Tumor Microenvironment.

WL

Waggoner Lab

@LabWaggoner · X

Review @CellReports

GM

Gregory Zivic, MD

@metacollectiveG · X

@jsoriamd Expand your perspective beyond Big Pharma narratives. $NWBO has #DCVax for all solid tumors that primes the immune system, creates cytokine release, is Dendritic Cell based, pulls T cells into tumor microenvironment, primes T and B cells, creates memory. Add Poly ICLC + PD-1 mAb https://t.co/1YWmxBCDFp

GM

Gregory Zivic, MD

@metacollectiveG · X

@JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot. When combined with TLR agonist Poly ICLC and Keytruda it goes nuts on the recurrent GBM tumor microenvironment. Dr. Liau at UCLA has stunning data on this and no one’s talking but a handful of us. https://t.co/rz01SKda8N

The October issue of #ScienceImmunology is out! This month's cover highlights a Review that delves into brain tumor development and examines factors contributing to the immunosuppressive brain tumor microenvironment. Learn about this and more: https://scim.ag/46HgHcl

J

Jenkoo

@Jenkoool · X

Saturday 25th 12:30-4pm 2025 EORTC-NCI-AACR Discovery and characterization of novel pre|CISION® technology compounds delivering complementary dual payloads to the tumor microenvironment following FAP cleavage. Likely RNS Monday 27th on AVA6207 & partners payload #avct https://t.co/kNlDJUykWS

In mice w melanoma & lung CA, the vaxx triggered a robust type I IFN response that “reprogrammed” the tumor microenvironment, turning otherwise immune-cold tumors responsive to checkpoint blockade. This was mechanistically dependent on IFN-I signaling via MDA5 activation by mRNA-lipid nanoparticles

CM

Cell Reports Medicine

@CellRepMed · X

Online now: Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment https://t.co/LrxvPvjb5F

CH is also emerging as a clinically relevant factor in solid tumor treatment, influencing the tumor microenvironment, treatment response, and the risk of therapy-related complications.

ON

Oncology News

@Oncologynewspro · X

A multicenter team in China published a study in Nature Genetics, mapping the tumor microenvironment of esophageal cancer. They found GPR116⁺ pericells suppress immunity and promote tumor metastasis via the EGFL6-β1-NFκB signaling pathway. #esophagealcancer #TME https://t.co/WggoW1nEaI

AS

Annals of Gastroenterological Surgery

@surgery81261 · X

Blue LED light may offer a new approach to cancer treatment.

や

やっさん

@kuanyi_vet · X

RT @GravityParticle: @sasabubucha mRNAワクチン接種後に、体内のⅠ型インターフェロン（IFN-I）やPD-L1の発現が一時的に上昇し、 腫瘍の免疫環境（Tumor Microenvironment）が「よりICIに反応しやすい」状態になった、…

LL

Lum Lab

@lum_lab · X

RT @LabWaggoner: Review @CellReports

SS

Stephan Schäperklaus

@SSchaeperklaus · X

@newscientist Fascinating synergy: mRNA-LNP innate immune activation (TLR signaling, interferon) likely primes tumor microenvironment for anti-tumor immunity. Timing matters—adjuvant stimulation during early immunotherapy could overcome T-cell exhaustion. What's the mechanism?

CI

Clinical & Translational Immunology

@ClinTransImmuno · X

Review highlights immunosuppressive “cold” tumor microenvironment as a barrier to checkpoint blockade in cholangiocarcinoma and outlines immunomodulatory and translational model strategies to enhance therapeutic response. @ASImmunology @WileyGlobal https://t.co/8GJ1XtJ6gk

Constructing a Model Using Clock‐Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas Br&Beh

HA

Hepatos_Aion

@Hepatos_Aion · X

RT @HepatomaRes:

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Troy

@troyjurach · X

RT @Chrest_brett: Should be noted that the tumor microenvironment is incredibly heterogeneous. There seems to be a negative correlation bet…

VH

Victoria Hendry

@HendryVictoria · X

RT @biorxiv_cancer: STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://t.co/26P5vjqzt…

BB

bioRxiv Cancer Bio

@biorxiv_cancer · X

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://t.co/26P5vjqztn #biorxiv_cancer

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://www.biorxiv.org/content/10.1101/2025.10.24.684275v1

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma https://www.biorxiv.org/content/10.1101/2025.10.24.684275v1

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Grok

@grok · X

@Euglossine @Rob66733000 @outbreakupdates In cancer immunotherapy, "immunologically cold" tumors refer to those with low immune cell infiltration (e.g., few CD8+ T cells in the tumor microenvironment), low PD-L1 expression (often TPS <1%), and minimal immune activation, making them resistant to checkpoint inhibitors like

In the case of cancer, you want tumors to be "immunologically hot," meaning that there's lots of infiltration of immune cells (especially killer T cells) and they are highly activated. Unfortunately, many tumors are cold (immune desert, immune excluded)... www.cell.com/immunity/pdf...

For some types of cancer, like metastatic melanoma, these immunotherapies have been revolutionary. But, unfortunately, most people do not appear to benefit from cancer immunotherapy. Why? Well, there are a lot of reasons, but I'm going to focus on one really big one: the tumor microenvironment.

