnePnT7

May 20, 2020 · 13 likes · 1 share · 4,987 followers View post →
exRNA
@exRNA · X

from @OhioState @MSE_UJN @MayoClinic @UTSW_RadOnc #JilinUniversity @IowaMed @PKU1898 @StanfordMed @HMethodistMD: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. https://t.co/jshs2xuBBu @JohnsHopkins #EVJournalClub 2/3

May 6, 2020 · 1 like · 2,149 followers View post →
FrenchSocEVs
@French_Soc_EVs · X

RT @KennethWWitwer: Cellular #nanoporation for scalable #EV production and #mRNA loading? Check out this #EVJournalClub paper @natBME https…

May 4, 2020 · 6 shares · 1,377 followers View post →
Tanina Arab
@ArabTanina · X

RT @KennethWWitwer: Cellular #nanoporation for scalable #EV production and #mRNA loading? Check out this #EVJournalClub paper @natBME https…

May 4, 2020 · 6 shares · 889 followers View post →
Tom Driedonks, PhD
@tomdriedonks · X

RT @KennethWWitwer: Cellular #nanoporation for scalable #EV production and #mRNA loading? Check out this #EVJournalClub paper @natBME https…

May 4, 2020 · 6 shares · 1,477 followers View post →
Kenneth W Witwer (he/him)
@KennethWWitwer · X

Cellular #nanoporation for scalable #EV production and #mRNA loading? Check out this #EVJournalClub paper @natBME https://t.co/TUHgNAK3pD with Michael Paulatis @HopkinsMedNews: Wed April 6, 12 noon (GMT-4) to join, see your email invitation or sign up at https://t.co/9sKDU43mcO https://t.co/z1LPWCnSeF

May 4, 2020 · 14 likes · 6 shares · 4,988 followers View post →
Invictus Samael
@InvictusSamael · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/bSOAdToFzQ

Feb 17, 2020 · 660 followers View post →
J Controlled Release
@JCRnEDITORS · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. | Nature Biomedical Engineering | https://t.co/cZ7rHSlq7d

Feb 17, 2020 · 8 likes · 2 shares · 7,796 followers View post →
Danielle Bogdanowicz
@D_R_Bogdanowicz · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Feb 16, 2020 · 22 shares · 207 followers View post →
Nature Biomedical Engineering
@natBME · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Feb 16, 2020 · 22 shares · 52,518 followers View post →
COST DARTER
@AON_Delivery · X

RT @OTSociety: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation #mRNA #oligodelivery @AON_Delive…

Jan 30, 2020 · 1 share · 474 followers View post →
Oligonucleotide Therapeutics Society
@OTSociety · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation #mRNA #oligodelivery @AON_Delivery @DahlmanLab @MooresResearch @AndaloussiLab https://t.co/s0eYcuctX8 https://t.co/lXsQwAyDDi

Jan 22, 2020 · 1 like · 1 share · 4,093 followers View post →
Aviva Lev-Ari
@AVIVA1950 · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 24, 2019 · 22 shares · 1,074 followers View post →
Yu-Kyoung Oh
@YuKyoungOh1 · X

RT @JCRnEDITORS: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. | Nature Biomedical Engineer…

Dec 19, 2019 · 1 share · 947 followers View post →
Eduardo Reategui, PhD
@ReateguiLab · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 17, 2019 · 22 shares · 216 followers View post →
Monica Venere, PhD
@VenereLabOSU · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 17, 2019 · 22 shares · 435 followers View post →
Pharma-Networking
@PharmaNetwrking · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 17, 2019 · 22 shares · 5,848 followers View post →
Rosy
@Rosy_Favicchio · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 17, 2019 · 22 shares · 412 followers View post →
Centre for Nanotechnology in Medicine (CNTM)
@CntmMcr · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 17, 2019 · 22 shares · 2,428 followers View post →
Betty Y.S. Kim, MD, PhD, FRCSC, FAIMBE
@BettyKimLab · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 1,872 followers View post →
J Controlled Release
@JCRnEDITORS · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. | Nature Biomedical Engineering | https://t.co/cZ7rHSlq7d

Dec 16, 2019 · 4 likes · 1 share · 7,796 followers View post →
Invictus Samael
@InvictusSamael · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 660 followers View post →
J Controlled Release
@JCRnEDITORS · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 7,796 followers View post →
Fatemeh Karimi
@FatemehhhKarimi · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 619 followers View post →
Christina Schmidt
@_Christina_Sch · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 526 followers View post →
Huaxiao 'Adam' Yang
@firstage5 · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 510 followers View post →
Yadaly Gassama
@YadGassama · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 29 followers View post →
Jacky GOETZ
@GoetzJacky · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 3,507 followers View post →
Francesca Taraballi, Ph.D. (she/her)
@TaraballiPhD · X

RT @natBME: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co…

Dec 16, 2019 · 22 shares · 785 followers View post →
Nature Biomedical Engineering
@natBME · X

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation https://t.co/zUI2lJC38D https://t.co/uHFmHqXrOW

Dec 16, 2019 · 66 likes · 22 shares · 52,518 followers View post →