Nat Cell Biol January 2020 PMID 31907414

Circadian control of the secretory pathway maintains collagen homeostasis.

Joan Chang, Richa Garva, Adam Pickard, Ching-Yan Chloé Yeung, Venkatesh Mallikarjun, Joe Swift, David F Holmes, Ben Calverley, Yinhui Lu, Antony Adamson, Helena Raymond-Hayling, Oliver Jensen, Tom Shearer, Qing Jun Meng, Karl E Kadler

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Mentions

Peak: 20 in Jan 2020

across 5 sources since Nov 2019

Extended reach

112,853

potential audience

Total likes

198

Video views

Mentions per month

Nov 2019 – Oct 2024

Where it's discussed

News42 articles
X / Twitter39 posts
Facebook5 posts
YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

Several discussions highlight the importance of the circadian rhythm in maintaining collagen, with phrases like 'regulates collagen homeostasis' and 'beauty sleep might be true after all,' indicating a focus on physiological and cosmetic implications. The tone combines scientific appreciation with casual interest, demonstrating both respect for the research and curiosity about its broader relevance.

AgreementModerate agreement

Most discussions recognize the significance of the study, with some posts explicitly congratulating the research team, indicating general support and acknowledgment of the findings.

InterestHigh interest

Posts show high curiosity about the mechanisms, particularly noting the circadian regulation of collagen and potential broader implications, as seen in comments about 'regulating secreted things' and 'beauty sleep'.

EngagementModerate engagement

While many posts reference the core findings, they tend to share brief summaries or praise rather than deep analysis, suggesting moderate engagement.

ImpactModerate impact

There is a sense that the research is considered impactful, especially given repeated mentions of its significance for tissue health and potential applications, although the tone remains optimistic rather than urgent.

Abstract in brief

Collagen is a key protein in vertebrates that lasts throughout life without renewal, despite ongoing synthesis and maintenance of collagen networks.
This study reveals a circadian regulation of collagen production and transport, with synthesis occurring at night and assembly during the day in mice.
Disruption of the circadian clock leads to abnormal collagen fibrils and accumulation, but this can be reversed with specific drug treatments, highlighting the importance of these rhythms for maintaining tissue function.

Read the full abstract

All mentions

Circadian Regulation of Collagen Production and Transport in Tissue Homeostasis

This video explains how the body's circadian clock controls collagen synthesis and transport, essential for maintaining tissue structure and function. Disruption affects collagen organization, but can be reversed with…

Carmen L · Jan 16, 2020 86 views

Circadian Regulation of Collagen Production and Homeostasis in Vertebrates

This video explains how the circadian clock controls collagen synthesis and transport, maintaining tissue integrity. Disruption can cause abnormal fibrils and accumulation, but can be reversed with targeted treatments.

醫指乾坤 · Oct 21, 2024 5 views

Jake Tuura

@jake_tuura · X

Aug 19, 2022 · 5 likes · 8,198 followers View post →

s. Peter Magnusson

@SPMagnuss · X

RT @KarlKadler: Two years on and our paper ‘Circadian control of the secretory pathway maintains collagen homeostasis’ Nat Cell Biol 22, 74…

Jan 24, 2022 · 3 shares · 423 followers View post →

Joan Chang

@tranejoan · X

RT @KarlKadler: Two years on and our paper ‘Circadian control of the secretory pathway maintains collagen homeostasis’ Nat Cell Biol 22, 74…

Jan 22, 2022 · 3 shares · 959 followers View post →

Chloé Yeung

@ccstorytime · X

RT @KarlKadler: Two years on and our paper ‘Circadian control of the secretory pathway maintains collagen homeostasis’ Nat Cell Biol 22, 74…

Jan 22, 2022 · 3 shares · 1,701 followers View post →

Karl Kadler

@KarlKadler · X

Jan 22, 2022 · 44 likes · 3 shares · 1,037 followers View post →

Annika Reads

@papersofnote · X

In this work from the @KarlKadler lab, the authors show that circadian regulation of secretory pathway components in tendon maintain collagen homeostasis. Which seems like a way to potentially regulate a LOT of secreted things! https://t.co/xQu5e0WqtE

Dec 20, 2020 · 1,064 followers View post →

Spencer Szczesny

@spence_sz3 · X

@ManuelKRausch1 @JeffWeissUT @ActaBio @TheRealAllenLin @KarlKadler https://t.co/AdjFYOqDsV

Oct 15, 2020 · 981 followers View post →

Riku Pasonen

@Raitziger · X

RT @JariLouhelainen: Beauty sleep might be true after all. Take care of your collagen! https://t.co/X7mzGJpkBW

Jan 22, 2020 · 1 share · 4,226 followers View post →

Jari Louhelainen

@JariLouhelainen · X

Beauty sleep might be true after all. Take care of your collagen! https://t.co/X7mzGJpkBW