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Lisa

@LisainNJUSA · X

RT @metacollectiveG: @jsoriamd Expand your perspective beyond Big Pharma narratives. $NWBO has #DCVax for all solid tumors that primes the…

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PediDevPath

@PediDevPath · X

RT @SocPediPath: “Fetal growth restriction shapes how the body responds to cancer.” In Platform Session III, Dr. Terry Morgan shared groun…

YD

Yehuda M. Danino

@DaninoYehuda · X

RT @LabWaggoner: Review @CellReports

TL

the paper link

@the_paper_link · X

Trend new: Li S, ..., Ma X (Cell Rep) __Metabolic regulation of immunity in the tumor microenvironment__ https://t.co/CQGrO5RI3a

MH

Matthew Hassan

@HassanClan · X

RT @metacollectiveG: @jsoriamd Expand your perspective beyond Big Pharma narratives. $NWBO has #DCVax for all solid tumors that primes the…

In mice w melanoma & lung CA, the vaxx triggered a robust type I IFN response that “reprogrammed” the tumor microenvironment, turning otherwise immune-cold tumors responsive to checkpoint blockade. This was mechanistically dependent on IFN-I signaling via MDA5 activation by mRNA-lipid nanoparticles

AW

Always Watching

@mightynio · X

RT @metacollectiveG: @jsoriamd Expand your perspective beyond Big Pharma narratives. $NWBO has #DCVax for all solid tumors that primes the…

Online now: Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment

RS

Richard S

@Richard01173388 · X

RT @FrontImmunol: New Research: Chimeric switch and inverted cytokine receptors in T cell therapy: reprogramming T cells to overcome immune…

Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic‐Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer

MR

Maria Robles

@RBioceutics · X

RT @PatrickHwuMD: T cell therapy has incredible potential, but tumors don’t give up territory easily. In case you missed it, in this episod…

RP

Raffaele Di Giacomo, PhD

@sciqst · X

Cancer doesn’t act alone—it recruits a neighborhood. The tumor microenvironment (TME) is becoming the target, not the backdrop.

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Dieter

@Wuhle · X

RT @LabWaggoner: Review @CellReports

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MedComm - Future Medicine

@MedComm_FutMed · X

PD-1 inhibitor + HDACi + Anti-VEGF = Immunologically Active tumor microenvironment in MSS/pMMR CRC! CAPability-01 confirms the triplet enhances CD8+ T cell infiltration. https://t.co/U7jrD1VL0A

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xxy

@xxy07255392 · X

RT @LabWaggoner: Review @CellReports

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Pouya Goleij

@pouya_gl · X

RT @LabWaggoner: Review @CellReports

Identifying the therapeutic potential of Niclosamide in overcoming IFN-gamma dependent cancer immune evasion in the Tumor Microenvironment https://www.biorxiv.org/content/10.1101/2025.10.24.684401v1

Identifying the therapeutic potential of Niclosamide in overcoming IFN-gamma dependent cancer immune evasion in the Tumor Microenvironment https://www.biorxiv.org/content/10.1101/2025.10.24.684401v1

BI

bioRxiv Immunology

@biorxiv_immuno · X

Identifying the therapeutic potential of Niclosamide in overcoming IFN-gamma dependent cancer immune evasion in the Tumor Microenvironment https://t.co/pmTwvebxa4 #biorxiv_immuno

GM

Gregory Zivic, MD

@metacollectiveG · X

@jsoriamd Expand your perspective beyond Big Pharma narratives. $NWBO has #DCVax for all solid tumors that primes the immune system, creates cytokine release, is Dendritic Cell based, pulls T cells into tumor microenvironment, primes T and B cells, creates memory. Add Poly ICLC + PD-1 mAb https://t.co/1YWmxBCDFp

Identification and characterization of tumor-associated astrocyte subpopulations and their interactions with the tumor microenvironment in experimental glioblastomas @PLOSBiology.org

VH

Victor Hernández

@VicHdez27 · X

RT @LabWaggoner: Review @CellReports

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nike

@wot_mikey · X

RT @LabWaggoner: Review @CellReports

Don't miss the amazing guest symposia included in your Cytokines 2025 registration! Sunday, Nov. 2 at 1:00pm PST.

TL

the paper link

@the_paper_link · X

Trend new: Ma J, ..., He F (Nat Commun) __FAP(+) fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus__ https://t.co/fXgd42Ojcd

Applications are now being accepted from postdocs for the annual Montefiore Einstein Comprehensive Cancer Center ExCEL Scholar Award Competition on March 16, 2026. Deadline for submission is November 14, 2025. Learn more here: montefioreeinstein.org/cancer/educa...

A co-phagocytosis strategy for metastatic cancer Zhen Fan & team validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: insight.jci.org/articles/vie...

JI

JCI insight

@JCI_insight · X

A co-phagocytosis strategy for metastatic cancer! Zhen Fan & team @MDAndersonNews validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: https://t.co/Zzos0itrPE

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sharky

@sharky508 · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

SP

Soc. Pediatric Path.

@SocPediPath · X

“Fetal growth restriction shapes how the body responds to cancer.” In Platform Session III, Dr. Terry Morgan shared groundbreaking findings showing that developmental programming, not just hormones, influences the tumor microenvironment and cancer growth. #SPPFallMeeting https://t.co/oYMHCz7NPe

MS

Morning Glory Sciences

@MorningGlorySci · X

Resistance in glioblastoma isn’t just genetic — it’s environmental. Part 3 dives into the tumor microenvironment shaping relapse and therapy failure.

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DavidMiles

@DavidMiles488 · X

$SONN Focused on developing immunotherapies targeting the tumor microenvironment (TME), the company is poised to benefit from the demand for immuno-oncology and the partnership potential of its FHAB/ADC platform. Target price: $5 in the short term https://t.co/nlX39mGWEC

#BtBsSeminar by Alfonso Urbanucci, from Tampere University and Oslo University Hospital. "Understanding the prostate tumor microenvironment", October 27, 2025, 4:30 PM, U3-10 room, #BtBs, #BtBsUNIMIB, #UNIMIB . #BtBsSeminars www.btbs.unimib.it/en/events/bt...

DU

Dipartimento di Biotecnologie e Bioscienze-UNIMIB

@BtBsUNIMIB · X

#BtBsSeminar by @AUrbanucci from Tampere University and Oslo University Hospital. "Understanding the prostate tumor microenvironment", October 27, 2025, 4:30 PM, U3-10 room, #BtBs, #BtBsUNIMIB, @unimib . #BtBsSeminars https://t.co/x7ILs9jVbT https://t.co/S7T8ps86Ok

DY

Dr Mehmet Yildiz

@DigitalMehmet · X

RT @LabWaggoner: Review @CellReports

EC

Emircan Chester

@emircan_chester · X

RT @LabWaggoner: Review @CellReports

CK

Christina Kent

@zasqk32874799 · X

RT @GenesNDiseases: This review explores the crosstalk between glutamine metabolism and the tumor microenvironment, evaluates emerging ther…

WF

WADUDU HEALTH FOUNDATION

@DrWangila · X

RT @LabWaggoner: Review @CellReports

な

なぎ

@932nayaO380000 · X

RT @LabWaggoner: Review @CellReports

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Lorenzo

@PillowLovegood · X

RT @LabWaggoner: Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are assoc…

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Nicolas Stocker

@NStockerSAT · X

RT @LabWaggoner: Review @CellReports

FF

Follicular Lymphoma Foundation

@Cure_FL · X

Science Simplified

D

Diana

@PharmphoodTM · X

RT @LabWaggoner: Review @CellReports

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MedJ

@MedJ0401 · X

MedJ at JSCO 2025 @jsco_2025 Masakazu Toi @ToiMasakazu (President of the Japanese Breast Cancer Society), Tokyo Metropolitan Komagome Hospital, Japan Decoding the mechanisms of ADC drugs beyond traditional therapies and their unique impact on the tumor microenvironment, https://t.co/hE9MRfm1JR

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CrowdedHead

@CrowdedHead · X

RT @LabWaggoner: Review @CellReports

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AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @LabWaggoner: Review @CellReports

AJ

Alejandro Sosa Juarez

@AlejandroSosaJ3 · X

RT @LabWaggoner: Review @CellReports

FM

Frank Paul Mora

@InTime_49 · X

RT @LabWaggoner: Review @CellReports

CB

_curious_bug_

@_curious_bug_ · X

RT @LabWaggoner: Review @CellReports

LF

Lifeboat Foundation

@LifeboatHQ · X

Role of hypoxia in cancer therapy by regulating the tumor microenvironment https://t.co/GJ0AoP2p0s

JO

Jacqueline Oliva

@Liszeth · X

RT @LabWaggoner: Review @CellReports

JR

Jorge Rosas

@guruesmx · X

RT @LabWaggoner: Review @CellReports

CP

Chrystal Paulos

@Chrystal_Paulos · X

RT @LabWaggoner: Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are assoc…

FI

Frontiers - Immunology

@FrontImmunol · X

New Research: Exercise induced immune regulation and drug efficacy in rhinitis nasopharyngeal carcinoma implications for tumor microenvironment single cell immune signal transduction https://t.co/m6SGzsewQA #FrontiersIn #Immunology

AW

Always Watching

@mightynio · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

LL

Lum Lab

@lum_lab · X

RT @jitcancer: New #JITC article: Envirotune-CAR-T: a hypoxia-responsive and glutamine-enhanced CAR-T cell therapy for overcoming tumor mic…

NF

Natural Killer Cell Function

@nkfd_deficiency · X

Metabolic regulation of immunity in the tumor microenvironment: https://t.co/YTWahT4naL

KP

Kevin John Parrish

@kparrish51 · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

AP

Ask Perplexity

@AskPerplexity · X

@AlBowers11 @NicHulscher Hey there! The "tumor microenvironment" refers to the specific area and all the cells immediately surrounding a tumor. Lipid nanoparticles (LNPs) are tiny carriers used to deliver substances like mRNA into cells, and scientific research is focused on using their tendency to

A

AlBowers1

@AlBowers11 · X

@AskPerplexity @NicHulscher What does this mean? 8. Tumor microenvironment – LNPs accumulate in tumors, speeding spread.