Jan 22, 2020 · 1 share · 386 followers View post →

the paper link

@the_paper_link · X

Trend new: *Chang J* et al (Nat Cell Biol) __Circadian control of the secretory pathway maintains collagen homeostasis.__ https://t.co/pqzGIzyfcB

Jan 11, 2020 · 137 followers View post →

Tgalli

@tgalli · X

RT @Montibeller_GG: Circadian control of the secretory pathway maintains collagen homeostasis https://t.co/suK6lDgOFh

Jan 9, 2020 · 1 share · 2,264 followers View post →

Luigi Montibeller

@Montibeller_GG · X

Circadian control of the secretory pathway maintains collagen homeostasis https://t.co/suK6lDgOFh

Jan 9, 2020 · 7 likes · 1 share · 428 followers View post →

Angelika Hausser

@AngelikaHausse7 · X

RT @rinatie_ceo: Circadian control of the secretory pathway maintains collagen homeostasis https://t.co/o4IM9KBMjm

Jan 9, 2020 · 1 share · 129 followers View post →

Rina Saltman

@rinatie_ceo · X

Circadian control of the secretory pathway maintains collagen homeostasis https://t.co/o4IM9KBMjm

Jan 9, 2020 · 1 like · 1 share · 3,562 followers View post →

Francis Villatoro

@emulenews · X

Circadian control of the secretory pathway maintains collagen homeostasis https://t.co/2ru2ZmBo10 https://t.co/dgW17oIKeR

Jan 8, 2020 · 1 like · 45,154 followers View post →

Hugo Angulo

@thermotronica · X

RT @cell_club: https://t.co/kfuHRuVFtR Circadian control of the secretory pathway maintains collagen homeostasis Nature Cell Bio.

Jan 7, 2020 · 1 share · 2,976 followers View post →

Cell Biology J-Club

@cell_club · X

https://t.co/kfuHRuVFtR Circadian control of the secretory pathway maintains collagen homeostasis Nature Cell Bio.

Jan 7, 2020 · 6 likes · 1 share · 6,188 followers View post →

Alan Hibbitts

@Alan_Hibbitts · X

RT @KarlKadler: Congrats to our team!

Jan 7, 2020 · 16 shares · 713 followers View post →

Andrew D'Lugos

@AndrewDLugosPhD · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 92 followers View post →

Siddharth Krishnan

@sidnificantdata · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 951 followers View post →

s. Peter Magnusson

@SPMagnuss · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 423 followers View post →

Abigail Mackey

@AbigailMackey1 · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 3,717 followers View post →

Rachel Lennon

@RLWczyk · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 1,827 followers View post →

Farshid Guilak

@Farsh_G · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 7,222 followers View post →

Ishier Raote

@ishier_raote · X

RT @ccstorytime: Need a suggestion for journal club? This one by @KarlKadler lab and me! https://t.co/nMS0ipnvzI #Circadian control of the…

Jan 6, 2020 · 8 shares · 1,274 followers View post →

Chloé Yeung

@ccstorytime · X

Jan 6, 2020 · 39 likes · 8 shares · 1,701 followers View post →

SwissMatrixBio

@SwissMatrixBio · X

RT @KarlKadler: Congrats to our team!

Nov 26, 2019 · 16 shares · 454 followers View post →

RUBICON network

@rubicon_network · X

RT @KarlKadler: Congrats to our team!

Nov 25, 2019 · 16 shares · 192 followers View post →

ErlerLab

@ErlerLab · X

RT @KarlKadler: Congrats to our team!

Nov 25, 2019 · 16 shares · 1,051 followers View post →

Judi Allen

@ProfJudiAllen · X

RT @KarlKadler: Congrats to our team!

Nov 23, 2019 · 16 shares · 3,315 followers View post →

franzappa

@franzappa2 · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 513 followers View post →

ASMB

@amsocmatbio · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 1,728 followers View post →

Davy Vanhoutte

@davy_vanhoutte · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 179 followers View post →

Joan Chang

@tranejoan · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 959 followers View post →

s. Peter Magnusson

@SPMagnuss · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 423 followers View post →

Ishier Raote

@ishier_raote · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 1,274 followers View post →

Tom Van Agtmael

@TomVanAgtmael · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 1,128 followers View post →

Sarah Snelling

@Sarah_JB_S · X

RT @KarlKadler: Congrats to our team!

Nov 22, 2019 · 16 shares · 2,162 followers View post →

Karl Kadler

@KarlKadler · X

Congrats to our team!

Nov 22, 2019 · 95 likes · 16 shares · 1,037 followers View post →

Circadian control of the secretory pathway maintains collagen homeostasis.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Circadian Regulation of Collagen Production and Transport in Tissue Homeostasis

Circadian Regulation of Collagen Production and Homeostasis in Vertebrates