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Nacho

@nachirulo21 · X

RT @LabWaggoner: Review @CellReports

AC

alphavestcapital.com

@alphavestcap · X

https://t.co/cmRYCu7OI9 $nwbo @alphavestcap https://t.co/tnKRGNEBgB https://t.co/ZrEunlY9mL #DCVax from $NWBO turns the tumor hot. When combined with TLR agonist Poly ICLC and Keytruda it goes nuts on the recurrent GBM tumor microenvironment. Dr. Liau at UCLA has stunning data https://t.co/lzKsGJQhWZ

AC

alphavestcapital.com

@alphavestcap · X

https://t.co/cmRYCu7OI9 $nwbo @alphavestcap https://t.co/tnKRGNEBgB https://t.co/ZrEunlY9mL #DCVax from $NWBO turns the tumor hot. When combined with TLR agonist Poly ICLC and Keytruda it goes nuts on the recurrent GBM tumor microenvironment. Dr. Liau at UCLA has stunning data https://t.co/lzKsGJQhWZ

AC

alphavestcapital.com

@alphavestcap · X

https://t.co/cmRYCu8mxH $nwbo @alphavestcap https://t.co/tnKRGNF969 #DCVax from $NWBO turns the tumor hot. When combined with TLR agonist Poly ICLC and Keytruda it goes nuts on the recurrent GBM tumor microenvironment. Dr. Liau at UCLA has stunning data on this and no one’s https://t.co/lzKsGJQPMx

VH

Victoria Hendry

@HendryVictoria · X

RT @LabWaggoner: Review @CellReports

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Davut

@Davut43623415 · X

RT @simon_troupe: RECENT STUDY: Unravelling the genetics and epigenetics of the ageing tumor microenvironment in cancer

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TRCH'r

@JustFactivist · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

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Catherine

@AhmedRa08415551 · X

RT @ScienceMagazine: A 2023 @SciImmunology Review contextualizes advances in CAR T cell #cancer immunotherapy, summarizing studies that exp…

JV

Johan Vanden

@JVanden · X

RT @JVanden: Ammonia: Cancer's Hidden Immunosuppressive Weapon > https://t.co/4aFBIr6iBO Ammonia accumulation in the tumor microenvironmen…

DH

Duke Health

@DukeHealth · X

Duke Health is advancing the treatment of chondrosarcomas with breakthrough discoveries in malignancy genes and the tumor microenvironment. Read more ➡️ https://t.co/hdul0AQlnZ @DukeCancer @DukeOrtho https://t.co/YMkvZonQ3b

JD

Jason R. Williams, MD, DABR

@jasonwilliamsmd · X

5/ ROS also shape the tumor microenvironment and immune response. Intermediate levels enhance T cell function and boost antitumor immunity. Too high? Immune exhaustion. Cancer manipulates this balance just as it hijacks the immune system.

WL

Waggoner Lab

@LabWaggoner · X

Review @CellReports

Review @cp-cellreports.bsky.social Metabolic regulation of immunity in the tumor microenvironment www.cell.com/cell-reports...

JS

john s

@johnjoescanlan · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

TN

The Biotech Newswire

@BiotechNewswire · X

New Research Team for Multispecific Biologics in Collaboration with Daiichi Sankyo Starts at the BioMed X Institute in Heidelberg. Research targets innovative pathways in the tumor microenvironment (TME) https://t.co/xHZYSzt7aE #biotech #Oncology https://t.co/ERBxULvFOD

JR

Jorge Rosas

@guruesmx · X

RT @LabWaggoner: Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are assoc…

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Neuromics

@Neuromics · X

Researchers from the University of Kentucky utilized our colorectal CAFs (https://t.co/X5wDUS23fy) in a new paper examining how CAFs contribute to chemotherapy resistance. Learn more: https://t.co/l0ZUROLpEh #cancerresearch #colorectalcancer https://t.co/NywY5c68QQ

New Journal for ImmunoTherapy of Cancer article: Envirotune-CAR-T: a hypoxia-responsive and glutamine-enhanced CAR-T cell therapy for overcoming tumor microenvironment-mediated suppression t.co/NESZ0VBVXQ #JITC #ImmunoSky

ON

Oncology News

@Oncologynewspro · X

Two Chinese research teams jointly published a study in Nature Metabolism. The research revealed that TAMs act as an acetic acid source in the tumor microenvironment, enhancing acetyl-CoA synthesis to drive liver cancer metastasis. The finding offers a potential target for HCC. https://t.co/1aNUjDkcuN

DY

Dr Mehmet Yildiz

@DigitalMehmet · X

RT @CellReports: Metabolic regulation of immunity in the tumor microenvironment https://t.co/GKipZI7ta7

TN

The Biotech Newswire

@BiotechNewswire · X

New Research Team for Multispecific Biologics in Collaboration with Daiichi Sankyo Starts at the BioMed X Institute in Heidelberg. Research targets innovative pathways in the tumor microenvironment (TME) https://t.co/xHZYSzt7aE #biotech #Oncology #BioMedX https://t.co/YsHGLMXolM

EC

Emircan Chester

@emircan_chester · X

RT @LabWaggoner: Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are assoc…

MG

Multi-Omics AWG - NASA GeneLab

@MultiOmicsAWG · X

RT @CellReports: Metabolic regulation of immunity in the tumor microenvironment https://t.co/GKipZI7ta7

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R

@Cooler_1982 · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

AD

Andrew Caravello, DO

@andrewcaravello · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

KC

Kauri Capital

@KauriCapital · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

S

SonnyJPS

@Golferpab1965 · X

RT @metacollectiveG: @JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot.…

FI

Frontiers - Immunology

@FrontImmunol · X

New Research: Correction: Study of epirubicin sustained–release chemoablation in tumor suppression and tumor microenvironment remodeling https://t.co/SNMzbddJqK #FrontiersIn #Immunology

YK

y2kstealth

@GoldAmman · X

@bradloncar Next $MDNAF mdna113?. MDNA113 is a novel, first-in-class tumor-targeted and conditionally activated bispecific anti-PD1-IL-2 Superkine. Conditional activation: Enzymes in the tumor microenvironment cleave the linker, releasing the IL-13 Superkine mask.

J

Jenkoo

@Jenkoool · X

Saturday 25th 12:30-4pm 2025 EORTC-NCI-AACR Discovery and characterization of novel pre|CISION® technology compounds delivering complementary dual payloads to the tumor microenvironment following FAP cleavage. Likely RNS Monday 27th on AVA6207 & partners payload #avct https://t.co/kNlDJUykWS

CV

Carlos Ventura

@Carlos_JVM · X

RT @CellReports: Metabolic regulation of immunity in the tumor microenvironment https://t.co/GKipZI7ta7

BH

Bilal Hasan

@Bilal_Hasan00 · X

@huzheng1 Fascinating work, Professor Hu! The integration of single-cell lineage tracing with genomic modeling offers great insight into metastatic organotropism. Could similar approaches be applied to study tumor–microenvironment interactions in pancreatic or colorectal cancers?

I

iOncologi

@ioncologi · X

This discovery shows how an infectious-disease vaccine can reprogram the tumor microenvironment, the same principle driving iOncologi’s UNIFYRs™ platform (Universal Immune FortifYing RNAs) — using universal mRNA vaccines to overcome immunotherapy resistance.

TN

The Biotech Newswire

@BiotechNewswire · X

New Research Team for Multispecific Biologics in Collaboration with Daiichi Sankyo Starts at the BioMed X Institute in Heidelberg. Research targets innovative pathways in the tumor microenvironment (TME) https://t.co/xHZYSztF0c #biotech #Oncology #BioMedX @EUdaiichisankyo https://t.co/TII72zO87V

GM

Gregory Zivic, MD

@metacollectiveG · X

@JohnnyTStine @EricTopol @Nature @MDAndersonNews @StevenLin_MDPhD @adam_grippin #DCVax from $NWBO turns the tumor hot. When combined with TLR agonist Poly ICLC and Keytruda it goes nuts on the recurrent GBM tumor microenvironment. Dr. Liau at UCLA has stunning data on this and no one’s talking but a handful of us. https://t.co/rz01SKda8N

MM

Mukul Vij, MD

@vij_mukul · X

RT @HepatomaRes:

Identification and characterization of tumor-associated astrocyte subpopulations and their interactions with the tumor microenvironment in experimental glioblastomas @PLOSBiology.org

Journals | Visualized Cancer Medicine | Article Highlight #OpenAccess This article highlights myCAFs as pivotal regulators of the tumor microenvironment and discusses how targeting these cells can enhance immunotherapy responsiveness and disrupt tumor growth mechanisms. ➡️ bit.ly/47iAXzY

Mechanistically, the tumor microenvironment factor TGFβ enhanced CPT1A expression and activity through an AMPK-dependent pathway, thereby promoting EMT.

Our new publication in @cp-immunity.bsky.social: Tertiary lymphoid structures with signs of functional adaptive immune responses in a subset of human gliomas. Association with longer overall patient survival and more immune-permissive tumor microenvironment. doi.org/10.1016/j.im...

Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment @cp-immunity.bsky.social www.cell.com/immunity/ful...

Identification and characterization of tumor-associated astrocyte subpopulations and their interactions with the tumor microenvironment in experimental glioblastomas @PLOSBiology.org

Dr. Dan Huh and colleagues present a microengineered system that enables vascularization of human tumor explants and their controlled perfusion with immune cells to model the activity of CAR-T cells in the tumor microenvironment.

The method identifies six pan-cancer conserved miRNAs and uncovers cell-type-specific regulatory networks, providing insights into miRNA-mediated mechanisms in cancer progression and the tumor microenvironment.

Want to understand the tumor microenvironment? Turn to our human primary cancer associated fibroblasts (CAFs). Our CAFs are consistently used in groundbreaking research. Learn more: www.neuromics.com/fibroblasts-... #cancerresearch #CAFs

Our PI Kirsi attended the 20th EANO meeting organized in Prague last week. She presented our work on hypoxia in the tumor microenvironment of diffuse astrocytomas and enjoyed sharing thoughts with Dr. David Zagzag about his work on hypoxia in chordomas @eanoassociation.bsky.social #EANO2025

Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function

Functional enrichment and immune profiling revealed SPATS2's involvement in cell cycle, DNA repair, metabolism, and modulation of the tumor microenvironment, with increased infiltration of immunosuppressive cells.

This real-world evidence study analyzed the tumor microenvironment of 45 advanced urothelial cancer patients treated with atezolizumab.

Inspiring session on the relevance of CNS border immunology in brain malignancies and of the tumor microenvironment!

Germline genetic risk converges through intercellular crosstalk in tumor microenvironment https://www.medrxiv.org/content/10.1101/2025.10.14.25337882v1

In @elife.bsky.social: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment doi.org/10.7554/eLif...

Review: Reprogramming NK cells in the tumor microenvironment: Challenges and therapeutic opportunities www.sciencedirect.com/science/arti...

Review @cp-molcell.bsky.social Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function www.cell.com/molecular-ce...

As we celebrate #BreastCancerAwarenessMonth, we spotlight #NASmember Kornelia Polyak, whose pioneering work on tumor heterogeneity and the tumor microenvironment is shaping the future of more personalized breast cancer care. Read her Q&A: www.nasonline.org/news/breast-...

Multifunctional nano-MOFs based on tumor microenvironment modulation for detecting singlet oxygen and enhancing photodynamic therapy http://pubs.rsc.org/en/Content/ArticleLanding/2025/NR/D5NR01806D

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins https://www.biorxiv.org/content/10.1101/2025.10.15.682084v1

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins https://www.biorxiv.org/content/10.1101/2025.10.15.682084v1

Citrullination in tumor immunity and therapy This Review by Michael R. Pitter & Weiping Zou discusses how citrullination regulates immune cell function within the tumor microenvironment and its potential as a target in cancer immunotherapy: www.jci.org/articles/vie...

Join @washugenetics.bsky.social TODAY at 12pm in Connor Auditorium when Guangyong Peng, MD, PhD, presents “Senescent T Cells in the Tumor Microenvironment: Emerging Challenges for Immunotherapy”, hosted by Tristan Li, PhD.

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Sept Highlights in Science Immunology

Online now: Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironment

Employing multi-omics analyses, the study sheds light on the complex processes underlying tumor initiation, progression, and the critical role of the tumor microenvironment.

Aignostics Unveils AI-Powered Application for Tumor Microenvironment Profiling #USA #Berlin #Aignostics #tumor_profiling #Atlas_HE-TME

Aignostics Launches AI-Powered Application for Tumor Microenvironment Profiling #Germany #Berlin #Aignostics #Tumor_Microenvironment #Atlas_HE-TME

Aignostics Launches AI-Powered Application for Tumor Microenvironment Profiling www.viv-media.com/infozx-37705...

Online now: Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment

Aignostics Unveils an AI-Driven App for Tumor Microenvironment Analysis #USA #Aignostics #AI_App #Atlas_HE-TME #Berlin,_New_York

Aignostics Unveils Atlas HE-TME: A Game Changer in Tumor Microenvironment Analysis #USA #New_York #Aignostics #Tumor_Microenvironment #Atlas_HE-TME

Aignostics Unveils Atlas HE-TME: Revolutionizing Tumor Microenvironment Analysis with AI Technology #USA #AI_Technology #Aignostics #Berlin_and_New_York #Atlas_HE-TME

Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment www.cell.com/cell-reports... @cp-cellrepmed.bsky.social

Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironment @cp-cellrepmed.bsky.social @harvardmed.bsky.social www.cell.com/cell-reports...

Joint analysis of expression and variation at single cell resolution by scVar [new] Analyzes single-cell transcriptomic data to detect mutations, facilitating the study of tumor heterogeneity and the tumor microenvironment.

Causal Modeling Reveals Cell-Cell Communication Dynamics in the Tumor Microenvironment During Anti-PD-1 Therapy in Breast Cancer Patients #SingleCell

Causal Modeling Reveals Cell-Cell Communication Dynamics in the Tumor Microenvironment During Anti-PD-1 Therapy in Breast Cancer Patients [new]

Causal Modeling Reveals Cell-Cell Communication Dynamics in the Tumor Microenvironment During Anti-PD-1 Therapy in Breast Cancer Patients https://www.biorxiv.org/content/10.1101/2025.10.08.681192v1

Causal Modeling Reveals Cell-Cell Communication Dynamics in the Tumor Microenvironment During Anti-PD-1 Therapy in Breast Cancer Patients https://www.biorxiv.org/content/10.1101/2025.10.08.681192v1

Discover how spheroids-on-chip are transforming preclinical cancer research!

The findings highlight the complex tumor microenvironment, with significant variability between patients and within individual tumors.

Glutamine: Targeted Metabolic Therapy in Tumors In the relentless pursuit of innovative cancer therapies, a novel target is capturing the attention of the oncology research community: glutamine metabolism within the tumor microenvironment (TME). The amino acid glutamine, long recognized for its…

This research paper explores the role of the CD47-SIRPα checkpoint in the tumor microenvironment of multiple myeloma. The authors review the preclinical evidence supporting the targeting of this axis to reactivate macrophage-mediated phagocytosis of myeloma cells.

These findings provide valuable insights into the mechanisms by which the tumor microenvironment influences PDAC progression and identify collagen XVII signaling as a potential therapeutic target for this devastating disease.

Thus, acidosis is not merely a byproduct of altered metabolism in tumors. Rather, it is a dominant factor in the tumor microenvironment that orchestrates a boost in mitochondrial energy production, thereby rendering cancer cells resilient to different types of stress.

Acidic Tumor Microenvironment Enhances Cancer Cell Survival and Proliferation Tumors represent one of the most inhospitable microenvironments within the human body, marked by severe deficiencies in oxygen, scarce nutrient availability, and an accumulation of metabolic byproducts, often harmful to…

Tertiary Lymphoid Structures Predict Esophageal Cancer Outcomes Recent advances in cancer immunology have spotlighted the critical role that tertiary lymphoid structures (TLS) play within the tumor microenvironment. These ectopic lymphoid aggregates, which develop at sites of chronic inflammation,…

Biology student Genèvive Pearce presents her honors project on lactic acidosis and pH balance in breast cancer. Using the seed-and-soil analogy, Genèvive explains how the tumor microenvironment, much like the soil surrounding a seed, shapes cancer growth and progression. youtu.be/otWPUZ8luvMv

A novel immunotherapy combination targeting specific immune signals has been shown in preclinical models to eliminate colorectal cancer liver metastases by reshaping the tumor microenvironment. doi.org/g955qz

Nanomedicine is emerging as a promising approach to enhance cancer immunotherapy, offering new strategies to improve drug delivery and reprogram the tumor microenvironment. doi.org/g955kz

Uncover the secrets of bladder cancer's tumor microenvironment! This study links key ICD genes to immune profiles, prognosis, and immunotherapy response, paving the way for personalized t...

IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice #gdTcells @jci.org

This suggests that the tumor microenvironment may play a role in how patients respond to this combination therapy . Evidence that #mitazalimab's mechanism of action , activating the immune system was a significant factor in patient outcomes. Several findings point to this conclusion

IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice @jci.org www.jci.org/articles/vie...

At the Tumor Heterogeneity, Plasticity and Therapy Conference (#THPT25) in Leuven from 10–12 December, Eduard Batlle from IRB Barcelona will show how the tumor microenvironment can facilitate immune evasion and metastasis. Abstract deadline: 8th of October vibbio.tech/THPT25

Why do cancer therapies often fail? Leon Strzadala proposes a novel therapeutic approach that includes dismantling of the tumor microenvironment adaptations (e.g. hypoxia), inhibiting oncogenic Ras signaling and restoring p53 activity. tinyurl.com/55af4p2z #cancer #therapy

Robust multicellular programs dissect the complex tumor microenvironment and track disease progression in colorectal adenocarcinomas #SingleCell

Loan Vulliard, et al.: Robust multicellular programs dissect the complex tumor microenvironment and track disease progression in colorectal adenocarcinomas https://arxiv.org/abs/2510.05083 https://arxiv.org/pdf/2510.05083 https://arxiv.org/html/2510.05083

Exosomal RNAs: Linking Cancer and Stem Cells In the intricate landscape of cancer biology, the tumor microenvironment (TME) emerges as a dynamic and multifaceted arena where cancer stem cells (CSCs) coexist and interact with a myriad of other cellular components. This environment is an ecosystem…

Robust multicellular programs dissect the complex tumor microenvironment and track disease progression in colorectal adenocarcinomas [new] CRC progress: multi-cell metab. & spatial change in TME.

It examines how these unique RNA molecules can regulate key signaling pathways, such as NF-κB and JAK/STAT, that are activated in the Epstein-Barr virus-infected tumor microenvironment.

The October issue of #ScienceImmunology is out! This month's cover highlights a Review that delves into brain tumor development and examines factors contributing to the immunosuppressive brain tumor microenvironment. Learn about this and more: https://scim.ag/46HgHcl

Steroid Differentiation Sculpts Adrenal Tumor Microenvironment In a groundbreaking study published in Nature Communications, a team of researchers has unveiled the complex interplay between steroid differentiation and the tumor microenvironment in adrenal tumors using an innovative single-nucleus…

in the setting of cancer, which maintains an immunosuppressive tumor microenvironment to prevent elimination by the immune system. We now have antibodies against CTLA-4 used for cancer treatment (immune checkpoint inhibitors): www.nejm.org/doi/full/10....

Preclinical studies demonstrate exercise's ability to modulate the tumor microenvironment and reduce growth, while observational studies link higher post-diagnosis exercise to lower mortality rates.

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week! scim.ag/46TGooP

Pancreatic Tumor Microenvironment: Challenges and Opportunities In the relentless battle against pancreatic ductal adenocarcinoma (PDAC), the medical community has been continuously confronted by the stubbornly poor outcomes associated with this formidable malignancy. Despite advances in…

This study examined PD-L1 expression and the tumor microenvironment in high-grade serous ovarian cancer patients enrolled in the NeoPembrOV/GINECO Phase II trial.

Unraveling the complex tumor microenvironment in ovarian cancer - PD-L1 expression varies across tissue types, impacting immunotherapy response. Insights into ovarian cancer biology could...

Using a breast tumor microenvironment-on-a-chip model, researchers at @asuengineering.bsky.social studied the interactions between triple-negative breast cancer, fibroblasts, and immune cells that drive tumor progression. advanced.onlinelibrary.wiley.com/doi/10.1002/... 9/ #organonchip

Fortunately, advances like human #breastcancer organoids, tumor microenvironment-on-chips, and computational modeling are opening new doors to more accurate insights into tumor biology, early detection, and treatment response. 3/

Emily Alefeld (Abteilung Neuroanatomie am Institut für Anatomie II); für “In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies”; www.nature.com/articles/s41... 6/6

POST-DOCTORAL POSITION TO STUDY THE TUMOR MICROENVIRONMENT IN AML #ScienceJobs #AcademicSky

pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders.

Signal or noise? > Targeting tumor microenvironment with biomimetic nanovesicles for non-small cell lung cancer gene therapy - Journal of Nanobiotechnology >> Comment below! #strategy #competitiveintelligence #marketing #competitivemarketing #pharmaceutical #biotech #healthcare #pharma

I don’t know if there’s a good way to explain to non-scientists what it’s like to have spent years with various mental pictures of different aspects of a complex system, here the tumor microenvironment, imagining how it might look or act, and then SEEING IT FOR REAL www.nature.com/articles/s41...

The paper discusses the clinical translation and application prospects of these metabolism-targeted nanodrug delivery systems in cancer therapy, providing insights into a novel approach to overcome the immunosuppressive tumor microenvironment.

Fibroblast miR-223-3p Boosts Colon Cancer Resistance In the relentless battle against colon cancer, groundbreaking research has illuminated a covert communication channel within the tumor microenvironment that escalates the malignancy and drug resistance of cancer cells. Scientists have discovered…

Revealing Shared Tumor Microenvironment Dynamics Related to Microsatellite Instability Across Different Cancers Using Cellular Social Network Analysis https://www.medrxiv.org/content/10.1101/2025.09.28.25336824v1

#NatMetabPicks | In @nature.com led by @danwahlmd.bsky.social‬ @lyssiotislab.bsky.social @dnagrathlab.bsky.social WN Al-Holou ( @umich.edu ) Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction.

Breakthrough Discovery Reveals How Arsenic Targets Acute Promyelocytic Leukemia In a groundbreaking study conducted by researchers at Harbin Medical University, the intricate landscape of the tumor microenvironment in acute promyelocytic leukemia (APL) patients undergoing arsenic trioxide (ATO)…

Chronic lymphocytic leukemia (CLL) cells reprogram their tumor microenvironment to promote drug resistance and tumor progression. Targeting the AP-1 transcription factor and stromal compartment may offer new treatment strategies.

Additionally, Mn2+-induced reactive oxygen species (ROS) amplify ferroptosis, and RIPK3-mediated necroptosis remodel the immunosuppressive tumor microenvironment by promoting M1 macrophage polarization and a Th1-type immune response.

Nanoshield-assisted gene therapy triggers non-apoptotic cell death, remodels the tumor microenvironment, and induces durable antitumor immunity, offering a promising synergistic approach ...

New #JITC article: MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment bit.ly/4gyafr8

Hypoxia within the tumor microenvironment drives chronic activation of ATF4, which promotes metabolic polarity and cell death of tumor-infiltrating CD8+ T cells @cp-immunity.bsky.social www.cell.com/immunity/ful...

Dual Tim-3 and STAT-3 Silencing Drives Tumor Regression In a groundbreaking study poised to reshape cancer immunotherapy, researchers have identified a promising therapeutic strategy that targets two pivotal molecular players within the tumor microenvironment: Tim-3 and STAT-3. This dual silencing…

Unlike PD-1 expression, CTLA-4 expression on ILC2 and interaction with macrophages is associated with the maintenance of a reactive state (prevent exhaustion) during chronic inflammation in the tumor microenvironment www.nature.com/articles/s41...

A new Fred Hutch study published last week in @cp-cellrepmed.bsky.social finds that many drugs initially written off as ineffective on cultured cancer cell lines in a Petri dish are effective when tested on tissues slices that more accurately represent the tumor microenvironment. bit.ly/3W73Z06

See how the #VisiumHD 3’ whole transcriptome assay powers comprehensive spatial characterization of the tumor microenvironment in our #AACR2025 poster. https://bit.ly/46Q9d6w

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Interest | Match | Feed

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Interest | Match | Feed

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Interest | Match | Feed

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Cancer immunotherapy (CIT) has become a standard of care in multiple indications. Apart fro... #biomarkers #cancer #immunotherapy Origin | Interest | Match

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Cancer immunotherapy (CIT) has become a standard of care in multiple indications. Apart fro... #biomarkers #cancer #immunotherapy Origin | Interest | Match

Biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment (2025) Cancer immunotherapy (CIT) has become a standard of care in multiple indications. Apart fro... #biomarkers #cancer #immunotherapy Origin | Interest | Match

Prior treatments can also alter the tumor microenvironment, affecting subsequent immunotherapy responses. Age-related factors, including immunosenescence, influence resistance, with older patients exhibiting higher tumor mutational burden and more immunogenic microenvironments.

The immunosuppressive tumor microenvironment, characterized by regulatory T cells and myeloid-derived suppressor cells, is another critical factor hindering ICI effectiveness. Additionally, metabolic changes and deficient antigen presentation further compound the resistance.

Unraveling the complexities of immunotherapy resistance in non-small cell lung cancer - genetic mutations, tumor microenvironment, and age-related factors hold the key to personalized tre...

#IMNN: OVATION 2 Translational Data Shows IMNN-001 Alters Tumor Microenvironment… buff.ly/jwPl7jD

New review article on our journal: Reprogramming the tumor microenvironment: synergistic mechanisms of antibody–drug conjugates and immune checkpoint inhibitors doi.org/10.1093/abt/... #OpenAccess #ADC #ICI #TME #irAE #IMER #Oncology

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#mdpiMedicina - Have a look at the top-cited paper ''Tumor Microenvironment'' More info at: https://t.co/saAVRmLfhv https://t.co/tXW7tITOjM